KEGG   Mus musculus (house mouse): 21974
Entry
21974             CDS       T01002                                 
Symbol
Top2b, D230016L12Rik, Top-2
Name
(RefSeq) topoisomerase (DNA) II beta
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu01524  Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    21974 (Top2b)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:mmu03032]
    21974 (Top2b)
   03036 Chromosome and associated proteins [BR:mmu03036]
    21974 (Top2b)
Enzymes [BR:mmu01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     21974 (Top2b)
DNA replication proteins [BR:mmu03032]
 Eukaryotic type
  DNA Topoisomerases
   21974 (Top2b)
Chromosome and associated proteins [BR:mmu03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    21974 (Top2b)
  Centrosome formation proteins
   Centriole proteins
    21974 (Top2b)
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT Toprim HATPase_c
Other DBs
NCBI-GeneID: 21974
NCBI-ProteinID: NP_033435
MGI: 98791
Ensembl: ENSMUSG00000017485
UniProt: Q64511
Position
14:complement(6038976..6104585)
AA seq 1612 aa
MAKSSLAGSDGALTWVNNATKKEELETANKNDSTKKLSVERVYQKKTQLEHILLRPDTYI
GSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDP
ESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCN
IFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKL
DKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHE
LANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNKAGVSV
KPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESI
LNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVS
GLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTL
RYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYS
IPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITL
AFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDN
ERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNL
AQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYD
DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPN
YKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTP
ALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKK
YETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKK
DLIQMLVQRGYESDPVKAWKEAQEKAAEEEDSQNQHDDSSSDSGTPSGPDFNYILNMSLW
SLTKEKVEELIKQRDTKGREVNDLKRKSPSDLWKEDLAAFVEELDKVEAQEREDILAGMS
GKAIKGKVGKPKVKKLQLEETMPSPYGRRIVPEITAMKADASRKLLKKKKGDPDTTVVKV
EFDEEFSGTPAEGTGEETLTPSAPVNKGPKPKREKKEPGTRVRKTPTSTGKTNAKKVKKR
NPWSDDESKSESDLEEAEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDAAAADDSNDLE
ELKVKASPITNDGEDEFVPSDGLDKDEYAFSSGKSKATPEKSSNDKKSQDFGNLFSFPSY
SQKSEDDSAKFDSNEEDTASVFAPSFGLKQTDKLPSKTVAAKKGKPPSDTAPKAKRAPKQ
KKIVETINSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKPSKTASKKPK
KTSFDQDSDVDIFPSDFTSEPPALPRTGRARKEVKYFAESDEEEDVDFAMFN
NT seq 4839 nt   +upstreamnt  +downstreamnt
atggccaagtccagcctcgcgggctctgacggggcgctgacctgggtgaacaatgctaca
aaaaaggaagagttggagacagcaaacaaaaatgactctactaagaagttgtctgttgag
agagtgtaccagaagaagacccaactggagcacattctccttcgtcctgatacatacatt
ggatcagtggagccactgacacagctaatgtgggtgtatgatgaagatgtagggatgaac
tgcagggaggtcacctttgttccaggcttatacaagatctttgatgaaattttggttaat
gctgctgacaacaagcagagggacaagaacatgacctgtattaaggtttctattgatcct
gaatctaatattataagcatttggaataatgggaaaggcattccagtagtagaacacaaa
gtagagaaagtttatgttcctgctttaatttttggacagcttttaacatcgagtaattat
gacgatgatgagaaaaaagttacaggaggccgtaatggttatggtgcaaagctttgtaat
atttttagtacaaagtttacagtagaaacggcttgcaaagaatacaaacatagttttaaa
cagacatggatgaataatatgatgaagacttctgaagccaaaattaaacattttgatggt
gaagattatacatgcataacattccagccagatctatccaaatttaagatggaaaaactt
gacaaggacattgtggccctcatgaccagaagagcatatgatttagctgggtcctgtaaa
ggagtcaaggtcatgtttaatgggaagaagttgcctgtaaatggatttcgcagctatgta
gacctttatgtgaaagacaaattggatgaaactggggtggctctcaaagttattcatgaa
cttgcaaatgaaagatgggatgtttgtctaaccttgagtgaaaaaggtttccagcagatc
agctttgtgaatagtattgcaactacaaaaggtgggcggcatgtggattatgtagtagat
caagttgttagtaaactgattgaagtagttaagaaaaagaacaaagctggtgtatcagtg
aaaccatttcaggttaaaaaccatatatgggtttttattaattgtcttattgaaaatcca
