#=GF ID   2C_adapt
#=GF AC   PF08793.14
#=GF DE   2-cysteine adaptor domain
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF SE   Iyer L
#=GF GA   22.00 22.00;
#=GF TC   22.00 22.10;
#=GF NC   21.80 21.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16494962
#=GF RT   Evolutionary genomics of nucleo-cytoplasmic large DNA viruses. 
#=GF RA   Iyer LM, Balaji S, Koonin EV, Aravind L; 
#=GF RL   Virus Res. 2006;117:156-184.
#=GF DR   INTERPRO; IPR014901;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The virus-specific 2-cysteine adaptor domain is found fused to
#=GF CC   OTU/A20-like peptidases and S/T protein kinases.  The domain
#=GF CC   associations of these proteins indicate that they might function
#=GF CC   as viral adaptors connecting the kinases and OTU/A20 peptidases
#=GF CC   to specific targets [1].
#=GF SQ   103
#=GS F2NYT7_9VIRU/129-163      AC F2NYT7.1
#=GS A0A6M8PRT8_RTRV/151-185   AC A0A6M8PRT8.1
#=GS A0A097I297_MELV/3-28      AC A0A097I297.1
#=GS A0A0D3R398_9VIRU/226-260  AC A0A0D3R398.1
#=GS A0A369RNE0_9METZ/36-63    AC A0A369RNE0.1
#=GS C3RWM0_FRG3V/244-278      AC C3RWM0.1
#=GS C3RWM0_FRG3V/5-39         AC C3RWM0.1
#=GS A0A0D3R398_9VIRU/332-366  AC A0A0D3R398.1
#=GS A7RCQ1_PBCVA/59-93        AC A7RCQ1.1
#=GS 019R_FRG3G/249-283        AC Q6GZV6.1
#=GS A0A0D3R398_9VIRU/93-127   AC A0A0D3R398.1
#=GS Q5YFM6_9VIRU/403-437      AC Q5YFM6.1
#=GS A0A2R3YA24_9VIRU/45-79    AC A0A2R3YA24.1
#=GS A0A2R3YAZ2_9VIRU/37-75    AC A0A2R3YAZ2.1
#=GS 019R_FRG3G/138-172        AC Q6GZV6.1
#=GS A0A6M8PRT8_RTRV/395-429   AC A0A6M8PRT8.1
#=GS VF380_IIV3/8-47           AC Q197F0.1
#=GS A0A4P8NQR7_9VIRU/167-201  AC A0A4P8NQR7.1
#=GS Q0E553_SFAVA/14-48        AC Q0E553.1
#=GS A4KXB6_HVAVE/60-94        AC A4KXB6.1
#=GS A0A2R3YA24_9VIRU/7-42     AC A0A2R3YA24.1
#=GS Q8QUQ6_ISKNN/37-75        AC Q8QUQ6.1
#=GS A0A068QKK2_9VIRU/33-72    AC A0A068QKK2.1
#=GS Q8QUQ5_ISKNN/164-198      AC Q8QUQ5.1
#=GS Q6YH42_9VIRU/73-107       AC Q6YH42.1
#=GS C3RWM0_FRG3V/138-172      AC C3RWM0.1
#=GS A0A4P8NQR7_9VIRU/7-42     AC A0A4P8NQR7.1
#=GS W8QE80_9VIRU/3-36         AC W8QE80.1
#=GS A0A4T0UTF1_9ACTN/60-85    AC A0A4T0UTF1.1
#=GS A0A3T0PNK7_9VIRU/299-333  AC A0A3T0PNK7.1
#=GS A4KXB6_HVAVE/211-245      AC A4KXB6.1
#=GS Q8QUQ5_ISKNN/7-42         AC Q8QUQ5.1
#=GS Q06VE0_TNAVC/175-209      AC Q06VE0.1
#=GS A0A3R8YPI2_9BURK/5-28     AC A0A3R8YPI2.1
