KEGG   Mus musculus (house mouse): 22289
Entry
22289             CDS       T01002                                 
Symbol
Kdm6a, Utx
Name
(RefSeq) lysine (K)-specific demethylase 6A
  KO
K11447  lysine-specific demethylase 6A [EC:1.14.11.68]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    22289 (Kdm6a)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:mmu03036]
    22289 (Kdm6a)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.68  [histone H3]-trimethyl-L-lysine27 demethylase
     22289 (Kdm6a)
Chromosome and associated proteins [BR:mmu03036]
 Eukaryotic type
  Histone modification proteins
   HMT complexes
    MLL3/MLL4 complex
     22289 (Kdm6a)
   Histone demethylases
    22289 (Kdm6a)
SSDB
Motif
Pfam: KDM6_C-hel JmjC TPR_1 KDM6_GATAL TPR_2 TPR_8 TPR_17 TPR_12 TPR_16 TPR_19 TPR_7 TPR_9 TPR_11 SNAP TPR_15 ANAPC3
Other DBs
NCBI-GeneID: 22289
NCBI-ProteinID: NP_001297373
MGI: 1095419
Ensembl: ENSMUSG00000037369
UniProt: O70546 Q3TPN3 Q3TNW2
Position
X:18027101..18147061
AA seq 1401 aa
MKSCGVSLATAAAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFG
FVRFHEDGARMKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQR
YYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFK
VNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLS
AQVKATILQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIG
KVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDL
GTLYESCNQPQDAIKCYLNATRSKNCSNTSGLAARIKYLQAQLCNLPQGSLQNKTKLLPS
IEEAWSLPIPAELTSRQGAMNTAQQNTSDNWSGGNAPPPVEQQTHSWCLTPQKLQHLEQL
RANRNNLNPAQKLMLEQLESQFVLMQQHQMRQTGVAQVRPTGILNGPTVDSSLPTNSVSG
QQPQLPLTRMPSVSQPGVHTACPRQTLANGPFSAGHVPCSTSRTLGSTDTVLIGNNHVTG
SGSNGNVPYLQRNAPTLPHNRTNLTSSTEEPWKNQLSNSTQGLHKGPSSHLAGPNGERPL
SSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKP
SGNTLTVPETSRQTGETPNSTASVEGLPNHVHQVMADAVCSPSHGDSKSPGLLSSDNPQL
SALLMGKANNNVGPGTCDKVNNIHPTVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNS
VTSLNSPHSGLHTINGEGMEESQSPIKTDLLLVSHRPSPQIIPSMSVSIYPSSAEVLKAC
RNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFC
TNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKI
WHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGKRRKGPFK
TIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPG
SRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDL
YEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNK
LQNVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWH
GRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKM
EDLMQVYDQFTLAPPLPSASS
NT seq 4206 nt   +upstreamnt  +downstreamnt
atgaaatcctgcggagtgtcgctcgctaccgccgccgccgccgccgccgccgccgctttc
ggtgatgaggaaaagaaaatggcggcgggaaaagcgagcggcgagagcgaggaggcgtcc
cccagcctgacagcggaggagagggaggcgctcggcggactggacagccgccttttcggg
ttcgtgaggtttcatgaagatggcgccaggatgaaggccctgctgggcaaggctgttcgc
tgctacgaatctctaatcttaaaagctgaagggaaagtggagtctgatttcttttgtcaa
ttaggtcacttcaacctcttattggaagattatccaaaagcattatctgcataccagagg
tactacagtttacagtctgattactggaagaatgctgcctttttatatggtcttggtttg
gtctacttccattacaatgcatttcagtgggctattaaagcatttcaggaggtgctttat
gtcgatcccagcttttgtcgagccaaggaaattcatttacgacttgggcttatgttcaaa
gtgaacacagactatgagtctagtttaaagcattttcagttagctttggttgactgtaat
ccctgcactttgtccaatgctgaaattcagtttcacattgcccacttatatgaaacccag
aggaagtatcattctgcaaaagaagcttatgagcaacttttgcagacagaaaacctttct
gcacaagtaaaagcaactattttacaacaattaggttggatgcatcacactgtggatctc
ctgggagataaggccaccaaggaaagttatgctattcagtatctccagaagtccttggaa
gcagatccaaattctggccagtcctggtatttccttggaaggtgctattcaagtattggg
aaagttcaggatgcctttatatcttacaggcaatctattgataaatcagaagcaagtgca
gatacatggtgttcaataggtgtgctctatcaacagcaaaatcagcctatggatgctttg
