#=GF ID   AEP1
#=GF AC   PF17049.9
#=GF DE   ATPase expression protein 1
#=GF AU   Llagostera M;0000-0001-8177-8321
#=GF SE   PHMMER:C5DCN9
#=GF GA   27.00 27.00;
#=GF TC   27.00 27.90;
#=GF NC   26.90 26.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   14562095
#=GF RT   Global analysis of protein localization in budding yeast. 
#=GF RA   Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS,
#=GF RA   O'Shea EK; 
#=GF RL   Nature 2003;425:686-691.
#=GF RN   [2]
#=GF RM   8445655
#=GF RT   Nuclear control of the messenger RNA expression for
#=GF RT   mitochondrial ATPase subunit  9 in a new yeast mutant.
#=GF RA   Ziaja K, Michaelis G, Lisowsky T;
#=GF RL   J Mol Biol. 1993;229:909-916.
#=GF DR   INTERPRO; IPR031467;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   ATPase expression protein 1 (AEP1) is a yeast mitochondrial
#=GF CC   protein [1]. It is essential for the expression of subunit 9 of
#=GF CC   mitochondrial ATP synthase [2].
#=GF SQ   35
#=GS G0VDF0_NAUCC/36-430       AC G0VDF0.1
#=GS A0A1G4JID8_9SACH/47-441   AC A0A1G4JID8.1
#=GS A0A0C7MXL8_9SACH/43-438   AC A0A0C7MXL8.1
#=GS A0A1E4TN99_PACTA/81-404   AC A0A1E4TN99.1
#=GS A0A7H9HQR7_9SACH/37-432   AC A0A7H9HQR7.1
#=GS A0A1G4J7L9_9SACH/43-435   AC A0A1G4J7L9.1
#=GS A0A1S7HDW7_9SACH/29-423   AC A0A1S7HDW7.1
#=GS A0A448YKD9_BRENA/211-456  AC A0A448YKD9.1
#=GS AEP1_CANGA/34-425         AC Q6FU41.1
#=GS A0A1E4S588_CYBJN/136-422  AC A0A1E4S588.1
#=GS A0A1G4MJ49_LACFM/43-437   AC A0A1G4MJ49.1
#=GS AEP1_ASHGO/35-407         AC Q759Y1.1
#=GS A0A1X7RAB6_9SACH/37-427   AC A0A1X7RAB6.1
#=GS AEP1_KLULA/42-437         AC Q6CIJ2.1
#=GS A0A1S7HTT2_9SACH/29-423   AC A0A1S7HTT2.1
#=GS AEP1_VANPO/39-432         AC A7TPS5.1
#=GS C4R1Y9_KOMPG/94-364       AC C4R1Y9.1
#=GS A0A4C2E9Y6_9SACH/29-423   AC A0A4C2E9Y6.1
#=GS A0A1E3QM33_9ASCO/66-410   AC A0A1E3QM33.1
#=GS J7SAW5_KAZNA/37-436       AC J7SAW5.1
#=GS C5M994_CANTT/287-452      AC C5M994.1
#=GS AEP1_LACTC/47-440         AC C5DCN9.1
#=GS A0A1E3PC54_WICAA/55-416   AC A0A1E3PC54.1
#=GS H2AM70_KAZAF/40-434       AC H2AM70.1
#=GS A0A1E3PFX0_9ASCO/276-515  AC A0A1E3PFX0.1
#=GS J7REB0_NAUDC/48-447       AC J7REB0.1
#=GS A0A5E8C1N4_9ASCO/155-299  AC A0A5E8C1N4.1
#=GS A0A1E5RBE9_9ASCO/39-357   AC A0A1E5RBE9.1
#=GS A0A7H9B884_ZYGMR/33-424   AC A0A7H9B884.1
#=GS G8C068_TETPH/73-466       AC G8C068.1
#=GS A0A1V2L528_CYBFA/183-441  AC A0A1V2L528.1
#=GS A0A1E4SQL4_9ASCO/192-417  AC A0A1E4SQL4.1
#=GS AEP1_YEAST/50-449         AC P32493.2
#=GS A0A875RVA3_EENNA/160-406  AC A0A875RVA3.1
#=GS G8ZQG0_TORDC/30-418       AC G8ZQG0.1
G0VDF0_NAUCC/36-430                  ........................................................................................................PSNVLHPFYE.PSKLEKFTLCFTENNP..TLCNGEAIIPTV.........TKRSNWPKPKL........VNGSITFNTSRGINKWLEEYRALKDSG.HRTVHftRINKEADVKDFLKPCFLNELSHPEL........KQLFTTLKEERGIEYIYASINNIVL-----.........ENKGLFHEDLYQFLL.QdSRINKIESLTLIVKSINHHLHSV....IDH.L..N.LIDPLLLRI..MIAIQERNF...PITEEMTK.......SLMKLLESINERFNI...KNCLYSFHPITRQYLL.DFFLQAE...KLTESKTLISSIVA.DKRIPEDQSVLQYFQ.....LLDKFFKNDKS....NSFFLNKL.L.CLSDILPI........LRS.....SKNPL.....MFKYIIQVCRTFNEVESLIRIMREC.eGNCKE.LIL.STMDSFI....VQTNSFSV.....DEMTNSANLSTLYGLTKELCRDEV..PNELIIKFLLAFALN.....................................................................................................
