KEGG   Mus musculus (house mouse): 19045
Entry
19045             CDS       T01002                                 
Symbol
Ppp1ca, Ppp1c, dism2
Name
(RefSeq) protein phosphatase 1 catalytic subunit alpha
  KO
K06269  serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu03015  mRNA surveillance pathway
mmu04022  cGMP-PKG signaling pathway
mmu04024  cAMP signaling pathway
mmu04114  Oocyte meiosis
mmu04218  Cellular senescence
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04270  Vascular smooth muscle contraction
mmu04390  Hippo signaling pathway
mmu04510  Focal adhesion
mmu04611  Platelet activation
mmu04720  Long-term potentiation
mmu04728  Dopaminergic synapse
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04810  Regulation of actin cytoskeleton
mmu04910  Insulin signaling pathway
mmu04921  Oxytocin signaling pathway
mmu04931  Insulin resistance
mmu05031  Amphetamine addiction
mmu05034  Alcoholism
mmu05168  Herpes simplex virus 1 infection
mmu05205  Proteoglycans in cancer
mmu05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    19045 (Ppp1ca)
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    19045 (Ppp1ca)
   04024 cAMP signaling pathway
    19045 (Ppp1ca)
   04022 cGMP-PKG signaling pathway
    19045 (Ppp1ca)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    19045 (Ppp1ca)
   04218 Cellular senescence
    19045 (Ppp1ca)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    19045 (Ppp1ca)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    19045 (Ppp1ca)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    19045 (Ppp1ca)
  09152 Endocrine system
   04910 Insulin signaling pathway
    19045 (Ppp1ca)
   04921 Oxytocin signaling pathway
    19045 (Ppp1ca)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    19045 (Ppp1ca)
   04270 Vascular smooth muscle contraction
    19045 (Ppp1ca)
  09156 Nervous system
   04728 Dopaminergic synapse
    19045 (Ppp1ca)
   04720 Long-term potentiation
    19045 (Ppp1ca)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    19045 (Ppp1ca)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    19045 (Ppp1ca)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    19045 (Ppp1ca)
  09165 Substance dependence
   05031 Amphetamine addiction
    19045 (Ppp1ca)
   05034 Alcoholism
    19045 (Ppp1ca)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    19045 (Ppp1ca)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    19045 (Ppp1ca)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:mmu01009]
    19045 (Ppp1ca)
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:mmu03021]
    19045 (Ppp1ca)
   03019 Messenger RNA biogenesis [BR:mmu03019]
    19045 (Ppp1ca)
   03041 Spliceosome [BR:mmu03041]
    19045 (Ppp1ca)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     19045 (Ppp1ca)
Protein phosphatases and associated proteins [BR:mmu01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    Catalytic subunits
     19045 (Ppp1ca)
Transcription machinery [BR:mmu03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     19045 (Ppp1ca)
Messenger RNA biogenesis [BR:mmu03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Cleavage and polyadenylation specificity factor (CPSF) complex
     19045 (Ppp1ca)
Spliceosome [BR:mmu03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   Other SAPs
    19045 (Ppp1ca)
SSDB
Motif
Pfam: Metallophos STPPase_N
Other DBs
NCBI-GeneID: 19045
NCBI-ProteinID: NP_114074
MGI: 103016
Ensembl: ENSMUSG00000040385
UniProt: P62137
Structure
Position
19:4242173..4245418
AA seq 330 aa
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIRYPENFFL
LRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDL
QSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHD
LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
KNKGKYGQFSGLNPGGRPITPPRNSAKAKK
NT seq 993 nt   +upstreamnt  +downstreamnt
atgtccgacagcgagaagctcaacctggactccatcatcgggcgcctgctggaagtgcag
ggctcacggcctgggaagaacgtgcagctgacagagaacgagatccgtggtctgtgcctc
aaatcccgggagattttcctgagccagcccattcttctggagcttgaggcgcccctcaag
atctgtggtgacatccatggccagtactatgaccttctacggctgtttgagtatggtggc
ttccctccagagagcaactacctcttcttgggggattatgtagatcggggcaagcagtct
ttggagaccatctgcctgttgctggcctataagatcagatacccggagaatttctttcta
cttcgtgggaaccatgagtgtgccagcatcaaccgcatttatggcttctatgatgaatgc
aagagaagatacaacatcaaactgtggaagacgttcactgactgcttcaactgcctgccc
attgcagccattgtggatgagaagatcttctgctgccacgggggcctgtctccagacttg
caatccatggagcagattaggcgtattatgcggcccacagacgtgcctgaccagggccta
ctgtgtgatctcctgtggtctgaccctgacaaggatgttcaaggctggggcgagaatgac
cgtggtgtctcctttacctttggggctgaggtggtagccaagttcctgcacaagcatgat
ttggacctcatctgcagagcacatcaggttgtagaagatggctatgagttctttgccaag
agacagttggtgacactcttctcagctcccaactactgtggagagtttgacaatgctggt
gccatgatgagtgtggatgagaccctcatgtgttccttccagatcctcaagcccgctgat
aagaataagggcaagtatgggcagttcagcggcctgaaccccggaggccggcccatcact
ccaccccgcaattctgccaaagccaagaaatag

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Ontology (6)   
   KEGG BRITE (6)   
Pathway (22)   
   KEGG PATHWAY (22)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (53)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (46)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (61)   
   RefSeq(nuc) (1)   
   GenBank (30)   
   EMBL (30)   
3D Structure (2)   
   PDB (2)   
Protein domain (2)   
   Pfam (2)   
All databases (151)   

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