#=GS A0A6M8PRT8_RTRV/221-255   AC A0A6M8PRT8.1
#=GS Q8QUQ5_ISKNN/45-79        AC Q8QUQ5.1
#=GS O41158_PBCV1/63-97        AC O41158.2
#=GS Q06VE0_TNAVC/79-113       AC Q06VE0.1
#=GS I2BFU9_9VIRU/364-398      AC I2BFU9.1
#=GS VF232_IIV6/64-98          AC Q91FU0.1
#=GS A0A2Z5UZF2_9VIRU/17-51    AC A0A2Z5UZF2.1
#=GS Q0E553_SFAVA/142-176      AC Q0E553.1
#=GS A0A0D3R398_9VIRU/156-190  AC A0A0D3R398.1
#=GS A0A068QL52_9VIRU/4-38     AC A0A068QL52.1
#=GS A0A4P8NQW5_9VIRU/53-87    AC A0A4P8NQW5.1
#=GS A0A291B0T2_9VIRU/32-66    AC A0A291B0T2.1
#=GS Q5YFM6_9VIRU/519-553      AC Q5YFM6.1
#=GS Q5YFM6_9VIRU/180-214      AC Q5YFM6.1
#=GS I2BFU9_9VIRU/417-451      AC I2BFU9.1
#=GS Q5YFM6_9VIRU/114-148      AC Q5YFM6.1
#=GS A0A6M8PRT8_RTRV/342-376   AC A0A6M8PRT8.1
#=GS A0A3T0PNK7_9VIRU/5-39     AC A0A3T0PNK7.1
#=GS A4KXB6_HVAVE/169-203      AC A4KXB6.1
#=GS I2BFU9_9VIRU/156-190      AC I2BFU9.1
#=GS I2BFU9_9VIRU/93-127       AC I2BFU9.1
#=GS A0A2R3YA24_9VIRU/123-157  AC A0A2R3YA24.1
#=GS V9SEA1_9VIRU/2-26         AC V9SEA1.1
#=GS A4KXB6_HVAVE/14-48        AC A4KXB6.1
#=GS T2AY63_9VIRU/3-28         AC T2AY63.1
#=GS Q06VE0_TNAVC/27-62        AC Q06VE0.1
#=GS A0A1J0FA53_9PHYC/60-94    AC A0A1J0FA53.1
#=GS G0T549_IRV9/5-43          AC G0T549.1
#=GS A0A3T0PNK7_9VIRU/138-172  AC A0A3T0PNK7.1
#=GS Q6YH42_9VIRU/5-39         AC Q6YH42.1
#=GS W8W2X2_9VIRU/5-43         AC W8W2X2.1
#=GS Q8QUQ5_ISKNN/123-157      AC Q8QUQ5.1
#=GS VF378_IIV6/4-38           AC Q91FE6.1
#=GS A0A068QLN5_9VIRU/58-92    AC A0A068QLN5.1
#=GS Q5YFM6_9VIRU/236-270      AC Q5YFM6.1
#=GS Q0E553_SFAVA/184-218      AC Q0E553.1
#=GS A0A2R3YA24_9VIRU/164-198  AC A0A2R3YA24.1
#=GS D2XB15_GBMV/3-28          AC D2XB15.1
#=GS I2BFU9_9VIRU/226-260      AC I2BFU9.1
#=GS Q5YFM6_9VIRU/341-375      AC Q5YFM6.1
#=GS A0A397ICS7_9GLOM/26-55    AC A0A397ICS7.1
#=GS 019R_FRG3G/5-39           AC Q6GZV6.1
#=GS Q5YFM6_9VIRU/8-42         AC Q5YFM6.1
#=GS Q5YFM6_9VIRU/63-97        AC Q5YFM6.1
#=GS C3RWM0_FRG3V/297-331      AC C3RWM0.1
#=GS Q0E553_SFAVA/60-94        AC Q0E553.1
#=GS A0A0D3R398_9VIRU/385-419  AC A0A0D3R398.1
#=GS A0A2Z5UZF2_9VIRU/214-248  AC A0A2Z5UZF2.1
#=GS Q5YFM6_9VIRU/461-495      AC Q5YFM6.1
#=GS 019R_FRG3G/68-102         AC Q6GZV6.1
#=GS A0A4P8NQW5_9VIRU/177-211  AC A0A4P8NQW5.1
#=GS W8W275_9VIRU/4-38         AC W8W275.1
#=GS Q6YH42_9VIRU/143-177      AC Q6YH42.1
