KEGG   Mus musculus (house mouse): 18750
Entry
18750             CDS       T01002                                 
Symbol
Prkca, Pkca
Name
(RefSeq) protein kinase C, alpha
  KO
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu04010  MAPK signaling pathway
mmu04012  ErbB signaling pathway
mmu04014  Ras signaling pathway
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04066  HIF-1 signaling pathway
mmu04070  Phosphatidylinositol signaling system
mmu04071  Sphingolipid signaling pathway
mmu04072  Phospholipase D signaling pathway
mmu04150  mTOR signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04270  Vascular smooth muscle contraction
mmu04310  Wnt signaling pathway
mmu04360  Axon guidance
mmu04370  VEGF signaling pathway
mmu04510  Focal adhesion
mmu04540  Gap junction
mmu04613  Neutrophil extracellular trap formation
mmu04650  Natural killer cell mediated cytotoxicity
mmu04664  Fc epsilon RI signaling pathway
mmu04666  Fc gamma R-mediated phagocytosis
mmu04670  Leukocyte transendothelial migration
mmu04713  Circadian entrainment
mmu04720  Long-term potentiation
mmu04723  Retrograde endocannabinoid signaling
mmu04724  Glutamatergic synapse
mmu04725  Cholinergic synapse
mmu04726  Serotonergic synapse
mmu04727  GABAergic synapse
mmu04728  Dopaminergic synapse
mmu04730  Long-term depression
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04911  Insulin secretion
mmu04912  GnRH signaling pathway
mmu04916  Melanogenesis
mmu04918  Thyroid hormone synthesis
mmu04919  Thyroid hormone signaling pathway
mmu04921  Oxytocin signaling pathway
mmu04925  Aldosterone synthesis and secretion
mmu04926  Relaxin signaling pathway
mmu04928  Parathyroid hormone synthesis, secretion and action
mmu04929  GnRH secretion
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu04935  Growth hormone synthesis, secretion and action
mmu04960  Aldosterone-regulated sodium reabsorption
mmu04961  Endocrine and other factor-regulated calcium reabsorption
mmu04970  Salivary secretion
mmu04971  Gastric acid secretion
mmu04972  Pancreatic secretion
mmu05017  Spinocerebellar ataxia
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05031  Amphetamine addiction
mmu05032  Morphine addiction
mmu05143  African trypanosomiasis
mmu05146  Amoebiasis
mmu05161  Hepatitis B
mmu05163  Human cytomegalovirus infection
mmu05164  Influenza A
mmu05170  Human immunodeficiency virus 1 infection
mmu05171  Coronavirus disease - COVID-19
mmu05200  Pathways in cancer
mmu05205  Proteoglycans in cancer
mmu05206  MicroRNAs in cancer
mmu05207  Chemical carcinogenesis - receptor activation
mmu05214  Glioma
mmu05223  Non-small cell lung cancer
mmu05225  Hepatocellular carcinoma
mmu05231  Choline metabolism in cancer
mmu05415  Diabetic cardiomyopathy
mmu05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    18750 (Prkca)
   04012 ErbB signaling pathway
    18750 (Prkca)
   04014 Ras signaling pathway
    18750 (Prkca)
   04015 Rap1 signaling pathway
    18750 (Prkca)
   04310 Wnt signaling pathway
    18750 (Prkca)
   04370 VEGF signaling pathway
    18750 (Prkca)
   04066 HIF-1 signaling pathway
    18750 (Prkca)
   04020 Calcium signaling pathway
    18750 (Prkca)
   04070 Phosphatidylinositol signaling system
    18750 (Prkca)
   04072 Phospholipase D signaling pathway
    18750 (Prkca)
   04071 Sphingolipid signaling pathway
    18750 (Prkca)
   04151 PI3K-Akt signaling pathway
