#=GF ID Acetyltransf_14
#=GF AC PF03421.20
#=GF DE YopJ Serine/Threonine acetyltransferase
#=GF PI Peptidase_C55; YopJ;
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Mistry J;0000-0003-2479-5322
#=GF SE Bateman A
#=GF GA 22.60 22.60;
#=GF TC 22.70 23.10;
#=GF NC 22.40 22.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 16728640
#=GF RT Yersinia YopJ acetylates and inhibits kinase activation by
#=GF RT blocking phosphorylation.
#=GF RA Mukherjee S, Keitany G, Li Y, Wang Y, Ball HL, Goldsmith EJ,
#=GF RA Orth K;
#=GF RL Science. 2006;312:1211-1214.
#=GF RN [2]
#=GF RM 12433923
#=GF RT Yersinia effector YopJ inhibits yeast MAPK signaling pathways by
#=GF RT an evolutionarily conserved mechanism.
#=GF RA Yoon S, Liu Z, Eyobo Y, Orth K;
#=GF RL J Biol Chem. 2003;278:2131-2135.
#=GF RN [3]
#=GF RM 17116858
#=GF RT Acetylation of MEK2 and I kappa B kinase (IKK) activation loop
#=GF RT residues by YopJ inhibits signaling.
#=GF RA Mittal R, Peak-Chew SY, McMahon HT;
#=GF RL Proc Natl Acad Sci U S A. 2006;103:18574-18579.
#=GF RN [4]
#=GF RM 20430892
#=GF RT The acetyltransferase activity of the bacterial toxin YopJ of
#=GF RT Yersinia is activated by eukaryotic host cell inositol
#=GF RT hexakisphosphate.
#=GF RA Mittal R, Peak-Chew SY, Sade RS, Vallis Y, McMahon HT;
#=GF RL J Biol Chem. 2010; [Epub ahead of print]
#=GF RN [5]
#=GF RM 22802624
#=GF RT Serine/threonine acetylation of TGFbeta-activated kinase (TAK1)
#=GF RT by Yersinia pestis YopJ inhibits innate immune signaling.
#=GF RA Paquette N, Conlon J, Sweet C, Rus F, Wilson L, Pereira A,
#=GF RA Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis
#=GF RA S, Fitzgerald KA, Stuart L, Silverman N;
#=GF RL Proc Natl Acad Sci U S A. 2012;109:12710-12715.
#=GF DR INTERPRO; IPR005083;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The Yersinia effector YopJ inhibits the innate immune response
#=GF CC by blocking MAP kinase and NFkappaB signaling pathways. YopJ is
#=GF CC a serine/threonine acetyltransferase which regulates signalling
#=GF CC pathways by blocking phosphorylation [1][2]. Specifically, YopJ
#=GF CC has been shown to block phosphorylation of active site residues
#=GF CC [3]. It has also been shown that YopJ acetyltransferase is
#=GF CC activated by eukaryotic host cell inositol hexakisphosphate [4].
#=GF CC This family was previously incorrectly annotated in Pfam as
#=GF CC being a peptidase family.
#=GF SQ 59
#=GS A0A160BXK2_9RALS/171-357 AC A0A160BXK2.1
#=GS A0A0F5JTZ7_9BURK/1-170 AC A0A0F5JTZ7.1
#=GS A0A014PYK8_9GAMM/69-245 AC A0A014PYK8.1
#=GS A0A0Q6XCB2_9BURK/393-581 AC A0A0Q6XCB2.1
#=GS Q8Y2L4_RALSO/386-577 AC Q8Y2L4.1
#=GS A0A0Q6VWW2_9BURK/57-238 AC A0A0Q6VWW2.1
#=GS A0A4Q2IS81_9BURK/20-195 AC A0A4Q2IS81.1
#=GS A0A0Q6XHS1_9BURK/11-197 AC A0A0Q6XHS1.1
#=GS A0A0Q9YD96_9COXI/201-358 AC A0A0Q9YD96.1
#=GS A0A0Q6XCB2_9BURK/94-286 AC A0A0Q6XCB2.1
