KEGG   Mus musculus (house mouse): 99439
Entry
99439             CDS       T01002                                 
Symbol
Duox1, 9930101G15Rik, Duox2, LNOX1, LNOX2, NOXEF1, NOXEF2, P138-TOX, THOX1, THOX2
Name
(RefSeq) dual oxidase 1
  KO
K13411  dual oxidase [EC:1.6.3.1 1.11.1.-]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04918  Thyroid hormone synthesis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09150 Organismal Systems
  09152 Endocrine system
   04918 Thyroid hormone synthesis
    99439 (Duox1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    99439 (Duox1)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.3  With oxygen as acceptor
    1.6.3.1  NAD(P)H oxidase (H2O2-forming)
     99439 (Duox1)
Membrane trafficking [BR:mmu04131]
 Others
  NADPH oxidases (Nox) and associated proteins
   NADPH oxidases
    99439 (Duox1)
SSDB
Motif
Pfam: An_peroxidase NAD_binding_6 FAD_binding_8 EF-hand_1 Ferric_reduct EF-hand_7 EF-hand_8 EF-hand_6 EF-hand_5 NAD_binding_1
Other DBs
NCBI-GeneID: 99439
NCBI-ProteinID: NP_001092767
MGI: 2139422
Ensembl: ENSMUSG00000033268
UniProt: A2AQ92
Structure
Position
2:122143525..122178454
AA seq 1551 aa
MGFHLALAWILLVGTLASLGAQNSISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYA
DGVYQPLKEPYLPNPRHLSNRVMRGSAGQPSLRNRTVLGVFFGYHVLSDLVSVETPGCPA
EFLNIYIPHGDPVFDPDKRGNVVLPFQRSRWDRNTGQSPSNPRDQSNQVTGWLDGSAIYG
SSHSWSDTLRSFSGGQLASGPDPAFPSDSQSSLLMWMAPDPSTGQGGPRGVYAFGAQRGN
REPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIAMYEWLPSFL
KQTPPEYPGYRPFLDPSISPEFVVASEQFLSTMVPSGVYMRNASCHFQGIPSHNSSVSGA
LRVCNSYWSREHPKLQRAEDVDALLLGMASQIAEREDHVVVEDMQDFWPGPLKFSRTDYL
ASCLQRGRDLGLPSYTKAREALGLSPISHWQDINPALSRSNGTVLEATAALYNQDLSRLE
LLPGGLLESHGDPGPLFSTIVLDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTSLRDI
LVAVTNVDPSALQPNVFFWLAGDPCPQPSQLSAKGLPACAPLFIRDYFEGSGFGFGLTIG
TLCCFPLVSLLSAWIVARLRKRNFKRLQRQDRQSIMSEKLVGGVEALEWQGRNEPCRPVL
VHLQPGQIRVVDGRLTVLRTIQLRPPQQVNLILSSNRGRRTLLLKIPKEYDLVLLFNMEE
ERQALVENVRGALKENGLSFQEWELREQELMRAAVTRQQRGHLLETFFRHLFSQVLDINQ
ADAGTLPLDSSTKVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSFREF
LDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVV
ESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQE
KICPSPRMSAHCARNNMKTASSPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHRE
KFQRSRRHQTVQQFKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTR
VGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRLIASTAIIL
TVLHSAGHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVLLLL
ALAIMYVFASHHFRRRSFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAIIY
VGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHP
FTLTSAPHEDTLSLHIRAAGPWTTRLREIYSPPTGDTCARYPKLYLDGPFGEGHQEWHKF
EVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVE
ENDRQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP
FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF
NT seq 4656 nt   +upstreamnt  +downstreamnt
atggggttccacttagctctggcctggattctcctggttgggacactggcttctttggga
gctcagaactccatttcttgggaggtacagcgatttgatggatggtataacaacctcatg
gagcacagatggggcagcaaaggctctcggctgcagcgccttgttccagccagctatgca
gatggtgtctaccagcccctgaaagaaccctacctgcctaacccccgacaccttagtaac
agggtcatgagaggttctgcagggcagccatctcttcggaaccgtacagtcctgggtgtc
ttctttggctaccacgtgctctcagacctggtgagtgtggaaacaccaggctgccccgca
gagttcctcaacatttacatcccgcatggggacccggtgttcgaccctgacaagcgcggg
aacgtggtgctgccctttcaaaggagccgctgggaccgcaacactggacagagccccagc
aacccccgggaccagagcaaccaggtgaccggctggctagatggcagcgccatctatggc
tcctctcattcctggagtgacactctgaggagcttctctggaggacagctggcttctggg
cctgaccctgctttcccatcggactcccagagctctctgctcatgtggatggcgccggac
ccctccacagggcagggagggccacggggggtgtatgccttcggggcccagcgcgggaac
agggagccctttctgcaggctctgggcttgttgtggtttcgctaccacaacctgtgtgcc
aggaagctggcgcaggagcacccgcactggggggatgaggaactgttccagcatgctcgc
aagagggtcattgccacctaccagaacattgcgatgtatgagtggctgcccagcttcctg
aagcaaactcctccggagtatccaggataccgtccatttctggaccccagtatctcccca
gagttcgttgtggcctctgagcagttcctctctaccatggtgccctctggggtctacatg
