KEGG   Mus musculus (house mouse): 22427
Entry
22427             CDS       T01002                                 
Symbol
Wrn
Name
(RefSeq) Werner syndrome RecQ like helicase
  KO
K10900  werner syndrome ATP-dependent helicase [EC:5.6.2.4]
Organism
mmu  Mus musculus (house mouse)
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:mmu03032]
    22427 (Wrn)
   03400 DNA repair and recombination proteins [BR:mmu03400]
    22427 (Wrn)
Enzymes [BR:mmu01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.4  DNA 3'-5' helicase
     22427 (Wrn)
DNA replication proteins [BR:mmu03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Other termination factors
    22427 (Wrn)
DNA repair and recombination proteins [BR:mmu03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    RecQ family DNA helicases
     22427 (Wrn)
SSDB
Motif
Pfam: DNA_pol_A_exo1 DEAD Helicase_C HTH_40 HRDC RQC RecQ_Zn_bind ResIII
Other DBs
NCBI-GeneID: 22427
NCBI-ProteinID: NP_001116294
MGI: 109635
Ensembl: ENSMUSG00000031583
UniProt: O09053 Q8BWH5 Q3TB25
Structure
Position
8:complement(33724400..33875591)
AA seq 1401 aa
METTSLQRKFPEWMSMQSQRCATEEKACVQKSVLEDNLPFLEFPGSIVYSYEASDCSFLS
EDISMRLSDGDVVGFDMEWPPIYKPGKRSRVAVIQLCVSESKCYLFHISSMSVFPQGLKM
LLENKSIKKAGVGIEGDQWKLLRDFDVKLESFVELTDVANEKLKCAETWSLNGLVKHVLG
KQLLKDKSIRCSNWSNFPLTEDQKLYAATDAYAGLIIYQKLGNLGDTAQVFALNKAEENL
PLEMKKQLNSISEEMRDLANRFPVTCRNLETLQRVPVILKSISENLCSLRKVICGPTNTE
TRLKPGSSFNLLSSEDSAAAGEKEKQIGKHSTFAKIKEEPWDPELDSLVKQEEVDVFRNQ
VKQEKGESENEIEDNLLREDMERTCVIPSISENELQDLEQQAKEEKYNDVSHQLSEHLSP
NDDENDSSYIIESDEDLEMEMLKSLENLNSDVVEPTHSTWLEMGTNGRLPPEEEDGHGNE
AIKEEQEEEDHLLPEPNAKQINCLKTYFGHSSFKPVQWKVIHSVLEERRDNVVVMATGYG
KSLCFQYPPVYTGKIGIVISPLISLMEDQVLQLELSNVPACLLGSAQSKNILGDVKLGKY
RVIYITPEFCSGNLDLLQQLDSSIGITLIAVDEAHCISEWGHDFRSSFRMLGSLKTALPL
VPVIALSATASSSIREDIISCLNLKDPQITCTGFDRPNLYLEVGRKTGNILQDLKPFLVR
KASSAWEFEGPTIIYCPSRKMTEQVTAELGKLNLACRTYHAGMKISERKDVHHRFLRDEI
QCVVATVAFGMGINKADIRKVIHYGAPKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNT
SRNLLIEIHDEKFRLYKLKMMVKMEKYLHSSQCRRRIILSHFEDKCLQKASLDIMGTEKC
CDNCRPRLNHCLTANNSEDASQDFGPQAFQLLSAVDILQEKFGIGIPILFLRGSNSQRLP
DKYRGHRLFGAGKEQAESWWKTLSHHLIAEGFLVEVPKENKYIKTCSLTKKGRKWLGEAS
SQSPPSLLLQANEEMFPRKVLLPSSNPVSPETTQHSSNQNPAGLTTKQSNLERTHSYKVP
EKVSSGTNIPKKSAVMPSPGTSSSPLEPAISAQELDARTGLYARLVEARQKHANKMDVPP
AILATNKVLLDMAKMRPTTVENMKQIDGVSEGKAALLAPLLEVIKHFCQVTSVQTDLLSS
AKPHKEQEKSQEMEKKDCSLPQSVAVTYTLFQEKKMPLHSIAENRLLPLTAAGMHLAQAV
KAGYPLDMERAGLTPETWKIIMDVIRNPPINSDMYKVKLIRMLVPENLDTYLIHMAIEIL
