KEGG   Mus musculus (house mouse): 216343
Entry
216343            CDS       T01002                                 
Symbol
Tph2, Ntph
Name
(RefSeq) tryptophan hydroxylase 2
  KO
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00380  Tryptophan metabolism
mmu00790  Folate biosynthesis
mmu01100  Metabolic pathways
mmu04726  Serotonergic synapse
Module
mmu_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    216343 (Tph2)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    216343 (Tph2)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    216343 (Tph2)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4  tryptophan 5-monooxygenase
     216343 (Tph2)
SSDB
Motif
Pfam: Biopterin_H ACT TH_ACT
Other DBs
NCBI-GeneID: 216343
NCBI-ProteinID: NP_775567
MGI: 2651811
Ensembl: ENSMUSG00000006764
UniProt: Q8CGV2
Position
10:complement(114914546..115020927)
AA seq 488 aa
MQPAMMMFSSKYWARRGLSLDSAVPEDHQLLGSLTQNKAIKSEDKKSGKEPGKGDTTESS
KTAVVFSLKNEVGGLVKALRLFQEKHVNMLHIESRRSRRRSSEVEIFVDCECGKTEFNEL
IQLLKFQTTIVTLNPPESIWTEEEDLEDVPWFPRKISELDRCSHRVLMYGTELDADHPGF
KDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKN
LPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYV
RHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTI
EFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKSFDPKTTCLQECLITTFQDAYFVS
DSFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALN
KMNQYLGI
NT seq 1467 nt   +upstreamnt  +downstreamnt
atgcagcccgcaatgatgatgttttccagtaaatactgggccaggagagggttgtccttg
gattctgctgtgccagaagatcatcagctacttggcagcttaacacaaaataaggctatc
aaaagcgaggacaagaaaagcggcaaagagcccggcaaaggcgacaccacagagagcagc
aagacagcggtagtgttctccttgaagaatgaagttggtgggctggtgaaagcacttaga
ctattccaggaaaaacatgtcaacatgcttcatatcgaatccaggaggtcccgacgaaga
agttctgaagtcgaaatcttcgtggactgcgaatgtggcaaaacggaattcaatgagctc
atccagttgctgaaatttcagaccaccattgtgaccctgaatccgcctgagagcatttgg
acggaggaagaagatctcgaggatgtgccgtggttccctcggaagatctctgagttagac
agatgctctcaccgagtcctcatgtacggcaccgagcttgatgccgaccatccaggattt
aaggacaatgtctatcgacagaggaggaagtattttgtggatgtggccatgggctataaa
tatggtcagcccattcccagggtcgagtacacagaagaagagactaaaacttggggtgtt
gtgttccgggagctctccaaactctacccgactcatgcttgccgggagtacctgaaaaac
ctccccctgctgaccaagtactgtggctacagggaagacaacgtgccgcaactggaagac
gtctccatgtttctgaaagagcgatctggcttcacagtgagaccagtggctggctacctg
agcccaagagacttcctggcgggcctggcctacagagtattccactgcacccagtacgtg
cggcatggctccgaccccctctacaccccggaaccagatacatgccatgaactcttggga
cacgtgccactgcttgcggatcccaagtttgctcagttttcccaagagataggcttagcg
tctctgggagcctcagatgaggacgttcagaaactagccacgtgctatttcttcacaatc
gagttcggcctttgcaagcaagagggtcaactgcgggcgtatggagcagggttactttcg
tccatcggagaattgaagcatgctctttccgacaaggcgtgtgtgaaatcctttgaccca
aagacgacctgcttgcaggaatgcctaatcaccacctttcaggacgcttactttgtttcg
gacagttttgaagaagccaaagaaaagatgagggactttgcaaagtcaattacccgtccc
ttctcggtatacttcaacccctacacgcagagcattgaaattctgaaagacaccagaagt
attgagaatgtggtgcaggacctgcgcagtgatttgaacacagtgtgtgatgccttgaat
aaaatgaaccaatatctggggatttga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (7)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (3)   
Protein domain (3)   
   Pfam (3)   
All databases (39)   

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