#=GF ID   Acc5b_avian_CoV
#=GF AC   PF05528.15
#=GF DE   Accessory protein 5b, avian coronavirus
#=GF PI   Coronavirus_5;
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_7342 (release 8.0)
#=GF GA   25.00 25.00;
#=GF TC   27.70 61.40;
#=GF NC   23.20 19.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9168126
#=GF RT   Sequence analysis of gene 3, gene 4 and gene 5 of avian
#=GF RT   infectious bronchitis virus strain CU-T2. 
#=GF RA   Jia W, Naqi SA; 
#=GF RL   Gene 1997;189:189-193.
#=GF RN   [2]
#=GF RM   27279618
#=GF RT   Infectious Bronchitis Coronavirus Limits Interferon Production
#=GF RT   by Inducing a Host Shutoff That Requires Accessory Protein 5b.
#=GF RA   Kint J, Langereis MA, Maier HJ, Britton P, van Kuppeveld FJ,
#=GF RA   Koumans J, Wiegertjes GF, Forlenza M;
#=GF RL   J Virol. 2016;90:7519-7528.
#=GF DR   INTERPRO; IPR008458;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Avian infectious bronchitis virus, a member of Coronaviridae
#=GF CC   family, has a single-stranded positive-sense RNA genome, which
#=GF CC   is 27 kb in length. Gene 5 contains two (5a and 5b) open reading
#=GF CC   frames [1]. This entry represents the host translation inhibitor
#=GF CC   5b (ORF 5b, also known as accessory protein 5b) which is
#=GF CC   involved in host translation shut off without degrading host
#=GF CC   RNA. It suppresses host gene expression which facilitates
#=GF CC   evasion from host type I interferon immune response [2].
#=GF SQ   5
#=GS A0A0F6WGI5_9GAMC/1-82  AC A0A0F6WGI5.1
#=GS A0A0S2ZX43_9GAMC/1-82  AC A0A0S2ZX43.1
#=GS B3FHV2_CVTKE/1-82      AC B3FHV2.1
#=GS A0A4D6FTQ4_9GAMC/1-77  AC A0A4D6FTQ4.1
#=GS NS5B_IBVB/1-82         AC Q89786.1
A0A0F6WGI5_9GAMC/1-82             .MNNSKDNPFSTATARKARV.FIRGGLNSVFFLNEKGQPEVCPFCTALVARGQLSQEHLFNNNI.LSWQAVKQLESQTPPRQSSN.......
A0A0S2ZX43_9GAMC/1-82             .MNNSKDNPFRGAIARKARI.YLREGLDCVYFLNKAGQAEPCPACTSLVFQGKTCEEHYYNNNL.LSWQAVRQLERQTSQRQSSN.......
B3FHV2_CVTKE/1-82                 .MNNSKDNPFRGAIARKARI.YLREGLDCVYFLNKAGQAEPCSACTSLVFQGKTCEEHINNNDL.LSWQAVRQLARQMPQRRSSN.......
A0A4D6FTQ4_9GAMC/1-77             m-----NNPFATATARKARVvCLNRGARSVYFLNKQGLPVPCPHCTTLVVRGLLCEEHQFDDNIyIGWHPEGTLE----------hartrvg
NS5B_IBVB/1-82                    .MNNSKDNPFRGAIARKARI.YLREGLDCVYFLNKAGQAEPCPACTSLVFQGKTCEEHIHNNNL.LSWQAVKQLEKQTPQRQSLN.......
#=GC seq_cons                     .MNNSKDNPFRGAIARKARI.YLREGLDCVYFLNKAGQAEPCPACTSLVFQGKTCEEHlaNNNL.LSWQAV+QLE+QTPQRQSSN.......
//