KEGG   Mus musculus (house mouse): 208266
Entry
208266            CDS       T01002                                 
Symbol
Dot1l, A630076O07, Dot1, KMT4, mDot1
Name
(RefSeq) DOT1 like histone lysine methyltransferase
  KO
K11427  [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00310  Lysine degradation
mmu01100  Metabolic pathways
mmu05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    208266 (Dot1l)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    208266 (Dot1l)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:mmu03036]
    208266 (Dot1l)
Enzymes [BR:mmu01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.360  [histone H3]-lysine79 N-trimethyltransferase
     208266 (Dot1l)
Chromosome and associated proteins [BR:mmu03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     208266 (Dot1l)
   HMT complexes
    Dot1-containing complex
     208266 (Dot1l)
SSDB
Motif
Pfam: DOT1
Other DBs
NCBI-GeneID: 208266
NCBI-ProteinID: NP_955354
MGI: 2143886
Ensembl: ENSMUSG00000061589
UniProt: Q6XZL8
Position
10:80590935..80631295
AA seq 1540 aa
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNATTPTKVP
ESKAAATEAPADSGAEEEKSGVATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSAAS
AERKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTQLHSPNPLLVAPTPP
ALQKLLESFRIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFGHCQAQKEE
IRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRA
RCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKTQRQQELLQLKSC
VPPDDALSLHLRGKGALGRELEADAGRLRLELDCAKISLPHLSSMSPELSMNGHAASYEL
CNAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLR
RHLSQDHTGASKAATSEPHPRPEHPKESSLPYQSPGLSNSMKLSPQDPPLASPATSPLTS
EKGSEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPS
PVPQPRDSSATLEKQTGASAHGAGGAGAGSRSLAVAPTGFYAGSVAISGALASSPAPLAS
GMESAVFDESSGPSSLFATMGSRSTPPQHPPLLSQSRNSGPASPAHQLTASPRLSVTTQG
SLPDTSKGELPSDPAFSDPESEAKRRIVFSISVGASSKQSPSTRHSPLTSGTRGDCVQSH
GQDSRKRSRRKRASAGTPSLSTGVSPKRRALPTVAGLFTQSSGSPLNLNSMVSNINQPLE
ITAISSPESSLKSSPTPYQDHDQPPVLRKERPLGLTNGAHYSPLTSDEEPGSEDEPSSAR
IERKIATISLESKSPPKTLENGGGLVGRKSAPSSEPINSSKWKSTFSPISDLGLAKAVDS
PLQAGSALSHSPLFSFRPSLEEPAAEAKLPTHPRKSFAGSLGAAEGPSPGTNPPNGLAFS
GGLAADLGLHSFNDGASLSHKGPDVTGLSASLSFPSQRGKDSTTEANPFLSRRQPEGLGG
LKGEGNANKESGESLPLCGPSDKASLPHGSRASKGRDRELDFKGGHNLFISAAAVPPGGL
LGGPGLVTVASSAGSATPTAQAPRPFLSTFAPGPQFTLGPMSLQANLGSVAGSSVLQSLF
STVPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGN
NT seq 4623 nt   +upstreamnt  +downstreamnt
atgggcgagaagctggagctgaggctcaagtcgcctgtgggcgccgagcccgccgtctac
ccgtggccgctgccggtctacgacaagcaccatgatgctgctcatgagattattgagact
atccggtgggtctgcgaggaaatcccagatctcaagctggccatggagaactatgtcctg
atcgactacgacaccaaaagttttgaaagcatgcagcggctgtgtgacaaatacaaccgg
gccatcgacagcatccaccagctgtggaagggcactacacagcccatgaagctgaatact
cggccgtccaatggacttctgcggcacatcctgcagcaggtatataaccactctgtcact
gacccggagaagcttaacaactacgagcccttctcccctgaggtgtatggggagacctcc
tttgacctggtggcccagatgattgatgagatcaagatgacagaggatgacctgtttgtc
gacctgggcagtggtgtggggcaggttgtccttcaggttgctgcggccaccaactgcaaa
catcactacggagtggagaaagcggacatcccagccaagtacgcagagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggaacga
ggtgacttcctctcagaggaatggagggaacggatcgccaacacgagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcgattcgcaaacatg
aaggaaggcggcagaatcgtatcctcaaagccctttgcccctctgaacttcaggatcaac
agcaggaacttgagtgacattggcaccatcatgcgtgtggtggagctgtcgcccctgaag
ggctctgtgtcgtggactggcaagcctgtctcctactatctgcacaccattgaccgcacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggagcaggaggca
gctaggcgaagacagcagcgagagaacaagagcaatgcgaccacgcccaccaaagtccct
gagagcaaagcagctgccactgaggcccccgcggattctggtgctgaggaagaaaaatca
ggtgtggctactgtcaaaaagccatctccctccaaagcccggaagaagaaactgaacaag
aaagggagaaagatggctggccggaaacgtgggcggcccaagaaaatgagtgctgccagt
gccgaacgcaagtctaagaagagccaaagcacactggatctcctgcactctccgccccca
