KEGG   Mus musculus (house mouse): 20963
Entry
20963             CDS       T01002                                 
Symbol
Syk, Sykb
Name
(RefSeq) spleen tyrosine kinase
  KO
K05855  spleen tyrosine kinase [EC:2.7.10.2]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04064  NF-kappa B signaling pathway
mmu04072  Phospholipase D signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04380  Osteoclast differentiation
mmu04611  Platelet activation
mmu04613  Neutrophil extracellular trap formation
mmu04625  C-type lectin receptor signaling pathway
mmu04650  Natural killer cell mediated cytotoxicity
mmu04662  B cell receptor signaling pathway
mmu04664  Fc epsilon RI signaling pathway
mmu04666  Fc gamma R-mediated phagocytosis
mmu05152  Tuberculosis
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05168  Herpes simplex virus 1 infection
mmu05169  Epstein-Barr virus infection
mmu05171  Coronavirus disease - COVID-19
mmu05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    20963 (Syk)
   04072 Phospholipase D signaling pathway
    20963 (Syk)
   04151 PI3K-Akt signaling pathway
    20963 (Syk)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    20963 (Syk)
   04613 Neutrophil extracellular trap formation
    20963 (Syk)
   04625 C-type lectin receptor signaling pathway
    20963 (Syk)
   04650 Natural killer cell mediated cytotoxicity
    20963 (Syk)
   04662 B cell receptor signaling pathway
    20963 (Syk)
   04664 Fc epsilon RI signaling pathway
    20963 (Syk)
   04666 Fc gamma R-mediated phagocytosis
    20963 (Syk)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    20963 (Syk)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    20963 (Syk)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    20963 (Syk)
   05168 Herpes simplex virus 1 infection
    20963 (Syk)
   05167 Kaposi sarcoma-associated herpesvirus infection
    20963 (Syk)
   05169 Epstein-Barr virus infection
    20963 (Syk)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    20963 (Syk)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    20963 (Syk)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     20963 (Syk)
Protein kinases [BR:mmu01001]
 Non-receptor tyrosine kinases
  SYK family
   20963 (Syk)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 Kdo ABC1
Other DBs
NCBI-GeneID: 20963
NCBI-ProteinID: NP_001185906
MGI: 99515
Ensembl: ENSMUSG00000021457
UniProt: P48025 Q3UPF7 Q6P1E0
Structure
Position
13:52736670..52802828
AA seq 629 aa
MAGSAVDSANHLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKA
HHYTIERELNGTYAISGGRAHASPADLCHYHSQEPDGLICLLKKPFNRPPGVQPKTGPFE
DLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGNISRDESEQT
VLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLV
EHYSYKPDGLLRVLTVPCQKIGAQMGHPGSPNAHPVTWSPGGIISRIKSYSFPKPGHKKP
APPQGSRPESTVSFNPYEPTGGPWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVYLD
RSLLTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ
LDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLE
ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY
YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN
LCWTYDVENRPGFTAVELRLRNYYYDVVN
NT seq 1890 nt   +upstreamnt  +downstreamnt
atggcgggaagtgctgtggacagcgccaaccacctgacctacttttttggcaacatcacc
cgggaagaggctgaagactacctggtccagggaggcatgaccgatgggctctacctgcta
cgccagagccgcaattacctgggtggttttgctttgtcggtggctcacaacaggaaggca
caccactacaccatcgagagggaacttaatggcacctacgccatctccgggggcagggcc
catgccagcccagcagacctctgccattaccactcccaggaacctgatggccttatctgc
ctccttaagaagcccttcaaccggcccccgggagtacagcccaagaccggaccctttgag
gacctgaaggagaacctcatcagggaatatgtgaaacagacctggaaccttcagggccag
gctctggagcaagccatcatcagccagaagccccagctggagaagctgatcgccaccacg
gcccatgagaagatgccctggttccatggcaacatctccagagatgaatcagagcagacg
gtcctcatagggtcaaagaccaatggaaaattcctgatcagggccagagacaacagcggc
tcctatgctctgtgcctgctgcacgaagggaaagtattgcactaccgcattgacagggac
aagaccgggaagctctccattcctgaggggaagaagtttgacaccctctggcagctagtg
gaacattactcttacaagccagatgggctactaagagtcctcacggtaccatgccaaaag
attggtgcacagatgggccacccaggaagcccaaatgcccatcccgtgacttggtcaccg
ggtggaataatctcaaggatcaaatcctactccttcccaaagcctggccacaaaaagcct
gccccaccccaagggagccgtccagagagcactgtgtccttcaacccctatgagccaacg
ggagggccctggggcccagacagaggccttcagagagaagccctgcccatggacacagag
gtgtacgagagcccttatgctgaccctgaagagatccggcccaaagaggtctacctggac
aggagcctgctgaccctggaggacaatgaactgggctccggtaacttcgggactgtgaaa
aagggatactaccaaatgaaaaaagttgtgaaaaccgtggctgtgaaaatcctgaagaac
gaggccaacgacccggctttgaaggacgagctgctggcagaggcgaacgtcatgcagcag
ctggacaacccctacattgtgcgcatgatcggaatctgcgaggcggagtcctggatgctg
gtgatggagatggcggagctggggccgctcaacaagtacctgcagcagaacaggcacatt
aaggataagaacatcatagagctggttcaccaggtttccatggggatgaagtatttggaa
gagagcaactttgtgcacagagatctggctgcgcggaacgtgcttctggtcacacagcac
tatgccaagatcagcgatttcggtctttccaaagccctgcgtgctgatgaaaactactac
aaggcccagacccacgggaagtggcccgtgaagtggtacgcccccgaatgcatcaactac
tacaagttctccagtaagagtgacgtctggagcttcggagtcctgatgtgggaagcgttc
tcctatgggcagaagccctacagagggatgaaagggagcgaagtgaccgccatgctggag
aaaggagagcggatggggtgccctgcaggatgcccgagagagatgtacgacctgatgaac
ctgtgctggacttacgatgtggagaacaggccaggattcacagctgtggaactgaggctt
cgcaattactactacgacgtggttaactaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (17)   
   KEGG PATHWAY (17)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (10)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (28)   
   RefSeq(nuc) (6)   
   GenBank (11)   
   EMBL (11)   
3D Structure (2)   
   PDB (2)   
Protein domain (5)   
   Pfam (5)   
All databases (79)   

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