#=GF ID   AID
#=GF AC   PF18767.5
#=GF DE   Activation induced deaminase
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Iyer LM
#=GF GA   27.30 27.30;
#=GF TC   27.40 28.30;
#=GF NC   27.20 26.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0109
#=GF RN   [1]
#=GF RM   21890906
#=GF RT   Evolution of the deaminase fold and multiple origins of
#=GF RT   eukaryotic editing and mutagenic nucleic acid deaminases from
#=GF RT   bacterial toxin systems.
#=GF RA   Iyer LM, Zhang D, Rogozin IB, Aravind L;
#=GF RL   Nucleic Acids Res. 2011; [Epub ahead of print]
#=GF RN   [2]
#=GF RM   29555751
#=GF RT   Diversification of AID/APOBEC-like deaminases in metazoa:
#=GF RT   multiplicity of clades  and widespread roles in immunity.
#=GF RA   Krishnan A, Iyer LM, Holland SJ, Boehm T, Aravind L;
#=GF RL   Proc Natl Acad Sci U S A. 2018;115:E3201.
#=GF RN   [3]
#=GF RM   17560271
#=GF RT   DNA deamination in immunity: AID in the context of its APOBEC
#=GF RT   relatives.
#=GF RA   Conticello SG, Langlois MA, Yang Z, Neuberger MS;
#=GF RL   Adv Immunol. 2007;94:37-73.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The activation induced deaminase is a vertebrate-specific member
#=GF CC   of the classical AID/APOBEC cytosine deaminases that is involved
#=GF CC   in antibody diversification [1].
#=GF SQ   20
#=GS A0A8D2EZ97_THEGE/8-88     AC A0A8D2EZ97.1
#=GS A0A1X7SU33_AMPQE/53-144   AC A0A1X7SU33.1
#=GS A0A1X7VXW5_AMPQE/136-224  AC A0A1X7VXW5.1
#=GS G3QWZ0_GORGO/8-88         AC G3QWZ0.2
#=GS A0A2K5IQF1_COLAP/8-88     AC A0A2K5IQF1.1
#=GS G1SB91_NOMLE/1-78         AC G1SB91.2
#=GS A0A1X7VWN1_AMPQE/136-224  AC A0A1X7VWN1.1
#=GS A0A2K5Y5U1_MANLE/8-88     AC A0A2K5Y5U1.1
#=GS A0A2K6KN52_RHIBE/4-81     AC A0A2K6KN52.1
#=GS A0A2K6DYG7_MACNE/8-88     AC A0A2K6DYG7.1
#=GS A0A1X7UFB4_AMPQE/83-165   AC A0A1X7UFB4.1
#=GS ABC3G_PANTR/8-68          AC Q7YR24.2
#=GS A0A2K6NY98_RHIRO/8-88     AC A0A2K6NY98.1
#=GS A0A2R9AMD2_PANPA/8-88     AC A0A2R9AMD2.1
#=GS A0A1X7UEF7_AMPQE/71-159   AC A0A1X7UEF7.1
#=GS H2R2C8_PANTR/8-88         AC H2R2C8.2
#=GS A0A2K5L947_CERAT/8-76     AC A0A2K5L947.1
#=GS A0A1X7UEF3_AMPQE/173-262  AC A0A1X7UEF3.1
#=GS A0A8I5TC19_PONAB/8-88     AC A0A8I5TC19.1
#=GS A0A1X7UF85_AMPQE/53-144   AC A0A1X7UF85.1
A0A8D2EZ97_THEGE/8-88                ......TVERMYRDTF..FYNFNNrpILSRRNTVWL-------CYEVKTRG..PSMPTWGTKIFRGQVPRSLIR----...APFQVLSSPLGQCPPP..HGRAQVQW..............
A0A1X7SU33_AMPQE/53-144              ......YKDAIHPEIM..FVSDNK..DPTLITELWITSTPSHMSTKALINH..FRSLPVKPDLHIGRIATSAFSMMAQh.rALMELIENGFNVTSWS..ELQVLYA-n.............
A0A1X7VXW5_AMPQE/136-224             ..tpgg----THAEIQ..FISDNQ..NPKTVTDLWIKNSPCASCSQSLIQY..FKDCPKKPTIYIGRIWHLNDSFDDQ...GLIDIIEAGFTLSVWG..ELNAL---ly............
G3QWZ0_GORGO/8-88                    ......TVERMYRGTF..SYNFNNrpILSRRNTVWL-------CYEVKTKG..PSRPPLDAKIFRGQVPRSFIR----...APFQVLGSPFGQCAPP..HGTAKVQW..............
