KEGG   Mus musculus (house mouse): 234779
Entry
234779            CDS       T01002                                 
Symbol
Plcg2, PLC-gamma-2, PLCgamma2, Plcg-2
Name
(RefSeq) phospholipase C, gamma 2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00562  Inositol phosphate metabolism
mmu01100  Metabolic pathways
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu04012  ErbB signaling pathway
mmu04014  Ras signaling pathway
mmu04020  Calcium signaling pathway
mmu04062  Chemokine signaling pathway
mmu04064  NF-kappa B signaling pathway
mmu04066  HIF-1 signaling pathway
mmu04070  Phosphatidylinositol signaling system
mmu04072  Phospholipase D signaling pathway
mmu04360  Axon guidance
mmu04370  VEGF signaling pathway
mmu04380  Osteoclast differentiation
mmu04611  Platelet activation
mmu04613  Neutrophil extracellular trap formation
mmu04625  C-type lectin receptor signaling pathway
mmu04650  Natural killer cell mediated cytotoxicity
mmu04662  B cell receptor signaling pathway
mmu04664  Fc epsilon RI signaling pathway
mmu04666  Fc gamma R-mediated phagocytosis
mmu04670  Leukocyte transendothelial migration
mmu04722  Neurotrophin signaling pathway
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04919  Thyroid hormone signaling pathway
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu04935  Growth hormone synthesis, secretion and action
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05169  Epstein-Barr virus infection
mmu05170  Human immunodeficiency virus 1 infection
mmu05171  Coronavirus disease - COVID-19
mmu05200  Pathways in cancer
mmu05205  Proteoglycans in cancer
mmu05206  MicroRNAs in cancer
mmu05214  Glioma
mmu05223  Non-small cell lung cancer
mmu05225  Hepatocellular carcinoma
Module
mmu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    234779 (Plcg2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    234779 (Plcg2)
   04014 Ras signaling pathway
    234779 (Plcg2)
   04370 VEGF signaling pathway
    234779 (Plcg2)
   04064 NF-kappa B signaling pathway
    234779 (Plcg2)
   04066 HIF-1 signaling pathway
    234779 (Plcg2)
   04020 Calcium signaling pathway
    234779 (Plcg2)
   04070 Phosphatidylinositol signaling system
    234779 (Plcg2)
   04072 Phospholipase D signaling pathway
    234779 (Plcg2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    234779 (Plcg2)
   04613 Neutrophil extracellular trap formation
    234779 (Plcg2)
   04625 C-type lectin receptor signaling pathway
    234779 (Plcg2)
   04650 Natural killer cell mediated cytotoxicity
    234779 (Plcg2)
   04662 B cell receptor signaling pathway
    234779 (Plcg2)
   04664 Fc epsilon RI signaling pathway
    234779 (Plcg2)
   04666 Fc gamma R-mediated phagocytosis
    234779 (Plcg2)
   04670 Leukocyte transendothelial migration
    234779 (Plcg2)
   04062 Chemokine signaling pathway
    234779 (Plcg2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    234779 (Plcg2)
   04919 Thyroid hormone signaling pathway
    234779 (Plcg2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    234779 (Plcg2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    234779 (Plcg2)
  09158 Development and regeneration
   04360 Axon guidance
    234779 (Plcg2)
