KEGG   Mus musculus (house mouse): 99586
Entry
99586             CDS       T01002                                 
Symbol
Dpyd, DHPDHase, DPD, E330028L06Rik
Name
(RefSeq) dihydropyrimidine dehydrogenase
  KO
K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00240  Pyrimidine metabolism
mmu00410  beta-Alanine metabolism
mmu00770  Pantothenate and CoA biosynthesis
mmu00983  Drug metabolism - other enzymes
mmu01100  Metabolic pathways
Module
mmu_M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    99586 (Dpyd)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    99586 (Dpyd)
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    99586 (Dpyd)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    99586 (Dpyd)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2  dihydropyrimidine dehydrogenase (NADP+)
     99586 (Dpyd)
SSDB
Motif
Pfam: DHO_dh Fer4_20 Fer4_21 Pyr_redox_2 Dus NAD_binding_8 Fer4_7 Pyr_redox_3 Fer4_10 Pyr_redox Fer4_6 Fer4_9 Fer4_2 Fer4 FAD_oxidored Fer4_8
Other DBs
NCBI-GeneID: 99586
NCBI-ProteinID: NP_740748
MGI: 2139667
Ensembl: ENSMUSG00000033308
UniProt: Q8CHR6
Position
3:118355758..119226573
AA seq 1025 aa
MAGVLSRDAPDIESILALNPRVQAHATLRSTAAKKLDKKHWKRNTDKNCFTCEKLESNFD
DIKHTTLGERGALREAVRCLKCADAPCQKSCPTSLDIKSFITSIANKNYYGAAKLIFSDN
PLGLTCGMVCPTSDLCVGGCNLHAAEEGPINIGGLQQFATEVFKAMNIPQIRNPSLPPPE
HMPEAYSAKIALFGAGPASISCASFLARLGYSNITIFEKQEYVGGLSTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSTDEMTLSSLKENGYRAAFIGIGLPEPKKDHIFQGLTQV
QGFYTSKDFLPLVAKSSKTGMCACHSPLPSIRGAVIVLGAGDTAFDCATSALRCGALRVF
IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKDGKIVAMQFVRTEQDETGNWV
EDEEQTVRLKADVVISAFGSVLEDPKVKEALSPIKFNRWGLPEVNPETMQTSEPWVFAGG
DVVGMANTTVESVNDGKQASWYIHKHIQAQYGTSVPSQPTMPLFYTPVDLVDISVEMAGL
RFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPLY
GPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKSDWMELSKMAEAS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVRVPFFAKLTPNVTDIVSI
ARAAKEGGADGVTATNTVSGLMGLKADGTPWPAVGIGRRTTYGGVSGTAIRPIALRAVTA
IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL
KSIEELADWDGQSPPIISHQKGKPVPRVAELMGQKLPSFGPYLEQRKKIIAASKIRQKDQ
NTACSPLQRKHFNSQKPIPAIKDVIGKSLQYLGTFGEMSIMEQVVALIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTVSDTCTGCTLCLSVCPIMDCIRMVSRATPYQPKRGLPLA
VKPVC
NT seq 3078 nt   +upstreamnt  +downstreamnt
atggcgggtgtgctgagcagggacgcgccggacatcgagagtatcctggctttaaaccct
cgagtacaagctcatgcaactctgcgttccaccgcagccaagaaactagacaagaaacac
tggaaaaggaacacggacaagaactgctttacctgtgagaagctggagagtaattttgat
gacatcaagcacacgactcttggtgagcgaggagctctccgagaagcagtgagatgcctg
aagtgcgcagatgctccctgccagaagagctgtcccacatctcttgacattaaatcattt
atcacaagtatcgccaacaagaactactatggtgcagctaagctgattttttctgataac
cctcttggtcttacttgtggaatggtttgtccaacatctgacctctgtgttggaggatgc
aacttacatgctgctgaagagggaccaattaatattggtgggctgcagcagtttgctact
gaggtgttcaaagcaatgaacatcccacagatcagaaacccatcgctgcctcctccggaa
