KEGG   Mus musculus (house mouse): 18797
Entry
18797             CDS       T01002                                 
Symbol
Plcb3, mKIAA4098
Name
(RefSeq) phospholipase C, beta 3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00562  Inositol phosphate metabolism
mmu01100  Metabolic pathways
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04062  Chemokine signaling pathway
mmu04070  Phosphatidylinositol signaling system
mmu04071  Sphingolipid signaling pathway
mmu04072  Phospholipase D signaling pathway
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04270  Vascular smooth muscle contraction
mmu04310  Wnt signaling pathway
mmu04371  Apelin signaling pathway
mmu04540  Gap junction
mmu04611  Platelet activation
mmu04613  Neutrophil extracellular trap formation
mmu04621  NOD-like receptor signaling pathway
mmu04713  Circadian entrainment
mmu04720  Long-term potentiation
mmu04723  Retrograde endocannabinoid signaling
mmu04724  Glutamatergic synapse
mmu04725  Cholinergic synapse
mmu04726  Serotonergic synapse
mmu04728  Dopaminergic synapse
mmu04730  Long-term depression
mmu04742  Taste transduction
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04911  Insulin secretion
mmu04912  GnRH signaling pathway
mmu04915  Estrogen signaling pathway
mmu04916  Melanogenesis
mmu04918  Thyroid hormone synthesis
mmu04919  Thyroid hormone signaling pathway
mmu04921  Oxytocin signaling pathway
mmu04922  Glucagon signaling pathway
mmu04924  Renin secretion
mmu04925  Aldosterone synthesis and secretion
mmu04926  Relaxin signaling pathway
mmu04927  Cortisol synthesis and secretion
mmu04928  Parathyroid hormone synthesis, secretion and action
mmu04929  GnRH secretion
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu04934  Cushing syndrome
mmu04935  Growth hormone synthesis, secretion and action
mmu04961  Endocrine and other factor-regulated calcium reabsorption
mmu04970  Salivary secretion
mmu04971  Gastric acid secretion
mmu04972  Pancreatic secretion
mmu04973  Carbohydrate digestion and absorption
mmu05010  Alzheimer disease
mmu05016  Huntington disease
mmu05017  Spinocerebellar ataxia
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05142  Chagas disease
mmu05143  African trypanosomiasis
mmu05146  Amoebiasis
mmu05163  Human cytomegalovirus infection
mmu05200  Pathways in cancer
mmu05415  Diabetic cardiomyopathy
mmu05417  Lipid and atherosclerosis
Module
mmu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    18797 (Plcb3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    18797 (Plcb3)
   04310 Wnt signaling pathway
    18797 (Plcb3)
   04371 Apelin signaling pathway
    18797 (Plcb3)
   04020 Calcium signaling pathway
    18797 (Plcb3)
   04070 Phosphatidylinositol signaling system
    18797 (Plcb3)
   04072 Phospholipase D signaling pathway
    18797 (Plcb3)
   04071 Sphingolipid signaling pathway
    18797 (Plcb3)
   04022 cGMP-PKG signaling pathway
    18797 (Plcb3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    18797 (Plcb3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    18797 (Plcb3)
   04613 Neutrophil extracellular trap formation
    18797 (Plcb3)
   04621 NOD-like receptor signaling pathway
    18797 (Plcb3)
   04062 Chemokine signaling pathway
    18797 (Plcb3)
  09152 Endocrine system
   04911 Insulin secretion
    18797 (Plcb3)
   04922 Glucagon signaling pathway
    18797 (Plcb3)
   04929 GnRH secretion
    18797 (Plcb3)
   04912 GnRH signaling pathway
    18797 (Plcb3)
   04915 Estrogen signaling pathway
    18797 (Plcb3)
   04921 Oxytocin signaling pathway
    18797 (Plcb3)
   04926 Relaxin signaling pathway
    18797 (Plcb3)
   04935 Growth hormone synthesis, secretion and action
    18797 (Plcb3)
   04918 Thyroid hormone synthesis
    18797 (Plcb3)
   04919 Thyroid hormone signaling pathway
    18797 (Plcb3)
   04928 Parathyroid hormone synthesis, secretion and action
    18797 (Plcb3)
   04916 Melanogenesis
    18797 (Plcb3)