A0A1G4JID8_9SACH/47-441              .......................................................................................................t-NDLNHAFYS.PNVAECVSLCMTEVRP..SLLDGLPVMPAI.........ITHPKNLTKIL........VNARCEFDTVRGVSKWITDLR--EKSV.NANKL..AIIEANSNSENVRPTKLNLEQKNQL........EQALFDASGATKPSLRVGKILQGLENLQNR........sNDQKLFSEEVFLCLM.Q.DYCRSESDLIAILNCAAKFLTID....IDQ.V..A.VAELILLQA..LYSIEKFDS...QPTPELAS.......SVTQFLHAIGDRFNA...QHYLLCQDAKISQELL.KFMVSVN...NLNDSKFIMSDLIG.RGLCPNKDLIETYLN.....LVDSAYPSKNN....RDQILRRF.A.YISDFLPV........FRT.....VLSPK.....IVHHLISNCRHFNEVGSLLELIESS..DLSDT.LLT.ESLPHFI....ERVGSLTR.....DKLQNSIGLNSLYHRVIN-VRISL.pLDDIQREFAMQF---aln..................................................................................................
A0A0C7MXL8_9SACH/43-438              ......................................................................................................yh--DSIHPFYR.PNVAERAILCATESCP..HLLDGHKIVPAV.........IKRPRDSTTTL........VNARWIFKSSHAVQNWLKEFNEFEVTR.QAESF..VLIQERDIEQIIRPSRLNPSQFSEL........QKFAELYKTQDTSTLDTVLVSGLIESLTSL.........PVIKVFSEEVFLYIL.Q.HYCSSKHGVIGLTHSMIEFLHKD....IDD.I..K.VAELLVLQL..LITLKKKQV...PVDSDVMS.......AVTDLVNAISERFHK...DNCVLSFSPVTVQAVL.DLHLQFG...DLNGAKMLLAHLVN.QRICPQCVVLEKYLL.....LVDEKIGPVDS....PEAFLKKF.A.YISDFKAI........LET.....AITPT.....SASLLIPYCRHFDEMVSLLDIMDRS..RLKKQ.IWD.QTLPQMV....RRVSLFES.....DAVMNSCNLTVLLQRAQRVYGSSL..SNKVLQAFIVQYATN.....................................................................................................
A0A1E4TN99_PACTA/81-404              ...........................................................................................fnvfkinlntnei----------.----------------..------------.........----------D........LNSKLSFRDGKNFLNWYYQGY--KDK-.NELIL..KPVDSLDLEYQDFKVNLN---NEVL........SNRILSLINDDQFDWSLEKLTNLFENDSQIsfn..psksDRFSIQFNHLVIFML.Q.NLSNNH-HHHVIYQSLCNYVIVN....LPK.I..NkSLDGIIFNF..VNLLLYNMS...PGNLNSFN.......CFENFLKEFPPKIL-...---LQNFGPFLVNDII.DLCLKYD...QLTRAKDFIDLLLN.NKFLPKISTLENYIQ.....ILSTSIVSKKM....NGSSFAKFnV.LTKNFNTV........YNK.....YLTKK.....IIDSLLPFIQHEQEFNSLVSFIENN..ENPVK.LFT.DSFTGLI....ET------.....------------------------..---------------yfrvltsdyk...........................................................................................
A0A7H9HQR7_9SACH/37-432              ........................................................................................................PSHIVHPFYV.PSTTEEIIACSTETFP..ALLDGKPIVPSL.........VNDTSAGSYHL........EMSSLRFKCVRGVANWLADLSTVANSS.SQVDY..RALNQQMTDLPLKPSKLSRIKHPLI........STLRELFAIEKSQQINPATLNAIIEQFIND.........KDLGVFSEDIYLYLL.Q.HHVNSTDKILTIIESIKLHLATT....IDQ.L..K.VVEQLVLHL..LVSLKRNKL...TITANLMT.......SFDDLLDAINKRFHV...QNCTTQFQPLVCEQIL.EYYIKVG...NLNESKRIISELIA.RKFLPAESTIVDYLK.....STNDQLNLDKT....PKGYLRAF.A.LVSDLRPA........FER.....ARNPL.....TFTYLIPLCRHMSEVTSLLTMIKNC..ENVKE.ILD.VNLIPFI....HKIIHIKD.....EPSVRSANLCSLYRMASPFYGDKL..PEKYSKAFLLSFA--dl...................................................................................................
A0A1G4J7L9_9SACH/43-435              .......................................................................................................c-ENHIHPFYQ.LNNAERGILCATENGP..QLLGGKKIVPVL.........RSSDLGRKEVL........TNARLVFKSVVGINKLLGSYHKFGEE-.-KP-L..AIIADRDIDQLLRSSRLGTTQVLKL........QEFSALLQEQK-SPANHLQIASIVDSLNSD........tHEAQVFSEEVFLYIL.Q.HFCNSKHGMISVALSIVDFLQKD....IDE.L..R.EAEVLLLQW..LVTIRQKNV...PRDQDIIE.......AFSNLTVAISDRFHI...SNCILHFSPPVTQAVL.EFYLDAG...LLSESKLLFTDLIS.KRFCVKSKLVEKYLA.....LIEDKVTIADL....NDRLLKKF.A.YISDFRPV........FET.....TLTPG.....ITEILISYCRHFDEVISLLELVERS..KATRQ.IWD.HVLPQLV....RRISLLDV.....NPVVNSCNLTVILNRAKNFYGSAL..SSKVQRAFIVQYAAN.....................................................................................................