aggaatgccagttgtcatttccaggggattcccagtcataactcaagtgtctctggagct
ctccgggtctgcaacagctactggagtcgagagcaccccaagctacaaagggctgaagat
gtggatgcactgctgctgggcatggcctcccagattgctgagagagaggaccacgtggtg
gttgaggacatgcaagatttctggcctgggccactgaagttttcccgtacagactacctg
gccagctgcctgcagaggggccgggatctaggcctgccttcttacaccaaagccagggag
gcactgggcctgtctcccatttcccactggcaggacatcaaccctgcactctccaggagc
aatggcactgtgctggaggccacagctgccctgtacaatcaggacctgtctcggctggag
ctactcccaggggggcttctggagagccatggagaccctggaccccttttcagcactatt
gtccttgaccagtttgtcaggctacgagatggtgaccgttactggtttgaaaacaccagg
aacggattgttctctaaggaagagatcgcagagatccgaaacacttccctacgggacatt
ctagtggctgtcaccaatgtggaccccagtgccctacagcccaatgtcttcttttggctt
gcaggagacccctgtccacagccaagtcagctcagcgccaagggcctgccagcctgtgcc
cccctcttcattcgggactatttcgaggggagtggatttggcttcggactcaccattggg
accctttgctgtttccccttagtcagcctccttagtgcctggattgttgcccggcttcga
aagaggaatttcaagaggctccagagacaagaccgccagagcatcatgtcggagaagctt
gtagggggagtggaagctttggagtggcagggccgcaatgaaccctgcaggccagtgctt
gtgcacttacagccgggacagattcgagtagtggatggcaggctcaccgtgctccggacc
atccagctgcgacccccacagcaggtcaacctcatcctgtccagcaaccgtggacgccgc
accctgctgctcaagatccccaaggagtatgacctggttctgttgtttaacatggaggag
gaacggcaggcactggtggaaaacgtcaggggagctctgaaggaaaatgggctgagcttc
caggagtgggaactgagggagcaggagctgatgagggcagcagtgaccaggcaacaacgg
ggccacctcctggagaccttcttcaggcaccttttctcccaggtgttagacatcaatcag
gctgatgcagggactctgcctctggattcctcgaccaaagtgcgtgaggccctgacctgt
gagctgagcagagctgagtttgcagactccctaggcctcaagccccaggacatgtttgtg
gagtccatgttttctctagccgacaaggatggcaatggctacctgtccttccgggagttc
ctggacatcctggtggtcttcatgaaaggctccccagaggagaagtctcgtcttatgttc
cgaatgtatgactttgatgggaacggtctcatttccaaggatgagttcattaggatgcta
aggtccttcatcgagatctccaacaactgcctgtccaaggcccagctggctgaggtggtt
gagtctatgttccgggagtctggcttccaggacaaggaggagctgacctgggaggacttc
cacttcatgctgcgggaccacgacagtgatctccgattcacacagctctgtgtcaaaggt
gtggaagtgccggaagtgatcaagaacctctgccggcgagcctcctacatcagccaggag
aagatctgcccttcgcccagaatgagcgcccactgtgcccgaaacaacatgaagactgcg
tcatcaccacagagactgcagtgccccatggacacagaccctcctcaagagattcgacgg
aggtttggcaaaaaggtaacttcattccagcccttactgttcactgaggcacaccgagag
aagtttcaacgcagccgccgccaccaaacggtgcagcagttcaagcgctttattgagaat
tacaggcgccacattggctgtgtggcggtgttttacaccatcactggggcgctcttcctg
gagagagcctactactatgcatttgcagcacaccacagcggcatcaccgataccacccgt
gtaggcatcatcctgtcccggggcacggcggccagcatctcctttatgttttcctacatc
ctgctcaccatgtgtcgcaacctcatcaccttcttgcgggagaccttcctcaaccgctac
attcccttcgatgctgccgtggacttccatcgcctcatcgcctccacggccatcatcctc
acagtcttacacagtgctggccacgtagtgaatgtgtacctgttctccatcagtccactc
agtgtcctctcttgcctcttccctggcctcttccacgatgatgggtcggagttccctcag
aagtattactggtggttcttccagactgtgccaggtctcactggggtcctcctgctcctg
gccctggccatcatgtacgtcttcgcctcccaccacttccgccgccgcagtttccggggc
ttctggctgacccatcacctctacatttttctctacattctgctcatcatacatggcagc
tttgctctgatccagatgccccggttccacatcttcttcctggtccctgcaattatttat
gtgggggacaagctggtgagcctgagccggaagaaggtggagatcagcgtggtgaaggct
gagctgctgccatcaggagtgacccacctgcggttccagaggcctcagggctttgagtat
aagtcagggcagtgggttcggattgcgtgcctggctctgggaaccaccgagtatcaccct
ttcacactgacttctgcaccccacgaggacacactcagcctgcacatccgggcggctgga
ccctggaccactcgcctcagggaaatctactcacccccaacgggtgacacctgtgccaga
tacccaaagctgtacctcgatggaccgtttggagagggccaccaggagtggcacaagttt
gaggtgtcagtgctggtaggagggggcattggagtcactccctttgcctccatcctcaaa
gacctggttttcaagtcatcagtcagctgccaagtgttctgtaagaagatctacttcatc
tgggtgacaaggactcagaggcagtttgagtggctggctgacatcatccgggaggtggag
gagaatgaccgccaggacctggtgtctgtgcacatctatattactcagctggctgagaag
ttcgacctcaggaccaccatgctgtacatctgtgagcggcacttccagaaggtgctgaac
aggagtctgttcacgggcctgcgctccatcacccactttggtcgccctccctttgagccc
tttttcaactctctgcaggaagtccacccccaagtccgaaagattggagtatttagctgt
ggtccccctggcatgaccaagaatgtggagaaggcttgtcagctcatcaacaggcaggac
aggactcatttttctcaccattatgagaacttctag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (6)   
   RefSeq(nuc) (4)   
   GenBank (1)   
   EMBL (1)   
3D Structure (3)   
   PDB (3)   
Protein domain (10)   
   Pfam (10)   
All databases (58)   

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