#=GS A0A6M8PRT8_RTRV/88-122    AC A0A6M8PRT8.1
#=GS G0T5B2_IRV9/4-38          AC G0T5B2.1
#=GS C3RWM0_FRG3V/68-102       AC C3RWM0.1
#=GS A7IY44_PBCVN/59-93        AC A7IY44.1
#=GS A0A2Z5UZF2_9VIRU/172-206  AC A0A2Z5UZF2.1
#=GS A0A3T0PNK7_9VIRU/246-280  AC A0A3T0PNK7.1
#=GS A0A4P8NQR7_9VIRU/45-79    AC A0A4P8NQR7.1
#=GS 019R_FRG3G/302-336        AC Q6GZV6.1
#=GS A0A3T0PNK7_9VIRU/68-102   AC A0A3T0PNK7.1
#=GS VF380_IIV6/7-45           AC Q91FE4.1
#=GS A0A4P8NQR7_9VIRU/126-160  AC A0A4P8NQR7.1
#=GS Q06VE0_TNAVC/221-256      AC Q06VE0.1
#=GS B3SDT9_TRIAD/36-63        AC B3SDT9.1
#=GS E3T4L7_CROVB/15-44        AC E3T4L7.1
#=GS Q5YFM6_9VIRU/283-317      AC Q5YFM6.1
#=GS A0A2Z5UZF2_9VIRU/63-97    AC A0A2Z5UZF2.1
F2NYT7_9VIRU/129-163                 .....d-CAEFDR.....NP.GVNPLTSRKIKIDGPVYKKLQKDCA-d..
A0A6M8PRT8_RTRV/151-185              .....p-CPEFAR.....DP.TRNPRTGRTIKRGGPVFRALERECA-d..
A0A097I297_MELV/3-28                 ...qks-------.....--.LVNPKTGRKILRGGPTHLAL------lek
A0A0D3R398_9VIRU/226-260             .....p-CPEFAR.....DP.TRNPRTGRTIKRGGPTYRALEAECA-d..
A0A369RNE0_9METZ/36-63               lkegye-------.....--.-INPTTGRQIKINGPTYRKIH-----nt.
C3RWM0_FRG3V/244-278                 ......VCERFAA.....DP.TRNPVTGSPLSRNDPLYTDLMEICKG...
C3RWM0_FRG3V/5-39                    ......YCDEFER.....NP.TRNPRTGRTIKRGGPVFRALERECS-d..
A0A0D3R398_9VIRU/332-366             ......VCERFAA.....DP.TRNPVTGSPLSRNDPLYTDLMEICKG...
A7RCQ1_PBCVA/59-93                   .....l-CAKWKT.....NP.LVNPATGRKIKKDGPVYKKIQQKCS-v..
019R_FRG3G/249-283                   ......VCERFAA.....DP.TRNPVTGSPLSRNDPLYTDLMEICKG...
A0A0D3R398_9VIRU/93-127              ......YCDEFER.....NP.TRNPRTGRTIKRGGPVFRALERECS-d..
Q5YFM6_9VIRU/403-437                 ......KCEEFLE.....NP.GINPETGKTIKHGGPVYTRLIKECA-k..
A0A2R3YA24_9VIRU/45-79               .....l-CAEYKR.....SP.RYNPWTDRRLAPGSPKHNLISGMCGG...
A0A2R3YAZ2_9VIRU/37-75               ......VCDDLALcs.qhTD.TYNPWTDRALLPDSPVHDMIDYVCNT...
019R_FRG3G/138-172                   .....p-CPEFAR.....DP.TRNPRTGRTIKRGGPTYRALEAECA-d..
A0A6M8PRT8_RTRV/395-429              ......TCEAFCR.....DP.TRNPVTGQKMRRNGIEYQMFAEECDC...
VF380_IIV3/8-47                      ......KCYEWDIak.kkSPlPKSPLTGRKLKQHGPTWKKITAECA-t..
A0A4P8NQR7_9VIRU/167-201             ......ECNEFER.....NP.HRNPETGRAIKANGPTSRSFKRRCDG...
Q0E553_SFAVA/14-48                   ......QCETFKR.....NKqAVSPLTNCPIDKFGRTAARFRKECD-...
