KEGG   Mus musculus (house mouse): 70549
Entry
70549             CDS       T01002                                 
Symbol
Tln2, 5730421P04Rik, mKIAA0320
Name
(RefSeq) talin 2
  KO
K06271  talin
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04015  Rap1 signaling pathway
mmu04510  Focal adhesion
mmu04611  Platelet activation
mmu04820  Cytoskeleton in muscle cells
mmu05166  Human T-cell leukemia virus 1 infection
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    70549 (Tln2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    70549 (Tln2)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    70549 (Tln2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    70549 (Tln2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    70549 (Tln2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    70549 (Tln2)
Exosome [BR:mmu04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   70549 (Tln2)
  Exosomal proteins of other cancer cells
   70549 (Tln2)
SSDB
Motif
Pfam: VBS Talin_middle I_LWEQ Talin_R4 FERM_f0 FERM_M FERM_N ACBP IRS OTU1_UBXL
Other DBs
NCBI-GeneID: 70549
NCBI-ProteinID: NP_001074711
MGI: 1917799
Ensembl: ENSMUSG00000052698
UniProt: Q71LX4 Q8CDM9 E9PUM4 Q68FD6 Q3TN69
Structure
Position
9:complement(67124371..67541357)
AA seq 2542 aa
MVALSLKICVRHCNVVKTMQFEPSTAVYDACRVIRERVPEAQTGQASDYGLFLSDEDPRK
GIWLEAGRTLDYYMLRNGDILEYKKKQRPQKIRMLDGSVKTVMVDDSKTVGELLVTICSR
IGITNYEEYSLIQETIEEKKEEGTGTLKKDRTLLRDERKMEKLKAKLHTDDDLNWLDHSR
TFREQGVDENETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFEKACEF
GGFQAQIQFGPHVEHKHKPGFLDLKEFLPKEYIKQRGAEKRIFQEHKNCGEMSEIEAKVK
YVKLARSLRTYGVSFFLVKEKMKGKNKLVPRLLGITKDSVMRVDEKTKEVLQEWPLTTVK
RWAASPKSFTLDFGEYQESYYSVQTTEGEQISQLIAGYIDIILKKKQSKDRFGLEGDEES
TMLEESVSPKKSTILQQQFNRTGKAEHGSVALPAVMRSGSSGPETFNVGSMPSPQQQVMV
GQMHRGHMPPLTSAQQALMGTINTSMHAVQQAQDDLSELDSLPPLGQDMASRVWVQNKVD
ESKHEIHSQVDAITAGTASVVNLTAGDPADTDYTAVGCAITTISSNLTEMSKGVKLLAAL
MDDDVGSGEDLLRAARTLAGAVSDLLKAVQPTSGEPRQTVLTAAGSIGQASGDLLRQIGE
NETDERFQDVLMSLAKAVANAAAMLVLKAKNVAQVAEDTVLQNRVIAAATQCALSTSQLV
ACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVRACQAATSDSELLKQVSAAASVVSQA
LHDLLQHVRQFASRGEPIGRYDQATDTIMCVTESIFSSMGDAGEMVRQARVLAQATSDLV
NAMRSDAEAEIDMENSKKLLAAAKLLADSTARMVEAAKGAAANPENEDQQQRLREAAEGL
RVATNAAAQNAIKKKIVNRLEVAAKQAAAAATQTIAASQNAAISNKNPSAQQQLVQSCKA
VADHIPQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAKAAVPTVSDQAAAM
QLSQCAKNLATSLAELRTASQKAHEACGPMEIDSALNTVQTLKNELQDAKMAAAESQLKP
LPGETLEKCAQDLGSTSKGVGSSMAQLLTCAAQGNEHYTGVAARETAQALKTLAQAARGV
AASTNDPEAAHAMLDSARDVMEGSAMLIQEAKQALIAPGDTESQQRLAQVAKAVSHSLNN
CVNCLPGQKDVDVALKSIGEASKKLLVDSLPPSTKPFQEAQSELNQAAADLNQSAGEVVH
ATRGQSGELAAASGKFSDDFDEFLDAGIEMAGQAQTKEDQMQVIGNLKNISMASSKLLLA
AKSLSVDPGAPNAKNLLAAAARAVTESINQLIMLCTQQAPGQKECDNALRELETVKGMLE
NPNEPVSDLSYFDCIESVMENSKVLGESMAGISQNAKTGDLPAFGECVGIASKALCGLTE
AAAQAAYLVGISDPNSQAGHQGLVDPIQFARANQAIQMACQNLVDPGSSPSQVLSAATIV
AKHTSALCNACRIASSKTANPVAKRHFVQSAKEVANSTANLVKTIKALDGDFSEDNRNKC
RIATTPLIEAVENLTAFASNPEFASIPAQISSEGSQAQEPILVSAKTMLESSSYLIRTAR
SLAINPKDPPTWSVLAGHSHTVSDSIKSLITSIRDKAPGQRECDYSIDGINRCIRDIEQA