A0A1S7HDW7_9SACH/29-423              ........................................................................................................PSQIIHPFYT.PTRTAELAACSQEVRG..RLMEGRKVFP-V.........LSRDAKDQPIL........ENRAVVWDTVKGANQWIQDYA-RQTTQ.AEEAV..HLVLEGKPDSLIVPSKLHKSGAPLM........DKLADLFGAERSKHFNSAALDSLVDELVSD.........DTSSVFCEDIYLYLL.Q.HHVNSAGKLIAIIDSIRAHMAVD....IDQ.M..Q.VAETLVLQT..LLSFQRNKI...GCTPELVA.......SFDRLIGAINDRFHT...RNCEFQFQPLITQCVL.AFYIAGG...KLSDSKKLFAHLIL.KGWAPREDITVQYLQ.....LVNRVIHDNDM....DTTILKKF.A.YISDFRPL........IKR.....GQSPA.....LFATLIPYCRHFGELSSLLSIVISN.tHNTKE.ILD.VTLLSIV....DAAAQMGK.....NKRFQSANLYEVYHSVLPYYKSHL..PNKFIKAFALKFAA-l....................................................................................................
A0A448YKD9_BRENA/211-456             ...............................................................................................vnllseyis----------.----------------..------------.........-----------........---------------------------.-----..-------------------------........------------------------------.........---------------.-.-----------------------....---.L..Q.VVEFDLLEL..ESLICQLAL...YGDTEEVK.......LIVSSFDKINEPN--...RTFLSSASQGLKLELF.DAYTRGK...DFQSAFKVFESLVAvNKSSPPAQSIENYLD.....LVSATANSIKS....-NFKNKKF.V.FNAYSAPV........AYS.....LRLPG.....VLNERIA------------------..-----.---.-------....--------.....------------------------..---------------vlimpwltenefpwfvnylrlspdygkvvrkfsfslietygkcmgthsgksssdkaisltafinqmeipldtfddatkelisklyakfksplaarlwldkl
AEP1_CANGA/34-425                    ........................................................................................................PEQLLHPFYR.PGNVSSLGLCMKEGKP..ALLDSKSIIPSI.........VQNSKTGNPVL........ANCSLAFSSVQGVSTWLKQYENLRETR.TTPF-..STIPFPDLNRYL--TSLPKSKVEII........EKAYTNLINNDGSHISKGIILELVHELSSD.........FELAVFSENILIFFL.N.DKVSKRSELACVLEAAFDLLDTH....IDQ.P..K.TIYKFLMAF..FAKYFEVPV...QTDTDLNT.......LMVKLLMKLENKFHL...ESMYSKMVPELTEALF.SFYTREG...NLHEANIAINDLIK.KGFIPKSEDIENYLT.....LINTKYPGHNS....-QDYMWRL.F.HIAHFEGL........IQS.....SDHPN.....LLKFLVQNCRHREEIETVFTIVAKN..KNSKI.LLE.HLTAPVI....DSISNMKM.....HRVPKSSLLSDYYKMMKFAFNNEL..SHQLKLLLLQGYIT-f....................................................................................................
A0A1E4S588_CYBJN/136-422             ..........................................................................................epllydeqvilqve----------.----------------..------------.........-----------........---------------------------.-----..-------------------------........---------TELGDVNKETLSTLLDTKITN.........SSNHLFTNDLKLRLV.I.EQHSLPGNIDDITRTAVDYMV-H....VDN.A..T.IATDIAKSL..LPRLESL--...---VKSRN.......SLLQLTQLVYRSLST...NYPIVEDDLELKTLYL.NNLISSK...EPELSFNILTELQS.CGYAPPRETMANYLA.....LLAKKVNYHDK....-KSNVKSL.V.LLQGLQSV........IFS.....TLSTD.....SARNLLLLCEHPDEISSVLDLVESTspSEIPQ.VFQ.ELEATVA....KKLFASKS....vRLSDASLKMSIIHRLQTHIENISI..NTKKL----------ilfdqv...............................................................................................
A0A1G4MJ49_LACFM/43-437              .......................................................................................................a-TQSIHPFYT.PNINERALLCLTERNP..ELLNGQPFIPAI.........STDPVTSEATL........VNARCQFHTVQDINRWVQEQRNK--SE.HGKKL..EIINEHNINRLLRTSKLDRNQLPRI........KRLTSLFAGTS-ESVNPDLINTIVESLVTDs.......sENNKIFSEEIFLYML.Q.HHTTSPEGLIGIIESIIFFLHRD....IDE.F..K.VAELLVLQC..LVSIQKKDI...KLTPALVS.......TIDRLTEAINQRFHS...TNCILQFEPCVIHVFL.EHYIKCG...KLAGCKILFADLIN.KGFCPNAELVTGYLN.....LIEEKIGSGVN....NEELLRKF.A.YISDFSPV........FHT.....VFSPQ.....IMEYLISYCRHFNEVLSLLLLAEQS..VMMKQ.IYD.TNLPQLI....RKVSLLTR.....NSLKNSANLCSLYDRAENYYGQNL..SDKVKSVFILQFAVN.....................................................................................................
