#=GF ID   AFP_2
#=GF AC   PF18815.5
#=GF DE   Bacterial antifreeze protein repeat
#=GF AU   Paladin L;0000-0003-0011-9397
#=GF AU   Piovesan D;0000-0001-8210-2390
#=GF SE   RepeatsDB
#=GF GA   25.00 15.00;
#=GF TC   25.80 38.40;
#=GF NC   24.30 14.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Repeat
#=GF RN   [1]
#=GF RM   21482800
#=GF RT   Anchored clathrate waters bind antifreeze proteins to ice.
#=GF RA   Garnham CP, Campbell RL, Davies PL;
#=GF RL   Proc Natl Acad Sci U S A. 2011;108:7363-7367.
#=GF DR   SO; 0001068; polypeptide_repeat;
#=GF CC   This family of proteins is involved in stopping the formation of
#=GF CC   ice crystals at low temperatures. The structure folds as a
#=GF CC   Ca(2+)-bound  parallel beta-helix with an extensive array of
#=GF CC   ice-like surface  waters that are anchored via hydrogen bonds
#=GF CC   directly to the  polypeptide backbone and adjacent side chains
#=GF CC   [1]. 
#=GF SQ   14
#=GS A0A370U5S2_9GAMM/2940-2990  AC A0A370U5S2.1
#=GS A0A6J4FZA9_9PROT/630-681    AC A0A6J4FZA9.1
#=GS A0A1N7PD72_9PROT/1327-1378  AC A0A1N7PD72.1
#=GS A0A7C9UXN2_9PROT/1241-1291  AC A0A7C9UXN2.1
#=GS A0A3M8Q7I0_9GAMM/2108-2159  AC A0A3M8Q7I0.1
#=GS A0A839IT97_9GAMM/241-284    AC A0A839IT97.1
#=GS A0A178MW64_9PROT/1872-1923  AC A0A178MW64.1
#=GS A0A178M6K2_9PROT/2591-2642  AC A0A178M6K2.1
#=GS V6F6A0_MAGGM/2785-2836      AC V6F6A0.1
#=GS Q2W5S0_MAGSA/3078-3129      AC Q2W5S0.1
#=GS A0A1N7PD72_9PROT/1761-1812  AC A0A1N7PD72.1
#=GS A0A6J4FVX6_9PROT/624-675    AC A0A6J4FVX6.1
#=GS A0A501WML7_9GAMM/627-676    AC A0A501WML7.1
#=GS A0A345J8C8_9PROT/5945-5996  AC A0A345J8C8.1
A0A370U5S2_9GAMM/2940-2990             fq---GGEGTDSIVFESYTYQDYLDNEDGIKWNIGGFENIKFSDGHVIGDASAF....
A0A6J4FZA9_9PROT/630-681               ..TVTGGAGNDSIELTGVTKAQWDANANGIKNYVKDFENIKFSDGQVIGDASAF....
A0A1N7PD72_9PROT/1327-1378             ..TLIGGSGTDTLVLSGYTVADWNNNVNGIQSKVSGFENIILSNGTVLGDSSA-a...
A0A7C9UXN2_9PROT/1241-1291             ..TLVGGEGEDTLVLNQYSLADWNNNLFGIQDHVSGFEKIVLTDGVVGGT----tet.
A0A3M8Q7I0_9GAMM/2108-2159             ki--DGGSGNDSIYLTAYTKSDYYNNVDYIKSRIYDFENIMMSDGIVKGNSSAF....
A0A839IT97_9GAMM/241-284               .k-VEGGSGNDSIHLESYTQEDWDNNVDNIQNLVKGFEQITFA-----------ess.
A0A178MW64_9PROT/1872-1923             ..TIDGGSGTDSIELSGVTKAEWDANANGVQGYVKNFENIKFSDGQVIGDASAF....
A0A178M6K2_9PROT/2591-2642             ..TVTGGSGTDSIELTGVTKAQWDANTNGIKGYVKDFENIKFSDGQVIGDASAF....
V6F6A0_MAGGM/2785-2836                 ..TVTGGSGTDSIELTGVTKAQWDANTNNIQGYVKDFENIKFSDGRVIGDASAF....
Q2W5S0_MAGSA/3078-3129                 ..TVSGGSGTDSIELTGVTKAQWDANVNNVKGYVKDFENIKFADGQVIGDATAF....
A0A1N7PD72_9PROT/1761-1812             ..TLIGGTGTDSLVLSGYTVADWNNNVNGIQSKVSGFENIKCSDGVVKGDSSAF....
A0A6J4FVX6_9PROT/624-675               ..TIDGGSGTDSIELTGVTKAQWDANTNNVQGYVKNFENIKFSDGQVIGDADAF....
A0A501WML7_9GAMM/627-676               kl--DGGDGVDKVYLASYTLADYNNNVDNIRSNTKNFESIQLNDGFVT------dtgn
A0A345J8C8_9PROT/5945-5996             yl--RGEEGNDSLILSSYTKADYDNNKDGIKYKISSFENIKFADGSIIGDPNAF....
#=GC seq_cons                          ..TlsGGoGsDSI.LouhTpA-WssNsssIpuhVpsFENIKFSDGpVlGDuoAF....
//