    18750 (Prkca)
   04150 mTOR signaling pathway
    18750 (Prkca)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    18750 (Prkca)
   04540 Gap junction
    18750 (Prkca)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    18750 (Prkca)
   04650 Natural killer cell mediated cytotoxicity
    18750 (Prkca)
   04664 Fc epsilon RI signaling pathway
    18750 (Prkca)
   04666 Fc gamma R-mediated phagocytosis
    18750 (Prkca)
   04670 Leukocyte transendothelial migration
    18750 (Prkca)
  09152 Endocrine system
   04911 Insulin secretion
    18750 (Prkca)
   04929 GnRH secretion
    18750 (Prkca)
   04912 GnRH signaling pathway
    18750 (Prkca)
   04921 Oxytocin signaling pathway
    18750 (Prkca)
   04926 Relaxin signaling pathway
    18750 (Prkca)
   04935 Growth hormone synthesis, secretion and action
    18750 (Prkca)
   04918 Thyroid hormone synthesis
    18750 (Prkca)
   04919 Thyroid hormone signaling pathway
    18750 (Prkca)
   04928 Parathyroid hormone synthesis, secretion and action
    18750 (Prkca)
   04916 Melanogenesis
    18750 (Prkca)
   04925 Aldosterone synthesis and secretion
    18750 (Prkca)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    18750 (Prkca)
   04270 Vascular smooth muscle contraction
    18750 (Prkca)
  09154 Digestive system
   04970 Salivary secretion
    18750 (Prkca)
   04971 Gastric acid secretion
    18750 (Prkca)
   04972 Pancreatic secretion
    18750 (Prkca)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    18750 (Prkca)
   04961 Endocrine and other factor-regulated calcium reabsorption
    18750 (Prkca)
  09156 Nervous system
   04724 Glutamatergic synapse
    18750 (Prkca)
   04727 GABAergic synapse
    18750 (Prkca)
   04725 Cholinergic synapse
    18750 (Prkca)
   04728 Dopaminergic synapse
    18750 (Prkca)
   04726 Serotonergic synapse
    18750 (Prkca)
   04720 Long-term potentiation
    18750 (Prkca)
   04730 Long-term depression
    18750 (Prkca)
   04723 Retrograde endocannabinoid signaling
    18750 (Prkca)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    18750 (Prkca)
  09158 Development and regeneration
   04360 Axon guidance
    18750 (Prkca)
  09159 Environmental adaptation
   04713 Circadian entrainment
    18750 (Prkca)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    18750 (Prkca)
   05206 MicroRNAs in cancer
    18750 (Prkca)
   05205 Proteoglycans in cancer
    18750 (Prkca)
   05207 Chemical carcinogenesis - receptor activation
    18750 (Prkca)
   05231 Choline metabolism in cancer
    18750 (Prkca)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    18750 (Prkca)
   05214 Glioma
    18750 (Prkca)
   05223 Non-small cell lung cancer
    18750 (Prkca)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    18750 (Prkca)
   05161 Hepatitis B
    18750 (Prkca)
   05171 Coronavirus disease - COVID-19
    18750 (Prkca)
   05164 Influenza A
    18750 (Prkca)
   05163 Human cytomegalovirus infection
    18750 (Prkca)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    18750 (Prkca)
   05143 African trypanosomiasis
    18750 (Prkca)
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    18750 (Prkca)
   05022 Pathways of neurodegeneration - multiple diseases
    18750 (Prkca)
  09165 Substance dependence
   05031 Amphetamine addiction
    18750 (Prkca)
   05032 Morphine addiction
    18750 (Prkca)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    18750 (Prkca)