AEP1_ASHGO/35-407                    ........................................................................................................PNQIMHPFLG.LTQTELGLLCCTECEP..RIRSGKQIIPAM.........VRDPMKDQTEY........THAKLQFPLLTNISAWVKDHAMYQYSS.EKQLVsaATLPAFKAAETEIPEAIRAVCQPSA........-----------------QSIEGII------.........AAGVVSTEDLFQFLL.E.TYPARAKTILPIL----------....LRE.Y..Q.KLPPAELHL..EGTLHRALL...AFEGQTVDke..dieVLNRLLDNYSTEFG-...RRYEQVLDATVLQQLL.RFYISGS...ALTNSRTTLQFLLK.RGVCPIPEVLDAYFL.....LLEKAISVKSQp.dlQARRLAKM.A.CIAGCAPI........LKH.....TITAT.....MLRVLTGCAAHTGEILHLVELAAGM..PSCKE.VLQ.ENAVQLV....NAVSSFAP....sPAVENCTNISLLLQRLEQIYPDGL..PKQFVHAASQAYMHN.....................................................................................................
A0A1X7RAB6_9SACH/37-427              ........................................................................................................PSEIIHPFYK.IGPLEQLLLNYRYKTS..SLLDGRPNFATF.........DRD----SQKY........IPKQLKLRSTPDLPEWVHNYSFHVHNNvFKDISsmIRITEKDIKNQIRESYITKDTSANI........ETIETLMAKNSKMK---EPFEPLNLVSLIDgv.....vmTTDGVYTEDLYTFVI.Q.KHCNHLNNITLTVNAIMLHMETM...kLDQ.F..F.VLEKLLSQL..VYTMRPQ-M...ELVARVESni..vlkKLDDLIQAIRMKFPN...----QIFQGTTNTQLM.DLYTNVS...YTITAHEYLKKLILvNNMLPEEQLVAEYIA.....MLTDCF--HD-....--DTTSKM.G.YISDLSSV........IES.....QMTSK.....MLHFTLPLCSHFNEIQRLLQIVTKK..KETYH.LMDkESLIAML....RQIEIVDD.....NDLSKGIDIIKIYNILL--EHNMV..SEQYVPIFV------eflar................................................................................................
AEP1_KLULA/42-437                    .......................................................................................................a-NKIVHPFYQyPNATERTALCITERNP..KLFNGKPVLPAF.........VRHPVTSESTL........VESRLSFDTVKDVSKWVQRIH----KS.GDRLFhkVNITSSDSGPKVRKTKLTSES-PFV........KQLDNFLNSHP-----QLSFETLDSELSKLfi....fhkGQEVIYLEEIFLYIL.Q.RDNLTVPQWKATLKTLPKYVGKE....IDD.I..D.MLNTLLIQW..VLSGEQLFT...KIDTPALN.......LLWNVIKSSRESLN-...QNIITNLNNVQLDKLF.DTFLKGK...DIKVSRILLETLAS.RRIMPSLPSIEEYIE.....LVGQAGQETDAg.ivPLERKSKL.Y.LLHVLSPV........FAS.....NLTCR.....MTDLLLPYCIHQSEIFALLDLALKS..KYSKD.IAK.SCVNNFV....LRIAQLKD.....SQVDNSLNISSLYYRIKAYNNGTV..PNANLLAFIIALLTN.....................................................................................................
A0A1S7HTT2_9SACH/29-423              ........................................................................................................PGQIIHPFYT.PTRTAELAACSQEVRG..RLMEGRKVFP-V.........LSRDAKDQPIL........ENRAVVWDTVKGANQWIQDYA-RQTTQ.AEEAV..HLVLEGKPDSLIVPSKLHKSGAPLM........DKLVDLFGTERSKHFNSAALDSLVDELVSD.........ETSSVFCEDIYLYLL.Q.HHVNSAGKLIAIIDSIMAHMAVD....IDQ.M..Q.VAETLVLQI..LLSFQRNKI...GCTPELVA.......SFDRLIGAINDRFHT...RNCEFQFQPLITQCVL.AFYILGG...KLSDSKKLFAHLIL.KGWAPREEITVQYLQ.....LVNRVIHDNDR....DTMILKKF.A.YISDFRPL........IKR.....GQSPA.....LFATLIPYCRHFGELSSLLSIIISN.aHNTKE.VLD.VTLLSII....DAAAQMGK.....NKRFQSANLYEVYHSVLPYYKSNL..PNKFIKAFALKFAT-l....................................................................................................
