#=GF ID   APOBEC1
#=GF AC   PF18769.5
#=GF DE   APOBEC1
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Iyer LM
#=GF GA   27.00 27.00;
#=GF TC   27.00 27.00;
#=GF NC   26.80 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0109
#=GF RN   [1]
#=GF RM   29555751
#=GF RT   Diversification of AID/APOBEC-like deaminases in metazoa:
#=GF RT   multiplicity of clades  and widespread roles in immunity.
#=GF RA   Krishnan A, Iyer LM, Holland SJ, Boehm T, Aravind L;
#=GF RL   Proc Natl Acad Sci U S A. 2018;115:E3201.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   APOBEC1 deaminates cytosine both in RNA and ssDNA and has roles
#=GF CC   in both mRNA editing and ssDNA mutagenesis as part of the
#=GF CC   defense against retroviruses and genomic retrotransposons [1].
#=GF SQ   34
#=GS A0A6J3HD98_SAPAP/1-99     AC A0A6J3HD98.1
#=GS A0A2I0LXZ8_COLLI/46-143   AC A0A2I0LXZ8.1
#=GS A0A8C3SN33_CHESE/35-136   AC A0A8C3SN33.1
#=GS ABEC1_MESAU/44-144        AC Q9EQP0.1
#=GS A0A8C0HCR5_CHEAB/44-145   AC A0A8C0HCR5.1
#=GS A0A0N4SVL6_MOUSE/44-113   AC A0A0N4SVL6.1
#=GS M3WB96_FELCA/44-144       AC M3WB96.2
#=GS I3N301_ICTTR/29-98        AC I3N301.2
#=GS A0A674I9Q6_TERCA/13-114   AC A0A674I9Q6.1
#=GS A0A7J7E9Y9_DICBM/1-101    AC A0A7J7E9Y9.1
#=GS A0A1U7U8J6_CARSF/79-179   AC A0A1U7U8J6.2
#=GS A0A674JJ80_TERCA/207-308  AC A0A674JJ80.1
#=GS A0A0N4SW85_MOUSE/44-121   AC A0A0N4SW85.1
#=GS A0A8C4VF81_9SAUR/43-144   AC A0A8C4VF81.1
#=GS A0A6P6IEI0_PUMCO/44-144   AC A0A6P6IEI0.1
#=GS A0A1S3AQ67_ERIEU/34-134   AC A0A1S3AQ67.1
#=GS A0A8J6H2U7_MICOH/43-113   AC A0A8J6H2U7.1
#=GS A0A2K6PRF3_RHIRO/1-99     AC A0A2K6PRF3.1
#=GS A0A8C3SK28_CHESE/35-136   AC A0A8C3SK28.1
#=GS A0A0D9RBS4_CHLSB/1-99     AC A0A0D9RBS4.1
#=GS A0A099ZZX4_CHAVO/30-127   AC A0A099ZZX4.1
#=GS A0A8C4XWF3_9SAUR/15-116   AC A0A8C4XWF3.1
#=GS A0A6J3HAZ4_SAPAP/56-156   AC A0A6J3HAZ4.1
#=GS H0ZSB3_TAEGU/60-157       AC H0ZSB3.2
#=GS L9KYP8_TUPCH/485-585      AC L9KYP8.1
#=GS A0A452HL77_9SAUR/30-131   AC A0A452HL77.1
#=GS W5NVH9_SHEEP/44-144       AC W5NVH9.1
#=GS A0A674JS73_TERCA/231-332  AC A0A674JS73.1
#=GS A0A8U0RT49_MUSPF/1-95     AC A0A8U0RT49.1
#=GS A0A670KDD5_PODMU/22-123   AC A0A670KDD5.1
#=GS A0A8B9C8T9_9AVES/19-117   AC A0A8B9C8T9.1
#=GS A0A8C3TJ69_CHESE/210-311  AC A0A8C3TJ69.1
#=GS A0A8C8VNB9_9SAUR/192-293  AC A0A8C8VNB9.1
#=GS A0A452E9Z9_CAPHI/37-137   AC A0A452E9Z9.1
A0A6J3HD98_SAPAP/1-99                .........................................ms----WKIW.RS...SG.K...N....T.....T.....N.........HVE...VNF...I...E...K...F.....TS...E..R..C..F.....H.SS..I....S.C.....SITW.FLSWSP..C..WE....CS.QAI.KEF.L.S....Q.H.P...G....V.T.LVIYVARLF..Q......H..M.....D.....Q.....Q.....N........R..Q.GLRDLV..N.S.G..V.TIQIM...........................
