KEGG   Mus musculus (house mouse): 24127
Entry
24127             CDS       T01002                                 
Symbol
Xrn1, Dhm2, exo, mXrn1
Name
(RefSeq) 5'-3' exoribonuclease 1
  KO
K12618  5'-3' exoribonuclease 1 [EC:3.1.13.-]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu03008  Ribosome biogenesis in eukaryotes
mmu03018  RNA degradation
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09120 Genetic Information Processing
  09122 Translation
   03008 Ribosome biogenesis in eukaryotes
    24127 (Xrn1)
  09123 Folding, sorting and degradation
   03018 RNA degradation
    24127 (Xrn1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:mmu03019]
    24127 (Xrn1)
   03009 Ribosome biogenesis [BR:mmu03009]
    24127 (Xrn1)
   03016 Transfer RNA biogenesis [BR:mmu03016]
    24127 (Xrn1)
   03036 Chromosome and associated proteins [BR:mmu03036]
    24127 (Xrn1)
Messenger RNA biogenesis [BR:mmu03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     24127 (Xrn1)
  mRNA degradation factors
   5'-3' decay
    5' exonucleases
     24127 (Xrn1)
Ribosome biogenesis [BR:mmu03009]
 Eukaryotic type
  Pre-60S particles
   RNases
    24127 (Xrn1)
Transfer RNA biogenesis [BR:mmu03016]
 Eukaryotic type
  tRNA degradation factors
   Rapid tRNA decay (RTD) pathway factors
    24127 (Xrn1)
Chromosome and associated proteins [BR:mmu03036]
 Eukaryotic type
  Gene silencing
   piRNA pathway
    24127 (Xrn1)
SSDB
Motif
Pfam: XRN_N XRN_M XRN1_D2_D3 XRN1_D1 SH3_12 Dicer_dimer Ppx_C
Other DBs
NCBI-GeneID: 24127
NCBI-ProteinID: NP_001298059
MGI: 891964
Ensembl: ENSMUSG00000032410
UniProt: A0A087WQN7
Position
9:95836803..95939859
AA seq 1719 aa
MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKI
FTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGE
TLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHK
IMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCA
PEETTFHLLHLSLMREYIDYEFSALKEKITFKYDIEKIIDDWILMGFLVGNDFIPHLPHL
HINHDALPLLYGTYIAILPELGGYINESGHLNLPRFERYLVKLSDFDREHFSEVFVDLKW
FESKVGNKYLNEAAGAAAEEAKNCKEKRKPKGQENSLSWAALDKSEGEGVASRDNFEDET
EDDDLFETEFRQYKRTYYMTKMGVDVVSDEFLANQAACYVQAIQWILHYYYHGVQSWSWY
YPYHYAPFLSDIRSISTLKIHFELGKPFKPFEQLLAVLPSASKNLLPTCYQHLMTSEDSP
IIEYYPPDFKTDLNGKQQEWEAVVLIPFIDETRLLEAMETCNHSLKKEERKRNQHSECLM
CWYDRDTEFTYSSPWPEKFPAIERCCTRYKMISLDAWRVDINKNKITRVDQKALYFCGFP
TLKHIKHKFFLKKSGVQVFQQSSRGENLMLEISVNAEPDELRIENIASAVLGKAVFVNWP
HLEEARVVAVSDGETKFYIEEPPGTQKVYLGKTAPPSKVIQLTDKEQSNWTKEIQGISEQ
YLRRKGIIINETSAVVYAQLLTGRKYQISQNGEVRLEKQWSKQILPFVYQTIVKDIRAFD
SRFSNIKTLDDLFPPRTMVFMLGTPYYGCTGEVQDSGDLITEGRIRVVFSIPCEPNLDAL
IQNQHKYSIKYNPGYVLAGRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFN
KKNEEVPGYTKKVGNEWMYSSAAEQLLAEYIERAPELFSYIAKNSQEDVFYEDDIWPGEN
ENGAEKVQEIITWLKGHPVSTLSRSSCDLHILDAAIVEKIEEEVEKCKQRKSNKKVRVTV
KPHLLYRPLEQQHGVIPDRDAEFRLFDRVVNVRESFSVPVGLRGTVIGIKGASREADVLF
EVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRCETGNQKLTAIVKPQPSVSHCSA
APSGHLGGLNHSPQSPFLPTQVPTKGDDEFCNIWQSLQGAGKIQHLQPTVQEKGAVLPQE
ISQVTEGHKSGFTDHSVRHQQRKHDSQRKFKEEYKSPKAECQSQKLSSKQTSGGSARCSI