QSGSDSRTQPPCDSSRKRRFPSSAESCESCKESKEAVTETKASSSESKRKLPEWFAKGNV
PSADTGSSSSMAKTKKKGLFS
NT seq 4206 nt   +upstreamnt  +downstreamnt
atggaaaccacttcactacagcggaaatttccagaatggatgtctatgcagagtcaaaga
tgtgctacagaagaaaaggcctgcgttcagaagagtgttcttgaagataacctcccattc
ttagaattccctggatccattgtttacagttatgaagctagtgattgctccttcctgtct
gaagacattagcatgcgtctgtctgatggcgatgtggtgggatttgacatggaatggccg
cccatatacaagccagggaaaagaagcagagtcgcagtgatccagttgtgtgtgtctgag
agcaaatgttacttgtttcacatttcttccatgtcagttttcccccagggattaaaaatg
ttactagaaaacaaatcaattaagaaggcaggggttgggattgaaggggaccagtggaaa
cttctgcgtgattttgacgtcaagttggagagttttgtggagctgacggatgttgccaat
gaaaagttgaagtgcgcagagacctggagcctcaatggtctggttaaacacgtcttaggg
aaacaacttttgaaagacaagtccatccgctgcagcaattggagtaatttccccctcact
gaggaccagaaactgtatgcagccactgatgcttatgctggtcttatcatctatcaaaaa
ttaggaaatttgggtgatactgcgcaagtgtttgctctaaataaagcagaggaaaaccta
cctctggagatgaagaaacagttgaattcaatctccgaagaaatgagggacctagccaat
cgttttcctgtcacttgcagaaatttggaaactctccagagggttcctgtaatattgaag
agtatttcagaaaatctctgttcattgagaaaagtgatctgtggtcctacaaacactgag
actagactgaagccgggcagtagttttaatttactgtcatcagaggattcagctgctgct
ggagaaaaagagaaacagattggaaaacatagtacttttgctaaaattaaagaagaacca
tgggacccagaacttgacagtttagtgaagcaagaggaggttgatgtatttagaaatcaa
gtgaagcaagaaaaaggtgaatctgaaaatgaaatagaagacaatctgttgagagaagat
atggaaagaacttgtgtgattcctagtatttcagaaaatgaactccaagatttggaacag
caagctaaagaagaaaaatataatgatgtttctcaccaactttctgagcatttatctccc
aatgatgatgagaatgactcctcctatataattgaaagtgatgaagatttggaaatggag
atgctgaagtctttagaaaacctaaatagtgacgtggtggaacccactcactctacatgg
ttggaaatgggaaccaatgggcgtcttcctcctgaggaggaagatggacacggaaatgaa
gccatcaaagaggagcaggaagaagaggaccatttattgccggaacccaacgcaaagcaa
attaattgcctcaagacctatttcggacacagcagttttaaaccggttcagtggaaagtc
atccattctgtattagaagagagaagagataatgttgttgtcatggcaactggatatggg
aagagtctgtgcttccagtatccgcctgtttatacaggcaagattggcattgtcatttca
cctctcatttccttaatggaagaccaagtcctccagcttgagctgtccaatgttccagcc
tgtttacttggatctgcacagtcaaaaaatattctaggagatgttaaattaggcaaatat
agggtcatctacataactccagagttctgttctggtaacttggatctactccagcaactt
gactctagtattggcatcactctcattgctgtggatgaggctcactgcatttcagagtgg
ggccatgatttcagaagttcattcaggatgctgggctctcttaaaacagcgctcccattg
gttccagtcattgcactctccgctactgcaagctcttccatccgggaagacattataagc
tgcttaaacctgaaagaccctcagatcacctgcactggatttgatcggccaaatctgtac
ttagaagttggacggaaaacagggaacatccttcaggatctaaagccgtttctcgtccga
aaggcaagttctgcctgggaatttgaaggtccaaccatcatctattgtccttcgagaaaa
atgacagaacaagttactgctgaacttgggaaactgaacttagcctgcagaacataccac
