KEGG   Mus musculus (house mouse): 21973
Entry
21973             CDS       T01002                                 
Symbol
Top2a, Top-2
Name
(RefSeq) topoisomerase (DNA) II alpha
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu01524  Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    21973 (Top2a)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:mmu03032]
    21973 (Top2a)
   03036 Chromosome and associated proteins [BR:mmu03036]
    21973 (Top2a)
Enzymes [BR:mmu01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     21973 (Top2a)
DNA replication proteins [BR:mmu03032]
 Eukaryotic type
  DNA Topoisomerases
   21973 (Top2a)
Chromosome and associated proteins [BR:mmu03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    21973 (Top2a)
  Centrosome formation proteins
   Centriole proteins
    21973 (Top2a)
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim
Other DBs
NCBI-GeneID: 21973
NCBI-ProteinID: NP_035753
MGI: 98790
Ensembl: ENSMUSG00000020914
UniProt: Q01320
Position
11:complement(98883773..98915037)
AA seq 1528 aa
MELSPLQPVNENMLMNKKKNEDGKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQM
WVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNVISIWNN
GKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVET
ASREYKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVR
RAYDIAGSTKDVKVFLNGNSLPVKGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCL
TMSERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNKGGVAVKAHQVKNHMW
IFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQI
QLNKKCSAVKHTKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKY
GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTD
QDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEIAFYSLPEFEEWKSS
TPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDR
KEWLTNFMEDRRQRKLLGLPEDYLYGQSTSYLTYNDFINKELILFSNSDNERSIPSMVDG
LKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNL
NLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEWY
IPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEE
LASNQYVINGEVAILDSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPSLITDYREYH
TDTTVKFVIKMTEEKLAEAERVGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRD
FFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPDEEENEESDTETSTSDSAAEAGPTFNYLLDMPLWYLTKEKKDE
LCKQRNEKEQELNTLKQKSPSDLWKEDLAVFIEELEVVEAKEKQDEQVGLPGKAGKAKGK
KAQMCADVLPSPRGKRVIPQVTVEMKAEAEKKIRKKIKSENVEGTPAEDGAEPGSLRQRI
EKKQKKEPGAKKQTTLPFKPVKKGRKKNPWSDSESDVSSNESNVDVPPRQKEQRSAAAKA
KFTVDLDSDEDFSGLDEKDEDEDFLPLDATPPKAKIPPKNTKKALKTQGSSMSVVDLESD
VKDSVPASPGVPAADFPAETEQSKPSKKTVGVKKTATKSQSSVSTAGTKKRAAPKGTKSD
SALSARVSEKPAPAKAKNSRKRKPSSSDSSDSDFERAISKGATSKKAKGEEQDFPVDLED
TIAPRAKSDRARKPIKYLEESDDDDDLF
NT seq 4587 nt   +upstreamnt  +downstreamnt
atggagttgtcaccgctgcagcctgtaaatgaaaatatgctaatgaacaaaaagaagaat
gaagatggcaagaaaagattgtctattgaaagaatctatcagaaaaaaacacaactggaa
catatactgctccgcccagatacctacattggctctgtggagttagtgacccagcaaatg
tgggtttacgatgaagatgttggcattaactacagggaagtcacttttgttcctggtttg
tataaaatctttgatgagattctagttaatgctgctgataacaaacaaagggacccaaaa
atgtcttgtattagagtcacaattgatccagaaaataatgtaattagcatctggaataat
gggaaaggaatccctgttgttgaacacaaagttgagaaaatatatgtcccagctctcata
tttggacaactcctgacctccagtaactatgacgacgatgagaagaaagtgacaggtggt
cgaaatggctatggagctaaactgtgtaacatattcagcaccaaatttactgtggaaaca
gccagtagagagtacaagaaaatgttcaaacagacgtggatggataacatggggagagct
ggtgacatggaactcaagccctttagtggagaagattatacatgtatcaccttccagcct
gacttatctaagtttaaaatgcaaagcctggacaaagatattgttgcactgatggtcaga
agagcatatgatatcgctggctccactaaagatgtcaaagtctttcttaatggaaatagt
ctgccagtgaaaggattccgcagttacgtggatttgtatttgaaggataaggtagatgaa
actgggaattcactgaaggtgatacatgaacaggtcaatccccggtgggaagtgtgctta
acaatgagcgagagaggcttccagcagattagcttcgtcaacagcattgcgacttctaag
ggcggcagacatgtcgattatgtagctgatcagattgtgagcaaactcgttgatgtggtg
aaaaagaagaacaagggcggggttgcagtgaaggctcatcaggtgaaaaatcacatgtgg
atttttgtaaatgccttaattgaaaacccaacctttgactctcaaacaaaagaaaacatg