KLLKRNESPGTSEAQKVVTSYPNAVHKPPSGIENFLASLNLSKENEAQLPHHGEPPDEAD
LSPQSFAMKGTRMLKEILKIDSPDTRDSKNDMKKSDNEATVSSRRDERGVSAHPKPTCHM
NKPHGTNEFQNVASVDSVCWPGQMPPVSTPVTELSRICSLVGMPQPDFSFLRTTQTMTVC
QVKLSNGLLVHGPQCHSESEAKERAALFALQQLGSLGVSFPLPPPIFTNYPPAVPPGAVP
PVFTQPTANIMPSSSHLFGSVSWRPPVPVAGNAFHYPSYPGTMPLAGGVPGGVHSQFIPL
QVTKKRVANRKNFENKEAQSSQATPLQTNKPGSSEATKMTPQESPPASSSSSQAAQPVSS
HVETASQGHVGSQPRSAPSSSKRKSRKLAVNFSVSKPSE
NT seq 5160 nt   +upstreamnt  +downstreamnt
atgggagtccccaagttttaccgatggatctcggagcggtacccctgcctcagcgaagtg
gtgaaggagcatcagattccagaatttgataacttgtacctggatatgaatgggattata
catcagtgttcccatcctaatgatgatgatgttcacttcagaatttcagatgacaaaatc
tttactgacatttttcactacttggaggtgttgtttcgaattattaaacctaggaaagtg
ttctttatggctgttgacggtgtggctcctcgagcaaaaatgaaccagcaacgcgggagg
cgttttaggtcagccaaggaggcagaagacaaaattaaaaaagcaatagaaaagggagaa
acacttcctacagaagccagattcgattccaactgtattacgccagggactgaattcatg
gccagattgcatgaacatctgaagtattttgtaaatatgaaaatttccacagacaaatca
tggcaaggtgttaccatctacttctcaggccatgagactcctggagaaggagagcataaa
atcatggaatttatcagatccgagaaagcaaagccagatcatgatccaaacaccagacat
tgtctttatggcttagatgctgacttgatcatgcttggattaacaagtcacgaggcacat
ttttctctcttaagagaagaagttcggtttggtggaaaaaaaacacaaagggtatgtgca
ccagaagaaacgacatttcacctcctacacttgtctttaatgagagagtatattgattat
gaattttcagcattaaaggaaaagatcacatttaaatatgatattgaaaaaattatagat
gattggattttgatgggatttcttgttggcaatgattttatccctcatctacctcattta
catattaatcatgatgcgctgcctcttctttatggaacatatattgctatcctgccagaa
cttggaggttatattaatgaaagtggacatctcaacttacctcgatttgagagatacctt
gtgaaactatcagattttgatcgagaacacttcagtgaagtttttgtggacctcaagtgg
tttgaaagcaaagttggtaacaagtatctcaatgaggcagcaggtgcagcagcagaagag
gcaaagaactgcaaggagaagagaaaaccgaagggtcaggaaaattctttaagttgggct
gcattagacaaaagtgaaggtgaaggagtagcttctagagataattttgaggatgagact
gaagatgatgatctgtttgaaactgaatttagacaatataagagaacatactacatgacg
aagatgggcgtcgatgtagtatctgatgagtttctggctaatcaggctgcctgttatgtt
caggctatacagtggatcttacactattactatcatggagtccagtcctggagctggtac
tatccctatcattacgcacccttcctatctgatatccgcagtatcagtacactcaaaatc
cattttgaactcggaaaacccttcaagccattcgagcagctgcttgctgtacttccatcg
gctagtaaaaatttgcttcctacatgctaccagcatttgatgaccagtgaagactcgcca
attatagaatattatccacctgatttcaaaactgatctaaatgggaaacaacaggaatgg
gaagctgtggtattaataccgtttattgatgagacgcgattattggaagccatggagaca
tgtaaccactccctcaaaaaagaagagaggaaaagaaaccagcacagtgagtgcctgatg
tgctggtatgacagagacacagagttcacctactcctctccatggccagaaaagttccct
gccatagaacgatgttgtacaaggtataaaatgatatcattagatgcttggcgcgtagac
ataaacaagaacaaaataaccagggttgaccagaaggcattatatttctgtggattccct
actttgaaacacatcaaacataaattttttttgaagaaaagtggtgttcaagtattccag
cagagtagtcgtggtgaaaacttgatgttggaaatttcagtaaatgcagaaccagatgaa
cttaggatagagaacatagcttcggcggtgctgggaaaggcagtctttgttaactggcct
catcttgaagaagctagagttgtggcagtatcagatggtgaaactaagttttacatagaa
gaacctccaggaacacagaaggtttatttgggaaaaactgccccaccatctaaagtcatc
caacttacagataaagaacaatcgaactggactaaagaaatacaaggaatttcagaacaa
tatctaagaagaaagggaataataataaatgaaacatctgctgttgtgtatgctcagttg
ctcacgggtcgtaaatatcaaatcagtcagaatggtgaagttcgtctagaaaaacagtgg
tcaaaacaaattcttccttttgtttatcaaactattgttaaggacatccgagcttttgac