gctggcatgaaaattagcgaaaggaaggacgttcatcataggttcctgagagatgaaatt
cagtgtgttgtagctactgtagcttttggaatgggcattaataaagctgacattcgcaaa
gttattcattatggtgcgcctaaggaaatggaatcctattaccaggaaattggtagagct
ggccgggatggacttcagagttcctgtcacttgctctgggctccagcagactttaacaca
tccaggaatctccttattgagattcacgatgaaaagttccggttatataaattaaagatg
atggtaaagatggaaaaataccttcactccagtcagtgtaggcgacgaatcatcttgtcc
cattttgaggacaaatgtctgcagaaggcctccttggacattatgggaactgaaaaatgc
tgtgataattgcaggcccaggctgaatcattgccttactgctaacaactcagaggacgca
tcccaagactttgggccacaagcattccagctactgtctgctgtggacatcctgcaggag
aaatttggaattgggattccgatcttatttctccgaggatctaattctcagcgtcttcct
gataaatatcggggtcacaggctctttggtgctggaaaggagcaagcagaaagttggtgg
aagaccctttctcaccatctcatagctgaaggattcttggtagaagttcccaaggaaaac
aaatatataaagacatgttccctcacaaaaaagggtagaaagtggcttggagaagccagt
tcgcagtctcctccgagccttctccttcaagctaatgaagagatgtttccaaggaaagtt
ctgctaccaagttctaatcctgtatctccagaaacgacgcaacattcctctaatcaaaac
ccagctggattaactaccaagcagtctaatttggagagaacgcattcttacaaagtgcct
gagaaagtttcttctgggactaacattcctaaaaaaagtgccgtgatgccgtcaccagga
acatcttccagccccttagaacctgccatctcagcccaagagctggacgctcggactggg
ctatatgccaggctggtggaagcaaggcagaaacacgctaataagatggatgtacctcca
gctattttagcaacaaacaaggttctgctggacatggctaaaatgagaccgactactgtt
gaaaacatgaaacagatcgacggtgtctctgaaggcaaagctgctctgttggcccctctg
ttggaagtcatcaaacatttctgtcaagtaactagtgttcagacagacctcctttccagt
gccaaacctcacaaggaacaggagaaaagtcaggagatggaaaagaaagactgctcactc
ccccagtctgtggccgtcacatacactctattccaggaaaagaaaatgcccttacacagc
atagctgagaacaggctcctgcctctcacagcagccggcatgcacttagcccaggcggtg
aaagccggctaccccctggatatggagcgagctggcctgaccccagagacttggaagatt
attatggatgtcatccgaaaccctcccatcaactcagatatgtataaagttaaactcatc
agaatgttagttcctgaaaacttagacacgtacctcatccacatggcgattgagattctt
cagagtggttccgacagcagaacccagcctccttgtgattccagcaggaagaggcgtttc
cccagctctgcagagagttgtgagagctgtaaggagagcaaagaggcggtcaccgagacc
aaggcatcatcttcagagtcaaagagaaaattacccgagtggtttgccaaaggaaatgtg
ccctcagctgataccggcagctcatcatcaatggccaagaccaaaaagaaaggtctcttt
agttaa

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Ontology (4)   
   KEGG BRITE (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (41)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (34)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (10)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (37)   
   RefSeq(nuc) (7)   
   GenBank (15)   
   EMBL (15)   
3D Structure (2)   
   PDB (2)   
Protein domain (8)   
   Pfam (8)   
All databases (104)   

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