KEGG   Mus musculus (house mouse): 50493
Entry
50493             CDS       T01002                                 
Symbol
Txnrd1, TR, TR1, TrxR1
Name
(RefSeq) thioredoxin reductase 1
  KO
K22182  thioredoxin reductase (NADPH) [EC:1.8.1.9]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00450  Selenocompound metabolism
mmu05200  Pathways in cancer
mmu05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    50493 (Txnrd1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    50493 (Txnrd1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    50493 (Txnrd1)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.1  With NAD+ or NADP+ as acceptor
    1.8.1.9  thioredoxin-disulfide reductase
     50493 (Txnrd1)
SSDB
Motif
Pfam: Pyr_redox_2 Pyr_redox_dim Pyr_redox Pyr_redox_3 FAD_binding_2 HI0933_like AlaDh_PNT_C Thi4 FAD_oxidored NAD_binding_8 GIDA DAO
Other DBs
NCBI-GeneID: 50493
NCBI-ProteinID: NP_001035988
MGI: 1354175
Ensembl: ENSMUSG00000020250
UniProt: Q9JMH6
Position
10:82669785..82733558
AA seq 613 aa
MPVDDCWLYFPASRGRTFVQTVWVAPTCPNCCWFPGFLPPVPRPPHVPRVLLRGPRGAVL
PASRPSKTLPSSSQTPCPTDPCICPPPSTPDSRQEKNTQSELPNKKGQLQKLPTMNGSKD
PPGSYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIP
KKLMHQAALLGQALKDSRNYGWKVEDTVKHDWEKMTESVQSHIGSLNWGYRVALREKKVV
YENAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSL
PYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIK
FIRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETVG
VKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKCD
YDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNKCYAKII
CNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSVTK
RSGGDILQSGCUG
NT seq 1842 nt   +upstreamnt  +downstreamnt
atgccagttgatgactgctggctgtacttcccagcttctcgaggtagaacctttgtgcag
actgtctgggtggcacccacttgccccaactgttgctggtttccaggttttctccctcca
gtcccccggccaccacatgtgccccgtgtgctgctgaggggccctcgtggggctgtgctt
cctgcttcacgtccctccaagacactcccctcctcatcccagacgccctgtcctactgac
ccctgtatctgccctccaccctccacacctgatagtaggcaggaaaaaaatacgcaatct
gagctgccgaacaaaaaaggccaacttcaaaagctgccaacaatgaatggctccaaagat
ccccctgggtcctatgacttcgacctgatcatcattggaggaggctcaggaggactggca
gcagctaaggaggcagccaaatttgacaagaaagtgctggtcttggattttgtcacaccg
actcctcttgggaccagatggggtctcggaggaacgtgtgtgaatgtgggttgcatacct
aagaagctgatgcaccaggcagctttgctcggacaagctctgaaagactcgcgcaactat
ggctggaaagtcgaagacacagtgaagcatgactgggagaaaatgacggaatctgtgcag
agtcacatcggctcgctgaactggggctaccgcgtagctctccgggagaaaaaggtcgtc
tatgagaatgcttacgggaggttcattggtcctcacaggattgtggcgacaaataacaaa
ggtaaagaaaaaatctattcagcagagcggttcctcatcgccacaggtgagaggccccgc
tacctgggcatccctggagacaaagagtactgcatcagcagtgatgatcttttctccttg
ccttactgcccggggaagaccctagtagttggtgcatcctatgtcgccttggaatgtgca
ggatttctggctggtatcggcttagacgtcactgtaatggtgcggtccattctccttaga
ggatttgaccaagacatggccaacaaaatcggtgaacacatggaagaacatggtatcaag
tttataaggcagttcgtcccaacgaaaattgaacagatcgaagcaggaacaccaggccga
ctcagggtgactgctcaatccacaaacagcgaggagaccatagagggcgaatttaacaca
gtgttgctggcggtaggaagagattcttgtacgagaactattggcttagagaccgtgggc
gtgaagataaacgaaaaaaccggaaagatacccgtcacggatgaagagcagaccaatgtg
ccttacatctacgccatcggtgacatcctggaggggaagctagagctgactcccgtagcc
atccaggcggggagattgctggctcagaggctgtatggaggctccaatgtcaaatgtgac
tatgacaatgtcccaacgactgtatttactcctttggaatatggctgttgtggcctctct
gaagaaaaagccgtagagaaatttggggaagaaaatattgaagtttaccatagtttcttt
tggccattggaatggacagtcccatcccgggataacaacaaatgttatgcaaaaataatc
tgcaaccttaaagacgatgaacgtgtcgtgggcttccacgtgctgggtccaaacgctgga
gaggtgacgcagggctttgcggctgcgctcaagtgtgggctgactaagcagcagctggac
agcaccatcggcatccacccggtctgtgcagagatattcacaacgttgtcagtgacgaag
cgctctgggggagacatcctccagtctggctgctgaggttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (58)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (51)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (136)   
   RefSeq(nuc) (4)   
   GenBank (66)   
   EMBL (66)   
Protein domain (12)   
   Pfam (12)   
All databases (229)   

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