acctttgattctcaaactaaggaaaacatgactctgcagcccaaaagttttgggtccaaa
tgccaactgtcagaaaaattttttaaagcagcctctaattgtggcattgtagaaagcata
ttgaactgggtgaaatttaaggctcagactcaactgaataagaagtgttcatcagtaaag
tacagtaaaatcaaaggcattcccaaactggatgatgccaatgatgctggtggcaaacat
tccctggagtgtacattaatattaacagagggggactccgccaaatctctagctgtatct
ggattaggtgtgattggtagggacagatatggagtcttcccactcaggggtaaaattctc
aatgtacgagaagcctctcataaacagattatggaaaatgcagagataaataatattatt
aaaatagttggtttgcaatacaagaaaagttatgatgatgcagaatctctgaaaacttta
cgttatggaaagattatgattatgactgatcaggatcaagatggttctcacatcaaaggc
ctgctaatcaattttattcatcacaattggccatcacttttgaagcatggttttcttgaa
gaattcattactcccattgtaaaggcaagcaaaaataagcaggaactttccttttatagt
attcctgaatttgatgagtggaaaaaacatatagaaaaccagaaagcctggaaaataaag
tactacaaaggattaggtaccagtaccgctaaagaagcaaaggaatattttgctgatatg
gaaaggcatcgcattttgtttagatatgctggacctgaagatgatgctgccatcaccttg
gcatttagtaagaagaagattgatgacagaaaagagtggttaaccaactttatggaggat
cggagacagcgtaggttacatggcctaccagagcaatttttatatggtacagcaacaaag
catttgacatacaatgatttcatcaacaaggaattgattctcttctcaaactcggacaat
gagagatctatcccatctcttgtggatggcttcaagccaggtcaacgaaaagttttgttt
acctgtttcaagaggaatgataaacgtgaagtgaaagtagcgcagctggctggatctgtt
gctgagatgtctgcttaccaccatggagaacaagcattgatgatgactattgtgaatttg
gctcagaattttgtgggcagtaataacattaacttgcttcagcccattggtcagtttgga
actcggcttcatggtggcaaagatgctgcaagccctcgttatattttcacaatgttgagc
tctctggcaagacttctttttccagctgtggatgataacttgcttaagttcctttatgat
gataatcaacgtgtagagccagagtggtatatccctataatccccatggttttgattaat
ggtgctgagggtattgggactggatgggcttgtaaactgcccaactatgatgctagagaa
attgtgaacaatgtcaggcggatgctagaaggtttggatcctcatcccatgcttccaaac
tataagaacttcaaaggcaccatccaggaacttggtcagaaccagtatgctgttagtggt
gagatatttgtggtggacagaaacacagtagagattacagaacttccagttagaacatgg
acacaggtatacaaggagcaggtcctagaacctatgcttaatggaacagataaaacaccg
gcactgatttctgattacaaagaatatcatactgacacaactgtgaagtttgtggtgaaa
atgacagaagagaaactagcgcaagcagaagctgctggcctgcataaagtttttaaactt
caaactactcttacttgcaattccatggtactctttgatcatatgggttgtctgaagaag
tatgaaactgtgcaagacattttgaaagaattctttgatttacggttaagttattatggt
ttacggaaggaatggcttgtaggaatgctgggagcagaatctacaaagcttaataatcaa
gcccgtttcattttagagaagatacaggggaaaattactatagagaataggtcaaagaaa
gatttgattcaaatgttagtccagagaggttatgaatctgacccagtgaaagcgtggaaa
gaagcacaagaaaaggctgcagaagaggaagattcacaaaaccaacatgatgacagttcc
tctgattcaggaactccttcaggccctgattttaattatattttaaatatgtctctatgg
tctcttactaaagaaaaagttgaagaactcattaaacagagagatacgaaagggcgagag
gttaatgatctcaagaggaagtctccttcagatctttggaaagaagacttagcagcattt
gttgaagaattggataaagtggaagcacaagagcgggaagatattctggcaggaatgtct
gggaaagcaataaaaggtaaagtcggcaaacccaaagtaaagaaacttcagctggaggag
acaatgccctcgccttacgggagaagaattgttccagagattactgctatgaaggcagat
gccagcagaaaattgctgaagaagaaaaagggtgatcctgataccacagtagtgaaagta
gaatttgatgaagaatttagtggaacaccagcagaaggtacaggagaggagacattgacc
ccatctgctcctgtaaataaaggccccaaacccaaaagagagaagaaggagcctggtacc
agggttagaaaaacacctacatcaactggtaaaactaatgcgaagaaagtgaagaaacgg
aatccttggtcagatgatgagtccaaatcagagagtgacttggaagaagcagaacctgtg
gttatcccaagagattctttgcttaggagagcagctgctgaaagacctaagtacactttt
gatttctcagaagaggaggatgatgatgctgctgctgctgatgacagtaatgatttagaa
gaactgaaagttaaagcatctcccataacaaatgatggggaagatgaatttgttccttca
gatggcttagataaagatgagtatgctttttcttcaggcaaatccaaagctactccagaa
aaatcttcaaatgacaaaaaaagtcaggattttggaaatcttttttcatttccttcatat
tctcagaagtcagaagatgattcagctaaatttgacagtaatgaagaagataccgcttct
gtttttgctccatcatttggtctgaagcaaacagataaacttccaagtaaaacagttgct
gctaaaaagggtaaaccaccttcagatacagcccctaaagctaagagagcccctaaacag
aagaagatagtagagactataaactctgactcagactctgaatttggcattccaaagaag
actacaacaccaaaaggtaaaggccgaggggcaaagaaaaggaaagcatcaggctcagaa
aatgaaggtgattataaccctggaaggaaaccatctaaaacagccagcaagaaaccgaag
aaaacatcttttgatcaggattcagatgtagacatcttcccctcagacttcacttctgaa
ccaccggctctcccacggactggtcgggctaggaaagaagtaaaatattttgcagagtct
gatgaagaagaagatgttgattttgcaatgtttaattaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   RefSeq(nuc) (1)   
   GenBank (11)   
   EMBL (11)   
Protein domain (6)   
   Pfam (6)   
All databases (62)   

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