KEGG   Mus musculus (house mouse): 18129
Entry
18129             CDS       T01002                                 
Symbol
Notch2, N2
Name
(RefSeq) notch 2
  KO
K20994  Notch 2
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu01522  Endocrine resistance
mmu04330  Notch signaling pathway
mmu04658  Th1 and Th2 cell differentiation
mmu04919  Thyroid hormone signaling pathway
mmu05165  Human papillomavirus infection
mmu05200  Pathways in cancer
mmu05206  MicroRNAs in cancer
mmu05207  Chemical carcinogenesis - receptor activation
mmu05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    18129 (Notch2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    18129 (Notch2)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    18129 (Notch2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    18129 (Notch2)
   05206 MicroRNAs in cancer
    18129 (Notch2)
   05207 Chemical carcinogenesis - receptor activation
    18129 (Notch2)
  09162 Cancer: specific types
   05224 Breast cancer
    18129 (Notch2)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    18129 (Notch2)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    18129 (Notch2)
SSDB
Motif
Pfam: EGF hEGF EGF_CA EGF_2 Ank_2 Ank Notch NOD NODP Ank_5 Ank_3 Ank_4 EGF_3 FXa_inhibition DL-JAG_EGF-like cEGF
Other DBs
NCBI-GeneID: 18129
NCBI-ProteinID: NP_035058
MGI: 97364
Ensembl: ENSMUSG00000027878
UniProt: O35516
Position
3:97920854..98057683
AA seq 2473 aa
MPALRPAALRALLWLWLCGAGPAHALQCRGGQEPCVNEGTCVTYHNGTGFCRCPEGFLGE
YCQHRDPCEKNRCQNGGTCVPQGMLGKATCRCAPGFTGEDCQYSTSHPCFVSRPCQNGGT
CHMLSRDTYECTCQVGFTGKQCQWTDACLSHPCENGSTCTSVASQFSCKCPAGLTGQKCE
ADINECDIPGRCQHGGTCLNLPGSYRCQCPQGFTGQHCDSPYVPCAPSPCVNGGTCRQTG
DFTFECNCLPGFEGSTCERNIDDCPNHKCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVD
ECLLQPNACQNGGTCTNRNGGYGCVCVNGWSGDDCSENIDDCAYASCTPGSTCIDRVASF
SCLCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECA
MANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTC
LCMPGFKGVHCELEVNECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTP
CLNGAKCIDHPNGYECQCATGFTGILCDENIDNCDPDPCHHGQCQDGIDSYTCICNPGYM
GAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGLNCEINFDDCASNPCMHGVCV
DGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINDVNGFRCICPEGPHHPSCYSQ
VNECLSNPCIHGNCTGGLSGYKCLCDAGWVGVNCEVDKNECLSNPCQNGGTCNNLVNGYR
CTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDVSGYTCHCMLPYTGKNCQTVLAPCSPN
PCENAAVCKEAPNFESFSCLCAPGWQGKRCTVDVDECISKPCMNNGVCHNTQGSYVCECP
PGFSGMDCEEDINDCLANPCQNGGSCVDHVNTFSCQCHPGFIGDKCQTDMNECLSEPCKN
GGTCSDYVNSYTCTCPAGFHGVHCENNIDECTESSCFNGGTCVDGINSFSCLCPVGFTGP
FCLHDINECSSNPCLNAGTCVDGLGTYRCICPLGYTGKNCQTLVNLCSRSPCKNKGTCVQ
EKARPHCLCPPGWDGAYCDVLNVSCKAAALQKGVPVEHLCQHSGICINAGNTHHCQCPLG
YTGSYCEEQLDECASNPCQHGATCNDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGG
TCIDLVNHFKCSCPPGTRGLLCEENIDECAGGPHCLNGGQCVDRIGGYTCRCLPGFAGER
CEGDINECLSNPCSSEGSLDCVQLKNNYNCICRSAFTGRHCETFLDVCPQKPCLNGGTCA
VASNMPDGFICRCPPGFSGARCQSSCGQVKCRRGEQCIHTDSGPRCFCLNPKDCESGCAS
NPCQHGGTCYPQRQPPHYSCRCPPSFGGSHCELYTAPTSTPPATCQSQYCADKARDGICD