AEP1_VANPO/39-432                    ........................................................................................................PKEIIHPFYR.PSQIEEFTLCSTERNP..SLMDGKPVFP--.........ISLPLLSTSVLp.....qlLYKKIIFPSVRNIVPWLKKFNYIRIKN.YSDEY..YTIDFKPLEMPTVESKLTITNFPEL........KILVDLLENTNGGRTDIHNFELCLNNILQK........rMSTRLFVEDIYIYLI.Q.NYVTTIPKLILVTKSIKNHLNNG....IDH.L..S.ILEKLVNEI..LYLVHSKKF...TMDLVLMN.......TFNGLLKEADNKFNT...HSSKFGFSETTKESLL.MLYIQAE...DIHSSKELLGNLIS.KKSYPKDEIILAYLD.....LINKAVYKSNP....ENAILQRL.S.YTSNFFNI........INH.....TTNPE.....ILRFFIHNSRHFKEIQCVLDMILKK..KNRKD.IVL.PLCIDLI....EKTVSVSD.....SAVSTSLNLTRLSDYFETMLGMNV..RIEAKEVFM------kk...................................................................................................
C4R1Y9_KOMPG/94-364                  ksqqdiyrtncdsdfdqllsrlnglgkyklgidhlvnyaaqqvsdpvsmeqlaskvvaredlnvkqkacfltrllsygghmvqhgshfssldhlveqvtyiade----------.----------------..------------.........-----------........---------------------------.-----..-------------------------........------------------------------.........---------------.-.-----------------------....---.-..-.---------..---------...--------.......---------------...---------ALQGLIL.RYYLKRG...QSRAFINLLEECLN.QSYLPSPDIIVDYIQ.....LVASQSAPGSL....--RSRKQ-.-.-LTPLAPI........IAR.....VSTPQ.....LVTELSNQLSTAKEFETYLTILTRL..PNWHQ.LIS.VGLSNLT....KAAIRTSSktngsNEAYASALLSQQLLRLESKAGSTL..SAKTE----------lvlslvqahis..........................................................................................
A0A4C2E9Y6_9SACH/29-423              ........................................................................................................PHQIIHPFYT.PTRAAELAASSKEIRS..KLLGGLKVVPAL.........ITN-WEGKPLL........RNRFIKFDTVKGVNLWLQEYSSRRKGA.EEAVY..RTLEGQPEA-LITPSKLYRSKVPLV........GKLTELFGSERTKHLNSTALDSVVDELVND.........KEKNLYCEDVYMYLL.Q.HHVNSEGKLIAIIESIKSHMGAN....IDQ.L..K.VAESLVLQL..LLSVNRNKL...SLTKELVN.......AYHQLIDAVNHKFYT...SACELQFDPLVIQCIL.EFHVLSG...NLNHSKKLLSHLIL.NGWAIKEDLSVKYLQ.....LVESKVRDEDR....DTRILKRF.A.YISDFRPL........VQR.....AQTPF.....FFAALVPYCRHFSELHSLLTVITNK.vHNTRE.VFD.VTLLSMI....EAMDNMGE.....NNRYKSANLYELHRTVLPYYDSNL..PVRFAKAFALQFAK-f....................................................................................................
A0A1E3QM33_9ASCO/66-410              ......................................................................................krdkqlmggslvhhkgga----------.----------------..------------.........-----------........--QPVTFNSFQLFLQWYQAYATVHSEG.LQPIR..----HEFSTPR---ASMEKSTVEAL........QAMSE---QGQFEDMSVTKVEELCEEFEAEfafqmsitpQKSNLLVADMLLYLL.Q.RETS-----ESVFQAVCEFVANH....TGQ.FrlS.SLDKIVSQL..IYTAGKSEH...ALTAVLDA.......SLEAVLH------HH...PNILAKTDLALIETLT.TLYIGTG...DLKKSTACLAILNE.NGVAPKVQTAETFLY.....LLEQNPEANVN....--------.N.YLAVLSGV........FST.....ALTPV.....MTSFFVNQITNFAELNALLHCIESS..SEAAA.IYA.VCQTELI....EVVFLLEA.....SQSE--------------------..---------------mtgpvmaaklaglahrikahalvsdesafllakyh..................................................................
J7SAW5_KAZNA/37-436                  ........................................................................................................PGQVIHPFYR.VSGRERLLMCYGDGPV..ALADGRPVFAS-.........VIEGKAGVGQL........VMGPVKLQNKAGVSQWLKEYTQRIDEE.SAVTLqeCHLAGEGASRKTLLTRDDRRLQEVV........-QLLEKQDPDEGAAADSVALNSLIDYILIS........rHHSGLFAEDIYSFILgDpRLVDTLEKVSLVIESVQGHMYTK....LDH.L..R.AVEPLLVQA..LQVADF--L...KNCTTEQHta..fdfTLDKLFQTVNRRFNY...NDCLRHFEPHVLLLLLrHYLHKSM...AAIRAKTVIERMIQ.QGIKPPQDSIDAYLR.....LLESKS-----....---RKEKL.V.FIADFRPL........IEN.....APSVT.....LLSFCIALCQHYNEIMCLVNIVMKQ.pQEQREqLLE.ALFPQLV....TKCEECSAkg.knSNLHKSADLCGVLNLFA-QNNIEL..PSNHAKLCIDHLLK-y....................................................................................................