A0A2I0LXZ8_COLLI/46-143              ...........................................W-RRGTIW.RN..wCS.N...N....P.....N.....Q.........HAE...VNF...L...K...N...Y.....FN...A..M..-..-.....-.PS..V....S.C.....SITW.VLSTTP..C..GK....CS.IKI.MEF.L.K....L.H.P...N....V.T.LEIYAAKLF..K......H..L.....D.....I.....R.....N........R..E.GLRNLA..K.N.G..V.IIHIM...........................
A0A8C3SN33_CHESE/35-136              ...........................................WGRSTKFW.RH..wCR.N...T....P.....T.....Q.........HAE...ITC...L...E...H...D.....FK...K..L..K..F.....R.PL..V....R.C.....SITW.LLSWSP..C..GK....CC.RCI.VEF.L.R....A.H.P...S....V.T.LKIKAAWLF..K......H..M.....D.....E.....R.....N........R..Q.GLRDLM..E.N.G..V.ALYIM...........................
ABEC1_MESAU/44-144                   ...........................................WGGRHNIW.RH...TG.Q...N....T.....S.....R.........HVE...INF...I...E...K...F.....TS...E..R..Y..F.....Y.PS..T....R.C.....SIVW.FLSWSP..C..GE....CS.KAI.TEF.L.S....G.H.P...N....V.T.LFIYAARLY..H......H..T.....D.....Q.....R.....N........R..Q.GLRDLI..S.R.G..V.TIRIM...........................
A0A8C0HCR5_CHEAB/44-145              ...........................................WGRSTKFW.RH..wCR.N...T....P.....T.....Q.........HAE...IAC...L...E...H...D.....FK...K..L..K..F.....R.PS..V....H.C.....SITW.FLSWSP..C..GK....CC.QSI.VEF.L.R....A.H.P...S....V.T.LKIKAAWLF..R......H..M.....D.....E.....R.....N........R..Q.GLRNLM..E.N.G..V.ALYIM...........................
A0A0N4SVL6_MOUSE/44-113              ...........................................WGGRHSVW.RH...TS.Q...N....T.....S.....N.........HVE...VNF...L...E...K...F.....TT...E..R..Y..F.....R.PN..T....R.C.....SITW.FLSWSP..C..GE....CS.RAI.TEF.L.S....R.H.P...Y....V.T.L--------..-......-..-.....-.....-.....-.....-........-..-.------..-.-.-..-.-----f..........................
M3WB96_FELCA/44-144                  ...........................................WGTSHRIW.RN...SG.R...N....T.....A.....N.........HVE...LNF...I...E...K...F.....TS...E..R..H..F.....C.PS..V....S.C.....SITW.FLSWSP..C..WE....CS.KAI.RGF.L.S....Q.H.P...S....V.T.LVIYVSRLF..W......H..L.....D.....Q.....Q.....N........R..Q.GLRDLV..N.S.G..V.TVQIM...........................
I3N301_ICTTR/29-98                   ...........................................WGTSRKIW.RN...SS.K...N....T.....T.....N.........HVE...VNF...I...E...K...F.....TA...E..R..H..F.....C.PS..I....S.C.....SITW.FLSWSP..C..WE....CS.KAI.REF.L.S....Q.H.P...N....M.T.LV-------..-......-..-.....-.....-.....-.....-........-..-.------..-.-.-..-.-----...........................
A0A674I9Q6_TERCA/13-114              ..........................................f-GHRKRSW.QS..cCH.S...T....R.....T.....E.........HAE...IHF...I...E...D...V.....FQ...E..Q..R..S.....D.PS..A....H.C.....SITW.YMSWSP..C..GY....CC.KQI.KDF.L.K....E.Q.P...N....V.N.LVIYVARIY..W......H..K.....R.....E.....I.....N........R..Q.GLRSLM..N.I.G..V.SIRVM...........................