   05415 Diabetic cardiomyopathy
    18750 (Prkca)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    18750 (Prkca)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    18750 (Prkca)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    18750 (Prkca)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    18750 (Prkca)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     18750 (Prkca)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   18750 (Prkca)
Membrane trafficking [BR:mmu04131]
 Endocytosis
  Lipid raft mediated endocytosis
   Caveolin-mediated endocytosis
    18750 (Prkca)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr C1_1 C2 Pkinase_C C1_2 ABC1 DUF4656
Other DBs
NCBI-GeneID: 18750
NCBI-ProteinID: NP_035231
MGI: 97595
Ensembl: ENSMUSG00000050965
UniProt: P20444 Q4VA93
Structure
Position
11:complement(107824213..108237360)
AA seq 672 aa
MADVYPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
NT seq 2019 nt   +upstreamnt  +downstreamnt
atggctgacgtttacccggccaacgactccacggcgtctcaggacgtggccaaccgcttc
gcccgcaaaggggcgctgaggcagaagaacgtgcatgaggtgaaagaccacaaattcatc
gcccgcttcttcaagcaacccaccttctgcagccactgcaccgacttcatctgggggttt
gggaaacaaggcttccagtgccaagtttgctgttttgtggttcataagaggtgccatgag
ttcgttacgttctcttgtccgggtgcggataagggacctgacactgacgaccccaggagc
aagcacaagttcaaaatccacacatacggaagccctaccttctgtgatcactgtgggtcc
ctgctctatggacttatccaccaagggatgaaatgtgacacctgcgacatgaatgttcac
aagcagtgtgtgatcaatgtccctagcctctgcggaatggatcacacagagaagaggggg
cggatttatctgaaggctgaggtcactgatgaaaagctccacgtcacggtacgagatgca
aaaaatctaatccctatggatccaaatgggctttcggatccttatgtgaagctgaaactt
atccctgaccccaagaatgagagcaaacagaaaaccaaaaccatccgctccacactgaat
cctcagtggaatgagtccttcacgttcaaattaaaaccttcagacaaagaccggcgactg
tctgtagaaatctgggactgggatcggacgactcggaatgacttcatgggatccctttcc
tttggtgtctcagagctaatgaagatgccggccagtggatggtataaactgctcaaccaa
gaagagggcgaatactacaatgtgcccattccagaaggagatgaagaaggcaacatggaa
ctcaggcagaagtttgagaaagccaagctaggccctgctggtaacaaagtcatcagccct
tcagaagacagaaagcaaccatccaacaacctggacagagtgaaactcacagacttcaac
ttcctcatggtgctggggaaggggagttttgggaaggtgatgcttgctgacaggaaggga
acggaggaactgtacgccatcaagatcctgaagaaggacgtggtgatccaggacgacgac
gtggagtgcaccatggtggagaagcgcgtgctggccctgctggacaagccgccatttctg
acacagctgcactcctgcttccagacagtggaccggctgtacttcgtcatggaatacgtc
aacggcggggacctcatgtaccacattcagcaagtcgggaaatttaaggagccacaagca
gtattctacgcagccgagatctccatcggactgttcttccttcataaaagagggatcatt
tacagggatctgaagctggacaatgtcatgctggactcagaagggcacatcaaaatcgcc
gactttgggatgtgcaaggaacacatgatggatggagtcacgaccaggaccttctgtggg
actccggactacattgccccagagataatcgcttaccagccgtacgggaagtctgtagat
tggtgggcgtacggtgtgctgctgtacgagatgctagccgggcagcctccgtttgatggt
gaagatgaagatgaactgtttcagtctataatggagcacaacgtgtcctaccccaaatcc
ttgtccaaggaagccgtctctatctgcaaaggacttatgaccaaacaccctgccaagcgg
ctgggctgcgggcccgagggagagagggatgtcagagagcatgccttcttcaggagaatc
gactgggagaaactggagaacagggagatccaaccaccattcaagcccaaagtgtgtggc
aaaggagcagaaaactttgacaagttcttcacgcgaggacagcctgtcttaacaccacca
gatcagctggtcattgctaacatagaccaatctgattttgaagggttctcgtatgtcaac
ccccagtttgtgcacccaatcttgcaaagtgcagtatga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (72)   
   KEGG PATHWAY (72)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (20)   
   RefSeq(nuc) (2)   
   GenBank (9)   
   EMBL (9)   
3D Structure (1)   
   PDB (1)   
Protein domain (8)   
   Pfam (8)   
All databases (122)   

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