#=GS A0A0Q8PB81_9BURK/16-199 AC A0A0Q8PB81.1
#=GS G2GZ67_9ENTR/18-182 AC G2GZ67.1
#=GS A0A078KYG8_9GAMM/7-169 AC A0A078KYG8.1
#=GS A0A328ZTJ4_9BURK/55-231 AC A0A328ZTJ4.1
#=GS A0A328Z5E4_9BURK/71-262 AC A0A328Z5E4.1
#=GS A0A1Y6ITH3_9VIBR/59-225 AC A0A1Y6ITH3.1
#=GS Q8Y2L4_RALSO/91-283 AC Q8Y2L4.1
#=GS Q1MTJ6_RALSO/1-95 AC Q1MTJ6.1
#=GS E9CMN8_9GAMM/46-225 AC E9CMN8.1
#=GS Y4LO_SINFN/42-211 AC P55555.1
#=GS A0A421DJQ9_9GAMM/1-168 AC A0A421DJQ9.1
#=GS Q8P4H6_XANCP/1-140 AC Q8P4H6.1
#=GS Q8Y164_RALSO/86-256 AC Q8Y164.1
#=GS A0A1H2PNN8_9BURK/55-227 AC A0A1H2PNN8.1
#=GS A0A1S6XIC2_9HYPH/43-214 AC A0A1S6XIC2.1
#=GS Q8ZMI3_SALTY/40-212 AC Q8ZMI3.1
#=GS A0A068QW43_9GAMM/4-172 AC A0A068QW43.1
#=GS A0A1S6XI99_9HYPH/102-274 AC A0A1S6XI99.1
#=GS A0A0M2KAV7_9GAMM/155-327 AC A0A0M2KAV7.1
#=GS F2JZ26_MARM1/145-319 AC F2JZ26.1
#=GS A1TQP0_ACIAC/91-261 AC A1TQP0.1
#=GS A0A2S0PDD2_9NEIS/267-438 AC A0A2S0PDD2.1
#=GS A0A0G4JW18_9GAMM/87-255 AC A0A0G4JW18.1
#=GS Q8XXI2_RALSO/155-342 AC Q8XXI2.2
#=GS A0A859PN67_9ENTR/14-184 AC A0A859PN67.1
#=GS A0A1S6XG80_9HYPH/28-201 AC A0A1S6XG80.1
#=GS A0A3S4G8F4_SALBN/25-197 AC A0A3S4G8F4.1
#=GS A0A0G3EL98_9BURK/1-39 AC A0A0G3EL98.1
#=GS A0A2G8DX34_9GAMM/26-198 AC A0A2G8DX34.1
#=GS A0A1H2PNL8_9BURK/49-221 AC A0A1H2PNL8.1
#=GS D2U4P0_9GAMM/27-200 AC D2U4P0.1
#=GS Q87GH0_VIBPA/21-193 AC Q87GH0.1
#=GS A0A078L0R4_9GAMM/3-160 AC A0A078L0R4.1
#=GS A0A0F5JSW9_9BURK/60-236 AC A0A0F5JSW9.1
#=GS A0A0G3ER55_9BURK/111-216 AC A0A0G3ER55.1
#=GS B2VJH3_ERWT9/142-315 AC B2VJH3.1
#=GS Q9RI13_YERPE/26-198 AC Q9RI13.1
#=GS A1TP56_ACIAC/85-258 AC A1TP56.1
#=GS A0A1S6XI49_9HYPH/25-198 AC A0A1S6XI49.1
#=GS W1IPC6_9GAMM/5-173 AC W1IPC6.1
#=GS A0A0G4JVB0_9GAMM/75-250 AC A0A0G4JVB0.1
#=GS A0A1Y6ITH2_9VIBR/146-320 AC A0A1Y6ITH2.1
#=GS Q8Y125_RALSO/174-347 AC Q8Y125.2
#=GS A0A2U8I5I1_9GAMM/435-609 AC A0A2U8I5I1.1
#=GS A0A370MZA9_9BURK/201-374 AC A0A370MZA9.1
#=GS A1TST1_ACIAC/148-332 AC A1TST1.1
#=GS A0A418X4N1_9BURK/113-286 AC A0A418X4N1.1
#=GS G6YIH2_9HYPH/1-161 AC G6YIH2.1
#=GS A0A4Z0KVH8_SALET/40-212 AC A0A4Z0KVH8.1
A0A160BXK2_9RALS/171-357 sslqrslaglqqaldrnldlevanfp-----------------.------IKNV.D..WAVVPLLMASENARNP....GLNLV.A..Lh...............mETAETAFDDDEEE....L.P.PL...VN.SRQfgafidsappgryrAIVN-...--..D.GA.....HTRAADIRKD.....-A......QGATVIVVDPL................--.--.-RKEKDEQE.Y.DGYAENVS.....A.EAG..E.....HARC..AFIPV..DLQKSAFGCRIFSMSLALKMH....AR.EADFTALHDA--lr......................................................................
A0A0F5JTZ7_9BURK/1-170 ..........................--MQDFIQALKHAERQG.K--QYPAAEL.D..QKFQPQMVAAQNHIHP....KLDVK.V..Fe..............asTSEPDALRQAIVN....T.G.RG...ER.WR-..............AVVNV...ER.iH.GKla.psHGIALDVSGG.....-R......GKVSVLAIDSV................--.WG.CTDTLAV--.-.--MTAA--.....L.KGV..K.....NAAL..TILNT..GTQKDVVNCKIFALANAKAMA....DA.GDLMVDLHKKN-f.......................................................................
