KEGG T01002: 21823

Mus musculus (house mouse): 21823

Entry

21823             CDS       T01002

Symbol

Name

(RefSeq) tyrosine hydroxylase

K00501

tyrosine 3-monooxygenase [EC:1.14.16.2]

Organism

mmu Mus musculus (house mouse)

Pathway

mmu00350

Tyrosine metabolism

mmu00790

Folate biosynthesis

mmu01100

Metabolic pathways

mmu04728

Dopaminergic synapse

mmu04917

Prolactin signaling pathway

mmu05012

Parkinson disease

mmu05030

Cocaine addiction

mmu05031

Amphetamine addiction

mmu05034

Alcoholism

Module

mmu_M00042

Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline

Brite

KEGG Orthology (KO) [BR:mmu00001]
09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    21823 (Th)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    21823 (Th)
09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    21823 (Th)
  09156 Nervous system
   04728 Dopaminergic synapse
    21823 (Th)
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    21823 (Th)
  09165 Substance dependence
   05030 Cocaine addiction
    21823 (Th)
   05031 Amphetamine addiction
    21823 (Th)
   05034 Alcoholism
    21823 (Th)
Enzymes [BR:mmu01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.2  tyrosine 3-monooxygenase
     21823 (Th)

SSDB

Motif

Pfam:

Biopterin_H TH_ACT TOH_N LTP_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

MGI:

Ensembl:

UniProt:

Position

7:complement(142446516..142453732)

AA seq 498 aa
MPTPSASSPQPKGFRRAVSEQDTKQAEAVTSPRFIGRRQSLIEDARKEREAAAAAAAAAV
ASAEPGNPLEAVVFEERDGNAVLNLLFSLRGTKPSSLSRALKVFETFEAKIHHLETRPAQ
RPLAGSPHLEYFVRFEVPSGDLAALLSSVRRVSDDVRSAREDKVPWFPRKVSELDKCHHL
VTKFDPDLDLDHPGFSDQAYRQRRKLIAEIAFQYKQGEPIPHVEYTKEEIATWKEVYATL
KGLYATHACREHLEAFQLLERYCGYREDSIPQLEDVSHFLKERTGFQLRPVAGLLSARDF
LASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGAS
DEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAV
QPYQDQTYQPVYFVSESFSDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIRRSL
EGVQDELHTLTQALSAIS

NT seq 1497 nt +upstreamnt +downstreamnt
atgcccacccccagcgcctcctcgccacagcccaagggcttcagaagagccgtctcagag
caggataccaagcaggccgaggctgtcacgtccccaaggttcattggacggcggcagagt
ctcatcgaggatgcccgcaaggagcgggaggcagcagcagctgcagcagcggctgcggta
gcctccgcggaacctgggaacccattggaggctgtggtattcgaggagagggatggaaat
gctgttctcaacctgctcttctccttgaggggtacaaaaccctcctcactgtctcgggct
ttgaaagtgtttgagacatttgaagccaaaatccaccacttagagacccggcctgcccag
aggccactggcaggaagcccccacctggagtactttgtgcgcttcgaggtgcccagtggc
gacctggctgccctcctcagttctgtgcgtcgggtgtctgacgatgtgcgcagtgccaga
gaggacaaggttccctggttcccaaggaaagtgtcagagttggataagtgtcaccacctg
gtcaccaagtttgaccctgacctggacctggaccatccgggcttctctgaccaggcgtat
cgccagcgccggaagctgattgcagagattgccttccaatacaagcagggtgagccaatt
ccccacgtggaatacacaaaggaggaaattgctacctggaaggaggtatacgccacgctg
aagggcctctatgctacccatgcctgccgggaacacctggaggctttccagcttctggaa
cggtactgtggctaccgagaggacagcattccacagctggaggatgtgtctcacttcttg
aaggaacggactggcttccagctgcgacccgtggccggtctactgtctgcccgtgatttt
ctggccagtctggccttccgtgtgtttcagtgcacacagtacatccgtcatgcctcctca
cctatgcactcacccgagccagactgctgccacgagctgctgggacacgtacccatgttg
gctgaccgcacatttgcccagttctcccaggacattggacttgcatctctgggggcttca
gatgaagaaattgaaaaactctccacggtgtactggttcactgtggagtttgggctgtgt
aaacagaatggggagctgaaggcttacggtgcagggctgctgtcttcctatggagagctc
ctgcactccctgtcagaggagcccgaggtccgggcctttgacccagacacagcagccgtg
cagccctaccaagatcaaacctaccagccggtgtacttcgtgtcagagagcttcagtgat
gccaaggacaagctcaggaactatgcctctcgtatccagcgcccattctctgtgaagttt
gacccgtacaccctggccattgatgtactggacagtcctcacaccatccggcgctcctta
gagggggtccaggatgagctgcacaccctgacccaagcactgagtgccattagctaa

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