A0A7J7E9Y9_DICBM/1-101               ...........................................WGRSHKTW.RY...SG.K...N....T.....T.....K.........HVE...INF...I...E...K...F.....TS...E..R..H..F.....S.PP..I....S.C.....SITW.FLSWSP..C..WE....CT.QAI.REF.L.S....Q.H.P...T....V.T.LVIYVARLF..H......H..M.....D.....Q.....Q.....N........R..Q.GLRDLI..N.S.G..V.TIQIM...........................
A0A1U7U8J6_CARSF/79-179              ...........................................WGTSCKIW.RN...SG.K...N....T.....S.....N.........HAE...VNF...L...E...K...F.....TS...E..R..H..F.....C.SS..T....S.Y.....SITW.FLSWSP..C..WE....CS.RAI.REF.L.S....Q.H.P...R....V.T.LVIYVARLF..W......H..M.....E.....P.....Q.....N........R..Q.GLRDLI..N.S.G..V.TIQIM...........................
A0A674JJ80_TERCA/207-308             ...........................................WGRSTKFW.RH..wCR.N...T....P.....T.....Q.........HAE...IAC...L...E...H...D.....FK...K..L..K..F.....R.PS..V....R.C.....SITW.FLSWSP..C..GK....CC.RCI.VEF.V.R....A.H.P...S....V.T.LKIKAAWLF..K......H..M.....D.....E.....R.....N........R..Q.GLRNLM..E.N.G..V.ALYIM...........................
A0A0N4SW85_MOUSE/44-121              ...........................................WGGRHSVW.RH...TS.Q...N....T.....S.....N.........HVE...VNF...L...E...K...F.....TT...E..R..Y..F.....R.PN..T....R.C.....SITW.FLSWSP..C..GE....CS.RAI.TEF.L.S....R.H.P...Y....V.T.LFIYIARLY..H......-..-.....-.....-.....-.....-........-..-.------..-.-.-..-.-----...........................
A0A8C4VF81_9SAUR/43-144              ...........................................WGSSTKFW.RK..wCL.N...T....P.....T.....Q.........HAE...INC...L...E...N...D.....FK...A..I..H..H.....G.PS..V....R.C.....SIIW.FLSWSP..C..GL....CC.RLI.IHF.L.R....A.H.P...K....V.T.LQIYIGRLF..R......H..R.....D.....E.....R.....N........R..Q.GLRDLV..S.S.G..V.NVYIM...........................
A0A6P6IEI0_PUMCO/44-144              ...........................................WGTSRRVW.RN...SG.R...N....T.....T.....N.........HVE...LNF...I...E...K...F.....TS...E..R..H..F.....C.PS..V....S.C.....SITW.FLSWSP..C..WE....CS.KAI.RGF.L.S....Q.H.P...S....V.T.LVIYVSRLF..W......H..L.....D.....Q.....Q.....N........R..Q.GLRDLV..N.S.G..V.TVQIM...........................
A0A1S3AQ67_ERIEU/34-134              ...........................................WGSSRNAW.RS...TA.R...N....T.....T.....R.........HAE...VNF...L...E...R...F.....AA...E..R..H..F.....D.KP..V....S.C.....SITW.FLSWSP..C..WE....CS.RAI.GAF.L.S....Q.H.P...Q....V.T.LAIHVARLF..H......H..E.....D.....E.....Q.....N........R..Q.GLRDLL..A.R.G..V.TLQVM...........................
A0A8J6H2U7_MICOH/43-113              ...........................................WGGRRSIW.RH...TS.R...N....T.....D.....K.........HVE...INF...I...E...K...L.....TS...Q..R..S..F.....R.PS..A....R.C.....SITW.FLSWSP..C..GE....CS.KAI.TEF.L.S....Q.H.P...N....V.T.LFI------..-......-..-.....-.....-.....-.....-........-..-.------..-.-.-..-.-----...........................
A0A2K6PRF3_RHIRO/1-99                .........................................ms----WKIW.RS...SG.K...N....T.....T.....N.........HVE...VNF...I...E...K...F.....TS...E..R..R..F.....H.SS..I....S.C.....SITW.FLSWSP..C..WD....CS.QAI.RKF.L.S....Q.H.P...G....V.T.LVIYVARLF..W......H..T.....D.....Q.....Q.....N........R..Q.GLRDLV..N.S.G..V.TIQMM...........................