C5M994_CANTT/287-452                 ........................................................................................vtsifdtyptimeglp----------.----------------..------------.........-----------........---------------------------.-----..-------------------------........------------------------------.........---------------.-.-----------------------....---.-..-.---------..---------...--------.......---------------...--------HDTLDK-L.AYLLSSK...NWELSRTLLQILLK.NNVCPSEDTVNEFLL....nFVNSDP-----....-ETKLKEL.L.FLKSI--V........YHR.....GVNEM.....TLQILLSTMRNINEFNKLIDLIRMK..DNYKE.VLE.KYQNILL....MTLKRVST.....KFTLHSAQFVRLLTE---------..---------------lgiqadidlvnkmqa......................................................................................
AEP1_LACTC/47-440                    .......................................................................................................i-GDSMHPFYS.PNIMERAILCASEIKP..ELLDGQPIVPAV.........IKQLKTLEPAL........VNTRWQPQSTQGLNDWLEPFRKMRRKS.SPL--..KLIENHEIDNVIRPSRIDSGRIPEL........RKFALMFEKEDAGILSASTIGSLIDRLAAD.........QEKAVFSEEVFLYIL.Q.HYCKSSQGIASVVDSITEFLHKD....IDD.L..K.TAETLLAHV..LMALRRNSI...PLTPRATS.......AILKLIDSVSTRFHR...PFCVVDFSPAVVQMTT.EFYVDSG...FLKESKVLFTDMVN.KERCPSAQLVEKYLG.....LIESVCGISTS....DNDFLKKF.V.YISNFRPI........FQT.....TMTPR.....ITEFLVSYCRHFDEILSLLVLVDHS..KVKKQ.IWD.LVLPQMI....RRVSLLTK.....DSAKNCCHLTVLYQKASRFYGMPL..STKVNKAFIIQYAVN.....................................................................................................
A0A1E3PC54_WICAA/55-416              .dhpihpfhrpsaasklikvlrphnkldagpifsleshtkgghkvnlspsfnssreaiafldklpqdyqilnpieqppissslsesaksqieemrtddvqswsk----------.----------------..------------.........-----------........---------------------------.-----..-------------------------........---------------------ILKARIVSK.........DGSIITNEDKLVFLL.EkTINSTPESVSNVIPLLKSYITF-....VEN.S..K.LVSNISQFF..LHQVLKYEY...ENPKQILQ.......EISEIEKLLADEYP-...---GVKKEPSFINVLL.KTHLHLK...EYAGTKLLIDSLIA.QGFTPDAKTVEMYLKfhvdkLISSKTLSVTK....NAQVKADF.FdSIIDMDDV........FHS.....VMNPN.....IAKLLLHGSDSLEEASSILKELQSK..IQGQE.LKD.TYKSFEV....RMVNIM--.....------------------------..---------------nqedrtfvphilqsalrntfyqkhervte........................................................................
H2AM70_KAZAF/40-434                  ........................................................................................................PEKLIHPFYR.ATPIEQFRLCYKQRNT..SIANGKPIFSSL.........ILHPKTFKTIL........TPISLKFNSNIGLHKWVNDYN------.-----..----LNLSTRKIQLCQLSNDTIPKFhlhdisddQQFKEIIQLMSRSKCEMEAIKPLALNSLLDyf....mlnSDKSIFLEDAYFSIL.Q.KHTHSIEGLKLVLGSMSMHIELS...vIDQ.F..R.TVEKLLFQA..LNTFNQ---...-LNTVKPI.......PLSELFFLIDEKFHL..eHHCTESFKPYIIEELI.HYYTKIK...DITTAKNLLNKLIFvNNIIPSISTISSYLD.....LVREKSQAKNK....KYCRQKQI.I.YISDLMPI........LEQ....pSSTLRkakllILKFLTPLCIHYNEILSLMRILKEN..NDMK-.LFL.SIKSHFI....DAIVKMET....rSNGEESRNLASFYMLVE----DDI..SDKDCTTFIHSFAS-t....................................................................................................
A0A1E3PFX0_9ASCO/276-515             ..........................................................................esrtdkshlteeiftrpivaesaeslstqf----------.----------------..------------.........-----------........---------------------------.-----..-------------------------........------------------------------.........---------------.-.-----------------------....---.-..-.---------..---------...--------.......SLEKLVQELKTQYF-...H--SYKENGLLNDRLF.GAISKSG...SFPRASQSIEKYINeDSSLPSSDSIEIYLD.....TLKRFLETKKAiyigDNFDTYAL.H.KIARLGPI........FKS....kHITPA.....VVKFMLPYIGDADSLASIMTTIRGS..WNRAA.ILN.QCQEELL....DTSVRCSN.....NSV---------------------..---------------ytdpvessfrdtlvmsrmfiiaeeleslpetkpslnfltklidynisysnisg................................................
