#=GF ID AbiJ_NTD5
#=GF AC PF18865.5
#=GF DE AbiJ N-terminal domain 5
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Burroughs AM;0000-0002-2229-8771
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF SE Iyer LM
#=GF GA 26.70 26.70;
#=GF TC 27.20 33.80;
#=GF NC 25.50 24.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 23768067
#=GF RT Comprehensive analysis of the HEPN superfamily: identification
#=GF RT of novel roles in intra-genomic conflicts, defense,
#=GF RT pathogenesis and RNA processing.
#=GF RA Anantharaman V, Makarova KS, Burroughs AM, Koonin EV, Aravind L;
#=GF RL Biol Direct. 2013;8:15.
#=GF DR INTERPRO; IPR040508;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Mostly alpha helical. Found fused to AbiJ-lke HEPN, and to other
#=GF CC domains presumably involved in defense [1].
#=GF SQ 48
#=GS A0A517TGW1_9BACT/1-89 AC A0A517TGW1.1
#=GS A0A149PYC4_9BURK/2-94 AC A0A149PYC4.1
#=GS I0K6N7_9BACT/4-96 AC I0K6N7.1
#=GS A0A6G6Y797_9SPHN/6-96 AC A0A6G6Y797.1
#=GS A0A315Y6M2_9EURY/1-93 AC A0A315Y6M2.1
#=GS A0A4Y4CXW2_ZOORA/1-93 AC A0A4Y4CXW2.1
#=GS Q2IKC4_ANADE/23-115 AC Q2IKC4.1
#=GS I2GRD4_9BACT/4-96 AC I2GRD4.1
#=GS A0A4T2AAG6_9RHOB/23-106 AC A0A4T2AAG6.1
#=GS X5DE63_9BACT/2-93 AC X5DE63.1
#=GS A0A0A0ESZ8_9GAMM/11-101 AC A0A0A0ESZ8.1
#=GS A0A1W2BVH5_9RHOB/1-68 AC A0A1W2BVH5.1
#=GS A0A2A9E4Y3_9MICO/8-73 AC A0A2A9E4Y3.1
#=GS A0A6M0IB83_9BACT/4-96 AC A0A6M0IB83.1
#=GS A0A1V8RQD5_9HYPH/3-95 AC A0A1V8RQD5.1
#=GS A0A2M9BAT9_9BACT/1-93 AC A0A2M9BAT9.1
#=GS A0A087BE75_9BIFI/2-95 AC A0A087BE75.1
#=GS A0A1I3FS77_9FLAO/1-93 AC A0A1I3FS77.1
#=GS Q7WXI6_CUPNH/11-102 AC Q7WXI6.1
#=GS A0A4R2I9D1_9ACTN/1-63 AC A0A4R2I9D1.1
#=GS A0A0E4A0H4_9BACT/4-96 AC A0A0E4A0H4.1
#=GS A0A1H3LL93_9RHOB/230-321 AC A0A1H3LL93.1
#=GS A0A5C6E9N3_9BACT/10-102 AC A0A5C6E9N3.1
#=GS A0A812S4Z2_9DINO/3-95 AC A0A812S4Z2.1
#=GS D5SSN8_PLAL2/1-93 AC D5SSN8.1
#=GS A0A1W6E740_9BACT/4-96 AC A0A1W6E740.1
#=GS X6D1K1_9HYPH/1-79 AC X6D1K1.1
#=GS A0A515A9N7_9BACT/4-95 AC A0A515A9N7.1
#=GS A0A6M5YEV2_9BACT/4-96 AC A0A6M5YEV2.1
#=GS E8N9G5_MICTS/7-79 AC E8N9G5.1
#=GS A0A7X8TFQ5_9HYPH/4-89 AC A0A7X8TFQ5.1
#=GS A0A1M7QQY0_9ACTN/8-79 AC A0A1M7QQY0.1
#=GS A0A327NUD6_9BACT/4-96 AC A0A327NUD6.1
#=GS I3ZEJ2_TERRK/7-99 AC I3ZEJ2.1
#=GS A0A1P9X4S9_9BACT/4-95 AC A0A1P9X4S9.1
#=GS A0A317C352_9GAMM/1-93 AC A0A317C352.1
#=GS A0A4Y9RIG8_9CAUL/3-95 AC A0A4Y9RIG8.1
#=GS A0A8J8MVT6_9RHOB/80-165 AC A0A8J8MVT6.1
#=GS A0A1I1PAR1_9BACT/4-93 AC A0A1I1PAR1.1
#=GS A0A2A2SIB7_9SPHN/1-93 AC A0A2A2SIB7.1
#=GS A0A090P3S2_9VIBR/1-94 AC A0A090P3S2.1
#=GS A0A160KQ74_9MICO/4-74 AC A0A160KQ74.1
#=GS A0A1P8R020_9GAMM/2-94 AC A0A1P8R020.1
#=GS A0A845GFJ6_9BURK/9-100 AC A0A845GFJ6.1
#=GS A0A2T0TII6_9BACT/4-95 AC A0A2T0TII6.1
#=GS Q7WXI7_CUPNH/10-99 AC Q7WXI7.1
#=GS A3VEW7_9RHOB/109-201 AC A3VEW7.1
#=GS A0A4Q2UEF0_9BACT/4-95 AC A0A4Q2UEF0.1
A0A517TGW1_9BACT/1-89 ..........m----KGQEFIDLKNRIK..ENFTDSDWRELA.VLVDAERLITADDRLLRSLRF.GDDDYEGCILKVLRRVFDADEANVEIVLNFLEERCGPEG----eci.......
