KEGG   Mus musculus (house mouse): 22171
Entry
22171             CDS       T01002                                 
Symbol
Tyms, Ts
Name
(RefSeq) thymidylate synthase
  KO
K00560  thymidylate synthase [EC:2.1.1.45]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00240  Pyrimidine metabolism
mmu00670  One carbon pool by folate
mmu01100  Metabolic pathways
mmu01232  Nucleotide metabolism
mmu01523  Antifolate resistance
Module
mmu_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    22171 (Tyms)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    22171 (Tyms)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    22171 (Tyms)
Enzymes [BR:mmu01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     22171 (Tyms)
SSDB
Motif
Pfam: Thymidylat_synt
Other DBs
NCBI-GeneID: 22171
NCBI-ProteinID: NP_067263
MGI: 98878
Ensembl: ENSMUSG00000025747
UniProt: P07607 Q544L2
Structure
Position
5:complement(30243544..30279261)
AA seq 307 aa
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYS
LRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSAR
QEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKD
LPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPG
DFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPT
IKMEMAV
NT seq 924 nt   +upstreamnt  +downstreamnt
atgctggtggttggctccgagctgcagtccgatgctcagcagctgagcgcggaagcccca
cggcatggagaactccagtacctgaggcaggtggagcacattttgcgctgcggcttcaag
aaggaggaccgcacgggcactggcaccctgtcggtgttcggcatgcaggcacgatacagc
ctgagagatgaatttcctctgctcacaaccaaacgagtgttctggaagggtgttttggag
gagttgttgtggtttatcaagggatccacaaatgctaaagaattgtcctcaaagggagtg
agaatctgggatgccaatggatcccgagattttctggacagcttgggattttctgcccga
caggaaggggacctgggcccagtttatggtttccaatggaggcattttggagcagagtac
aaagatatggattcagattactcgggacaaggagtagaccagctgcaaaaagtgattgac
accatcaaaaccaaccctgatgacagaagaatcatcatgtgtgcctggaacccaaaagat
cttcccctgatggcactgcctccttgccatgccctctgtcagttctatgtggtgaatggg
gaactgtcttgccagctttaccagaggtcaggagatatgggtctgggcgtgcccttcaac
attgccagctatgctctgctcacctacatgattgcacatatcacaggcctgcagccaggt
gattttgtccacactttgggagatgcacatatttacctgaatcatatagagccgctgaaa
attcagctacagcgagaaccaagacctttcccaaagctcaaaatccttcgaaaagttgag
acaatcgatgatttcaaagttgaagactttcagattgaagggtataatccacatccaacg
attaaaatggaaatggctgtttag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (31)   
   RefSeq(nuc) (7)   
   GenBank (12)   
   EMBL (12)   
3D Structure (10)   
   PDB (10)   
Protein domain (1)   
   Pfam (1)   
All databases (76)   

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