J7REB0_NAUDC/48-447                  ........................................................................................................IKKLWHPFYK.PSSIEQFKMCFTELDPanQFEEFKPFLIEIdenmenlcyTTQDKTFSHLLkgyfydlkQNESIDYQLMKG-EFWEERRRTRETN-.-----..---------------QVNQAGNPEF........DALTNILFHNDWTY--KFKVEELNVKITKLv.......mNSSNLFCEDIYLWLL.DpKIFKSIENLQIIIDSITIHLSSPdallLDH.F..S.MIEPIILRI..VKSFSE-EL...RPTTSIMN.......CFTNLFESINHEFNIpniQHCFTKFNPLTLQYLL.LFFLRSTgdyHLNECKLLIDLLILyHKKIPLESSIIDYLI.....SLNKKNSTHLG....---AADKL.R.YVRSIGLI........LNQ.....LNDIK.....TFQELLPMCQSTIEIIHLLKIIRSK..DNGIH.MIR.QLIPSVI....TYINNLSN.....DELVNSSNLCFLLKFLK---DSKIikNDKIRRQFMLGFAIN.....................................................................................................
A0A5E8C1N4_9ASCO/155-299             ..................................................................................................enftrs----------.----------------..------------.........-----------........---------------------------.-----..-------------------------........------------------------------.........---------------.-.-----------------------....---.-..-.---------..---------...--------.......---------------...------------QNIFfQLLSRSG...SIKQAENVLEKMVT.LGVSLTDRSIDEFFS.....TLERYLFASRN....-VSHLSRI.E.YNNSVKEIlfkfrkflLSQ.....NITPS.....MADLLLEFSAYLDEFYGVMNMIEDS..SHCDE.ILS.KCQPKII....QTAVRCSI.....------------------------..---------------phshwae..............................................................................................
A0A1E5RBE9_9ASCO/39-357              .......................................................................................................y-NNVISPFYV.PLDHEILQFVYQNEPK..KLLDGGPFLHKL.........HSDAQVSPDYCk......sTSYSLKTDAGPGSTEWLFQWTAFLRKL.NSLDL..S-VAPFLHKQFTXKSPFQNEN-GQV........-DLAKKYSIQE----LSTEIDCII-----Q.........ADPLLFKHQIILYMV.Q.QNNFFKKNQEAILSAYLKYMKHE....VND.P..K.ECNGFFIEV..FKTVEALGI...TLSPESSE.......ILNQIIEQ----FVS...RNSVEAFEKLAIVGVL.DFFISRK...DVYQANSYLTVLLA.NGLAPQSNTLSSFID.....LVEDPVFFSTL....-GSILKKX.S.NAEIFKKL........LPY.....IDHHK.....KLQFLIKSNEHNLE-----------..-----.---.-------....--------.....------------------------..---------------nfnicvlsfhk..........................................................................................
A0A7H9B884_ZYGMR/33-424              ........................................................................................................PTQILHPFYS.PSRNEELTACFKEVRP..ELLDGKRIMPCL.........LKDSVTLAPIL........KYCSLKFDTVRGVNKWLQEFNDGRSQ-.--KRY..VFIDDKDTTKYCKPSKLEGTTPPEV........KELAELFNAQE-KDIELQTLDSVLDELLTS.........ESFPVFCEDIFSYLL.E.HHVKSIENITVIVDSIKCRLHSD....IDQ.F..T.VAENLIFQV..LLCMKKKNM...EASSKFMA.......SLEDLLDTLGHRFHL...PSTASQFQPEVNQAVL.EYFINVG...KVNECKTTLGHIIS.EGFLPKERISVKYLQ.....LLDKKFGTQPS....ESNLLKKF.A.YISDFRPI........IEN.....GETSC.....LFNHLIYYCRHFNEVASLCDIIKKR..VCAKE.IFD.DCLGSFI....AQTGNLGS.....SNMERSSNLCSLYLTVLPYYKNKL..PERHSALFISEFAK-h....................................................................................................
G8C068_TETPH/73-466                  .......................................................................................................v-TKIAHPFYK.PSKIEGMTLCCTEVKP..QLLSGKGIMPIM.........KTDQNQHTTIS........FDNRLTFKSVRNISKWIKNNREIIKEK.NMNIG..NFISLTESAHKHSKVKINIFKYDSL........KNFINKLENNEEISLNVNDFDSVANKLCKS.........EDSKYFLEDFYLYIL.Q.NHIKSDKTCILLIKSVENLFQGS....INN.I..R.VIDDLLLQI..FHTVEENNIdseKLRTEMMT.......FLNFLEDVFNNEISN...----LGLSSTTKQHIL.NMYIKSG...CLDKSKTLLFNIIEnTNNLNKTSIVTTYLN.....LIDRLSVNWDD....--AISRKM.E.YAINIGGI........LNK.....INEPK.....VFEFYIRNCRHYKELEALVQIIVEK.eDNFI-.LLD.NLKKELV....NKAGNLST.....RNTENIINLSMLYNTLETSTTSKI..PKSIAYEFIKVVIA-k....................................................................................................
A0A1V2L528_CYBFA/183-441             ..................................................................................gllemkiqnedghqitsaqkmg----------.----------------..------------.........-----------........---------------------------.-----..-------------------------........------------------------------.........---------------.-.----------YLI---ENYLNKD...tIETvY..K.CVETFVLQAdnPQTALRAFT...HINLSTIKlgyrqnqRFFELVETLYNTIID...TYPALNTTPDVRISYL.DALIHYK...RNTQAYQILVSLSK.DGYSPTPQLVAKYIK.....NITIKKGNSNT....--AILQQL.L.HLD---NV........IFT.....TISPT.....TLKPLLAITTTIDEISSLLDLLQLH.hPDTIAsLIP.HIESDIV....TALSNANKn...kAKTNNAQTFAT-------------..---------------rlavltrianwsawcndtkkfiik.............................................................................