actttacaagccaagagctttggatcaacatgtcaattaagtgaaaagttcatcaaagct
gcaattggttgtggtattgtggaaagcatactaaactgggtgaagttcaaggctcaaatc
caactgaacaagaagtgttcagctgtaaaacataccaaaatcaagggaatccccaaactt
gatgatgccaacgatgcagggagccgaaactctactgaatgcacacttatcctgactgag
ggagactcagcaaaaactctagccgtttcaggccttggagtggttggaagagacaaatat
ggggtgttccctcttagaggaaagatactcaatgtgcgagaagcctctcataaacagatc
atggaaaatgctgaaattaacaatatcatcaagattgtgggtctccagtacaagaaaaac
tatgaagatgaagattcattgaaaactcttcgttatgggaagatcatgattatgacagat
caggaccaagatggttcccacatcaaaggcttgctgatcaattttatccatcacaattgg
ccatctcttctgcgacatcgttttctagaagaatttatcactcccattgtaaaggtgtcc
aaaaataagcaagaaatagcattctatagtcttcccgagtttgaagaatggaaaagttcg
actccgaatcataaaaagtggaaagtcaaatactacaaaggtttgggcaccagcacatca
aaggaagctaaggaatattttgcagatatgaaacgacatcgtattcagttcaaatactct
ggccctgaagatgatgctgcgatcagcctggcctttagtaaaaaacaagttgatgatcga
aaggaatggttaactaattttatggaagacagaagacagcggaagttacttggccttcct
gaggattatttgtatggacaaagcacttcgtacctgacctataatgacttcataaacaag
gaactcatcctcttctccaactctgataatgaaaggtctatcccatccatggtagacggt
ttgaaaccaggtcagagaaaggttttgtttacttgtttcaaacggaatgacaagcgagaa
gtgaaggttgcccagttagctgggtcagtggcagaaatgtcctcttatcaccatggtgag
atgtcactgatgatgaccattatcaatttggcgcagaattttgtgggtagcaataatttg
aaccttttacagcccattggtcagtttggaaccaggctgcatggtggcaaggactcagct
agtcctaggtacatctttacaatgctcagccctttggctcggttgttgtttcctccaaaa
gatgatcacacattacggtttctatatgatgacaaccaacgtgttgagcctgaatggtac
attcctataatacccatggtgctgataaatggtgctgagggaattggtactgggtggtcc
tgcaaaatccccaactttgatgtgcgtgaagttgtgaataatatcagacggcttctggat
ggagaggagcccctacccatgctcccaagttataagaatttcaaaggtactattgaagaa
ctggcttcaaatcagtatgtgattaatggagaagtagctattctggattctacaaccatt
gaaatctcagagcttcccatccgaacgtggactcagacatataaagaacaggttctagaa
cccatgttgaatggaactgagaagacaccctctctaataacagactatagggaataccat
acagataccactgtgaagtttgtcataaagatgactgaagaaaaactggcagaggcagag
agagtcggcctacacaaagtcttcaaactccagagtagtctcacttgcaactctatggtg
ctttttgaccatgtaggttgcttaaagaaatatgacactgtgttggatattctaagagac
ttctttgagctcaggcttaaatattatggattaagaaaagaatggcttctaggaatgctt
ggtgcagaatcttctaaactgaataatcaagctcgctttatattagagaaaatagatggc
aaaatagtcattgaaaataaacctaaaaaagaattaattaaagttctgattcagagaggc
tacgactctgaccctgtgaaagcctggaaagaagctcagcagaaggttccagatgaagaa
gaaaatgaagaaagtgacactgaaaccagcaccagtgactctgcagccgaggctgggccg
accttcaactaccttctcgacatgcccctgtggtatctgaccaaggagaagaaggatgag
ctgtgcaaacaaagaaacgagaaggaacaagagctcaacacattaaagcaaaagagtcca
tcagatctgtggaaggaagatctggctgtttttattgaagaactggaggttgtcgaggcc
aaggaaaagcaggatgaacaagtgggccttcctggaaaggcggggaaagcaaaggggaag
aaagcacagatgtgtgctgacgtcttgccttctcctcggggcaaaagagtcatcccccaa
gtgactgtggagatgaaagctgaggcagagaagaaaattaggaagaaaattaagagtgaa
aacgttgagggtacccctgctgaggatggtgcggaaccaggaagcctccggcaacgaata
gagaagaagcagaagaaagagccaggtgcaaagaagcagactacattgccgtttaagcct
gtcaaaaaagggaggaagaaaaacccctggtctgactctgagtcagacgtgagcagtaat
gaaagtaacgttgatgtccctcctcgacaaaaagagcaaagaagtgctgcagcaaaagcc
aaattcacagtggatttagactcggatgaagatttctcaggtttggatgagaaggatgag
gatgaagatttcctcccattagatgctactccacctaaggccaaaatccccccaaaaaat
actaaaaaagcactgaagacccagggaagctccatgtcggtagttgatcttgaaagtgat
gttaaggacagtgtgccagcttctccaggcgttcctgctgctgacttcccagcggaaact
gaacagtcaaagccatccaaaaagaccgtgggagtgaagaagacagcaaccaaaagccag
tcttcagtctccactgctggtaccaaaaagagagctgcgccaaagggaaccaaatcagat
tcagccttgagtgctcgtgtctcggaaaaacctgctcctgccaaagccaagaacagtcgc
aaaaggaagccatcttcttctgatagctctgactctgattttgagagagcaatttctaaa
ggtgccacgagcaagaaagcaaagggagaggaacaggacttccctgtggacttggaagac
acgatagctcctcgagccaaatctgaccgggcgaggaagccaattaagtacctggaggag
tccgatgacgatgacgacctcttctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (35)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (27)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (28)   
   RefSeq(nuc) (4)   
   GenBank (12)   
   EMBL (12)   
Protein domain (6)   
   Pfam (6)   
All databases (82)   

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