A0A8C3SK28_CHESE/35-136              ...........................................WGRSTKFW.RH..wCR.N...T....P.....T.....Q.........HAE...ITC...L...E...H...D.....FK...K..L..K..F.....R.PL..V....R.C.....SITW.LLSWSP..C..GK....CC.RCI.MEF.L.R....A.H.P...S....V.T.LKIKAAWLF..K......H..M.....D.....E.....R.....N........R..Q.GLRDLM..E.N.G..V.ALYIM...........................
A0A0D9RBS4_CHLSB/1-99                ..........................................m---SRKIW.RS...SG.K...N....T.....T.....N.........HVE...VNF...I...E...K...L.....TS...E..R..R..F.....H.SS..V....S.C.....SVTW.FLSWSP..C..WE....CS.QAI.REF.L.S....Q.H.P...G....V.T.LVIYVARLF..W......H..T.....D.....Q.....Q.....N........R..Q.GLRDLV..N.S.G..V.TIQIM...........................
A0A099ZZX4_CHAVO/30-127              ...........................................W-SRGTIW.RN..wCS.N...N....S.....T.....Q.........HAE...VNF...L...E...N...C.....FK...A..M..-..-.....-.PS..V....S.C.....SITW.FLSTTP..C..GR....CS.RRI.LKF.L.R....V.H.P...N....V.T.LKIHAAKLF..K......H..L.....D.....M.....R.....N........R..Q.GLKNLA..M.H.G..V.IIRIM...........................
A0A8C4XWF3_9SAUR/15-116              ...........................................WGNSSKIW.RN..wCR.N...T....S.....T.....Q.........HAE...INF...L...E...N...A.....FK...E..R..S..F.....N.PF..T....H.C.....SITW.FLSWSP..C..WK....CS.RSM.VEF.L.K....T.H.P...K....V.N.LQMYVSRLF..R......H..M.....D.....E.....R.....N........R..Q.GLRNLM..E.S.G..V.ALYIM...........................
A0A6J3HAZ4_SAPAP/56-156              ...........................................WGMSWKIW.RS...SG.K...N....T.....T.....N.........HVE...VNF...I...E...K...F.....TS...E..R..C..F.....H.SS..I....S.C.....SITW.FLSWSP..C..WE....CS.QAI.KEF.L.S....Q.H.P...G....V.T.LVIYVARLF..Q......H..M.....D.....Q.....Q.....N........R..Q.GLRDLV..N.S.G..V.TIQIM...........................
H0ZSB3_TAEGU/60-157                  ...........................................W-RRGSIW.RN..wCL.N...N....H.....E.....Q.........HAE...VNF...L...E...N...H.....FN...D..R..-..-.....-.PQ..T....P.C.....SITW.FLSTSP..C..GK....CS.RRI.LDF.L.R....S.H.P...N....V.T.LVIYAAKLF..K......H..H.....D.....I.....R.....N........R..Q.GLRNLN..M.N.G..V.TIRIM...........................
L9KYP8_TUPCH/485-585                 ...........................................WGRSQKLW.RS...SG.R...N....T.....T.....N.........HVE...VNF...I...G...K...L.....TS...E..R..H..F.....Q.PA..I....G.C.....SVTW.FLSWSP..C..WE....CC.KAI.GEF.L.S....Q.H.P...N....V.K.LVIYVARLF..H......H..T.....D.....E.....R.....N........R..Q.GLRDLI..N.S.G..V.TIQIM...........................
A0A452HL77_9SAUR/30-131              ..........................................s-GVSTKFW.RK..wCL.N...T....P.....T.....Q.........HAE...INC...L...E...N...D.....FK...A..I..H..H.....G.PS..V....H.C.....SIIW.FLSWSP..C..GL....CC.RLI.IHF.L.R....A.H.P...K....V.T.LQIYIGRLF..R......H..R.....D.....E.....R.....N........R..Q.GLRDLV..S.S.G..V.NVYIM...........................
