KEGG   Mus musculus (house mouse): 232223
Entry
232223            CDS       T01002                                 
Symbol
Txnrd3, TGR, TR2
Name
(RefSeq) thioredoxin reductase 3
  KO
K22182  thioredoxin reductase (NADPH) [EC:1.8.1.9]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00450  Selenocompound metabolism
mmu05200  Pathways in cancer
mmu05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    232223 (Txnrd3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    232223 (Txnrd3)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    232223 (Txnrd3)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.1  With NAD+ or NADP+ as acceptor
    1.8.1.9  thioredoxin-disulfide reductase
     232223 (Txnrd3)
SSDB
Motif
Pfam: Pyr_redox_2 Pyr_redox_dim Pyr_redox Glutaredoxin Pyr_redox_3 AlaDh_PNT_C Thi4 FAD_binding_2 DAO HI0933_like NAD_binding_8 FAD_oxidored FAD_binding_3 GIDA Lycopene_cycl GST_N_3
Other DBs
NCBI-GeneID: 232223
NCBI-ProteinID: NP_001171529
MGI: 2386711
Ensembl: ENSMUSG00000000811
UniProt: Q99MD6
Structure
Position
6:89620970..89652511
AA seq 652 aa
MEKPPSPPPPPRAQTSPGLGKVGVLPNRRLGAVRGGLMSSPPGRRARLASPGTSRPSSEA
REELRRRLRDLIEGNRVMIFSKSYCPHSTRVKELFSSLGVVYNILELDQVDDGASVQEVL
TEISNQKTVPNIFVNKVHVGGCDRTFQAHQNGLLQKLLQDDSAHDYDLIIIGGGSGGLSC
AKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKLMHQAALLGHALQDAKKYG
WEYNQQVKHNWEAMTEAIQSHIGSLNWGYRVTLREKGVTYVNSFGEFVDLHKIKATNKKG
QETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGCTLVVGASYVGLECAG
FLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLEQQGVKFQRKFTPILVQQLEKGLPGKL
KVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGLEKIGVKINEKNGKIPVNDVEQTNVP
HVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSLEKCDYINIPTTVFTPLEYGCCGLSE
EKAIEMYKKENLEVYHTLFWPLEWTVAGRDNNTCYAKIICNKFDNERVVGFHLLGPNAGE
ITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCUG
NT seq 1959 nt   +upstreamnt  +downstreamnt
ctggagaagccaccgtccccgccgccgcctcctcgggcgcagacctcgcccgggctgggg
aaggttggagtcctccccaaccgccgcctgggtgctgtccgtggcggcctcatgtcgtcg
ccacccggccgccgcgcccgcctggcctcccctgggaccagccgcccgtcttctgaggcc
cgcgaggagctgcggcgccgcctgcgggacctcatcgagggcaacagggtgatgatcttc
agcaagagttactgtccacacagcacgcgggttaaggaactcttttcgtccttgggagtg
gtctataacatcctggaacttgatcaagttgatgacggggccagtgttcaggaagtgctg
acagaaatcagtaaccagaaaacggtgcccaatatttttgtgaataaagtgcacgtgggt
ggatgtgaccgaactttccaggcacatcagaatggtttactgcagaagctcctccaagat
gactcggctcatgattacgacctcatcatcatcggcgggggttctggcggcctctcttgt
gccaaggaagctgccaacttgggaaagaaggtcatggtgctagactttgtggtcccatcg
cctcagggcacgacctggggccttggcggcacctgtgtgaacgtaggctgtattccaaag
aagctgatgcatcaggcagccctcctggggcatgctttgcaagatgccaagaaatatggc
tgggagtataaccagcaggtgaagcacaactgggaggccatgacagaagctatccagagc
cacattggctccttgaactggggctacagggtaacccttcgggagaaaggcgtgacctat
gtcaactccttcggggagtttgtggacctgcataaaataaaggcaaccaataagaaaggg
caggaaacgttttacacggcttcgaagtttgtcatagcaacaggtgaaaggcctcggtac
ttgggaatccagggagataaagagtactgtattacgagtgacgacctgttctctctgcca
tactgcccgggatgtacattagtcgtaggcgcttcttatgttggtctggagtgtgcgggc
tttttggctggtttggggttagatgtgacagtcatggtacgctccgtccttcttcgtggc
tttgatcaagaaatggcagagaaagtgggatcctacctggaacaacaaggtgtcaagttc
caaaggaaattcacccccattttggttcaacagttggagaaaggtttaccaggaaaattg
aaagtcgtggctaagtccaccgaaggaccggaaacagtagaagggatatacaacacggtt
ttgttagcaattggtcgtgactcctgtacaaggaaaatagggctggagaagatcggggtc
aaaatcaatgagaagaatggcaaaataccagtaaacgatgtggagcagaccaacgtgcct
catgtttatgctattggggacatactggacggcaaaccagagctcacccccgttgccata
caggcaggcaagctgctagctcgaagactctttggggtctctttagaaaagtgtgattat
attaacatcccaacaacggtgttcacacctctggaatatggctgttgtggactgtcggaa
gagaaagccatcgaaatgtataaaaaagagaatctggaagtgtatcacaccttgttttgg
cctctcgagtggacagttgctggcagagacaacaacacctgttatgcaaagataatctgc
aacaaattcgacaacgaacgtgtggtgggatttcaccttctggggccaaatgctggtgaa
atcacgcagggatttgcagctgcaatgaaatgtgggctcacgaagcagctactggatgat
accattggaatccaccccacctgtggtgaggtattcacaacattggaaatcacaaagtcc
tcagggctggacattactcagaaaggctgctgaggctag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (48)   
   RefSeq(nuc) (4)   
   GenBank (22)   
   EMBL (22)   
3D Structure (1)   
   PDB (1)   
Protein domain (16)   
   Pfam (16)   
All databases (115)   

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