KEGG   Mus musculus (house mouse): 227197
Entry
227197            CDS       T01002                                 
Symbol
Ndufs1, 5830412M15Rik, 9930026A05Rik
Name
(RefSeq) NADH:ubiquinone oxidoreductase core subunit S1
  KO
K03934  NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00190  Oxidative phosphorylation
mmu01100  Metabolic pathways
mmu04714  Thermogenesis
mmu04723  Retrograde endocannabinoid signaling
mmu04932  Non-alcoholic fatty liver disease
mmu05010  Alzheimer disease
mmu05012  Parkinson disease
mmu05014  Amyotrophic lateral sclerosis
mmu05016  Huntington disease
mmu05020  Prion disease
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05208  Chemical carcinogenesis - reactive oxygen species
mmu05415  Diabetic cardiomyopathy
Module
mmu_M00143  NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    227197 (Ndufs1)
 09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    227197 (Ndufs1)
  09159 Environmental adaptation
   04714 Thermogenesis
    227197 (Ndufs1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    227197 (Ndufs1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    227197 (Ndufs1)
   05012 Parkinson disease
    227197 (Ndufs1)
   05014 Amyotrophic lateral sclerosis
    227197 (Ndufs1)
   05016 Huntington disease
    227197 (Ndufs1)
   05020 Prion disease
    227197 (Ndufs1)
   05022 Pathways of neurodegeneration - multiple diseases
    227197 (Ndufs1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    227197 (Ndufs1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    227197 (Ndufs1)
Enzymes [BR:mmu01000]
 7. Translocases
  7.1  Catalysing the translocation of protons
   7.1.1  Linked to oxidoreductase reactions
    7.1.1.2  NADH:ubiquinone reductase (H+-translocating)
     227197 (Ndufs1)
SSDB
Motif
Pfam: Molybdopterin Fer2_4 NADH-G_4Fe-4S_3 NADH_dhqG_C Fer2
Other DBs
NCBI-GeneID: 227197
NCBI-ProteinID: NP_001153510
MGI: 2443241
Ensembl: ENSMUSG00000025968
UniProt: Q91VD9
Structure
Position
1:complement(63182751..63215981)
AA seq 727 aa
MLRIPIKRALIGLSNSPKGYVRTTGTAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQI
PRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFL
LANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCT
RCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNVIDICPVGALTSKPYAFTA
RPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQ
RLTEPMVRNEKGLLTYTSWEDALSRVAGMLQNFEGNAVAAIAGGLVDAEALVALKDLLNK
VDSDNLCTEEIFPTEGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRK
SWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGRHSFCEVLKDAKKPMVVLGSSA
LQRDDGAAILVAVSNMVQKIRVTTGVAAEWKVMNILHRIASQVAALDLGYKPGVEAIRKN
PPKMLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGAPMADVILPGAAYTEKSATYVNTE
GRAQQTKVAVTPPGLAREDWKIIRALSEIAGITLPYDTLDQVRNRLEEVSPNLVRYDDIE
ETNYFQQASELAKLVNQEVLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQA
VEEPSIC
NT seq 2184 nt   +upstreamnt  +downstreamnt
atgttaaggatacctataaaaagggccttgataggcctttctaattctcctaaaggatat
gttcgcacaactggcacagcagcaagtaacttgattgaagtatttgttgatggtcagtct
gtcatggtggaaccaggaaccactgttctgcaggcttgcgagaaggtcggcatgcaaatc
cctcgattctgttaccatgaaaggttgtctgttgctggaaattgcaggatgtgcctggta
gagattgagaaagctccaaaggttgtcgctgcttgtgctatgcctgtaatgaagggctgg
aatatcttgacaaactcggaaaaatctaagaaagccagagaaggtgtgatggagttctta
ttagcaaatcacccattggattgtcctatttgtgaccagggaggtgaatgtgatctgcag
gaccagtccatgatgtttggaagtgataggagccgatttctagaggggaagcgtgctgtg
gaggacaagaacattgggcccctagtaaagaccatcatgactagatgcatccagtgtacc
cggtgcatcaggtttgcaagtgagattgcaggagtagatgatttgggaacaacaggaaga
ggaaatgacatgcaagttggcacatacattgaaaaaatgtttatgtctgaactgtctggg
aatgtcattgatatctgccctgtaggggccctaacctctaagccttatgcctttactgcc
cggccttgggaaacaagaaagacagagtccattgatgtaatggatgcagtgggaagtaac
attgtggttagcacaagaactggagaggtaatgaggattttgccaagaatgcatgaagat
attaatgaagaatggatctctgataaaaccaggtttgcttatgatggactaaaacgtcaa
agacttactgaaccaatggtcagaaacgaaaaagggcttttaacttatacctcctgggaa
gatgcactctctcgtgtagctggaatgttacagaattttgaaggcaatgctgtggcagcg
attgcaggaggcttggtggatgctgaagccttagtagctctgaaagacttgcttaataaa
gttgactctgacaacttatgcactgaagagatcttccccactgaaggagctggtacagac
ttacgttccaattatcttctcaataccacaattgctggtgtggaagaagcagatgttgtt
cttctagttggtacaaatccacgttttgaggcaccgctgtttaatgctagaattagaaag
agctggcttcataatgacttaaaagtggccctcatcggtagtccagtggacctcacttac
agatacgaccatctaggagactctcctaaaattctgcaagacattgcttcagggaggcat
tcattctgcgaggtcttaaaggatgctaaaaaaccaatggtggttttaggcagttctgca
ctccagagagatgatggagcagcaattcttgtagctgtgtccaacatggtacaaaagatt
cgagtgacaaccggtgttgctgcagagtggaaagttatgaatattctgcataggattgca
agccaggtagctgctttggaccttggctataaacctggggtagaagcgattaggaagaac
cctcccaaaatgctgtttcttctgggagcagatggaggttgtatcacgcgacaggacttg
ccaaaggattgtttcattgtttatcaaggacaccatggtgatgttggtgctcccatggct
gatgttattctcccaggggctgcttacacagaaaagtctgctacttatgtcaatactgag
ggcagagctcagcaaaccaaagtagcagtgacgcctcctggcttggcacgagaagactgg
aaaatcataagagctctctctgagattgcaggtatcactcttccatatgacactctggat
caagtaaggaaccgtcttgaagaggtctctcctaatctggttcgatatgatgatattgaa
gaaactaattactttcagcaagcaagtgagcttgccaagctagtaaaccaggaggttctt
gctgacccactcgttccacctcagctaactataaaagacttctatatgacagactccatt
agcagagcctcacagacaatggccaagtgtgtcaaagctgtcaccgagggcgctcaggca
gtagaggagccgtccatatgctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (14)   
   KEGG PATHWAY (13)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (57)   
   RefSeq(nuc) (11)   
   GenBank (23)   
   EMBL (23)   
3D Structure (10)   
   PDB (10)   
Protein domain (5)   
   Pfam (5)   
All databases (132)   

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