A0A2K5IQF1_COLAP/8-88                ......TVEQMYQRTF..FYNFNNrpILSRRNTVWL-------CYEVKTRG..PSMPTWGAKIFRGQVPRSLIR----...APFQVLSNPLGQCPPP..HGRAQVQW..............
G1SB91_NOMLE/1-78                    ...mvd---GMDPHTF..SYNFNNrpILSRRNTVWL-------CYEVKTKD..PSRPRLDTEIFRGKVPRSLIR----...APFQVLGSLLGQC---..--------pagpvasp......
A0A1X7VWN1_AMPQE/136-224             ......TPDSIHVVIQ..FIKDKP..LPSNNTELWIKKSPCSSCSSRLLDL..YKFSP-KPTLYIGAISRPHHSDDDK...GLIQLLKEGFNIKVWD..PLVDENDC..............
A0A2K5Y5U1_MANLE/8-88                ......TVERMYRGTF..FYNFNNrpILSRRNTVWL-------CYKVKTRG..PSMPTWGTKIFRGQVPRSLIR----...APFQVLSSPLGQCPPP..HGRAQVQW..............
A0A2K6KN52_RHIBE/4-81                ......TVERMYQRTF..FYNFNNrpILSRRNTVWL-------CYEVKTRG..PSMPTWGAKIFRGL---SLIR----...APFQVLSNPLGQCPPP..HGRAQVQW..............
A0A2K6DYG7_MACNE/8-88                ......TVERMYRGTF..FYNFNNrpILSRRNTVWL-------CYEVKTRG..PSMPTWGTKIFRGQVPRSLIR----...APFQVLSNPLAQCPPP..HGRAQVQW..............
A0A1X7UFB4_AMPQE/83-165              .....d-DDREHAEEV..FIEIVH..DIRDIDVIWISNSPCKRCAEKLIRH..FESKCNKPNIYIGRFKDKA------...ALKRMKENGFSIKVWE..T-------kynkdv........
ABC3G_PANTR/8-68                     .....p-VERMYQDTF..SDNFYNrpILSHRNTVWL-------CYEVKTKG..PSRPPLDAKIFRGQVYS--------...----------------..--------klkyhpem......
A0A2K6NY98_RHIRO/8-88                ......TVERMYRRTF..FYNFNNrpILSRRNTVWL-------CYEVKTRG..PSMPTWGAKIFRGQVPRSLIR----...APFQVLSNPLGQCPPP..HGRAQVQW..............
A0A2R9AMD2_PANPA/8-88                ......TVERMYRGTF..FYNFNNrpILSRRNTVWL-------CYEVKTKG..PSRPRLDTKIFRGQVPKSFIR----...APFQVLSSPFGQCAPP..HGTAQVQW..............
A0A1X7UEF7_AMPQE/71-159              .....d-SVLRHAIEV..FTDSTR..NPETITRLWIKNPPCRRCCSCLVKL..Y--PIGKPTVYIGMNSDNNDSWADK..eGLKLLIKNGFKLKVWT..QLNIQTCQ..............
H2R2C8_PANTR/8-88                    ......TVERMYRGTF..FYNFNNrpIISRRNTVWL-------CYEVKTKG..PSRPRLDTKIFRGQVPKSFIR----...APFQVLSSPFGQCAPP..HGTAQVQW..............
A0A2K5L947_CERAT/8-76                ......TVERMYRGTF..FYNFNNrpNLSRRNTVWL-------CYEVKTRG..PSMPTWGTKIFRGQVPPRLIT----...----------------..--------gyrqelsqlgkq..
A0A1X7UEF3_AMPQE/173-262             .....n-DKDDHAEIK..FIDDNK..DPFEITDLLIKNSPCHECSEKLLKH..FEDLNNKPTIHVGRIWHLYDSDDDN...GIIELLKDEFDIIVWE..DLHSLICT..............
A0A8I5TC19_PONAB/8-88                ......TVERMYRGTF..FYNFNNrpILSRRNTVWL-------CYKVKTKG..PSRPPLNAKIFRGQVPRSLIR----...APFQVLSSPFGQCAPP..HGTAQVQW..............
A0A1X7UF85_AMPQE/53-144              ......YKDAIHPEIM..FVSDNK..DPTLITELWITSTPSHMSTKALINH..FRSLPVKPGLHIGRIATSAFSMMAQh.rALMELIENGFNVTSWS..ELQVLYA-n.............
#=GC seq_cons                        ......TVERMYptTF..FYNFNNRPILSRRNTVWL.......CYEVKT+G..PShPshcsKIFRGpVs+ShIp.......A.hQlLpsshu.ss.s..chpupsph..............
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