SLAAVSQSLATRDDISVEALQEQLTSVVQEIGHLIDPIATAARGEAAQLGHKVTQLASYF
EPLILAAVGVASKMLDHQQQMTVLDQTKTLAESALQMLYAAKEGGGNPKAQHTHDAITEA
AQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVK
YSKAIAVTAQEMMTKSVTNPEELGGLASQMTTDYGHLALQGQMAAATAEPEEIGFQIRTR
VQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARSVTEKVSLVLSALQAGNKGTQACI
TAATAVSGIIADLDTTIMFATAGTLNAENGETFADHRENILKTAKALVEDTKLLVSGAAS
TPDKLAQAAQSSAATITQLAEVVKLGAASLGSNDPETQVVLINAIKDVAKALSDLIGATK
GAASKPADDPSMYQLKGAAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIEYIKQELTV
FQSKDIPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLIAC
KQASFYPDVSEEVRTRALRYGTECTLGYLDLLEHVLVILQKPTPELKHQLAAFSKRVAGA
VTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETL
DFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARM
VAAATSSLCEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAA
GNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARK
KLAQIRQQQYKFLPTELREDEG
NT seq 7629 nt   +upstreamnt  +downstreamnt
atggtggccctatccttaaagatctgtgtccgccactgcaatgtggtgaagaccatgcag
tttgagccatctacagctgtgtatgacgcttgtcgagtcattagggagagagtacctgag
gcacagactgggcaagcttctgactatgggctgtttctctccgatgaagacccaaggaaa
gggatttggctagaagcaggtcggacactggattactacatgttgcggaatggggacatt
ctggagtacaagaagaaacagaggcctcagaaaatccgaatgttggatggctctgtgaag
acggtgatggtagatgactccaagacggtgggggagctcctggtcacgatctgcagcagg
ataggaataacaaattatgaagaatactctttaatccaagaaaccattgaagaaaagaaa
gaagaagggacaggcacactaaaaaaagataggacgttgttacgagatgagaggaagatg
gagaagctgaaggccaaactgcacacagatgatgacttaaattggctagatcacagccgg
acattcagagagcaaggcgtggatgaaaatgaaacattgttgctccgacggaagttcttt
tactctgatcagaatgtggactcgagagacccggtgcagttgaacttgctttatgtccag
gctcgggatgacatcctgaatggctctcaccctgtctccttcgagaaggcctgtgagttt
ggtgggttccaagcccagatacagtttggacctcacgtggaacacaaacacaagcctgga
ttcttagatctaaaggagttcctgccaaaagagtacatcaagcagagaggagccgagaag
cgaatatttcaggaacataaaaactgtggagagatgagtgaaatagaagccaaggtgaag
tacgtcaaactcgcccggtccctccggacatatggggtgtcctttttcctagtgaaggaa
aaaatgaaaggcaagaacaagttggttccccgtctcctgggcatcaccaaggactccgtc
atgcgtgtggatgagaagaccaaggaggtgcttcaggagtggcctctcaccacggtcaag
cgctgggccgcttcacccaagagcttcacactggattttggggagtaccaagagagctac
tattcagtacaaaccacagagggggagcaaatatcccagctgattgcaggatacattgat
atcatcctcaaaaagaaacaaagcaaagatagatttggcctggaaggggatgaggagtca
actatgttggaagaatcagtttccccaaaaaaatctaccatcctgcagcagcagttcaac
cggactgggaaagcagagcatggttcggtagcactgccagctgtcatgcgctctggctcc
agtgggcctgagacgttcaatgttggcagcatgccgtcaccacagcagcaggtcatggtc
ggacagatgcaccgaggacacatgcctccgctgacgtcggcacagcaagcccttatgggg
accatcaacacaagcatgcacgctgtccagcaggctcaggatgacctcagcgagctcgac
tcgctgccacccctcggccaagatatggcatctagggtatgggttcagaacaaagtggat
gaatccaagcatgaaatccactctcaagtcgatgctatcacagctgggacagcttcagtt
gtcaacctcacagctggtgaccctgcagacactgactacacagccgtgggctgtgcaatc
actaccatttcttccaacctgaccgaaatgtccaagggggtcaagctgctggcagccctc
atggacgatgacgtgggcagtggggaggatcttctcagagctgccaggaccctcgccggg
gctgtgtctgatttgctgaaggctgtgcagcctacttcaggagagcctcgacagactgtt
ttgactgctgccggaagcatcggccaagccagtggagatctcctcagacagattggagag
aacgagacggatgagagattccaagatgttttaatgagtctagctaaggctgttgccaat
