KEGG   Mus musculus (house mouse): 17768
Entry
17768             CDS       T01002                                 
Symbol
Mthfd2, NMDMC
Name
(RefSeq) methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
  KO
K13403  methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00670  One carbon pool by folate
mmu01100  Metabolic pathways
mmu01240  Biosynthesis of cofactors
Module
mmu_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    17768 (Mthfd2)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.15  methylenetetrahydrofolate dehydrogenase (NAD+)
     17768 (Mthfd2)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     17768 (Mthfd2)
SSDB
Motif
Pfam: THF_DHG_CYH_C THF_DHG_CYH AlaDh_PNT_C PirA-like
Other DBs
NCBI-GeneID: 17768
NCBI-ProteinID: NP_032664
MGI: 1338850
Ensembl: ENSMUSG00000005667
UniProt: P18155
Position
6:complement(83282686..83302926)
AA seq 350 aa
MASVSLLSALAVRLLRPTHGCHPRLQPFHLAAVRNEAVVISGRKLAQQIKQEVQQEVEEW
VASGNKRPHLSVILVGDNPASHSYVLNKTRAAAEVGINSETIVKPASVSEEELLNSIRKL
NNDENVDGLLVQLPLPEHIDERKVCNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGV
WEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQL
KKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVQDPVTAKPKLVGDVDFEGVKK
KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRPEELEVFKSKQRGVATN
NT seq 1053 nt   +upstreamnt  +downstreamnt
atggcttcagtttccttgttgtctgcgttggctgtgcggttgttgcgccccacgcacggc
tgccacccccgcctacagcccttccacctggcggcagtgcgaaatgaagccgttgtcatt
tctggaaggaaactggcccagcagatcaagcaagaagtacagcaggaggtggaagagtgg
gtggcctcaggcaacaagcggccacacctcagtgtcattctggttggtgacaatcccgcc
agtcactcctatgttctcaacaaaaccagggcagcagctgaagtgggaatcaacagtgag
acaattgtgaaaccagcctcagtttcagaggaagagctgctgaattcaatcaggaagctg
aacaacgatgagaacgtagatggcctccttgttcagctgccactcccagagcacattgat
gagaggaaggtctgcaatgccgtttctcctgacaaggatgttgatggctttcatgtcatt
aacgtggggcgaatgtgcttggaccagtactctatgctgccagcaaccccatggggcgtg
tgggagataattaagcgaacaggcattccaaccttagggaagaatgtggtagtggctggc
aggtcaaaaaacgttggaatgccgattgcaatgttgctgcacacagatggagctcacgaa
cggcccgggggtgatgccacagtcacaatatctcatcgatacactcccaaagagcagctg
aagaagcacacgatccttgcagacattgtaatatctgccgctggcattccaaatctgatc
acagctgacatgatcaaggaaggagcagcggtcatcgatgtgggaataaacagagttcaa
gatcctgtcactgcaaagcccaaattggttggagatgtggattttgaaggagtcaagaag
aaagctggttatatcactcccgtccctggtggtgtgggtcccatgaccgtggccatgctc
atgaagaacaccattattgccgcaaagaaagtgctaagaccagaggagctggaagtgttc
aagtccaaacagcgcggagtcgccaccaactag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (49)   
   RefSeq(nuc) (3)   
   GenBank (23)   
   EMBL (23)   
Protein domain (4)   
   Pfam (4)   
All databases (88)   

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