   04924 Renin secretion
    18797 (Plcb3)
   04925 Aldosterone synthesis and secretion
    18797 (Plcb3)
   04927 Cortisol synthesis and secretion
    18797 (Plcb3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    18797 (Plcb3)
   04270 Vascular smooth muscle contraction
    18797 (Plcb3)
  09154 Digestive system
   04970 Salivary secretion
    18797 (Plcb3)
   04971 Gastric acid secretion
    18797 (Plcb3)
   04972 Pancreatic secretion
    18797 (Plcb3)
   04973 Carbohydrate digestion and absorption
    18797 (Plcb3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    18797 (Plcb3)
  09156 Nervous system
   04724 Glutamatergic synapse
    18797 (Plcb3)
   04725 Cholinergic synapse
    18797 (Plcb3)
   04728 Dopaminergic synapse
    18797 (Plcb3)
   04726 Serotonergic synapse
    18797 (Plcb3)
   04720 Long-term potentiation
    18797 (Plcb3)
   04730 Long-term depression
    18797 (Plcb3)
   04723 Retrograde endocannabinoid signaling
    18797 (Plcb3)
  09157 Sensory system
   04742 Taste transduction
    18797 (Plcb3)
   04750 Inflammatory mediator regulation of TRP channels
    18797 (Plcb3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    18797 (Plcb3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    18797 (Plcb3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    18797 (Plcb3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    18797 (Plcb3)
   05142 Chagas disease
    18797 (Plcb3)
   05143 African trypanosomiasis
    18797 (Plcb3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    18797 (Plcb3)
   05016 Huntington disease
    18797 (Plcb3)
   05017 Spinocerebellar ataxia
    18797 (Plcb3)
   05022 Pathways of neurodegeneration - multiple diseases
    18797 (Plcb3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    18797 (Plcb3)
   05415 Diabetic cardiomyopathy
    18797 (Plcb3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    18797 (Plcb3)
   04934 Cushing syndrome
    18797 (Plcb3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    18797 (Plcb3)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     18797 (Plcb3)
Membrane trafficking [BR:mmu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    18797 (Plcb3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    18797 (Plcb3)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PI-PLC-Y PH_14 EF-hand_like C2 DUF1154
Other DBs
NCBI-GeneID: 18797
NCBI-ProteinID: NP_001277278
MGI: 104778
Ensembl: ENSMUSG00000024960
UniProt: P51432
Position
19:complement(6931081..6951738)
AA seq 1234 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTVKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFPLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRSSQARLLIEKYETNKQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGPSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAEAAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLSAGIPLPSPQDLMGRILVKNKKRHRPSTGVPDS
SVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKTSLEPQKSLGE
ESLSREPNVPMPDRDREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEMSTLVNYVEP
VKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNY
MPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVI
VDGIVANALRVKVISGQFLSDKKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEE
PFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALL
IYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTETYQETPCQQ
PGSQLPSNPTPNPLDASPRWPPGPTTSSTSSSLSSPGQRDDLIASILSEVTPTPLEELRS
HKAMVKLRSRQDRDLRELHKKHQRKAVALTRRLLDGLAQARAEGKCRPSPSALGKATNSE
DVKEEEEAKQYREFQNRQVQSLLELREAQADVETKRKLEHLRQAHQRLKEVVLDTHTTQF
KRLKELNEREKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLE
EAQKQRHERLVAGQQQVLQQLEEEEPKLLAQLTQECQEQRERLPQEIRRCLLGETAEGLG
DGPLVACASNGHAPGSGGHLSSADSESQEENTQL
NT seq 3705 nt   +upstreamnt  +downstreamnt
atggcgggcgcgaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtgaccctgcgtgtggaccctaatggcttcttcttgtactggacaggacccaacatggag
gtggacacactggacatcagctccatcagggacacaaggacaggtcgttatgcccgcctg