gctgctgccatgttagtactgaaggcgaagaatgtggcccaggtggctgaagacaccgtc
ctacagaacagggtgatcgccgcagccacccagtgtgccctctctacctcgcagcttgtg
gcgtgtgctaaggtggtgagccccaccatcagctctcccgtgtgccaggagcagctgatc
gaagctgggaagctggtggaccgctctgtggaaaactgtgtccgagcctgccaggcggcc
accagtgatagcgagctcctgaagcaggtcagcgcggcggccagtgtggtcagccaggcc
ctgcacgacctcctgcagcatgtgcggcagttcgccagccgaggcgagcccattggccgc
tatgaccaggccaccgacaccatcatgtgtgtcactgagagcatcttcagttccatgggc
gatgctggtgagatggtgcgccaagcccgggtgctagcccaggccacatcagatctcgtc
aatgccatgaggtcagatgcggaggctgagattgacatggagaattccaagaagctcctg
gcggccgcaaagctcttggctgactccactgcccgcatggtggaagctgcgaagggggct
gcagccaacccagagaatgaagaccagcagcagaggctgagagaagctgccgagggtctc
cgagtagcaaccaatgccgctgcgcagaatgctattaagaaaaaaatcgtcaaccggctg
gaggttgcagccaagcaggctgcagctgctgccacacagaccatcgcagcctcccagaat
gcagccatctccaacaagaacccctcagcccagcaacaactggtccagagctgcaaggcg
gtggctgatcacatccctcagctagtgcagggcgtgagagggagccaagcacaagcagaa
gacctcagtgcccagctggctctcatcatctccagccagaacttcctgcagcctggaagc
aagatggtgtcctctgctaaggcggcggtgcccactgtgagtgaccaggctgcagccatg
cagttgagtcagtgtgccaagaacctggcaaccagcctggccgagctgcgcacagcctcg
cagaaggcccacgaagcctgtggccccatggaaatagattctgcactgaacactgtgcag
actctcaagaatgagctgcaggacgccaagatggccgctgcagaaagtcaactgaaacca
cttccaggagaaacgctggaaaagtgtgctcaggacctgggaagcacctctaagggagtg
ggctcctccatggcacagctcctgacctgtgctgctcaaggcaatgagcattacacaggc
gtggcagcaagagaaacagcccaggccctgaaaacactggcccaggctgcccggggagtg
gcggcatccacaaatgatcctgaggctgctcatgccatgttagactctgctcgggatgtg
atggagggctctgccatgctcatccaggaagccaagcaggcactaattgcacctggagac
acagagagtcagcagagattagcccaggtggccaaagctgtgtctcactcactgaataac
tgcgtgaattgccttcctggacagaaggatgtggatgtcgccttgaagagcatcggggag
gccagcaagaagctacttgtagattcgctacctccaagcacaaagcccttccaggaggcc
cagagtgagctgaaccaggctgctgctgatctgaaccaatctgctggggaagtcgtccat
gccacaaggggccagagtggagagctggcagccgcttctggaaaattcagtgatgacttt
gacgagttcctggatgccggcattgagatggctggccaggcacagacaaaagaagaccag
atgcaagtgatagggaacctgaagaatatctcgatggcgtccagcaagctcctgctggcc
gccaagtctctctctgtagatcctggagctcccaacgcaaaaaatctcctggctgcagct
gcaagagctgtgacagagagcatcaatcagctcatcatgctgtgtactcagcaggcccct
gggcagaaggagtgtgacaacgccctgcgtgagctcgagactgtcaaggggatgttggaa
aacccgaatgagcctgtgagcgacctctcttattttgactgcattgagagtgtgatggag
aactccaaggttctgggcgagtcaatggcagggatttcacagaatgccaagactggagac
ctccctgccttcggagaatgtgtggggattgcatctaaggctctctgtgggctgacagag
gcagcagcccaggctgcgtatctggttggcatctctgatccgaacagccaggcaggtcac
caaggcctggtggaccccatccagtttgccagggctaaccaggcgatccagatggcatgt
cagaacttggtggaccctggcagcagcccatcacaggttctgtcggctgccactattgtt
gccaagcacacatcagccttatgcaatgcctgccgcatcgcctcatccaagacggccaac
cctgttgccaagcggcactttgtccagtcagccaaggaggttgccaacagcaccgccaac
ctggtcaagaccatcaaggccctggatggggatttctctgaagacaatcgcaataagtgt
cgaattgctaccacgcccttgatcgaggcggtggagaacctaacagcgtttgcatcaaac
cccgagtttgccagcattcctgcacagatcagctctgagggctcccaggcgcaggaacca
atcttggtctcagccaagaccatgctggagagctcatcgtacctcatccgcaccgcgcgc
tctctggccatcaaccccaaagatccgcccacctggtccgtgttggctggacactcccac
actgtgtctgactccattaagagtctcatcacgtctatcagggacaaagccccagggcag