A0A149PYC4_9BURK/2-94 .......vdye----LGKRVLALREKVV..ADFNAGDWEEIG.LLTGFSDQISRHPRLLRSLAW.GDEDYAGNALTMIRETAEQDENAFEIFERCVAEKYPEESQ---fvs.......
I0K6N7_9BACT/4-96 ..........p-TKLQTQRLFALHDFVR..EQFTKMDWYRLA.YLTDTLDLIEDHPRLLRSLDF.DDDDYDGNSLQVLLKLISLNPQHLDTLDEYVADRKARAVH---pti.......
A0A6G6Y797_9SPHN/6-96 .........ls--DSDRKRLIALTRIAV..TNFNSGDWQILG.AETGAMDVVTGHDRLLRSLSF.GDPDYSGNAHAVMFQIVGRDPANLQRIEDVI------------igmygepeva
A0A315Y6M2_9EURY/1-93 ........mtk---NLKLKSLELGNLII..ENETHVDWENIL.GAFEFDYLLDQIPRLVQSQYW.GDPDYKDCVIKVIYHSIEDNKNNAFQMIQYILNNCT-------eldedmi...
A0A4Y4CXW2_ZOORA/1-93 ........mtp---TDRKKVAVIAKYAV..ESFSESDWYSLG.QITGNLKAVTDHPRLLRALSF.GDDDYESCAIQVIDEVFNSDSSSIAEIIEYFDIDLWYSNKAP-e.........
Q2IKC4_ANADE/23-115 .......dpla----LAKRLIALRARIV..ATFNAGNWEEVG.LLSGQSKIITGHDRLLRSLSW.HDEDYEGNVLTVLRRISDRDVRALDVIEEYLNEKFPGEEKTE-y.........
I2GRD4_9BACT/4-96 ..........q-SKQKALRLFALHEFIR..DHFTKSDWIKLG.YLTDNQELIEEHPRLLRSLDF.KDDDYEGNIMQVLSKLISENNSNLIEIERIIEDKKLRLS----spty......
A0A4T2AAG6_9RHOB/23-106 ........rfk---------VELAEIVA..NAYRISDWKKFA.HRFGLEEEILDHPRFTRSMEW.GDEDYEGHVLDLVDYLCSKNIPALTALFEIPSV----------qsklsdd...
X5DE63_9BACT/2-93 ..........i-KKEQQKELIDIKNQIA..KHFTKSDWLDLG.YSLGCYDVIEGHSRLLKSLSF.GDEDYEGNILEVLTEILKRDQKNFNEIKSYIENKFAT------plvsd.....
A0A0A0ESZ8_9GAMM/11-101 ........pls-----GKTLLALGEAAE..AQFDSTDWTKFA.YEVDEANLICNHPRLLRSLSF.GDTDYGECVLQVVRHLQNNRPSALGALAQRPKIRTWIEENAP-d.........
A0A1W2BVH5_9RHOB/1-68 ..........m-----------------..---------EIG.LLTGWTSYIQGHDRLLRSLSW.SDPDYPGNVLDMLVVMKNRNDGSLEKVQTYVMQKFSNVAT---ats.......
A0A2A9E4Y3_9MICO/8-73 .........qn----------AIAAYAA..DKWTDTEWRVFG.RETGTSDIIDGHSRLYRSLGF.GDDDYPDAAAEVVRQILASE-----------------------avee......
A0A6M0IB83_9BACT/4-96 ..........q-NKYRTRRLFDLHEFIQ..DHFTKSDWIKVG.YLTDSVELIEDHPRLLRSLDF.KDDDYEGNSLQVLSKLISESSGNLHELEHFVEAKKATMTRP--vr........
A0A1V8RQD5_9HYPH/3-95 ..........v-DAEQRRKVVEFKNIAV..ANFSSSNWIELG.SLTDRFDLVNDHPRLLRSLSF.GDDDYDGCALQVLMAMVEHAPENFGEVERYITSRFGGGGES--vs........