A4KXB6_HVAVE/60-94                   ......VCKKFLA.....NK.SVSPYSGRPIKRGAKLYNDLTKHCSG...
A0A2R3YA24_9VIRU/7-42                ......KCNQLRQ.....NKyTVNPVSNRNIAPRGDTANTLRRICEQ...
Q8QUQ6_ISKNN/37-75                   ......VCNDLALcs.qhTD.TYNPWTDRALLPDSPVHDMIDYVCNT...
A0A068QKK2_9VIRU/33-72               ......KCDEWKQrgrlvTS.PVNPFTNRKIKKDGPTYKKVELICN-p..
Q8QUQ5_ISKNN/164-198                 ......QCRAFEE.....NP.DVNPNTGRRISPTGPIASSMRRRCM-n..
Q6YH42_9VIRU/73-107                  .....p-CPEFAR.....DP.TRNPRTGRTIKRGGHVFRALERECA-d..
C3RWM0_FRG3V/138-172                 .....p-CPEFAR.....DP.TRNPRTGRTIKRGGPTYRALEAECA-e..
A0A4P8NQR7_9VIRU/7-42                .....i-CNTFKR.....SGySVNPVTKRTISPSGSVSKTMQNVCS-r..
W8QE80_9VIRU/3-36                    ......ECTEWRN.....NP.SINPLTNRYIKKGGKVYKQLEDKCG-...
A0A4T0UTF1_9ACTN/60-85               .....e---LFPR.....SP.QANPTTGRKMRRDGPLR---------pk.
A0A3T0PNK7_9VIRU/299-333             ......TCEAFCR.....DP.TRNPVTGQKMRRNGIEYQMFAEECDC...
A4KXB6_HVAVE/211-245                 ......KCMAFDK.....ND.KKNPFTGRSIRPEQPAYRMVYSMCHG...
Q8QUQ5_ISKNN/7-42                    ......KCNQLRN.....NRyTVNPVSNRAIAPRGDTANTLRRICEQ...
Q06VE0_TNAVC/175-209                 .....n-CTKFIN.....ND.KINPKTNKNIKYKGPTYKKIVTKCKQ...
A0A3R8YPI2_9BURK/5-28                ..kack-------.....-K.TVNPATGRAVEPTSPAHR--------a..
A0A6M8PRT8_RTRV/221-255              .....p-CPDFAR.....DP.TRNPRTGRTIKRGGPTYRALEAECA-d..
Q8QUQ5_ISKNN/45-79                   .....l-CAEYKR.....SP.RYNPWTDRTLAPGSPKHNLISGMCGG...
O41158_PBCV1/63-97                   .....l-CSKWKA.....NP.LVNPATGRKIKKDGPVYEKIQKKCS-v..
Q06VE0_TNAVC/79-113                  ......KCTEFLS.....NP.RENPITGRKLAANKPTYKKFVKVCG-s..
I2BFU9_9VIRU/364-398                 ......VCERFAA.....DP.TRNPVTGSPLSRNDPLYVDLMEICGG...
VF232_IIV6/64-98                     ......ECEQWLA.....NK.GINPRTGKAIKIGGPTYKKLEMECK-e..
A0A2Z5UZF2_9VIRU/17-51               ......QCETFIR....nNK.AVSPLTNKPIDVHGRAAARFRRDCN-...
Q0E553_SFAVA/142-176                 ......YCTNFHR.....DE.SRNPLTGKKLVPTSPIRKAWHKMCSG...
A0A0D3R398_9VIRU/156-190             .....p-CPEFAR.....DP.TRNPRTGRPIKRGGPVFRALERECA-d..
A0A068QL52_9VIRU/4-38                .....i-CKDWHE.....QP.LVNPVTNRIIKKNGPTYRELEKKCG-p..
A0A4P8NQW5_9VIRU/53-87               .....l-CNDYSR.....DP.MRNPWTKRPMTRDSRMHNIMKYICE-d..
A0A291B0T2_9VIRU/32-66               ......VCIQWFN.....NP.NVNPRTNRKIKTFGPTYRALTDEC--tr.
Q5YFM6_9VIRU/519-553                 .....d-CFAFQR.....NP.GINPVTGKAIKIGGPKYKSLVKACG-e..