agggaatgtgactactccattgatggcatcaaccggtgcatcagggacatcgagcaggcc
tccctggccgcggtcagccagagcctggccacgagggatgacatctctgtggaggcccta
caggagcagctgacctcagtggtccaagaaatcggacatcttattgatcccattgccaca
gctgcccgaggagaagctgcccaacttggacataaggtgacacagctggcgagctacttt
gagcccttgatcttagctgcagttggtgtcgcctccaagatgctggaccatcaacaacag
atgacagtgctggaccagaccaagactcttgcagagtctgccctgcagatgctgtatgca
gccaaggaaggtggaggtaaccccaaggcacagcacacccacgacgccatcacagaggct
gcgcagctgatgaaggaagctgtggatgacatcatggtgacactgaatgaagcagccagt
gaggtgggactggtgggaggcatggtggacgccatcgcagaggctatgagcaagctggat
gaaggcacacctccagaaccaaagggaacgtttgttgactaccagacgactgtggttaaa
tactccaaagccattgccgtcacagctcaggaaatgatgactaagtcggttactaacccg
gaggagttgggaggcctggcttcacaaatgaccactgactatgggcacctggctctccag
ggccagatggcagcagccaccgccgaaccagaggagattggattccagattcgcacacgt
gtgcaggaccttggccatggctgtatcttcctggtgcaaaaggcaggagccctccaggtg
tgccccacagacagctacaccaagagggagctgatcgagtgtgcccgctctgtcactgag
aaggtgtccttggtgctgtctgctctccaggctggaaacaaggggacccaggcatgcatc
acggccgcaactgcagtttctgggatcattgccgatctggacaccaccattatgtttgca
acagctggcacactgaatgcagagaacggcgagacctttgccgatcacagggagaacatt
ctgaagacagccaaggccttggtggaagacacaaagctcctcgtgtctggggctgcatcc
actccagacaagctggcccaggccgctcagtcctcagcagccaccatcacccagctggca
gaggtggtcaagctgggggccgccagcctgggctccaatgaccctgagacccaggtggta
ctgataaatgccatcaaagacgtggccaaggccctttccgatctcattggtgctaccaag
ggagctgccagcaagccggctgacgacccctccatgtaccagctcaaaggagccgccaag
gtgatggtgaccaatgtcacctcccttcttaagactgtgaaggcagtggaagacgaggcc
acccggggcacaagggcacttgaggccaccatcgagtacataaaacaggagctcacagtg
ttccagtcaaaagacatacctgaaaagacatcatcacccgaggaatcaataagaatgacg
aaaggtatcaccatggcaacagcgaaagccgtggcagctgggaactcatgtagacaagag
gatgtaattgcaaccgccaatctgagcaggaaggctgtctcagatatgttgatagcttgc
aagcaagcatccttctaccctgatgtcagtgaagaggtgcgaaccagagccttgcggtat
ggcacagaatgcaccttgggctacctggacctactagaacacgtcttggtgatccttcaa
aagccaaccccggaactcaagcatcagctggctgctttctccaagagagttgctggagct
gtgacggagctcatccaggcagcggaagccatgaaaggaacagagtgggtggatccagaa
gacccaaccgtcattgcagaaactgagttactgggagctgcagcatccattgaagccgct
gccaagaagttagagcagctgaagccaagagcaaagccaaagcaagcagacgagaccctg
gattttgaagaacagatcttagaagctgctaaatccattgctgctgccacaagtgccctg
gtcaaatcggcctcagcagcccagagggagctggtagcccaaggcaaggtgggctccatc
cctgccaatgctgccgatgatggacagtggtcccaggggctgatctctgccgcccggatg
gtggcggcagcaaccagcagtctctgtgaggcagccaatgcctctgtgcagggacatgcc
agtgaggaaaagctcatctcatccgccaagcaggtcgcagcttcaaccgctcagctgctg
gtggcctgcaaggtgaaggccgaccaggattcagaggccatgaagcggctacaggcggca
ggaaatgctgtgaaaagagcctcagacaatcttgttcgtgcagcccagaaggcagcattt
ggcaaagctgatgatgacgatgttgtggtgaaaaccaagttcgtgggaggcattgctcag
atcattgcagcccaggaggaaatgctgaagaaagaacgagagctggaggaagccaggaag
aagctggcccagatccgccagcagcagtacaaattcctccccacagagctgagggaagat
gagggctaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (21)   
   UniProt (5)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (45)   
   RefSeq(nuc) (15)   
   GenBank (15)   
   EMBL (15)   
3D Structure (1)   
   PDB (1)   
Protein domain (10)   
   Pfam (10)   
All databases (105)   

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