EACNSHACQWDGGDCSLTMEDPWANCTSTLRCWEYINNQCDEQCNTAECLFDNFECQRNS
KTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCASDQPENLAEGTLIIVVLLPPEQLLQ
DSRSFLRALGTLLHTNLRIKQDSQGALMVYPYFGEKSAAMKKQKMTRRSLPEEQEQEQEV
IGSKIFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLSYPLVSVFSELESPRNAQL
LYLLAVAVVIILFFILLGVIMAKRKRKHGFLWLPEGFTLRRDSSNHKRREPVGQDAVGLK
NLSVQVSEANLIGSGTSEHWVDDEGPQPKKAKAEDEALLSEDDPIDRRPWTQQHLEAADI
RHTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANII
TDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVA
ADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKS
ALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDIT
DHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVLCGPNRSFLSLKHTPM
GKKARRPNTKSTMPTSLPNLAKEAKDAKGSRRKKCLNEKVQLSESSVTLSPVDSLESPHT
YVSDATSSPMITSPGILQASPTPLLAAAAPAAPVHTQHALSFSNLHDMQPLAPGASTVLP
SVSQLLSHHHIAPPGSSSAGSLGRLHPVPVPADWMNRVEMNETQYSEMFGMVLAPAEGAH
PGIAAPQSRPPEGKHMSTQREPLPPIVTFQLIPKGSIAQAAGAPQTQSSCPPAVAGPLPS
MYQIPEMPRLPSVAFPPTMMPQQEGQVAQTIVPTYHPFPASVGKYPTPPSQHSYASSNAA
ERTPSHGGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGGGGGQRGPGTH
MSEPPHSNMQVYA
NT seq 7422 nt   +upstreamnt  +downstreamnt
atgcccgctctgcgtcccgccgcgctgcgggcgctgctgtggctctggctgtgcggcgcg
ggccccgcgcacgctttgcagtgtcgaggtggtcaagagccctgtgtaaatgaagggacc
tgtgttacctaccacaacggcacaggcttctgccgatgtccagagggcttcttgggagaa
tattgccaacatcgagacccctgtgagaaaaaccgctgtcagaatggtggtacttgtgtg
ccgcagggcatgttggggaaagctacctgccgatgtgctccaggattcacaggagaggac
tgccaatactccacctctcacccctgctttgtgtcccgcccttgtcagaatgggggtacc
tgtcacatgctcagccgggacacctacgagtgcacctgccaagtcggcttcacagggaag
cagtgtcagtggacagatgcctgtctatctcatccctgcgaaaatggaagcacctgtaca
tctgtggccagccagttctcctgcaaatgccctgcaggcctcacagggcagaagtgtgaa
gctgatatcaatgagtgtgacattccaggacgctgccaacatggtggcacctgcctcaac
cttcctggttcctacagatgccaatgtcctcagggcttcacaggccagcactgtgacagc
ccttatgtgccctgtgcaccctcgccctgcgtcaacggaggcacctgtcgtcagactggc
gacttcactttcgaatgcaactgcctgccaggttttgaagggagcacctgtgagcggaat
atcgacgactgccccaaccacaagtgtcagaatggaggagtttgtgtggatggtgtcaat
acctacaattgccgctgtccccctcagtggactgggcagttctgcacagaagatgtggac
gagtgtctgttgcagcccaacgcttgtcagaatggaggcacctgcaccaaccgaaacgga
ggctatggctgcgtgtgtgtgaacggctggagcggagatgactgcagcgagaatatcgat
gactgtgcctatgcttcctgcacgccagggtccacctgcattgaccgcgtggcctccttc
tcctgcctgtgtccggagggaaaggcgggtctcctgtgccatctggatgatgcctgtatc
agcaacccttgtcacaagggggcgctgtgtgacaccaaccccctgaacgggcagtacatt
tgcacctgcccacagggctacaagggcgctgactgcacagaagacgtggatgagtgtgct
atggccaacagtaacccttgtgagcatgcaggaaagtgtgtgaatacagatggcgccttc
cactgtgagtgtctgaagggctacgcagggcctcgctgtgagatggacatcaacgagtgt
cattcagacccctgccagaacgacgccacctgcctggataagatcggaggcttcacctgt
ctgtgcatgccaggtttcaaaggtgtgcattgtgagctggaggtaaatgaatgccagagc
aacccgtgtgtgaacaacgggcagtgtgtggacaaagtcaaccgcttccagtgtctgtgt
ccccctggcttcacaggaccagtgtgccagatcgacattgatgactgctccagtactccc
tgcctgaatggggccaagtgcatcgatcacccgaatggctatgaatgccagtgtgccaca
ggtttcactggcatattgtgtgatgagaacatcgacaactgtgacccagatccttgccac
catggccagtgccaggatgggatcgactcctacacctgcatctgcaaccctgggtacatg
