KEGG   Mus musculus (house mouse): 269951
Entry
269951            CDS       T01002                                 
Symbol
Idh2, E430004F23, IDPm, Idh-2
Name
(RefSeq) isocitrate dehydrogenase 2 (NADP+), mitochondrial
  KO
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00020  Citrate cycle (TCA cycle)
mmu00480  Glutathione metabolism
mmu01100  Metabolic pathways
mmu01200  Carbon metabolism
mmu01210  2-Oxocarboxylic acid metabolism
mmu01230  Biosynthesis of amino acids
mmu04146  Peroxisome
mmu05230  Central carbon metabolism in cancer
Module
mmu_M00009  Citrate cycle (TCA cycle, Krebs cycle)
mmu_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    269951 (Idh2)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    269951 (Idh2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    269951 (Idh2)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    269951 (Idh2)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.42  isocitrate dehydrogenase (NADP+)
     269951 (Idh2)
SSDB
Motif
Pfam: Iso_dh
Other DBs
NCBI-GeneID: 269951
NCBI-ProteinID: NP_766599
MGI: 96414
Ensembl: ENSMUSG00000030541
UniProt: P54071
Structure
Position
7:complement(79744594..79768356)
AA seq 452 aa
MAGYLRAVSSLCRASGSARTWAPAALTVPSWPEQPRRHYAEKRIKVEKPVVEMDGDEMTR
IIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYSI
QKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVQTVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGKQ
NT seq 1359 nt   +upstreamnt  +downstreamnt
atggccggctacctgcgggctgtgagctcgctctgcagagcctcgggctcagcgcggacc
tgggcaccggcagcactgactgtccccagctggccggagcagccgcggcgccactatgct
gagaagaggatcaaggtggagaagccggtagtggagatggacggtgacgagatgacccgg
atcatctggcagttcatcaaggagaagctcatcctgcctcacgtggatgttcagctcaag
tattttgaccttgggcttccaaaccgtgaccagaccaatgaccaggtcaccattgactct
gctctggccacccagaagtacagtgtggctgtcaagtgtgccacaatcacccctgatgag
gcccgtgtggaagagttcaagctgaagaaaatgtggaagagccctaacggaacgatccgg
aacatccttgggggaaccgtcttcagagagccaatcatctgcaaaaacatcccccgcctt
gtccctggctggaccaagcccatcaccattggcaggcacgcccatggcgaccagtacaag
gccacagattttgtggtagatcgagctggcacgttcaagttggtcttcaccccaaaggat
ggcagcagtgccaaggagtgggaggtgtataacttccctgccggaggcgttgggatgggg
atgtacaacaccgacgagtccatttcgggcttcgcgcacagctgcttccagtactctatc
cagaagaaatggccgctctacttgagcaccaagaacaccattctgaaggcctatgacggg
cgtttcaaggacatcttccaggagatctttgacaagcactataagactgacttcgacaag
aataagatctggtatgaacatcggctcatcgacgacatggtggcccaggtgctcaagtct
tccggtggctttgtgtgggcttgcaaaaactatgatggagacgtgcagtctgacatcctg
gctcaaggctttggctccctcggcctgatgacatctgtgctggtctgccctgatgggaag
acaattgaggctgaggctgctcatgggacagtcacccgccattaccgagaacaccagaag
ggccggcccaccagtaccaaccctattgccagcatctttgcctggacacggggtctggag
catcgtgggaagctggatgggaaccaggaccttatcaggtttgcacagacgctggagaag
gtgtgcgtgcagactgtggagagcggagcgatgaccaaggacctggctggctgtatccat
ggcctcagcaatgtgaagctgaacgagcacttcctgaacaccacagacttcctggacacc
attaagagcaacctggacagagctctgggcaagcagtag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (8)   
   KEGG MODULE (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (45)   
   RefSeq(nuc) (3)   
   GenBank (21)   
   EMBL (21)   
3D Structure (2)   
   PDB (2)   
Protein domain (1)   
   Pfam (1)   
All databases (91)   

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