tctcgtttctccaatatcaagacattggatgacttgtttccaccgagaactatggtcttt
atgcttggaactccttattatggctgcactggagaagttcaggattcaggagacttgatt
acagaagggagaattcgtgtggttttcagcattccatgtgagccaaatcttgatgcttta
atacagaatcagcataaatactctataaagtacaacccaggatatgtgttggccggtcgc
cttggcgtgagtggataccttgtttcaaggtttacaggaagtatttttattggaagagga
tctaggagaaaccctcatggagaccataaagcaaatgtgggtttaaatctcaaattcaac
aagaaaaatgaggaagtccctggctatacaaagaaagtggggaacgagtggatgtactcg
tcggcagcagagcagctcctcgcagagtacatagagagagcaccagaactgttcagttat
atagcaaaaaacagccaagaagatgtattctatgaagatgacatctggcctggagaaaat
gagaacggggctgagaaagttcaagaaattattacttggctaaaaggacatcctgtcagt
actctgtctcggtcttcttgtgacttgcacattctggatgcagccattgttgaaaaaatc
gaggaagaagttgagaagtgcaagcaaagaaagagcaacaagaaagtccgagtaacagtg
aagccccatttgctgtacagacccttagagcagcagcatggagtcattcctgatcgggat
gccgagttccggctctttgatcgcgttgtgaacgtgagagagagcttctccgtgccagtc
ggccttcgaggcaccgtcattggaattaaaggggctagcagagaagctgatgtactattt
gaagtattatttgatgaggaatttcccggaggcttaacaataaggtgctcacctggtagg
ggataccgactgccaacaagtgccttggtgaacctttctcatgggagtcggtgtgaaact
ggaaaccagaagttgacagccattgtgaaaccacaaccttctgtgagtcactgtagtgca
gctccctccgggcacttgggaggcctcaaccactctcctcagtcaccttttcttcctact
caggtacctacaaaaggtgatgatgaattttgcaacatttggcaatctctacagggagct
ggaaaaattcaacacttgcagccgacagtacaagagaagggtgcagttctacctcaagaa
ataagtcaagtaactgaaggtcataaatctggctttactgaccacagtgtcagacatcag
cagagaaaacatgactcgcaacgaaaatttaaggaagaatataaaagtcctaaagctgag
tgtcagagtcaaaagttgtccagtaaacagacttctggagggtctgccagatgtagtatt
aaactattgaagagaaatgaaagtccaggaacttcagaagcccagaaggttgtaactagt
tacccaaatgcagtgcataagcctccctctgggattgagaactttttagcatctttgaat
ctctctaaggagaatgaagcacagctacctcatcatggagagcctccagatgaggcggat
ttgtccccgcagtcctttgctatgaaaggaacacggatgcttaaagaaattctgaaaatt
gatagccctgacacaagagacagcaagaatgatatgaagaaatctgataatgaagccact
gtttcttctagaagagatgagcgtggagtgtcagcacatcctaagccaacatgccatatg
aacaagcctcatgggactaacgagttccaaaatgtggcatcggtggacagtgtgtgttgg
ccaggccagatgcctcctgtgtccacaccagtaactgaactttctcgaatttgttccctt
gttggaatgccacaacctgatttctcctttctgcgaacaacacagacaatgacagtttgt
caggtaaaattgtctaatggcttactggtacatgggccacagtgccactctgaaagtgaa
gccaaggagagagctgctctttttgctttacagcaactgggctccttgggtgtgagtttt
cctttgcctccacccatatttacaaattatcctcctgcggtaccacctggagccgtccct
cctgtttttacccaacctactgctaatataatgccttcatcgtctcatctctttggctca
gtgtcatggagaccaccagtgccagttgctgggaatgccttccactatccttcatatcct
ggaaccatgcccttggctggaggagtgccaggcggagtgcacagtcagttcatacctctg
caggttaccaaaaaaagagttgcaaacagaaagaattttgagaataaggaggcccagagt
tctcaggccacaccacttcagactaacaagccagggtcttctgaagccaccaaaatgact
ccacaagaaagtccaccagcctcttcatcatcctctcaggctgcccagcccgtgtcttct
catgttgaaactgcctcccaaggccatgttgggtcccaaccaaggtcagcgccaagctcc
tcaaaaaggaagtcgagaaaactggccgtcaacttcagcgtttctaaaccttcggaataa

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (2)   
   KEGG PATHWAY (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   RefSeq(pep) (8)   
DNA sequence (42)   
   RefSeq(nuc) (10)   
   GenBank (16)   
   EMBL (16)   
Protein domain (7)   
   Pfam (7)   
All databases (94)   

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