#=GF ID   ATR13
#=GF AC   PF16829.9
#=GF DE   Avirulence protein ATR13, RxLR effector
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_2lai
#=GF GA   25.00 25.00;
#=GF TC   28.40 82.00;
#=GF NC   22.20 21.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22194684
#=GF RT   Structural elucidation and functional characterization of the
#=GF RT   Hyaloperonospora arabidopsidis effector protein ATR13.
#=GF RA   Leonelli L, Pelton J, Schoeffler A, Dahlbeck D, Berger J, Wemmer
#=GF RA   DE, Staskawicz B;
#=GF RL   PLoS Pathog. 2011;7:e1002428.
#=GF DR   INTERPRO; IPR031791;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   ATR13 is expressed by the plant pathogen oomycete
#=GF CC   Hyaloperonospora. Such phytopathogenic oomycetes like the one
#=GF CC   that infects Arabidopsis, Hyaloperonospora arabidopsidis (Hpa),
#=GF CC   grow intercellularly, forming parasitic structures called
#=GF CC   haustoria. Haustoria play a role in feeding and suppression of
#=GF CC   host defence systems. A whole range of pathogen proteins, called
#=GF CC   effectors, are secreted across this haustorial membrane, a
#=GF CC   subset of which are further translocated across the plant plasma
#=GF CC   membrane by an unknown mechanism that is present in both plants
#=GF CC   and animals.  ATR13 is an RxLR effector from the downy mildew
#=GF CC   oomycete, and is a very dynamic protein. It contains two
#=GF CC   surface-exposed patches of polymorphism, one of which is
#=GF CC   involved in the specific recognition by host R-genes. The
#=GF CC   R-gene-products detect the presence of the infection by
#=GF CC   recognising the effector proteins. Once detected, the host
#=GF CC   R-genes trigger apoptosis of the host cell. The R-gene-products
#=GF CC   carry a specific motif, RxLR, that is recognises the effector
#=GF CC   proteins [1].
#=GF SQ   2
#=GS ATR13_HYAAE/117-187  AC M4C367.1
#=GS ATR13_HYAAE/54-106   AC M4C367.1
ATR13_HYAAE/117-187             hgrhvsk-------------------------------------SKMAHDRHVSKSEKAPIQYASVADYLKKIYPGTDIERIVSTLKRHDEVGAKDLGAKLQTAV---asq
ATR13_HYAAE/54-106              .......SFGLGKAQDPLDKFFRKIINSRKPIETSYSAKGIHEKIIKAYDRHVFESKKA-------------------------------------------------h..
#=GC seq_cons                   .............................................hhAaDRHV.cScKA.................................................t..
//