catatgccggaagcctactcagcaaaaattgcactttttggtgcagggcctgcgagtata
agctgtgcctcctttttggctcggttgggctattccaacattactatattcgaaaaacaa
gaatatgttggtggtttaagcacttctgaaatccctcagtttcgactcccatatgacgtc
gtgaattttgagattgagctcatgaaggaccttggtgtaaagataatttgtggtaaaagc
ctttccaccgatgaaatgactcttagctctttgaaagaaaatggctacagagctgcattt
attggaataggcttgccagaacccaaaaaggaccatattttccaaggcttgacacaagtc
cagggattttacacatctaaagactttctgccacttgtcgccaaaagcagtaaaacagga
atgtgcgcctgtcactctccattgccatccataaggggagccgtgattgtactcggagct
ggagatactgcgtttgactgtgcaacatccgctctgcgctgtggagcccttcgcgtgttc
atcgtcttcagaaagggctttgttaatattcgagctgttccagaggagatggagctcgct
aaggaagagaaatgtgaatttttgcctttcctctcgccacggaaggttatagtcaaagat
ggaaagattgtggcaatgcaatttgttcgaactgagcaagatgaaaccggaaactgggtg
gaagatgaagagcagacggtgcggctaaaggctgatgtggttattagtgcctttggatct
gtcctggaggatcccaaagtgaaagaagcattgagtcccatcaagtttaacagatggggt
ctcccagaagtaaatccagaaaccatgcaaaccagtgaaccatgggtgtttgcaggtggt
gatgttgtgggtatggctaacaccacagtggaatctgtcaacgatggaaagcaagcttca
tggtacattcacaagcacatacaggcacaatatggaacctcagtgccttctcagcctaca
atgcccctattttacactccggttgacttagtggacatcagcgtggaaatggcagggttg
aggtttcccaatccctttggccttgccagtgcgacaccagccactagcacaccaatgatt
cgaagggcctttgaagctggctggggttttgctctgaccaaaactttctctcttgataag
gacatcgtgacaaacgtctcaccaagaatcatccgggggacaacttctggccccttgtat
ggccctggacaaagctcctttcttaacattgagctcatcagtgagaaaacagctgcatat
tggtgtcacagtgtcaccgaactaaaggctgacttcccggacaatatcctgatcgccagc
atcatgtgcagttacaacaagagtgactggatggaactctccaaaatggctgaggcttct
ggagcagatgccctggagttaaatttatcgtgtccacatggcatgggggagagaggaatg
ggcctggcttgtgggcaggatccagagctggtgaggaacatctgtcgctgggttaggcaa
gctgttcgggttccattttttgccaagttgaccccaaatgtcactgatattgtaagcatc
gcaagagcagcaaaggaaggtggagcagatggtgtaacagccaccaacaccgtctcgggt
ctgatgggactgaaagctgatggcacaccctggcctgctgtgggcattggaaggaggact
acatatggaggagtgtcaggaactgctatcaggcccattgctttgagagctgtgaccgcc
attgcccgtgctttgcctgggtttcctattttggccacaggtggaattgactcagctgaa
agtggacttcagtttcttcatagtggtgcttcagttcttcaggtatgcagcgctattcag
aatcaggacttcactgtgattgaagattactgcactggactcaaagccctgctttatctg
aagagcattgaagagttagcagactgggatggtcagagtccacccattataagtcatcag
aaagggaaaccagttccacgcgttgctgagctcatgggacagaaactgcccagctttgga
ccttaccttgaacagcgcaagaaaatcatagcagcaagcaaaatcagacagaaagatcaa
aacacagcttgctcacctctccagagaaagcactttaactcgcaaaagcctattcctgcc
atcaaggatgtaattggaaaatcactgcaatacctgggaacatttggtgagatgagcatc
atggaacaagttgtggccctgatcgatgaggaaatgtgcatcaattgcggcaaatgttac
atgacctgtaatgactctggctaccaggctatccagttcgatccagaaactcacctgcct
accgttagcgacacatgtacaggctgtactctctgcctcagcgtctgccctattatggac
tgtatcaggatggtttccagggcaacaccttatcaaccaaagagaggcctaccattagcc
gtgaagccggtgtgttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (18)   
   RefSeq(nuc) (2)   
   GenBank (8)   
   EMBL (8)   
Protein domain (16)   
   Pfam (16)   
All databases (74)   

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