KEGG   Mus musculus (house mouse): 66725
Entry
66725             CDS       T01002                                 
Symbol
Lrrk2, 4921513O20Rik, 9330188B09Rik, D630001M17Rik, Gm927, cI-46
Name
(RefSeq) leucine-rich repeat kinase 2
  KO
K08844  leucine-rich repeat kinase 2 [EC:2.7.11.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu05012  Parkinson disease
mmu05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    66725 (Lrrk2)
   05022 Pathways of neurodegeneration - multiple diseases
    66725 (Lrrk2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    66725 (Lrrk2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    66725 (Lrrk2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    66725 (Lrrk2)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     66725 (Lrrk2)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: TKL group
  LRRK family
   66725 (Lrrk2)
Membrane trafficking [BR:mmu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    66725 (Lrrk2)
Exosome [BR:mmu04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   66725 (Lrrk2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr LRR_8 Roc LRR_4 COR Ras LRR_1 Arf LRR_9 Ank_2 ABC_tran AAA_22 MMR_HSR1 Ank_3 PduV-EutP T2SSE nSTAND3 GTP_EFTU G-alpha AAA_7 AAA_16 Arm TniB Kdo MobB NACHT cobW AAA_29 FtsK_SpoIIIE TrwB_AAD_bind AAA_33 SRP54 AAA_23
Other DBs
NCBI-GeneID: 66725
NCBI-ProteinID: NP_080006
MGI: 1913975
Ensembl: ENSMUSG00000036273
UniProt: Q5S006 Q9CQG8
Position
15:91556994..91700327
AA seq 2527 aa
MASGACQGCEEEEEEEALKKLIVRLNNVQEGKQIETLLQLLEDMLVFTYSDRASKLFEDK
NFHVPLLIVLDSYMRVASVQQAGWSLLCKLIEVCPGTLQSLIGPQDIGNDWEVLGIHRLI
LKMLTVHHANVNLSIVGLKALDLLLDSGKLTLLILDEECDIFLLIFDAMHRYSANDEVQK
LGCKALHVLFERVSEEQLTEFVENKDYTILLSTFGSFRRDKEIVYHVLCCLHSLAVTCSN
VEVLMSGNVRCYNLVVEAMKAFPTNENIQEVSCSLFQKLTLGNFFNILVLNEVHVFVVKA
VRQYPENAALQISALSCLALLTETIFLNQDLEERSETQEQSEEEDSEKLFWLEPCYKALV
RHRKDKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKDVFQAA
AHALSTLLEQNVNFRKILLAKGVYLNVLELMQKHAHAPEVAESGCKMLSHLFEGSNPSLD
TMAAVVPKILTVMKAHGTSLSVQLEALRAILHFVVPGLLEESREDSQCRPNVLRKQCFRT
DIHKLVLVALNRFIGNPGIQKCGLKVISSLAHLPDATETLSLQGAVDSVLHTLQMYPDDQ
EIQCLGLHLMGCLMTKKNFCIGTGHLLAKILASTLQRFKDVAEVQTTGLQTTLSILELSV
SFSKLLVHYSFDVVIFHQMSSSVVEQKDEQFLNLCCKCFAKVAVDDELKNTMLERACDQN
NSIMVECLLLLGADANQVKGATSLIYQVCEKESSPKLVELLLNGGCREQDVRKALTVSIQ
KGDSQVISLLLRKLALDLANNSICLGGFGIGKIDPSWLGPLFPDKSSNLRKQTNTGSVLA
RKVLRYQMRNTLQEGVASGSDGKFSEDALAKFGEWTFIPDSSMDSVFGQSDDLDSEGSES
SFLVKRKSNSISVGEVYRDLALQRCSPNAQRHSNSLGPVFDHEDLLRRKRKILSSDESLR
SSRLPSHMRQSDSSSSLASEREHITSLDLSANELKDIDALSQKCCLSSHLEHLTKLELHQ
NSLTSFPQQLCETLKCLIHLDLHSNKFTSFPSFVLKMPRITNLDASRNDIGPTVVLDPAM
KCPSLKQLNLSYNQLSSIPENLAQVVEKLEQLLLEGNKISGICSPLSLKELKILNLSKNH
IPSLPGDFLEACSKVESFSARMNFLAAMPALPSSITSLKLSQNSFTCIPEAIFSLPHLRS
LDMSHNNIECLPGPAHWKSLNLRELIFSKNQISTLDFSENPHVWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDGLHLNFDFKHVGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKPELGMQGATVGIDVRDWSIQI
RGKRRKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPTIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKAVPTEFPVINRKHLLQLVNEH
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVDGCLK
HPKGIISRRDVEKFLSKKKRFPKNYMMQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNRPESFLKITVPSCRKGCILLGRVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDELMKKAEEGDLLINPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLHDIWTTGSRIMEGLRFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELICLMRHILIPKNIIVECMVATNL
NSKSATLWLGCGNTEKGQLSLFDLNTERYSYEEVADSRILCLALVHLAAEKESWVVCGTQ
SGALLVINVEEETKRHTLEKMTDSVTCLHCNSLAKQSKQSNFLLVGTADGNLMIFEDKAV
KCKGAAPLKTLHIGDVSTPLMCLSESLNSSERHITWGGCGTKVFSFSNDFTIQKLIETKT
NQLFSYAAFSDSNIIALAVDTALYIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEVMVKL
NKESKHQLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMAT
AQLGSLKNVMLVLGYKRKSTEGIQEQKEIQSCLSIWDLNLPHEVQNLEKHIEVRTELADK
MRKTSVE
NT seq 7584 nt   +upstreamnt  +downstreamnt
atggccagtggcgcctgtcagggctgcgaagaggaagaggaggaggaggctctgaagaag
ttgatagtcaggctgaataatgtccaggaaggcaagcagatcgagacgttgcttcagctc
ctggaggacatgctggtgttcacctactcggaccgcgcctccaagttatttgaagataaa
aatttccacgtgcctctgttgattgtcctggactcctacatgagagttgccagtgtacag
caggcggggtggtcacttctgtgcaaattaatagaagtctgtccagggacattgcaaagc
ttaataggaccccaggatattggaaatgattgggaagtccttggtattcaccggctgatt
cttaaaatgttaactgttcatcacgccaatgtaaacctgtcaatagttggactaaaagcc
ttggatctcctcctagattcaggtaaactcaccttgctgatactggatgaagaatgtgat
attttcttgttaatttttgatgccatgcacagatattcagccaatgatgaagtccaaaaa
ctgggatgcaaagctttacacgtgctttttgagagagtttccgaggaacagctgactgag
tttgtggagaacaaagattacacgatactgctgagtacgttcggcagcttcagaagggac
aaggagattgtgtaccacgtactttgctgcttgcattccctggcggttacatgcagcaat
gtagaggtcctcatgagtgggaatgtccggtgctacaatcttgtggtggaggccatgaaa
gccttccccaccaatgaaaacatccaagaggtgagctgctccttgttccagaagcttaca
ttaggtaactttttcaacatcctggtgttgaacgaagtgcatgtctttgtggtgaaagcg
gtccgacagtatcctgagaacgcagccttacagatctctgcactcagctgtttagcactc
ctcactgagactattttcttaaaccaagacttggaggaaagaagtgagactcaagagcag
agcgaagaggaagacagtgagaagcttttctggctggaaccctgctataaagccctggtg
cgccatcgaaaggacaaacacgtgcaggaggctgcctgctgggcactaaataacctcctt
atgtaccagaacagtttgcatgagaagatcggagatgaagatggccagttccctgcgcac
agggaagtgatgctgtctatgctgatgcactcttcttccaaagatgtcttccaagcagct
gcacatgctctgtccactctcttggaacaaaatgttaatttcaggaaaatcctgctggca
aaaggagtatacctgaatgtcttggaattgatgcagaagcatgcccatgcgcctgaggtg
gcagagagtggctgcaagatgctgagtcacctgtttgaaggaagtaacccttctctggat
acaatggcagcagtggtccctaaaatactaacagtgatgaaagcccacggaacgtctctg
tcagtccagctggaggcgctgcgagctatcttgcatttcgttgtgccaggactattggaa
gaatccagggaggactctcaatgcagaccaaatgtgctcagaaaacagtgtttcaggact
gacatccacaagctggttctagtcgctctgaacaggttcattgggaatcctgggattcag
aaatgtggattgaaagtaatctcttctctcgcgcaccttcctgatgccacagagacattg
tccctgcaaggagcagttgactcagtcctccacaccttacagatgtatccagatgaccaa
gaaattcagtgtctgggcttacaccttatgggatgcttgatgacaaagaagaatttctgc
atagggacagggcacctcctggcaaaaattctggcttccactttgcagcgctttaaagat
gttgctgaggtgcagactacaggattacagacaaccctgtcaatacttgagctgtcagta
tctttctccaagctgctagtgcactattcctttgatgtggtgatatttcatcagatgtct