ggagccatctgtagtgaccagattgatgaatgctacagcagcccttgcttgaacgatggg
cgctgcattgacctggtgaatggttaccagtgcaactgccaaccaggcacatcaggcctt
aattgtgaaattaattttgatgactgtgccagcaacccttgtatgcacggagtctgtgtg
gacggcatcaatcgctacagctgtgtgtgctctccgggattcacaggccagaggtgcaat
attgacattgatgagtgtgcctccaacccctgtcgcaagggtgcgacgtgcatcaatgat
gtgaatggtttccggtgtatatgccccgagggaccgcatcatcctagctgctactcacag
gtgaacgagtgcctgagcaatccctgcatccacggaaactgtactggaggtctcagtggc
tataagtgcctctgcgatgcaggctgggttggtgtcaactgtgaggtggacaaaaatgag
tgtctttctaacccatgccagaatggaggaacgtgcaataacctggtgaatggctacagg
tgtacctgcaagaaggggttcaaaggctacaactgccaggtgaatatagatgagtgtgcc
tccaacccgtgtctgaaccaaggaacctgctttgatgacgtcagtggctacacttgccac
tgcatgttgccttacacaggcaagaactgtcaaacagtgttggctccctgttccccaaac
ccgtgtgagaatgctgctgtttgtaaagaggcacccaattttgagagcttcagctgcttg
tgtgctcctggctggcaaggtaaacgatgtacagttgacgttgatgagtgtatctccaag
ccgtgtatgaacaatggtgtctgccacaacactcagggcagctacgtgtgtgagtgtcct
cccggcttcagtgggatggactgtgaagaggacatcaatgattgccttgccaacccctgc
cagaacggaggctcctgtgtggaccatgtgaataccttctcctgccagtgccatcctggc
ttcataggggacaagtgccagacagacatgaatgagtgtctgagcgagccctgtaagaat
ggggggacctgctccgactatgtcaacagttacacctgcacatgccctgcgggcttccac
ggagtccactgtgaaaacaacattgacgagtgcactgagagctcctgcttcaatggcggc
acgtgtgttgatggaatcaactctttctcttgcttgtgccccgtgggtttcactggtccc
ttctgcctccatgatatcaatgagtgcagctctaacccgtgcctgaatgctggaacgtgt
gttgatggtctgggtacctaccgatgcatctgtcccttgggctacaccgggaaaaactgt
cagaccctggtgaacctctgcagccggtctccgtgtaaaaacaaaggaacttgtgttcag
gaaaaggcaaggccccactgtctgtgtccgcctggatgggatggtgcatactgtgatgtg
ctcaacgtgtcctgtaaggcggcagccttgcagaaaggagtacctgttgaacacttgtgc
cagcactcgggcatctgtatcaatgctggcaacacccatcactgccagtgccccctgggc
tacacggggagctactgcgaggagcagcttgatgagtgtgcatccaatccatgccagcac
ggtgccacctgcaatgacttcatcggaggatacagatgtgagtgtgttccaggatatcag
ggtgtcaactgtgagtatgaagtggacgagtgccagaaccaaccctgccagaatggaggc
acctgcatcgaccttgtgaaccatttcaagtgttcgtgtcccccaggcacccggggcctg
ctgtgtgaagagaacatcgatgaatgtgctgggggcccccactgccttaacggtggccag
tgcgtggaccggattggaggctacacttgtcgctgtttgcctggctttgctggggagcgg
tgtgagggggacatcaacgaatgcctgtccaacccttgcagctcagagggcagcctggac
tgcgttcagctcaaaaataactacaactgtatctgccgcagcgccttcacgggccggcac
tgtgaaaccttcctagatgtgtgtccccagaagccttgcctgaacggagggacttgtgcc
gtggctagcaacatgcccgatggcttcatctgtcgttgtcccccagggttctctggggcg
agatgccagagcagctgtggacaagtgaagtgcaggagaggggagcagtgtatccacact
gactcgggacctcgctgcttctgcctgaaccccaaggactgcgagtcaggatgtgccagt
aacccctgccagcatgggggcacctgctatcctcagcgccagcctcctcactattcctgc
cgctgccctccgtcgttcgggggcagccactgcgaactctacacagcccccaccagcacc
cctcctgctacctgtcagagtcagtactgcgccgacaaggctcgggatggcatctgtgac
gaggcctgcaatagtcatgcctgccagtgggatggaggtgactgttccctcactatggag
gacccctgggccaactgcacctccactcttcgctgctgggaatacatcaacaaccagtgt
gatgagcagtgcaacaccgcagagtgcctgtttgacaactttgagtgccagaggaatagc
aagacgtgcaagtatgacaaatactgtgcagaccacttcaaagacaaccactgtgatcag
ggatgcaacagcgaggagtgtggctgggatgggctggactgcgcttcggaccagcctgag
aacctggcagagggcaccctgatcatcgtggtgctcctgccccctgaacagctgctgcag
gattcgcgaagcttcttgagggccctgggcaccctgctccacaccaacttgcgcattaaa
caagattctcagggcgctctcatggtgtacccctactttggggagaagtcagctgccatg
