#=GF ID   2L_N_poxvirus
#=GF AC   PF21584.1
#=GF DE   Poxvirus, 2L, N-terminal domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE   ECOD:EF20420
#=GF GA   27.00 27.00;
#=GF TC   29.10 261.00;
#=GF NC   25.40 24.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0343
#=GF RC   Paper describing PDB structure 3it8
#=GF RN   [1]
#=GF RM   19838188
#=GF RT   Crystal structure of TNFalpha complexed with a poxvirus
#=GF RT   MHC-related TNF binding protein.
#=GF RA   Yang Z, West AP Jr, Bjorkman PJ;
#=GF RL   Nat Struct Mol Biol. 2009;16:1189-1191.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found at the N-terminal end of 2L protein from
#=GF CC   Yaba-like disease virus (YLDV) and similar proteins from
#=GF CC   poxvirus. 2L binds tumour necrosis factor-alpha (TNFalpha) to
#=GF CC   inhibit host antiviral and immune responses. This entry
#=GF CC   represents the alpha1- alpha2 superdomain which consists of an
#=GF CC   antiparallel beta-sheet that is topped by two alpha-helices. It
#=GF CC   shows similarity with the same domain in classical class I MHC
#=GF CC   molecules and MHC homologs (Pfam:PF00129) [1].
#=GF SQ   5
#=GS Q77G89_SWPV1/22-198  AC Q77G89.1
#=GS Q6TV04_YMTV5/20-193  AC Q6TV04.1
#=GS Q9DHW0_YLDV/19-191   AC Q9DHW0.1
#=GS Q08FZ2_DPV83/21-196  AC Q08FZ2.1
#=GS Q08FH2_DPV84/21-196  AC Q08FH2.1
Q77G89_SWPV1/22-198             LVYNYTYTLQDD..NhRYDFEVTDYFNDILIKRLKLNSETGRPELrN.EPPTWFNETKIRYYPKNNYNFMFWLNRMSETLDEIN..KLPETSnpYKTMSLTIGCTDLRQLQVNFGYVTVGGNIWTRFDPKNKRFSKVRSRTFPKVGMLTVKSQHWERVMEHLGSMVTLTCPFTADDYYKISK
Q6TV04_YMTV5/20-193             LRYNYTVTVK-N..G.LYDGVFFDYYNDQLVTRISYNHETRHGNV.N.SRASWFDISKSPHTPGDDYHFNFWYPLMKDTLESINsnKNESDK..CSSLSLILGCYETGSLFGSYGYVESSGGPLARYSTKDKKFLKMTDKGFPKVGMLTVHGPSWQTVKKYVGGFVYAGCLLAIFDYQKMAK
Q9DHW0_YLDV/19-191              LKYNYTVTLKDD..G.LYDGVFYDHYNDQLVTKISYNHETRHGNV.N.FRADWFNISRSPHTPGNDYNFNFWYSLMKETLEEIN..KNDSTK..TTSLSLITGCYETGLLFGSYGYVETANGPLARYHTGDKRFTKMTHKGFPKVGMLTVKNTLWKDVKAYLGGFEYMGCSLAILDYQKMAK
Q08FZ2_DPV83/21-196             LVYNYTFTRYDKttG.KKEFDVTDTFNNVLIKHYKLNHETGRPEQ.KhTIPKWFNETKIKHYPKDDYHYSFWLGQLENTLSEIN..KLEGNK..HESISLIVGCTDLIQLYTQFGYVEVDGKILTRFDTKNKRFTKVKSHTFPKVGMLTVTSPFWNDIMKYFGSIVAVTCGITANDYWKLAK
Q08FH2_DPV84/21-196             LVYNYTFTKHDKttG.KKEFDVTDTFDDILIKKFKLNHETGGPEQkN.MVPTWFNETKIKYYPTDNYHYNFWLNQLENTLDEIN..KVKGTN..YNRFSLIVGCTDLIQLYTHFGYVELEYDILARFDTTNKRFSKVRSHGFPKVGMLTVNSPFWGDIMKYFGSIVALTCGITANDYWKLAK
#=GC seq_cons                   LVYNYTaTl+Dc..G.+YDF-VTDaFNDlLIK+lKLNHETG+PEl.N.phPoWFNETKI+HYPsDDYHFNFWLspMc-TL-EIN..Kl-uTK..asSlSLIlGCTDLtQLassFGYVEluGsILARFDTKNKRFoKV+S+GFPKVGMLTV+SPaWpDVMKYlGShVslTCulTAsDYaKlAK
//