A0A2M9BAT9_9BACT/1-93 ..........m-TKVSGKEIVALKNRVC..SLFTHDDWLDIA.YITGSEELVKGHYRLLQSLHF.RDDDYERSALEVLKSIADQDKNNIQEIRDFIESKYPDN-----ielks.....
A0A087BE75_9BIFI/2-95 ..........i-DRNHIARVKRIKDYVL..NEFDSGDWEFLAtYLGDKGNIISSHPRLLRSLHF.GDEDYAACVGDVLGKLLKEEPEVLDLLEGMVNEKGSESTV---vsa.......
A0A1I3FS77_9FLAO/1-93 ...........MDKTQGKELLEIKNIIL..KQFGQSEWLELG.FYLGCNDIIENHPRLLRSLSF.GDEDYEGNVLTVLDEIIKLDTNNFKEIKIYLSEKFSNPQVSE-y.........
Q7WXI6_CUPNH/11-102 ..........d-DAKRNKAFATFAKVLE..RRFSESDWASFG.-HEHNIEEIYGNDHLLRSAQY.GNSDYRLCILRTLEFLFDDYAKALKALLTDASLHNTLKREDP-d.........
A0A4R2I9D1_9ACTN/1-63 mlavgktlaav-----------------..--RDRGTWMQLA.LLTDTRDEIEGHRRLLRALAF.GDDDYEGAVYHVLPFV---------------------------lgdlt.....
A0A0E4A0H4_9BACT/4-96 ..........q-NKQRTLRLFALHEFIQ..DHFTKSDWIKVA.YLTDSLELIEDHPRLLRSLDF.KDDDYEGNSLQVLSKLISESNSNLYEIEHFVEAKKVTMNRP--nr........
A0A1H3LL93_9RHOB/230-321 .......pqpd-----PLNLIQIKDIMV..DKFDQENFLEIG.VVTGWTNHIRRHPRLLRSLSW.GDPDYPGNVLDLITAMDEAQDGSIDKLKSYIDSKFSSEY----raat......
A0A5C6E9N3_9BACT/10-102 ......dsvai-----GKQIIGLKNQVV..DGFNESHWRELG.LMTGFQDRVNNHPRLLRSLSW.GDEDYEGLALEFLQQMVHADPANLEVITEFVQSKCPEAG----efis......
A0A812S4Z2_9DINO/3-95 .......drpd----RELLVVALKRAIE..DTFDRSDWEELG.LLTGTTDRLDNHPRLYRSLHF.GDDDYGGCVVDVLPEVLGANLENLEDVLDFTKLDEWLQEHEP-r.........
D5SSN8_PLAL2/1-93 ...........MNSANRKKVAVITSYVQ..QSFSESDWYAIG.QLTGQLNTISGHSRLLRALNF.GDDDYSGCAAEVLDRIFSANESAIDEVIDHFDIDLWYQQKSP-e.........
A0A1W6E740_9BACT/4-96 .........lt--SSQMQQLFALHEYIR..DQFTKMDWIKLA.YITDSLDLIEDHPRLLRSLDF.NDDDYEGNSLQVLARIVGNDSAYLADIEQFVNDKKANGKKPP-a.........
X6D1K1_9HYPH/1-79 ..........m---------------AV..EHFKHENWLELG.TLTGCYDLISSHSRLLRSLSF.GDDDYAGCALEVLMRIVEREEANFSEVDNYIGGKFGGGG----qtis......
A0A515A9N7_9BACT/4-95 ..........q-NKQRTFRLFALHEFIQ..DHFSKSDWIKVG.YLTDSLELIEDHPRLLRSLDF.KDDDYEGNSLQVLSKLISESTSNLYEIERFVEAKKAT------lirpv.....
A0A6M5YEV2_9BACT/4-96 ..........q-NKQRTARLFALHEFVR..EHFTKSDWFKIA.YLTDCVELVEDHPRLLRSLDF.RDDDYDGNSLQVLSKMINESNSNLYELERYVELRKAAI-----krpvs.....
E8N9G5_MICTS/7-79 ..qdapanlve---------LAIGKCLI..AEMDDSRWTEIG.LLTGTKEQIYKHPRLLRSLRF.NDEDYDGHVYDMVPTLLGAE-----------------------etw.......
A0A7X8TFQ5_9HYPH/4-89 ......dpsir------LAILPLKARVA..KLFDKESWLEVA.TLTDSYDLVTGHSRLLRSLEW.GDGDYDGHVLEVLTSIVEKNPSNLDTVSQYADQ----------ldgg......
A0A1M7QQY0_9ACTN/8-79 .......niik---------LAVARAII..DTFDQGKWHEIG.LITNTLDDIEGHPRLLRSMRF.GDDDYSACVYQMIPIILDEQT----------------------gskgia....