Q5YFM6_9VIRU/180-214                 .....r-CAAFDR.....DP.TRNPITGRPIKRDGPVYRRLVEDCEG...
I2BFU9_9VIRU/417-451                 ......TCEAFCR.....DP.TRNPVTGQKMRRNSIEYQMVAEECDC...
Q5YFM6_9VIRU/114-148                 ......KCDEFRR.....DP.SRNPITGKTIKVGGPVYRKLEKECS-p..
A0A6M8PRT8_RTRV/342-376              ......VCERFAA.....DP.TRNPVTGSPLSRNDPLYTDLMEICKG...
A0A3T0PNK7_9VIRU/5-39                ......YCDEFER.....NP.TRNPRTGRTIKRGGPMFRALERECS-d..
A4KXB6_HVAVE/169-203                 .....l-CATFSR.....NE.SINPITGKKLIGTSPIRKAWHRMCAG...
I2BFU9_9VIRU/156-190                 .....p-CPEFAR.....DP.TRNPRTGRTIKRGGPVFRALERECA-d..
I2BFU9_9VIRU/93-127                  ......YCDEFER.....NP.TRNPRTGRTIKREGPVFRALERECS-d..
A0A2R3YA24_9VIRU/123-157             .....a-CALYYD.....DP.TVNPFTDGPLRRYSPMDDLLYRNCE-p..
V9SEA1_9VIRU/2-26                    ....qh-------.....--.LVNPETGRNILRNGPTHLSL------lrr
A4KXB6_HVAVE/14-48                   ......QCETFIR....nNK.AVSPLTNKPIDVYGRAAARFRRDCN-...
T2AY63_9VIRU/3-28                    ...qks-------.....--.LVNPKTGRKILRGGPTHLAL------lek
Q06VE0_TNAVC/27-62                   ......QCEDFIS.....SLqKKNPITNRKIDVFGSTAASLRRNCS-m..
A0A1J0FA53_9PHYC/60-94               .....l-CSKWKA.....NP.LVNPATGRKIKKDGPVYEKIQKKCMG...
G0T549_IRV9/5-43                     ......KCKEWAKd..rlSPsPKNPLTNRKIKVGGPKYKELDKDCE-e..
A0A3T0PNK7_9VIRU/138-172             .....p-CPEFAR.....DP.TRNPRTSRTIKRGGPTYRALEAECA-d..
Q6YH42_9VIRU/5-39                    ......YCDEFER.....NP.TRNPRTGRTIKRGGPVFRALERECS-d..
W8W2X2_9VIRU/5-43                    ......KCKEWAKd..rlSPtPKNPLTNRKIKVGGPKYKELDKDCE-e..
Q8QUQ5_ISKNN/123-157                 .....a-CALYYD.....DP.TVNPFTDEPLRRYSPIDDLLYRNCE-s..
VF378_IIV6/4-38                      ......KCSKWHE.....QP.LINPLTNRKIKKNGPTYKELERECG-p..
A0A068QLN5_9VIRU/58-92               .....d-CEEWIK.....NP.GVNPKTGRAIKIGGPVYKKLEKECG-e..
Q5YFM6_9VIRU/236-270                 ......KCDEFHR.....DP.SVNPATGRPIKYGGPAFRKLLRECG-d..
Q0E553_SFAVA/184-218                 ......KCIAFDK.....ND.KINPFTGRPINENNDTYRMIYSMCHG...
A0A2R3YA24_9VIRU/164-198             ......QCRAFEA.....HP.DVNPNTGRKISPTGPIASSMRRRCM-n..
D2XB15_GBMV/3-28                     ...qks-------.....--.LVNPKTGRKILRGGPTHLAL------lek
I2BFU9_9VIRU/226-260                 .....p-CPEFAR.....DP.TRNPRTGRTIKRGGPTYRALEAECA-d..
Q5YFM6_9VIRU/341-375                 ......KCSAFLR.....DP.ATNPSTGKNIKEGGPTYNKLMRECS-d..
A0A397ICS7_9GLOM/26-55               ....gr----WRK.....PK.IYNPKTNRMIAIDGPTYNKL------ird
019R_FRG3G/5-39                      ......YCDEFER.....NP.TRNPRTGRTIKRGGPVFRALERECS-d..