   04380 Osteoclast differentiation
    234779 (Plcg2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    234779 (Plcg2)
   05206 MicroRNAs in cancer
    234779 (Plcg2)
   05205 Proteoglycans in cancer
    234779 (Plcg2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    234779 (Plcg2)
   05214 Glioma
    234779 (Plcg2)
   05223 Non-small cell lung cancer
    234779 (Plcg2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    234779 (Plcg2)
   05171 Coronavirus disease - COVID-19
    234779 (Plcg2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    234779 (Plcg2)
   05169 Epstein-Barr virus infection
    234779 (Plcg2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    234779 (Plcg2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    234779 (Plcg2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    234779 (Plcg2)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     234779 (Plcg2)
Membrane trafficking [BR:mmu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    234779 (Plcg2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    234779 (Plcg2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y C2 SH3_1 SH3_9 PH PH_12 SH3_2 PH_14 GDPD EF-hand_like
Other DBs
NCBI-GeneID: 234779
NCBI-ProteinID: NP_758489
MGI: 97616
Ensembl: ENSMUSG00000034330
UniProt: Q8CIH5
Structure
Position
8:118225014..118361881
AA seq 1265 aa
MTTMVNVDTLPEYEKSQIKRALELGTVMTVFNARKSTPERRTVQMIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRHKAECCFTILYGTQFVLSTLSLATDSKEDAV
KWLSGLKILHQEAMSASTPTMIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSGI
KFLKDKLVEIGAQKDELSFEQFHLFYKKLMFDQQKSILDEFKKDSSVFILGNTDRPDASA
VYLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKV
FKEVLGDMLLTKPTEASADQLPSPSQLREKIIIKHKKLGPKGDVDVNVEDKKDEHKPQGE
LYMWDSIDQKWTRHYCAIADAKLSFGDDIEQAVEEEPVQDTPPTELHFGEKWFHKKVESR
TSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMENGVMKYY
LTDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGTNSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQII
EDNPLGSLCKGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKMDTKENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVE
TKADSIVRQKPVDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRSEKYDPMPLESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SRFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgaccaccatggtcaacgtggacacccttccagaatatgagaagagtcagatcaagaga
gcgctggagttagggacggtgatgaccgtgttcaacgcccgcaaatccaccccagagcgg
aggacagtacagatgatcatggagactcggcaggtggcatggagcaagaccgcagacaag
attgaaggcttcctggacatcatggagataaaggaaatccgtccggggaagaactccaag
gactttgagcgagccaaggctgtccgccacaaggcagaatgttgcttcaccatcctctac
ggcacccagtttgtcctcagcacgctcagtttggcaacggactcaaaggaggatgcggtg
aagtggctctctggtttgaagatcctacaccaggaagcgatgagtgcatccacccccaca
atgattgagagttggctgagaaaacagatttattcagtagatcaaacccgaagaaacagc
atcagcctccgggagctgaagaccatcttgcccctggtcaacttcaaagtgagcggcatc
aagtttctcaaggacaagctggtggaaatcggcgcacagaaagatgagctcagctttgaa
cagttccatctcttctataagaaactcatgtttgaccagcaaaaatcgatacttgacgaa
ttcaaaaaagactcctccgtgttcatcctaggaaacacagaccggccggatgcctcggct
gtctacctgcaggacttccaaaggtttcttttacatgaacagcaggagctatgggctcag
gatctgaacaaagtccgggagcggatgaccaagtttatcgacgacacaatgagagagacc
gcagagcccttcttatttgtggatgagttcctcacgtatctgttctcccgggagaacagc