A0A327NUD6_9BACT/4-96 ..........q-NKQRTFRLFALHEFIQ..DHFTKSDWIKVG.YLTDSLELIEDHPRLFRSLDF.KDDDYEGNSLQVLSKLISESTSNLYEIERFVDVKKSTMNR---sir.......
I3ZEJ2_TERRK/7-99 .........ta--LSHEARILRVKKIAL..EHFKEEHWTEMA.SEIGCADLLIVREESLGSVSW.GDDAYAATVLKILAAIVQRNPSDIEKLEIYAEKCLSHAEAG--sf........
A0A1P9X4S9_9BACT/4-95 ..........p-TKQRTARLFALHEFIR..ERFTKADWFRIA.HLTNCLELVEDHPRLLRSLDF.RDDDYDGNSLQVLSKIIGESNTNLYEIERYVELRKAT------irrsd.....
A0A317C352_9GAMM/1-93 ...........MNSSERKRVSVISKYAI..ASFTEGDWLTLG.QITGKVKEVTGHGRLFRSLSF.GDDDYSFCVAEVLDSIFSSDTNLINEVVDHFDIDLWYQQKDP-t.........
A0A4Y9RIG8_9CAUL/3-95 ........ldp---HSGKRVLQIARVAG..DKFTEGKWLELG.LLTNSHDIVTGHSRLLRSLSW.GDPDYPDNVLAVLTQIVARDEANLGIIENYLSGEIEP------egenis....
A0A8J8MVT6_9RHOB/80-165 ......lgrfk---------VELAEIVA..KAYGSSNWKKFA.IRFGLDREISDHPRFLRSCDW.GDHDYEGHVINLIDHLCRQNVPALMVLFEIPRV----------qkelsdd...
A0A1I1PAR1_9BACT/4-93 ..........q-TKQKTLRLFALHEFIQ..DHFTKSDWIKVG.YLTDSVELIEDHPRLLRSLDF.KDDDYEGNSLQVLSKLISESHSNLYEIERFVEAKKA-------tfir......
A0A2A2SIB7_9SPHN/1-93 ...........MSDQDRQYLIRLARIAV..ANFNAGDWKELG.VHLGALDVITGHDRLLRSLSF.ADPDYSGHAHGVLFSLAERNPRNLGTIASFVRDKYGDDGE---lvs.......
A0A090P3S2_9VIBR/1-94 .........mq---EHQQKIYALRKRIVaiEGFDQADWITIG.DATDCQHIIESHPRLLRALSF.GDPDYPTAVGDVLKSMFAYHRNSLDDVTNFLDRNYPLA-----nnvsv.....
A0A160KQ74_9MICO/4-74 .mdalqlaaga--------------YTA..DTWDQSNWREFG.RETGMSDILSQHSRLYRSQDF.GDDDYPDAALEVLGWILT-------------------------ghaacfs...
A0A1P8R020_9GAMM/2-94 .........ps--RISGQELIQLKDAIV..QDFDSSNWRELG.ALTNMIDEVDRHPRLLRSLSF.GDPDYDGLALTFLRKMIGQEDENLDIALKYIHKTCGDAGENV-s.........
A0A845GFJ6_9BURK/9-100 ..........d-SKKRGALILALRKAIV..SEFTTEDWREFG.YLSGESDFIQRHDRLLRSLHW.RDPDYGDCVLQALERFSREGWDVVDQLINHPKLT---------sqllaeip..
A0A2T0TII6_9BACT/4-95 ..........p-NRQRTARLFALHEFAR..DHFTKSDWFRIA.HLTDTVELIEDHPRLLRSLDF.RDDDYEGNSLQVLSKIISVGATNLAELERYVEEQKSRVA----har.......
Q7WXI7_CUPNH/10-99 ..........d-AALRGKLLLAMRKALV..ARFEKLDWIDLG.----FEHEIGIKQRILQGSQFkSNDDYPDLVHDLLVRLYSEKPAVLKALVLHPRLQSAIEADVP-q.........
A3VEW7_9RHOB/109-201 ..........s-HSAEPLNLLQLKDLIV..ENFDQENFLEIG.VLSGWTNQIRNHSRLLRSLSW.RDPDYPGNVLDLITRMDDAGDGSIEKLRTYIEEKFSIEAQA--at........
A0A4Q2UEF0_9BACT/4-95 ..........e-TKQRTARLFALHEFVR..AYFTKADWFRVA.YLTDNVDLIEDHPRLLRSLDF.RDDDYDGNSLQVLSKLIGEGTSNLTELERYVDSRKAS------lsrya.....
#=GC seq_cons ..........t....pttplhsL+chlh..cpFscuDWhclG.hlTssh-lIpsHsRLLRSLsF.uD-DYpGssLpVLscllspssssltplppalptchs.......t.........
//