Q5YFM6_9VIRU/8-42                    ......VCEDFHL.....DP.SRNPRTGKLIKEGGPVYRKLMEECT-e..
Q5YFM6_9VIRU/63-97                   ......KCDEFRR.....DP.SRNPTTGRPIKIDGPIYKKLIRECG-e..
C3RWM0_FRG3V/297-331                 ......TCDAFCR.....DP.TRNPVTGHKMRRNGIAYQMFAEECDC...
Q0E553_SFAVA/60-94                   ......VCKKFLA.....NK.TVSPYSGRPIKPGKKLYNDLEKHCSG...
A0A0D3R398_9VIRU/385-419             ......TCEAFCR.....DP.TRNPVTGQKMRRNGIEYQMFAEECDC...
A0A2Z5UZF2_9VIRU/214-248             ......KCMAFDK.....ND.KKNPFTGRSIRPEQAAYRMVYSMCHG...
Q5YFM6_9VIRU/461-495                 ......KCQKFRQ.....NR.RHNPENGKRIKKGGPVYMRLVKECA-k..
019R_FRG3G/68-102                    .....p-CPEFAR.....DP.TRNPRTGRPIKRGGPVFRALERECA-d..
A0A4P8NQW5_9VIRU/177-211             .....l-CKRFDR.....NP.NINPISERRISPHGAIAKGLRSKCAG...
W8W275_9VIRU/4-38                    .....n-CAKWHS.....QP.LVNPVTNRKIKVGGPKYKELEQKCG-p..
Q6YH42_9VIRU/143-177                 .....p-CPEFAR.....DP.TRNPRTGRTIKRGGPVFRALERECA-d..
A0A6M8PRT8_RTRV/88-122               ......YCDEFER.....NP.TRNPRTGRTIKRGGPVFRALERECS-d..
G0T5B2_IRV9/4-38                     ......KCVMWHL.....QP.LVNPVTNRKIKRGGLVYQKLEQECG-p..
C3RWM0_FRG3V/68-102                  .....p-CPEFAR.....DP.TRNPRTGRPIKRGGPVFRALEMECA-d..
A7IY44_PBCVN/59-93                   .....l-CAKWKT.....NP.LVNPATGRKIKKDGPVYKKIQQKCS-v..
A0A2Z5UZF2_9VIRU/172-206             .....l-CATFSR.....NE.SINPITGKKLIGTSPIRKAWHRMCAG...
A0A3T0PNK7_9VIRU/246-280             ......VCERFAA.....DP.TRNPVTGSPLSRNDPLYTDLMEICGG...
A0A4P8NQR7_9VIRU/45-79               ......YCRSYNA.....NP.SVNPWTGKPLTNNSSLHTTIRNLCN-s..
019R_FRG3G/302-336                   ......TCEAFCR.....DP.TRNPVTGQKMRRNGIEYQMFAEECDC...
A0A3T0PNK7_9VIRU/68-102              .....p-CPEFAR.....DP.TRNPRTGRTIKGGGPVFRALERECA-d..
VF380_IIV6/7-45                      ......KCDEWEKi..rlNSsPKNPFTKRNVKKDGPTYKKIDLICKH...
A0A4P8NQR7_9VIRU/126-160             .....a-CARYVM.....ER.DINPFTDKPLTKYSPLADALYRECE-d..
Q06VE0_TNAVC/221-256                 .....m-CNEFHQ.....NAkKKNPITGRKIAVGSVVQRRIVSQCGG...
B3SDT9_TRIAD/36-63                   lkegye-------.....--.-INPTTGRQIKINGPTYRKIH-----nk.
E3T4L7_CROVB/15-44                   .....q---KWHY.....NK.TVNPRTNRPIKVNGKIYQYLNK----q..
Q5YFM6_9VIRU/283-317                 .....m-CDEFRR.....DP.TKNPITGRTIKTGGPVHTRLLGECA-d..
A0A2Z5UZF2_9VIRU/63-97               ......VCKKFLA.....NK.SVSPYSGRPIKRGAKLYNDLTKHCSG...
#=GC seq_cons                        .......CtcFtc.....sP.shNPhTGRsI+psGPsactLpccCs....
//