KEGG   Mus musculus (house mouse): 19055
Entry
19055             CDS       T01002                                 
Symbol
Ppp3ca, 2900074D19Rik, CN, Caln, Calna, CnA
Name
(RefSeq) protein phosphatase 3, catalytic subunit, alpha isoform
  KO
K04348  serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04010  MAPK signaling pathway
mmu04020  Calcium signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04114  Oocyte meiosis
mmu04218  Cellular senescence
mmu04310  Wnt signaling pathway
mmu04360  Axon guidance
mmu04370  VEGF signaling pathway
mmu04380  Osteoclast differentiation
mmu04625  C-type lectin receptor signaling pathway
mmu04650  Natural killer cell mediated cytotoxicity
mmu04658  Th1 and Th2 cell differentiation
mmu04659  Th17 cell differentiation
mmu04660  T cell receptor signaling pathway
mmu04662  B cell receptor signaling pathway
mmu04720  Long-term potentiation
mmu04724  Glutamatergic synapse
mmu04728  Dopaminergic synapse
mmu04921  Oxytocin signaling pathway
mmu04922  Glucagon signaling pathway
mmu04924  Renin secretion
mmu05010  Alzheimer disease
mmu05014  Amyotrophic lateral sclerosis
mmu05020  Prion disease
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05031  Amphetamine addiction
mmu05152  Tuberculosis
mmu05163  Human cytomegalovirus infection
mmu05166  Human T-cell leukemia virus 1 infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05170  Human immunodeficiency virus 1 infection
mmu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmu05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    19055 (Ppp3ca)
   04310 Wnt signaling pathway
    19055 (Ppp3ca)
   04370 VEGF signaling pathway
    19055 (Ppp3ca)
   04020 Calcium signaling pathway
    19055 (Ppp3ca)
   04022 cGMP-PKG signaling pathway
    19055 (Ppp3ca)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    19055 (Ppp3ca)
   04218 Cellular senescence
    19055 (Ppp3ca)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    19055 (Ppp3ca)
   04650 Natural killer cell mediated cytotoxicity
    19055 (Ppp3ca)
   04660 T cell receptor signaling pathway
    19055 (Ppp3ca)
   04658 Th1 and Th2 cell differentiation
    19055 (Ppp3ca)
   04659 Th17 cell differentiation
    19055 (Ppp3ca)
   04662 B cell receptor signaling pathway
    19055 (Ppp3ca)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    19055 (Ppp3ca)
   04921 Oxytocin signaling pathway
    19055 (Ppp3ca)
   04924 Renin secretion
    19055 (Ppp3ca)
  09156 Nervous system
   04724 Glutamatergic synapse
    19055 (Ppp3ca)
   04728 Dopaminergic synapse
    19055 (Ppp3ca)
   04720 Long-term potentiation
    19055 (Ppp3ca)
  09158 Development and regeneration
   04360 Axon guidance
    19055 (Ppp3ca)
   04380 Osteoclast differentiation
    19055 (Ppp3ca)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    19055 (Ppp3ca)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    19055 (Ppp3ca)
   05170 Human immunodeficiency virus 1 infection
    19055 (Ppp3ca)
   05163 Human cytomegalovirus infection
    19055 (Ppp3ca)
   05167 Kaposi sarcoma-associated herpesvirus infection
    19055 (Ppp3ca)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    19055 (Ppp3ca)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    19055 (Ppp3ca)
   05014 Amyotrophic lateral sclerosis
    19055 (Ppp3ca)
   05020 Prion disease
    19055 (Ppp3ca)
   05022 Pathways of neurodegeneration - multiple diseases
    19055 (Ppp3ca)
  09165 Substance dependence
   05031 Amphetamine addiction
    19055 (Ppp3ca)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    19055 (Ppp3ca)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:mmu01009]
    19055 (Ppp3ca)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     19055 (Ppp3ca)
Protein phosphatases and associated proteins [BR:mmu01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Calcineurin (PPP3/ PP2B)
    Catalytic subunits
     19055 (Ppp3ca)
SSDB
Motif
Pfam: Metallophos
Other DBs
NCBI-GeneID: 19055
NCBI-ProteinID: NP_032939
MGI: 107164
Ensembl: ENSMUSG00000028161
UniProt: P63328
Structure
Position
3:136375778..136643488
AA seq 521 aa
MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALASETNGTDSNGSNSSNIQ
NT seq 1566 nt   +upstreamnt  +downstreamnt
atgtccgagcccaaggcgattgatcccaagttgtcgacgaccgacagggtggtgaaagcc
gttccatttccaccaagtcaccggctgacagcaaaggaagtgtttgataatgatgggaaa
cctcgtgtggatatcttaaaagcacatctcatgaaggagggcaggctggaagaaagtgtt
gcattgagaataataacagagggtgcttcgattctccgacaggaaaaaaacttgctggat
atcgacgcaccagtcacagtttgtggggacatccatggacaattctttgacttgatgaag
ctctttgaagtgggaggatctcctgccaacactcgctacctcttcttaggggactatgtt
gacagagggtacttcagtatcgaatgtgtgctgtatttgtgggccttgaaaattctttac
cccaaaacactgtttttacttcgcggaaaccatgaatgtaggcacctcacagagtatttc
acgtttaaacaagaatgtaaaataaagtattcagaacgcgtttatgacgcctgtatggat
gccttcgactgccttcccctggctgcgctaatgaaccagcagttcctgtgtgtacacggt
ggtttgtctccagagattaacactctagatgacatcagaaaattagaccgattcaaagaa
ccacctgcttatgggcccatgtgtgacatcctatggtcagaccccctggaggactttgga
aatgagaagactcaggaacatttcactcacaacacagtcagaggctgttcgtacttctac
agttacccagctgtgtgtgacttcctgcagcacaataatttgttgtccatactccgcgcc
cacgaagcccaggatgcagggtaccgcatgtacaggaaaagccaaacaacaggcttcccg
tctctaattacaatcttctcggcaccaaattacttagatgtgtacaataacaaagctgca
gtgttgaagtacgagaacaatgtgatgaacatcaggcagttcaactgctccccgcatccg
tactggctcccaaatttcatggatgttttcacctggtcgctgccatttgttggggagaaa
gtgactgagatgctggtcaatgttctcaacatctgctccgacgatgaactggggtcagaa
gaagatggatttgacggagccacggccgcagcccggaaggaagtcatcagaaacaagatc
cgagcaataggcaaaatggccagagtgttctcagttctcagagaagagagtgagagtgtc
ctgacactgaagggcctgaccccaactggcatgctccccagcggagtgctctctggcggg
aaacagactctgcaaagcgctactgttgaggctattgaggctgatgaagccatcaaagga
ttttcaccacaacataagatcactagcttcgaggaggccaagggcttagaccgaattaac
gagaggatgccacctcgcagagacgccatgccctctgacgccaaccttaactccatcaac
aaggctctcgcctcagagactaacggcacggacagcaatggcagtaatagcagcaatatc
cagtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (33)   
   KEGG PATHWAY (33)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (73)   
   RefSeq(nuc) (11)   
   GenBank (31)   
   EMBL (31)   
3D Structure (1)   
   PDB (1)   
Protein domain (1)   
   Pfam (1)   
All databases (144)   

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