aagaagcagaagatgacacgcaggtctcttcctgaggagcaggagcaggagcaggaggtg
ataggctctaagatatttctggagatcgacaaccgacagtgtgttcaagattcagaccag
tgcttcaaaaacacagatgcggcagctgctctcctggcttctcatgccatccaagggacc
ctatcctaccctctagtgtctgttttcagtgaactggagagtccaagaaacgcccagctt
ctctatctgctcgcggtcgctgttgtcatcatcctgttcttcatcctgctgggggtcatc
atggccaagcggaagcgcaagcatggcttcctctggctgccggaagggttcaccctccgc
cgagactctagcaatcacaagcgccgtgaacctgtgggacaggatgccgtggggctgaaa
aatctctccgtgcaagtgtcagaggctaacctgattggttctgggacaagtgaacattgg
gttgatgatgaaggaccccagccaaagaaagccaaggctgaggatgaggctttgctgtcg
gaagatgaccccatcgatcgacggccctggacacagcagcaccttgaagctgcagacatc
cgccacactccatccctggcactcactcctcctcaggcagaacaggaggtggacgtgctg
gacgtgaatgtccgaggcccagatgggtgtactccactgatgctggcttctctccgagga
ggcagctcagacctgagtgatgaagacgaagatgctgaggactcttctgccaacatcatc
acagacttggtctaccaaggtgccagccttcaagcacagacagaccgcactggcgagatg
gccctgcaccttgcagcccgctattcgagagctgatgctgccaaacgcctcctggatgct
ggtgcggatgcaaatgcccaggacaacatgggccgatgtcctcttcacgctgcggtggca
gcagacgcccaaggtgtctttcagattctgatccgcaaccgtgtaaccgatctggatgcc
agaatgaacgatggtactacccccctgatcctggctgcccgcctggctgtggaaggaatg
gtggcagagttgatcaattgccaagcagatgtcaatgcagtggatgaccatggaaaatct
gccctccactgggcagctgctgtcaataatgtggaggcgactcttctgctgttgaagaat
ggggccaacagagatatgcaggacaataaggaagagacacctttgtttcttgctgcccga
gagggaagttatgaagcggccaaaatcctgttagaccattttgccaaccgggacatcact
gaccacatggaccgccttccccgggatgtggctcgggaccgcatgcaccatgacatcgtt
cgcctcctggacgagtataacgtgactcccagccctccgggaacggtcttgacttctgcg
ctctcacctgtcctctgtgggcccaacaggtctttcctcagtctgaagcacaccccaatg
ggtaagaaggctaggcggcccaacaccaagagcaccatgcccacgagcctgcctaacctt
gccaaggaggccaaggatgccaagggcagcaggaggaagaagtgtctgaacgagaaggtc
cagctgtccgagagctcagtgactctatcccccgtcgattcgctcgagtctcctcacacg
tatgtctccgatgccacatcctctcccatgatcacatcccctggaatcttacaggcctcg
cccacccccctgctggctgctgccgccccggctgccccagtgcacacacagcatgcgctg
tctttctctaaccttcatgacatgcagcctttggctcctggagccagcaccgtgctcccc
tcggtcagccagctgctatcccaccaccacatcgcgcccccaggtagtagcagtgcagga
agcttgggcaggttacatccagttcctgtcccagcagactggatgaaccgtgtggagatg
aacgagacccagtacagtgaaatgtttggcatggtcctggctcctgcagagggagcccac
cctggcatagcagctccccagagcagacctccggaagggaagcacatgtccacccagcgg
gagcccttgcctcccatcgtgactttccagcttatcccaaaaggcagcattgcccaggca
gccggagctccccagacgcagtccagttgccctccagctgttgcaggccccttgccctct
atgtaccagatcccagagatgccccgtttgcccagtgtggctttcccacctaccatgatg
ccccagcaggaggggcaggtagctcagaccattgtgccaacctatcatcctttcccagcc
tctgtgggcaagtaccccacacccccttcccaacacagttacgcctcctcaaatgctgct
gagcgaacccccagtcatggtggtcacctccagggcgagcacccatacctgacaccatcc
ccagagtctcctgaccaatggtcaagctcttcaccacactctgcatctgactggtcagat
gtgaccaccagcccaactcctggaggtggtggaggcggtcagcggggacccggaacacac
atgtccgagccaccacacagcaacatgcaggtgtatgcatga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (9)   
Genome (1)   
   KEGG GENOME (1)   
Gene (143)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (136)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
Protein domain (16)   
   Pfam (16)   
All databases (190)   

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