gccccaccctcagcctcaccccaggatgcgtacagggcacctcacagcccattctaccag
ctacctccaagcacgcagctgcactcacccaacccactgctagtggcacccaccccacct
gcgctgcagaagcttttagagtccttcagaatccagtacctgcagttcctggcttataca
aagaccccgcagtacaaggctaacctacagcagcttctggaccaggagaaggagaagaac
acacagctcctgggcacagcccagcagctcttcggccattgccaggcccaaaaggaagaa
atccgcaggctgttccagcagaagctggatgagttgggcgtgaaggcgctgacctacaat
gacctgattcaggcccagaaggaaatctctgcccacaaccagcagctgcgggaacagtcg
gaacagctggagaaggacaacagcgagcttcggagccagagcctgcggctgctcagggcc
cggtgtgaggagctgaggcttgactggtccacactgtccttggagaacctgcggaaagag
aagcaggccctgaggagccagatctcagagaagcagcggcactgcctggagctgcagatc
agcatcgtggagctcgagaagacccagcgccagcaggagctcctgcagttaaagtcctgt
gtaccaccagatgatgctttgtctttgcatctgcgtggcaagggtgccctgggccgagag
ctggaggctgatgctgggcgcttacgccttgagctggactgtgccaagatctccctgcca
cacctcagcagcatgagccctgagctgtccatgaacggccatgctgccagctatgagctc
tgcaatgcagctagtcggccatcatccaagcagaacacaccccagtacctggcctctccc
ttggaccaggaggtcgtaccttgtacccctagccacagtggccggcctcggctagaaaag
ctgtctggcctggctttgcctgattacacccggttgtcacctgccaagattgtgttgagg
cggcacctgagccaggaccacactggggctagcaaagcagctaccagtgagccacaccct
cggccagagcaccccaaggagagcagccttccctaccagagccctggcttgtccaacagc
atgaagctcagcccccaggatccaccactggcctccccggcaacctcgcccctcacctcc
gagaaaggtagtgagaagggtgtgaaggagcgtgcctacagcagccacggggagaccatc
accagcctacctgttagcattccactcagcacagtgcagcccaacaagctgccggtcagc
atcccactggccagcgtggtgctgcccagccgtgctgagagggcgaggagcactcccagc
cctgtgccacagccccgggactcttcagccacacttgagaagcagactggtgcttctgcc
catggtgcagggggtgctggagcaggaagcaggagcctcgctgtggcgcccacaggtttc
tatgctggttcggtggccatcagtggggccctggccagcagcccagcacctctggcctct
ggaatggaatctgctgtttttgatgaatcctctggccccagcagcctctttgccaccatg
gggtctcgcagcacaccaccacaacacccacctctcctgtcgcagtcccgcaactcgggt
cctgcctctcctgcccaccaactcacagccagtccccgcctgagtgtgaccactcagggc
tcgctgccagacaccagcaaaggggaactgccttctgatcctgccttctcagacccagag
agcgaagcaaaaaggaggattgtgttcagcatttcagttggtgccagctccaagcagtca
ccttccaccaggcatagccccttgacttctggcacccgaggggactgtgtgcagagccac
ggacaggacagtcgtaagcgcagcagaaggaagcgtgcatcagctggaacacctagcctc
agcacgggtgtgtcccccaagcgccgggctctgccaactgttgctggcctctttacacag
tcctcggggtctcctcttaatctcaactccatggtcagcaacatcaaccagccactggag
atcacagccatctcatcccctgagagctccctgaagagctcccccaccccataccaggac
catgaccagcctccggtgctcaggaaggaacggcctctaggactaactaatggggcccac
tactcgccactgacctcagatgaggagccaggctctgaggatgagcccagcagtgcccga
attgagagaaaaattgcaacaatctctttagaaagcaaatctcccccgaagacactggaa
aatggtggtggcttggtgggaaggaagtcagccccttcgagcgagcctatcaacagcagc
aaatggaagtctaccttctctcctatctctgacctcggcttggccaaggctgtggacagt
ccgctacaggctggctctgccctgagccacagccccctgttctctttccggccgtccctg
gaggagcctgctgctgaggccaagctccccactcacccaaggaaaagctttgcgggctct
ctgggtgcagccgaggggccaagccctggcaccaaccctcccaacggcctggccttcagt
gggggccttgctgcagacctcggtttacacagcttcaatgatggtgcttccctctcccac
aagggcccggatgtgactggcctgagtgcctccctgagcttcccatcccagaggggcaag
gacagtaccacagaggccaaccctttcctcagcaggcggcagcccgagggcctgggtggc
ttgaagggtgagggcaacgcaaacaaggagtcaggagagagcctgcccctgtgcgggccc
tcggacaaggcctcactgccacatggcagcagggccagcaaaggtcgtgaccgtgagctg
gacttcaagggcggccacaacctcttcatctctgctgcagccgtgcctccaggtggcctc
cttggtggccctggtcttgtaactgtggcttcttctgcgggcagtgcaacacccactgcc
caggctccccggcctttcctgagcacctttgcccccgggccccagtttactctgggcccc
atgtccctgcaggccaacctgggctctgtggccggctcctctgtgctgcagtccttgttc
agcactgtgccagctgctgcaggcctggtgcatgtgtcgtccactgcgacccgattgacc
aactcacacaccatgggcagcttctcttctggggtggccggcggaaccgttggaggtaat
tag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (40)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (33)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   RefSeq(pep) (7)   
DNA sequence (37)   
   RefSeq(nuc) (9)   
   GenBank (14)   
   EMBL (14)   
Protein domain (1)   
   Pfam (1)   
All databases (103)   

Download RDF
DBGET integrated database retrieval system