A0A014PYK8_9GAMM/69-245 .........................p-ELLHYAKRVMENAEAG.K-PDAEITHL.D..AQNISTLASAYNHAFP....ALNLK.V..F.................NSGSDFLSHVYHN....D.E.EG...AY.--R..............AIVKL...SG..N.SE.....HRVAVDLRNH.....PD......QTKTMLVIESAt..............aHT.YK.NGHAETLPG.Y.IPLRDNID.....K.YLS..N.....SCKM..AVIEV..DAQKSHHDCIIFSLNFALAAY....QKdHETFNDLHEKL-r.......................................................................
A0A0Q6XCB2_9BURK/393-581 ......................qgme----AYVHELGRAAKGE.A---PQPTPR.D..AEFMGLLIDVENTLDP....QLRLS.A..Hrvdp.........vqlaALDPAAINDLWQS....V.A.TG...VR.SGAd...........whATLDL...GG..-.--.....HHAALSARHD.....PDn....hAHVSLVVVDGTg.............spL-.--.---------.-.--------.....-.---..-.....----..-----..---------------------....--.------------lregggegltkllgdrlqamlrgtghagqgkvrlthfdvsarqpdidnalfavlsaknlkdfrdigeahaea
Q8Y2L4_RALSO/386-577 ...................vealtdh----------LDALRRA.CKGKADMPAPrD..AEFLDLLVEVENKLDP....QLRLS.A..Hkida.........prlaVRDPGAIASLAPV....V.A.DG...VR.GGGd...........whATLDI...GD..-.-G.....HHVAVAARHD.....AAh....pTHVSLAVLDGAg..............sPF.SP.ANWRDLAST.V.AKCLDAAG.....N.GRT..G.....KVWL..TYVDA..SSQATTSNSALFALRATKEMKesglQH.DGLIDQMHKN--al......................................................................
A0A0Q6VWW2_9BURK/57-238 .........................q-KISAYVDELRTHLKNH.T----EPEPR.D..HLFLDVLASSENIRTP....GLNLR.I..L.................RSAKSALHAVARA....L.A.DA...PP.PGAapga......lqwqAVFD-...--..D.GG.....HRVAASVRID.....RDd....pGRASVILIDSRl.............kgAK.DH.HGHAENIHDpA.LPTLSQTL.....D.SKG..L.....KLQV..TYMST..DAQR-NLGCTIFALS-AVKKM....HD.SAAIDQMHSD--al......................................................................
A0A4Q2IS81_9BURK/20-195 ....................srieaq------LARMQQYFHLE.RHADRTTLND.D..VENMPHFVDLSNRRHP....DLHLF.I..A.................DSPSAMLQRIKIM....P.P.EF...HL.--R..............CVVRS...SE..N.TIg..gaHHLYADIRRE.....AN......RPLSILLIEPAd..............fKY.NQ.NGRSMVL--.-.ALLILMMP.....D.PYF..A.....GRRM..ACFNA..AAQMSGSDCLIFCIDFALKAH....RH.AEEFLALHA---ih......................................................................
A0A0Q6XHS1_9BURK/11-197 .........................s-KLQTIRQHFTTLLAGN.WSPGPMDDDF.D..HAMLPIMVAAENKRTP....NLKLT.V..L.................PTGTGLVQWLENK....P.Q.PEpkwYE.KAKpy.........nerVMFTM...PG..F.SA.....HKVVADVMQD.....SK......GNVSVLVVEPLg..............fKE.NA.QIAMRDVAL.P.TILKAVQN.....S.PLG..K.....KISV..TVLAL..DTMKSDNDCRIFGLSAASKMA....DQ.PKYFEALHAQNI........................................................................
A0A0Q9YD96_9COXI/201-358 ................lnhhgcqlfa-----------------.----------.-..-EDMNVFVEQKNARHQ....KLGGP.F..HgkvicsqtpsslalldpIAFDTLSQDIQDI....Q.T.GF...KP.RTQ..............FYIYA...NV..N.FS.....HCMALDIERE.....ED......GTLHILSFDSA................--.QH.IAQYYLL--.-.-EKLTAFL.....E.KNK..I.....NFKI..TACQS..GLQRSMINCEIFSH-------....--.------------lflqdsakvr..............................................................
A0A0Q6XCB2_9BURK/94-286 .........................q-EMKGYLAELRLMHAAG.R----ELPRSrD..TQFLDLLVVMENARNA....SLRLS.A..Qaidhe......aldkgdAAAMKAVAGLARA....A.I.EG...MG.QGSw............hAVLSV...DG..-.--.....HEVAVAAEHD.....EKh....pARLSLIVVDSAssl..........lssGQ.WR.QIARLVGQH.M.NRALADEG.....K.PTD..A.....QVWV..SCLSTstEVTATCGGSTIFSLA-AAREM....PH.DPDIQKLHKD--vl......................................................................
