KEGG   Mus musculus (house mouse): 26410
Entry
26410             CDS       T01002                                 
Symbol
Map3k8, Cot, Cot/Tpl2, Est, Estf, Tpl-2, Tpl2, c-COT
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 8
  KO
K04415  mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04010  MAPK signaling pathway
mmu04620  Toll-like receptor signaling pathway
mmu04660  T cell receptor signaling pathway
mmu04668  TNF signaling pathway
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    26410 (Map3k8)
   04668 TNF signaling pathway
    26410 (Map3k8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    26410 (Map3k8)
   04660 T cell receptor signaling pathway
    26410 (Map3k8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    26410 (Map3k8)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     26410 (Map3k8)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: STE group
  Other
   26410 (Map3k8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_fungal HTH_8 ABC1 RIO1
Other DBs
NCBI-GeneID: 26410
NCBI-ProteinID: NP_031772
MGI: 1346878
Ensembl: ENSMUSG00000024235
UniProt: Q07174 Q3UEB8
Position
18:complement(4331325..4352978)
AA seq 467 aa
MEYMSTGSDEKEEIDLLIKHLNVSEVIDIMENLYASEEPGVYEPSLMTMYPDSNQNEERS
ESLLRSGQEVPWLSSVRYGTVEDLLAFANHVSNMTKHFYGRRPQECGILLNMVISPQNGR
YQIDSDVLLVPWKLTYRNIGSGFVPRGAFGKVYLAQDMKTKKRMACKLIPIDQFKPSDVE
IQACFRHENIAELYGAVLWGDTVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHILKG
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVKMTEDVYLPKDLRGTEIYMSPEVIL
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIAGDCSPG
MRELIEAALERNPNHRPKAADLLKHEALNPPREDQPRCQSLDSALFERKRLLSRKELQLP
ENIADSSCTGSTEESEVLRRQRSLYIDLGALAGYFNIVRGPPTLEYG
NT seq 1404 nt   +upstreamnt  +downstreamnt
atggagtacatgagcactggaagtgacgagaaagaagaaattgatttattaattaagcat
ttaaacgtgtcagaagtcatagacataatggagaacctttatgcaagtgaagagccagga
gtgtatgagcccagtctgatgaccatgtatccagacagcaatcaaaatgaggaacgttcg
gagtcactgcttcggagtggccaggaggttccctggctgtcatctgtcagatatgggacc
gtggaggatctgcttgcatttgcaaaccatgtctccaatatgacaaagcatttttatgga
cgtcgaccacaagaatgtggaattttattaaatatggtaatcagtccccagaatggccgc
taccaaatcgattcggatgttctccttgttccttggaagctgacatacaggaacatcggc
tctggtttcgttcctcggggggcctttggaaaagtatacttagcccaagacatgaagaca
aagaaaagaatggcgtgcaaactgatccctatagatcagtttaagccatcggatgtggaa
atccaggcctgtttccggcatgagaacattgctgagttatatggtgccgtcctatggggc
gatactgtccatctctttatggaagccggcgagggagggtctgttctggagaaactggag
agttgtgggcccatgagagaatttgaaattatttgggtgacgaagcacattctcaaggga
cttgattttctgcactccaagaaagtgatccaccatgatattaaacctagcaacattgta
ttcatgtctacaaaagctgttttggtagattttggcctgagtgttaagatgactgaagat
gtctatcttcccaaggacctccggggaacagagatatacatgagcccagaggtgatccta
tgtcggggccattccacaaaagccgacatctacagccttggagccacactcatccacatg
cagacaggcaccccaccctgggtgaagcgctaccctcgatcagcctatccctcctaccta
tacattatccacaagcaggcacctcccctggaagacatcgctggtgactgcagtccaggc
atgagggagctgatagaagctgccctggagaggaaccccaaccaccgccccaaagcagca
gacctactgaaacatgaagccctgaatcccccaagagaggaccagccacgatgtcagagt
ctggactctgccctctttgaacggaagaggctgctgagcaggaaggaactacaacttcct
gagaacattgctgattcatcatgcacaggcagcaccgaagagtctgaagtgctcaggaga
cagcgttccctctacattgacctcggagctctggctggctacttcaatattgttcgtggg
ccaccaaccctggaatacggctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (26)   
   RefSeq(nuc) (6)   
   GenBank (10)   
   EMBL (10)   
Protein domain (6)   
   Pfam (6)   
All databases (63)   

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