KEGG   Mus musculus (house mouse): 74256
Entry
74256             CDS       T01002                                 
Symbol
Cyld, 2010013M14Rik, 2900009M21Rik, C130039D01Rik, CDMT, CYLD1, EAC, mKIAA0849
Name
(RefSeq) CYLD lysine 63 deubiquitinase
  KO
K08601  ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04064  NF-kappa B signaling pathway
mmu04217  Necroptosis
mmu04380  Osteoclast differentiation
mmu04622  RIG-I-like receptor signaling pathway
mmu04625  C-type lectin receptor signaling pathway
mmu04668  TNF signaling pathway
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    74256 (Cyld)
   04668 TNF signaling pathway
    74256 (Cyld)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    74256 (Cyld)
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    74256 (Cyld)
   04625 C-type lectin receptor signaling pathway
    74256 (Cyld)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    74256 (Cyld)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:mmu01002]
    74256 (Cyld)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:mmu04121]
    74256 (Cyld)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     74256 (Cyld)
Peptidases and inhibitors [BR:mmu01002]
 Cysteine peptidases
  Family C67
   74256 (Cyld)
Ubiquitin system [BR:mmu04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UBP/USP
    74256 (Cyld)
SSDB
Motif
Pfam: CYLD_phos_site CAP_GLY UCH
Other DBs
NCBI-GeneID: 74256
NCBI-ProteinID: NP_001121643
MGI: 1921506
Ensembl: ENSMUSG00000036712
UniProt: Q80TQ2
Position
8:89423506..89478574
AA seq 952 aa
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRV
PSTKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLAITNCEERLSLFRNRLRLS
KGLQVDVGSPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDNGLESDFAGPGDTMQVEPPPLEINSRVSLKV
GESTESGTVIFCDVLPGKESLGYFVGVDMDNPIGNWDGRFDGVQLCSFASVESTILLHIN
DIIPDSVTQERRPPKLAFMSRGVGDKGSSSHNKPKVTGSTSDPGSRNRSELFYTLNGSSV
DSQQSKSKNPWYIDEVAEDPAKSLTEMSSDFGHSSPPPQPPSMNSLSSENRFHSLPFSLT
KMPNTNGSMAHSPLSLSVQSVMGELNSTPVQESPPLPISSGNAHGLEVGSLAEVKENPPF
YGVIRWIGQPPGLSDVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSR
FASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLD
STLFCLFAFSSALDTVLLRPKEKNDIEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRK
ILEKVEAASGFTSEEKDPEEFLNILFHDILRVEPLLKIRSAGQKVQDCNFYQIFMEKNEK
VGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDT
PRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCSTQVHLHPRRLNHSYHPVSLPKDL
PDWDWRHGCIPCQKMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIP
QVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK
NT seq 2859 nt   +upstreamnt  +downstreamnt
atgagttcaggcctgtggagccaagagaaagttacttcaccctactgggaagaacggatt
ttttatctgcttcttcaagaatgcagtgtaacagacaaacaaactcagaagctgctgaaa
gtacccaaagggagtataggacagtacatccaagaccgttctgtggggcattcaagagtt
ccttccacaaaaggcaagaaaaatcagattggattaaaaatcttggagcaaccgcatgca
gttctgtttgttgatgaaaaggatgttgtagaaataaatgaaaaattcacagagttactg
ttggcaattaccaactgtgaggagaggctcagcctatttagaaacagactccgactaagt
aaaggcctccaggtagacgtgggcagtcctgtgaaagtacagctgcgatctggggaagag
aaatttccaggagttgtacgcttcagaggacctttattagcggagaggacggtgtcgggg
attttctttggagtagaattattggaagaaggtcgtggtcaaggtttcacggatggggta
tatcaagggaagcagcttttccagtgtgatgaggactgtggcgtgtttgttgcattggac
aaactagaacttatagaagatgatgacaatggattggaaagtgattttgcaggcccagga
gatacaatgcaggttgaacctccccctttggaaataaactccagagtttctttgaaggtt
ggagaaagtacagaatctggaacagtaatattctgtgatgttttaccaggaaaagagagt
ctaggatattttgttggtgtggacatggataaccctattggcaactgggatggaaggttt
gatggagtacagctctgtagttttgcaagtgttgaaagtacaattctcctgcacatcaat
gacatcatcccagatagcgtgacacaggaaaggaggcctcccaaacttgcctttatgtca
agaggtgtaggtgacaaaggttcatctagtcataataaaccaaaggttacaggatctacc
tcagaccctggaagtagaaacagatctgaattattttataccttaaatgggtcatctgtt
gactcacaacaatccaagtccaaaaatccatggtacattgatgaagttgcagaagaccct
gcaaagtcacttacagagatgtcttcggacttcggacattcatctcctccaccgcagcct
ccttccatgaactccttgtctagcgagaacagattccactccttacccttcagcctgaca
aagatgcccaatactaatggcagcatggctcatagtccactctctctgtcagtgcagtct
gtgatgggggagctgaacagcacacctgtccaggagagtccacccttgcccatctcttct
gggaatgcacacgggctagaggtgggctcactggctgaagtaaaagagaaccccccgttc
tatggggttatccgttggattggccagccaccagggctcagtgacgtgctagctggactg
gaactggaagatgaatgcgcaggctgtacagatggaactttcaggggcacgcggtatttc
acgtgtgccctgaagaaggcactgtttgtgaaactgaagagctgcagaccggactctagg
tttgcatccttgcagcctgtttccaatcaaattgaaaggtgtaactctttagcatttggg
ggctatttaagtgaagtagtagaagaaaatactccacctaaaatggaaaaggaaggttta
gagataatgattggaaagaagaaaggcatccagggccattacaattcttgttacttagac
tcaactttattctgcttatttgcttttagttctgccctggacactgtgttacttagaccc
aaagagaagaatgatatagagtattacagtgagactcaggagctactgaggacagagata
gtcaatcctctgagaatatatggatatgtgtgtgccacaaagattatgaaactgaggaaa
atacttgaaaaagttgaggctgcatcaggttttacctctgaagaaaaagatcctgaagaa
ttcttaaatatcctgtttcatgatattttaagggttgaaccattgttaaaaataagatca
gcaggtcaaaaagttcaagactgtaacttctatcaaatttttatggaaaaaaatgagaaa
gttggagtacccacaattcagcagttattagaatggtcttttatcaacagcaacctgaaa
tttgcagaggcaccatcatgcttgattatccagatgcctcggtttggaaaagactttaaa
ctatttaaaaaaatttttccttccctggaattaaatataacagatttacttgaagacact
cccaggcagtgccgcatctgtggaggacttgcgatgtacgagtgcagggagtgctatgac
gatccggacatctcagctgggaagatcaagcagttctgtaagacctgcagcactcaggtt
caccttcatcccaggaggttgaatcattcttatcatccagtatcacttcccaaagacttg
cctgactgggactggagacacggctgcatcccctgtcagaagatggagttatttgctgtt
ctctgcatagaaacgagccactatgttgcttttgtgaagtatgggaaggatgactctgcc
tggcttttctttgacagcatggcggatcgagatggtggtcagaatggcttcaacattcca
caagtgacgccctgcccagaagtgggagagtacttgaagatgtctctggaggacctgcac
tctttggattccagaaggattcaaggctgtgcgcgcagacttctttgcgatgcatacatg
tgcatgtaccagagtccaaccatgagcctgtacaaataa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (29)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (27)   
DNA sequence (62)   
   RefSeq(nuc) (28)   
   GenBank (17)   
   EMBL (17)   
Protein domain (3)   
   Pfam (3)   
All databases (130)   

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