tccagtgttgtagaacaaaaggatgagcagttcctcaatctatgttgcaaatgctttgca
aaagtggccgtggatgatgagctgaaaaacaccatgctagagagagcctgcgatcagaat
aacagcatcatggttgaatgtttgctcctcttgggagctgatgccaaccaagtgaagggg
gcaacttctttaatctatcaggtatgtgagaaagagagcagtcctaaattggtggaactg
ttgcttaatggtggttgtcgtgaacaagatgtacggaaggccctgaccgtaagcatccaa
aagggcgacagccaggtcatcagcttgctcctcaggaaacttgccctggacctggccaac
aacagcatttgccttggaggatttggcataggaaaaattgatccttcttggcttggtcct
ttatttccagataagtcatccaatttaaggaagcaaacaaacacaggatctgtcctagcg
aggaaagtgctccggtatcagatgagaaacacccttcaagaaggcgtggcctcaggcagt
gacggcaagttttctgaagacgcgctggcgaaatttggagaatggacctttattcccgac
tcttctatggacagtgtgtttggccagagcgatgatctggatagcgaaggcagcgagagc
tcatttctcgtgaagaggaagtccaactcaattagtgtaggggaagtttacagagatcta
gctctgcagcgctgctcaccaaatgctcagaggcattccaattcgctgggtcctgttttt
gaccatgaagacttactgagacgaaaaagaaaaatactgtcttcagatgagtctctcagg
tcctcaaggctgccgtcccatatgaggcaatcagatagctcttcttccctggcttctgag
agagaacacatcacgtcgttagacctatctgccaacgaactcaaagatattgatgctctg
agccagaagtgttgcctcagtagccacctggaacatctcaccaaactggaacttcaccag
aattcactcacgagcttcccacagcagctgtgtgagactctgaagtgtttgatacacttg
gatttgcacagtaacaaattcacctcatttccctctttcgtgttgaaaatgccacgtatc
accaacctagatgcctctcgaaatgacatcgggccaacagtagttttagaccctgcgatg
aagtgtccaagcctcaaacagttgaatctgtcctataaccagctctcttcaatcccagag
aatcttgcccaagtggtggagaaacttgagcagctcctactggaaggaaataaaatatcc
gggatttgctctcccctgagcctgaaggaactgaagattttaaatcttagtaaaaatcac
attccatccctacctggagattttcttgaggcttgttcaaaagtcgagagtttcagtgct
cgcatgaattttcttgctgcaatgcctgccttaccttcttccataacgagcttaaaattg
tctcagaactctttcacgtgcattccagaagcgattttcagtcttccgcacttgcggtcc
ttggatatgagccacaacaacattgaatgtctgccgggacctgcacattggaagtctctg
aacttaagggaactcatttttagcaagaatcagatcagcaccttagactttagtgagaac
ccacacgtgtggtcaagagtagagaaactgcatctctctcataataaactgaaagagatt
cctccagaaattggctgccttgaaaatctgacgtctctcgacgtcagttacaacttggaa
ctgaggtccttcccaaatgaaatggggaagttgagcaagatatgggatcttcccttggac
ggactgcatctgaattttgactttaagcacgtaggatgcaaggccaaagacatcataagg
tttctacaacaacgtctgaaaaaggctgtaccctacaaccgaatgaagctcatgattgtg
ggaaatacggggagcggtaagaccactttactgcaacaactcatgaaaatgaagaaacca
gaacttggcatgcagggtgccacagtcggcatagacgtgcgagactggtccatccaaata
cggggcaaaaggagaaaggacctggttctaaacgtgtgggattttgcaggtcgtgaggaa
ttctacagcactcacccccacttcatgacccagagagccctctacctggctgtctatgat
ctcagcaaggggcaggcagaggtggacgccatgaagccctggctcttcaatatcaaggct
cgtgcctcttcttccccggtgattctggtgggcacacatttggatgtttctgatgagaag
cagcggaaagcgtgcataagcaaaatcacgaaggaactcctaaataagcgaggattcccc
accatccgggactaccactttgtgaatgccaccgaggagtcagatgcgctggcaaagctt
cggaaaaccatcataaatgagagccttaatttcaagatccgagatcagcctgtggttggg
cagctaattccagattgctacgtagaactggagaaaatcattttatcagagcggaaagct
gtgccgactgagtttcctgtgattaaccggaaacacctgttacagctcgtgaacgaacat
cagctgcagctggatgagaacgagctcccacacgccgttcacttcctaaatgagtcggga
gttcttctgcattttcaagaccctgccctgcagctaagtgacctgtactttgtggaaccc
aagtggctttgtaaagtcatggcacagatcttgacagtgaaggtagacggctgtctgaaa
catcctaagggcatcatttcccggagagatgtggaaaaattcctttcaaagaagaagcga
ttcccgaagaactatatgatgcaatactttaaactattagaaaaatttcagatcgcattg