atctgggacgagaagtacgatgcagtggacatgcaggacatgaacaaccccttgtcccac
tactggatctcctcttcccacaacacgtacctcactggggaccagctgcgtagtgagtcc
tccacggaagcgtatatccgctgtctgcgcgctggttgccgctgcattgagctggactgc
tgggacgggcctgatgggaagcccattatctaccacggctggacacggaccaccaagatc
aagtttgatgatgttgttcaggccatccgagaccacgcctttgttacctccagcttcccc
gtcatcttgtctatcgaggagcactgcagtgtggagcagcaacgtcacatggccaaggtg
ttcaaggaagtgttaggagacatgctgttgacgaagcccacagaggccagtgctgaccag
ctgccctcgcccagtcagcttcgtgagaagatcattatcaagcataagaagctgggtccc
aagggtgatgtcgacgtcaacgtggaggacaagaaagatgagcacaagccccagggcgag
ctgtatatgtgggactccatcgaccagaaatggacgcgccactactgtgccattgctgac
gccaagctgtccttcggtgatgacattgaacaggctgtggaggaggagccggtccaggac
actccccccacggagctgcattttggggagaaatggttccacaagaaggtggagagtagg
accagtgcggagaagctgctgcaagagtactgtgctgagaccggggccaaggacggcacc
ttcctggtgcgggagagcgagaccttccccaatgactacacactctccttctggcggtct
ggccgggtgcagcactgccggatccggtctactatggagaatggggtcatgaagtactac
ctgaccgacaacctcacgttcaacagcatctacgccctcatccagcactaccgtgaggca
cacctgcgctgcgcggagttcgagctgcggctcacagacccggtgcccaaccccaaccca
cacgagtccaagccgtggtactatgacagtctgagcaggggggaagcggaggacatgctg
atgcggatcccccgagatggagccttcctcatccggaagagggaggggaccaactcctac
gccatcaccttcagggccaggggcaaggtgaaacattgtcgcatcaaccgggacggacgc
cacttcgtgctgggcacctctgcctactttgagagcctggtggagcttgtcagctactac
gagaagcacgcgctctatcgcaagatgaggcttcgataccccgtgaccccggagctcctg
gagcgatataatatggaaagagacatcaactctctttatgacgtcagcaggatgtatgtg
gacccaagtgagatcaacccttccatgcctcagaggaccgtgaaagcgctctatgactac
aaagccaagcgcagcgacgagctgaccttctgccgcggtgccctcatccacaatgtctcc
aaggagcccgggggatggtggaaaggggactacgggacccggatccagcagtacttcccg
tccaactatgtcgaggatatctcggcaggcgatgctgaggagatggaaaagcagattatt
gaagacaatcccctcgggtctctctgcaaaggcatattggatcttaatacctacaacgtt
gtgaaggccccccaggggaaaaaccagaaagccttcgtctttatcctggagcctaagaaa
cagggagatcctcccgtggagttcgcgaccgaccgtgtggaggagctgtttgagtggttt
cagagcatacgggagatcacttggaagatggacaccaaggagaacaacatgaagtactgg
gagaggaaccagtccatcgccattgagctctcggacttggttgtatactgcaagccaact
agcaaaaccaaggaccatttggaaaatcccgacttccgagaaatccgctcttttgtggag
acgaaggcagacagcattgtcaggcaaaaacctgtcgatctattgcgatacaatcagaag
ggcctgacccgagtctaccccaagggacagagagttgactcttcgaactatgaccccttc
cgtctgtggctgtgcggctcccagatggtggcactcaatttccagactccagacaaatac
atgcagatgaaccacgcgctgttttcgctcaatgggcgaacaggctacgtcctgcagcct
gagagcatgcgctctgagaagtatgatccgatgcccctggagtcccagaggaagatcctg
atgacactcactgtcaaggttcttggtgcacgccacctccctaaactagggcggagtatt
gcctgtccttttgtggaggtggaaatctgcggggctgagtatgacagcaacaaattcaag
acgacggttgtgaatgacaatggcctcagccctgtctgggctccaactcaggagaaggtg
acatttgagatctatgatccaaaccttgccttcctacgctttgtggtctacgaagaagac
atgttcagtgatcccaacttcctggctcatgccacgtaccccattaaaggcatcaaatcc
gggtttagatcagtccctctgaagaatgggtacagtgaagacatcgagctggcatccctc
ctggttttctgtgagatgaggccagtcctggagagtgaagaggaactctattcctcctgt
cgccaactgcggaggcggcaagaagagctcaacaaccagctcttcctttacgacacgcac
cagaacctgcgcggagccaaccgtgatgccctggtgaaggagttcaatgttaacgagaat
cagctgcagctgtaccaggagaagtgcaaccggaggctgagagagaagagagtaagcaac
agcaggttctactcctag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (38)   
   KEGG PATHWAY (37)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
3D Structure (2)   
   PDB (2)   
Protein domain (12)   
   Pfam (12)   
All databases (96)   

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