W5NVH9_SHEEP/44-144                  ...........................................WGNSRDVW.RH...SG.K...N....T.....T.....K.........HVE...RNF...I...E...K...I.....AS...E..R..H..F.....R.PS..I....S.C.....SISW.YLSWSP..C..WE....CS.KAI.REF.L.N....Q.H.P...N....V.T.LVIYIARLF..Q......H..M.....D.....P.....Q.....N........R..Q.GLKDLF..H.S.G..V.TIQVM...........................
A0A674JS73_TERCA/231-332             ...........................................WGRSTKFW.RH..wCR.N...T....P.....T.....Q.........HAE...IAC...L...E...H...D.....FK...K..L..K..F.....R.PS..V....R.C.....SITW.FLSWSP..C..GK....CC.RCI.VEF.V.R....A.H.P...S....V.T.LKIKAAWLF..K......H..M.....D.....E.....R.....N........R..Q.GLRNLM..E.N.G..V.ALYIM...........................
A0A8U0RT49_MUSPF/1-95                ...........................................------MW.RN...TG.K...N....T.....A.....N.........HVE...LNF...I...E...K...F.....TS...E..R..R..Y.....C.PS..T....H.C.....SITW.FLSWSP..C..WE....CS.KAI.RGF.L.S....Q.C.P...S....V.T.LVIYVTRLF..W......H..M.....D.....P.....Q.....N........R..Q.GLRDLL..K.S.G..V.TVRIM...........................
A0A670KDD5_PODMU/22-123              ...........................................WGRSRRYW.RN..wCT.S...N....R.....T.....H.........HAE...INF...L...E...N...A.....CE...E..I..D..R.....R.TT..T....P.C.....TVTW.FLTWSP..C..GK....CS.GRI.KQF.L.Q....E.H.P...N....V.T.LEIRAAKLF..N......H..N.....Y.....K.....F.....N........Q..K.GLRDLA..N.F.G..V.RIYIM...........................
A0A8B9C8T9_9AVES/19-117              .........................................wm--GFCKVW.KG..wCT.N...N....S.....A.....Q.........HAE...VNF...L...E...N...C.....FK...P..L..-..-.....-.SS..V....S.C.....SITW.VLSTTP..C..GK....CS.RRI.LEF.L.R....T.H.P...N....V.T.LEIFAAKIF..K......H..L.....D.....I.....R.....N........R..Q.GLRNLM..M.K.G..V.IIRII...........................
A0A8C3TJ69_CHESE/210-311             ...........................................WGSSNKFW.RK..wCP.N...T....P.....T.....H.........HAE...INC...L...E...N...D.....FK...A..I..H..H.....R.PS..V....R.C.....SIIW.FLSWSP..C..GL....CC.RLI.VHF.L.R....A.H.P...K....V.T.LQIYIGRLF..R......H..R.....D.....E.....R.....N........R..Q.GLRDLV..S.S.G..V.NVHIM...........................
A0A8C8VNB9_9SAUR/192-293             ...........................................WGNSTKVW.RN..wCQ.N...T....G.....T.....Q.........HAE...INF...L...E...N...T.....LK...E..R..I..L.....N.PL..T....H.C.....SITW.FLSWSP..C..WK....CS.QSV.VEF.L.K....T.Y.P...Q....V.N.LKMYIARLF..W......H..E.....N.....K.....Y.....N........R..Q.GLRDLV..T.N.G..V.TIR--ni.........................
A0A452E9Z9_CAPHI/37-137              ...........................................WGNSRDVW.RH...SG.K...N....T.....T.....K.........HVE...RNF...I...E...K...I.....AS...E..R..H..F.....H.PS..I....S.C.....SIFW.YLSWSP..C..WE....CS.KAI.REF.L.N....Q.H.P...N....V.T.LVIYIARLF..Q......H..T.....D.....P.....Q.....N........R..Q.GLKDLW..I.Q.-..-.-----lsvlcic....................
#=GC seq_cons                        ...........................................WGpSp+lW.Rp...ss.p...N....o.....T.....p.........HsE...lNF...l...E...+...h.....hp...E..R..+..F.....p.PS..l....p.C.....SITW.FLSWSP..C..hc....CS.+uI.hEF.L.p....p.H.P...s....V.T.LhIYsARLF..p......H..h.....D.....p.....p.....N........R..Q.GLRDLh..p.s.G..V.sl.IM...........................
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