caagcttatatttgtgctgtacaattggaccacggtcatgctgcagcctggatggatcta
ggcactctctatgaatcctgcaaccaacctcaggatgctattaaatgctatttaaatgca
actagaagcaaaaattgtagtaatacctctggacttgcagcacgaattaagtatttacag
gctcagttgtgtaaccttccacaaggtagtctacagaataaaactaaattacttcctagt
attgaggaggcatggagcctaccaatccccgcagagcttacctccaggcagggtgccatg
aacacagcacagcagaatacttctgataattggagtggtggcaatgcaccacctccagta
gaacaacaaactcattcatggtgtttgacaccacagaaattacagcacttggaacagctc
cgagcaaacagaaataatttaaatccagcacagaaactaatgctggaacagctggaaagt
cagtttgtcttaatgcagcaacaccaaatgagacaaacaggagttgcacaggtacggcct
actggaattcttaatgggccaacagttgactcatcactgcctacaaactcagtttctggc
cagcagccacagcttcctctgaccagaatgcctagtgtctctcagcctggagtccacact
gcctgtcctaggcagactttggccaatggacccttttctgcaggccatgttccctgtagc
acatcaagaacactgggaagtacagacactgttttgataggcaataatcatgtaacagga
agtggaagtaatggaaacgtgccttacctgcagcgaaacgcacccactctacctcataac
cgcacaaacctgaccagcagcacagaggagccgtggaaaaaccaactatctaactccact
caggggcttcacaaaggtccgagttcacatttggcaggtcctaatggtgaacgacctcta
tcttccactgggccttcccagcatctccaggcagctggctctggtattcagaatcagaat
ggacatcccaccctgcctagcaattcagtaacacagggggctgctctcaatcacctctcc
tctcacactgctacctcaggtggacaacaaggcattaccttaaccaaagagagcaagcct
tcaggaaacacattgacggtgcctgaaacaagcaggcaaactggagagacacctaacagc
actgccagtgttgagggacttcctaatcatgtccatcaggtgatggcagatgctgtttgc
agtcctagccatggagattctaagtcaccaggtttactaagttcagacaatcctcagctc
tctgccttgttgatgggaaaagctaataacaatgtgggtcctggaacctgtgacaaagtc
aataacatccacccaactgtccatacaaagactgataattctgttgcctcttcaccatct
tcagccatttccacagcaacaccttctcctaagtccactgaacagacaaccacaaacagt
gttaccagccttaacagccctcacagtgggctgcacacaattaatggagaaggaatggaa
gaatctcagagccccattaaaacagatctgcttctagttagccacagacctagtcctcag
atcataccatcaatgtctgtgtccatatatcccagctcagcagaagttctgaaagcttgc
aggaatctaggtaaaaacggcctgtctaatagtagcattctgttggataaatgtccgcct
ccaagaccaccatcctcaccataccctcccttgccaaaggacaagttgaatccacctaca
cctagtatttatttggaaaataaacgtgatgctttctttcctccattacatcaattttgt
acaaacccaaacaaccctgttacagtaatacgtggccttgctggagctcttaaattagac
ttgggacttttctctactaaaactttggtggaagctaacaatgaacatatggtagaagtg
aggacacagttgttacaaccagcagatgaaaattgggaccctactggaaccaagaaaatc
tggcactgtgaaagtaatagatctcatactacaattgctaaatatgctcagtaccaggcc
tcctcattccaagaatcattgagagaagaaaatgagaaaagaagtcaccataaagaccac
tcagacagtgaatctacatcatcagataattctgggaaaagaagaaaaggaccctttaaa
accattaagtttgggaccaacattgacctgtctgatgacaaaaagtggaagttacagcta
catgagctgactaaacttcctgccttcgtgagagttgtatctgcaggaaatcttttaagc
cacgttggtcatactatactgggcatgaacacagttcaactatacatgaaagttccagga
agcagaacaccaggtcatcaagaaaataacaacttctgttcagttaatataaatattggc
ccaggtgactgtgaatggtttgttgttcctgaaggctactggggtgttttgaatgacttc
tgtgaaaaaaataatttgaatttcttaatgggttcttggtggcccaaccttgaagatcta
tatgaagcaaatgttccagtgtataggtttattcagcgacctggagatctggtctggata
aatgctggcactgttcattgggttcaagctattggctggtgcaacaatattgcttggaat
gttggtccacttacagcctgtcagtataagttagcagtggaacgttatgaatggaacaag
ttgcaaaatgtaaagtcaatagtacccatggttcatctttcctggaatatggcacgaaat
atcaaggtttcagatccaaagctttttgaaatgattaagtattgtcttctgagaacgctg
aagcaatgtcagacattgagggaagctctaattgctgcaggaaaagagatcatatggcac
gggcggacaaaagaagaaccagctcattattgtagtatttgtgaggtggaggtttttgat
ctgctttttgtcactaatgagagtaattctcgaaaaacctacatagtacattgccaagat
tgtgcacgaaaaacaagtgggaatctggaaaattttgtggtgctagaacagtacaaaatg
gaggatctgatgcaagtctatgaccaatttacattagctcctccattaccatccgcctca
tcttga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (20)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (16)   
DNA sequence (38)   
   RefSeq(nuc) (16)   
   GenBank (11)   
   EMBL (11)   
Protein domain (16)   
   Pfam (16)   
All databases (111)   

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