cccaaggaccctaagattcgagaagtactgggctttggaggtcctgacacccggctggag
gagaaactgatgacagtggtggccgggccagatccagtaaataccacattcttgaacttc
atggccgtgcaagatgacacagtcaaggtctggtcagaggagttgtttaaactggccatg
aacatattggctcagaacgcctcccggaacaccttcctgcggaaagcatacacgaagctg
aagctgcaggtgaaccaggatggacggattccggtcaagaacattctgaagatgttctcg
gcggacaagaagcgggtggagacggcgctggagtcctgtggcctcaacttcaaccgaagt
gagtccattcgccctgatgagtttcccttggaaatttttgagcggttcttgaataaactg
tgtctgcgcccggatattgacaagatcctgctggagataggtgccaagggcaagccgtac
ctcactctggagcagctcatggactttatcaaccagaagcagagagacccgagactcaac
gaagtgctgtacccgccacttcggtcctcacaggctcggctgctcattgagaagtacgag
acgaacaaacagttcctggagcgcgaccagatgtctatggagggcttcagccgctacctg
ggaggggaggagaatggtatcctgcctctggaggccctggatctgagcatggacatgacc
cagccactgagcgcatattttatcaactcctcacacaacacctatctcactgcgggccag
ctggctggaccatcatcggtggagatgtaccgccaggcactgctgtggggctgccgctgt
gtggagctggatgtatggaagggacggccaccggaggaagagcctttcatcactcatggt
ttcaccatgaccactgaggtgccattgcgtgatgtgctagaggccatcgctgaggcagcc
ttcaagacctcgccctaccctgtcatcctctcctttgagaaccatgtcgactcggcaaag
cagcaggccaagatggctgagtactgccgctctatctttggggatgcgctgctcattgac
cctctcgacaaatacccgctatctgcgggcatccccctgcctagtccacaggacctgatg
ggccgtatcctggtgaagaataagaagcgacatcggcccagcacaggtgtccctgacagc
tcagtgcgcaagcggcctctggaacagagcaactcggccttgagtgagagctcggccgcc
acagagccctcctcacctcagcttgggtcccccagctccgacagctgccctggcctaagc
aatggggaggaggtgggactcgagaagaccagcctggagcctcagaagtctctaggtgag
gagagcctcagccgggaacctaatgtgcccatgcctgaccgtgaccgagaggatgaggag
gaagatgaagaagaagaggaaacaacggatccaaaaaagcccaccactgatgagggcaca
gccagcagtgaggtcaatgccacggaggagatgtcaacgctcgtcaactacgttgagccc
gtcaagttcaagtccttcgaggctgctcgaaaaaggaacaagtgcttcgagatgtcatcc
ttcgtggagaccaaggcaatggagcaactgaccaagagtcctatggagtttgtggaatac
aacaaacagcagctcagccgcatctaccctaagggcacacgagtggactcctccaactac
atgcctcagctcttctggaacgtgggttgccagcttgttgccctcaacttccagaccttg
gatttgccaatgcagctcaacgcaggcgtgtttgagtacaatgggcgcagcgggtacttg
ctcaagcccgagtttatgcggcggccggacaagtcttttgatcccttcactgaggtcatc
gtagatggcatagtggccaacgccttgcgggtcaaggtgatttcggggcagttcctgtct
gacaagaaggtgggcatctacgtcgaggtggacatgtttggcctcccagttgacacaaga
cgcaaatatcgtacccggacatcccaggggaactcattcaaccctgtgtgggacgaggaa
ccctttgacttccccaaggttgtgctgcccacgctggcctcacttcgcatcgcagccttt
gaggagggtggcaaatttgttgggcaccgtatcctgcctgtctctgctatccgctcagga
taccactatgtctgcctgcgaaacgaggccaaccaacctttgtgcctgcctgccctgctt
atctacactgaagcttctgactacatcccagatgaccaccaggactatgcggaggccttg
attaaccccatcaagcacgtaagcctaatggaccagcgggccaagcaactagccgctctc
attggggagagtgaggctcaggccagcacagagacatatcaggagaccccgtgtcaacag
ccagggtcacagctcccctccaaccccacacctaacccactggatgcctcacctcgctgg
ccccccggtcctaccacttcctccactagctcctccctcagtagcccagggcagcgagat
gatttgattgccagcatcctctctgaggtgacccctacacctctagaggagctcagaagc
cacaaggctatggtgaagctacggagccggcaggatcgagacctgcgggagttgcataag
aagcaccagcgcaaggctgtggccctcacccgccgccttctggatggcctggcccaggcc
agggctgaggggaagtgccggccctcccccagtgccctgggcaaggccaccaactcggag
gacgtgaaggaggaagaggaggccaaacagtatcgagagttccagaaccgacaagtacag
agcctgttggagctgagggaagcccaggcagatgtggagaccaagcggaagctggagcat
ctacgacaggctcatcagcggctcaaggaggttgtcctggatacacacacaacacagttc
aagaggctgaaggagctgaatgaaagggagaagaaggaactccagaagatcctggacagg
aagcgcaacaacagcatctcagaggccaagacaagggagaaacacaagaaggaggtggaa
ctgacagagattaatcggcggcacatcactgagtcggtaaactccatcagacggctggaa
gaggcccagaagcagcgccatgaacgcctggtggcagggcaacagcaagtcctccagcag
ctagaggaagaggaacccaagctgctggcccagctgacccaggagtgtcaggaacagcga
gagaggttgccccaggagatccgtcggtgcctgctgggcgagacagcagagggactgggg
gacggccccctggtggcctgtgccagcaatggtcatgcacctgggagtggtgggcacctg
tccagcgctgactcggagagccaggaggagaacacccagctttga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (61)   
   KEGG PATHWAY (60)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (36)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (28)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (42)   
   RefSeq(nuc) (4)   
   GenBank (19)   
   EMBL (19)   
Protein domain (7)   
   Pfam (7)   
All databases (167)   

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