A0A1E4SQL4_9ASCO/192-417             ...............................................etasvflikhvkqeelsvllsyieaklencslqgcseilkafidrarssnsttsqgp----------.----------------..------------.........-----------........---------------------------.-----..-------------------------........------------------------------.........---------------.-.-----------------------....---.-..-.---------..---------...--------.......LMMSLYTNAVGLFP-...-PILSSLSPDQLDNLA.YLLSKHG...NTEQSKVILGTLIQeQKLCPSQDTLDAYVS.....QLENRK-DTLS....YGEFVTEL.N.ILK---PA.......fFHA.....RLTPT.....IFKVLLGVVTDRTELDQLLRLVRVK..S--GE.LVK.EFHYEIL....AKTVEVQKg...lTGLEKDIQLTQMVRL---------..---------------lvdenvk..............................................................................................
AEP1_YEAST/50-449                    ........................................................................................................PEEIIHPFYQ.PTAIEQFTACATEYNP..SLLDGKKIAPSL.........IKHPVSLKTIL........VDSKLKFDDIRGVNKWLMEFVARRQH-.QRNI-..VLTPASKSVRSFHVLHLSSTDIAKL........RGLENILSEIENTNDLQSRVESVNNELQNIfd....rdsKQTRLFCENILAYLI.K.NYGNSTEKLILLINVTEMQLYSR....LDQ.M..K.AMNIILYNI..LCKVEANEN..pPYSPTLVT.......ALENLLAAINNRFFP...GRCENSLHPIVIEQLL.SYFIKTG...NLNESKNFLGHLIK.KGILPEATIINRYLE.....AIDVHFDKSTK....IFDIRSKF.A.FIADLAPI........IEN.....YGTID.....LFKFLIPMCRHFDELCSLLNIIRKS..NNAKR.AVD.STLPIFI....KKVLTFTK.....DPMINSGNLSTVFNIVSPIYGQNV..PSEFVEKFILSFA--lq...................................................................................................
A0A875RVA3_EENNA/160-406             ............................................llyllkekseqsasairslaqyvafevvefdqaeieglvgqlaingemdhasliissfdk----------.----------------..------------.........-----------........---------------------------.-----..-------------------------........------------------------------.........---------------.-.-----------------------....---.-..-.---------..---------...--------.......------------INGp.aTNFINSASPSIKLELF.DGYTCSR...SFQLASEYLESLIIvDKACPPTESIEKYLE.....MVSSIAGAIKS....-NFRSKKL.V.FNAYSSSV........AYTmrvpgTLSAK.....LVKIIIPWL-TKSEFPWFVNFLKLC..PGYQN.VMP.KCAGKLLetyaKEIGRLDD.....SNVDKSISLTAFISQME-IPKSSF..---------------dsetkqliatlyatf......................................................................................
G8ZQG0_TORDC/30-418                  ........................................................................................................PGQMIHSFYS.PSLTEELTTCFTEKYP..SLLGGKPIMPAL.........VRDPKTQEARL........QMKSLTFKSVRGVVDWLETFRSMRSSD.STY--..EVMEDRMIADLVKPSKLTRVNTPLV........SQLRELFGSQESRKINSRTLNAMVEQFVND.........RELGVFSEDVYLYLL.Q.HHVNSPEKIISIIESIKLHLKSH....IDQ.F..S.VVEALVLQI..LVSLKKNEL...HLSELLVN.......SFNDLLSEINNRFHI...PNCTTQFQPIVAQEIL.ELYIKMR...KFTESKRLFSYLIS.KKFCPSDRVTVSYLK.....TLSEEV-----....PRDTLKEF.A.LISDFRPI........IER.....AQNPK.....IFYYLIPLCRHVDEATSLLTIIKTS..RNVKE.ILD.VNITSFI....SRITTLKN.....DPMITSATLCTLYRMASPFYHQKL..PEKISNAFVLAFS--rl...................................................................................................
#=GC seq_cons                        .........................................................................................................tp.hHPFYt..s.htthhhs.pp..s..tlhtGt.hhs.h.........hpp....t.hh..........ttl.apshtsh.pWltpht.h..p...........h.....t..h..splp..t...h........pth.t.h..pp......ttlpslhtph.t..........pp.tlasE-lhhalL.p.phspp.tplhhllpuh..aht.p....lDp.h..p.hh-.llhph..lhshpp..h....hssphhs.......shppLlptlspcFp....pphhhphpPhlhpplL.chalpss...plppuKpllspLIp.pshtPpppslppYLp.....Llspphtspsp.....tphhc+h.s.alushpsl........lpp.....shoPp.....lhchLlshCpHhsEltoLLsllppp..pstcp.lhs.pshsphl....cphsphsp.....sth.pShsLstlhphh....t.pl..spph...hh......h....................................................................................................
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