ccaataggggaagaatatcttctggttccaagcagcttgtctgaccacaggccagtgata
gagctcccccactgtgagaactctgagatcatcatccggctgtacgaaatgccgtacttt
cccatgggattttggtcaagattgattaaccgattacttgaaatctcacccttcatgctt
tctggcagagagagagcactacgccctaacaggatgtattggcggcaaggcatctacttg
aattggtctccagaagcatactgtctggtaggctctgaagtcttagacaatcgacctgag
agtttcttgaaaatcacagttccgtcttgtagaaaaggttgtattcttctgggccgagtt
gtggatcatattgactcactcatggaagaatggtttcccgggttactggagattgacatt
tgtggggaaggagaaactctgttgaagaaatgggcattgtacagttttaatgatggtgaa
gaacatcagaagatcttgcttgatgagttgatgaagaaggctgaagaaggagacctgtta
ataaatccagaccaaccaaggctcactattccaatatcccagattgctccggacttgatc
ttggctgacctgcctagaaatatcatgttgaacaatgatgagttggaatttgaggaagca
ccagagtttctcttaggcgatggaagttttggatccgtttatcgagctgcctacgaagga
gaggaagtggctgtgaagatttttaataagcacacatctcttaggctgttaagacaagag
ttggtggtcctttgtcaccttcaccaccccagcctgatatccttgctggcggctggtatt
cgtcctcggatgttggtaatggagttggcctccaaaggttccttggatcgcctgctgcag
caggacaaagccagcctcaccagaaccctccagcacaggatcgcgttgcatgtggccgac
ggcctgaggtatctccactcagccatgattatttaccgtgacctgaagccccacaatgtg
ctgctttttaccctgtatcccaatgctgccatcattgcgaagattgcggactacgggatc
gcacagtactgctgcaggatgggaataaagacatcagagggcaccccagggttccgggca
cctgaagttgccagggggaatgtcatttataaccaacaggccgatgtttattcttttggc
ttactacttcacgatatttggacaactgggagtaggattatggagggtttgaggttccca
aatgagtttgatgagttagccatacaagggaagttgccagatccagttaaagaatatggc
tgtgccccatggcctatggttgagaagttaattacaaagtgtttgaaagaaaatcctcaa
gaaagacccacttctgcccaggtctttgacattttgaattcggctgaattaatttgcctc
atgcgacacattttaatacctaagaacatcattgttgaatgcatggttgccacgaatctc
aatagcaagagtgcgactctctggttgggatgtgggaacacagaaaaaggacagctttcc
ttatttgacttaaacacggaaagatacagctatgaggaagttgctgatagtagaatactg
tgcttggctttggtgcatctcgctgctgagaaagagagctgggttgtgtgcgggacacag
tctggggctctcctggtcatcaatgttgaagaggagacaaagagacacaccctggaaaag
atgactgattctgtcacttgtttgcattgcaattcccttgccaagcagagcaagcaaagt
aactttcttttggtgggaactgctgatggtaacttaatgatatttgaagataaagccgtt
aagtgtaaaggagctgcccccttgaagacactacacataggcgatgtcagtacgcccctg
atgtgcctgagcgagtccctgaattcatctgaaagacacatcacatggggagggtgtggc
acaaaggtcttctccttttccaatgatttcaccattcagaaactcatcgagacaaaaacc
aaccagctgttttcttacgcagctttcagcgattctaacatcatagcgctggcagtagac
acagccctgtatattgccaagaaaaacagccctgtcgtagaggtgtgggacaagaaaaca
gaaaagctctgtgaattaatagactgtgtgcacttcttaaaggaggtgatggtaaaacta
aacaaggaatcgaaacatcagctgtcctactctgggagggtgaaggccctctgcctgcag
aagaacacggctctctggatcggaactggaggaggccacatcttactcctggatctttct
actcggcgagttatccgcaccattcacaatttctgtgattctgtgagagccatggccaca
gcacaattaggaagccttaagaatgtcatgctggttttggggtacaagcggaagagtaca
gagggtatccaagaacaaaaagagatacaatcttgtttgtctatttgggacctcaatctt
ccacacgaggtgcaaaatttagaaaaacacattgaagtaagaacagaattagctgataaa
atgaggaaaacatctgttgaatag

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (49)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (41)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (26)   
   RefSeq(nuc) (4)   
   GenBank (11)   
   EMBL (11)   
Protein domain (34)   
   Pfam (34)   
All databases (124)   

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