A0A0Q8PB81_9BURK/16-199 ....rlarsvqdltsaltegrayhdv----------------N.MQPDERIYQN.D..RKNIALMINYLDANIP....GLLLH.AksF.................DTPTAFAVYLRDS....L.D.EP...RH.ER-..............ALIRM...GE..N.EA.....HYTVVDYMIK.....VKcsgpesNQVSVMAFDPS................--.-S.TPTAAVALG.V.GRL-GNAL.....H.AAV..P.....QVVA..SYTLS..NAQTSPKDCIVFALLYATKLC....LR.REIFK-------srqav...................................................................
G2GZ67_9ENTR/18-182 .......................fcf-----------------.---------T.D..TPFLPDIITDQNLKKP....GLNAT.F..C.................DSTEFFATELAKL....V.A.QK...NP.SAR..............FVVKT...NS..L.AR.....HYCAFDYRLI.....-N......GKVSVIGVESTsfmpvsikgalnptivNL.NR.YSAQLLL--.-.INAKESLK.....K.AVG..E.....H-TF..IMLPI..NIQNSPHGCGIFCVSFISKMF....KE.KKIFDALHEKNI........................................................................
A0A078KYG8_9GAMM/7-169 ...........nkllaqlsklkkghd-----------------.-------AGL.D..AEGIKVILHNHNRVNP....NKNPI.T..L.................VQNDNFAEVINET....L.K.NH...DK.SKPgr..........yqFIVK-...--..S.GA.....HYTTVDLEID.....EQ......GHAKALVLDAA................--.ND.MRFIPLL-T.K.LSSIEGIE.....R.VYY..A.....EGKT..N--RD..NIQKDNISCPVFALSHAMALQ....S-.------------ldiynhleqeev............................................................
A0A328ZTJ4_9BURK/55-231 ..................aaldtemr--------KVRVDIHAR.RQPDADTLKA.D..LSNIRSIVQAQNLRKP....GLELS.Y..H.................GSSESLVDAMRNL....D.T.SQ...NH.QFR..............AIFRI...DNrpQ.GM.....HHAVVDVRVK.....PD......MPPTVIAMETA................--.-T.MGAGDNIDS.Y.SEFVDQLR.....SvPGM..Q.....EARV..VVIDA..EAQKSDADCVMFGLSFASRMH....KD.AGLLEGWHEKL-a.......................................................................
A0A328Z5E4_9BURK/71-262 ........................ph--LLAYLRQMERELENQlERPMASDTNS.D..MHHLDDIMEALNATTP....SLNLC.K..Yafefn.......qqlegLKKTGLVTQLFEG....M.Q.TQ...GQ.WH-..............AIFD-...-R..D.GK.....HRSAMSVQCA.....-K......DSASLVIVDSL................PA.DS.ITEEVHTGT.W.TRVLEELQwfldrK.RNFveP.....RTQLraHIVFT..HAQKSDEGCTIFALSAAKKM-....AS.STAIADLHR---qal.....................................................................
A0A1Y6ITH3_9VIBR/59-225 .......................hnm---QEIHQHL-STLRQQ.NWSAGSMEAVfD..TALLPTMIQAEKAHNP....ENTVI.F..H.................D---DIFDELGEI....D.T.EQ...TR.---..............QVLMQ...TP..Q.MF.....HYVAADIREM.....-N......GRRSVIILDSL................--.-A.DNPRNSIYD.N.PEVKDSLM.....S.SLF..P.....EDKV..AVLCM..NMQKSFYECQIFALNATTKMA....KH.ADFMDDLHQL--nl......................................................................
Q8Y2L4_RALSO/91-283 ..........................ESMRQYLAELKTAAHAD.PNLRVETPGHrD..AEFLDLLVAVENARHP....KLALS.A..Htisl.........ntlnTTNPAAVASLARN....L.E.TS...MR.SREp...........whAVVDI...GG..-.--.....HAMALSVRHH.....PEq....pKQISMIVVNSAgeh..........lsvPE.WN.LMATLLAGH.L.NHKLEQAG.....D.PKG..V.....RIVL..HCLNT..GIQKTNHGGAIFALS-AVKAM....PG.DEDIGKLHAH--al......................................................................
Q1MTJ6_RALSO/1-95 ......................rlra-----------------.----------.-..----------------....-----.-..-.................-------------....-.-.--...--.---..............-----...--..D.HD.....HVVSADVRTV.....-G......PAVSILILEPV................DQ.FS.VR--RLL--.-.ESCLEEMA.....G.LLP..S.....NAAV..SVLIH..DSQKSKFDCAIFALHAASKMV....DE.RRFLDALHAE--ha......................................................................
E9CMN8_9GAMM/46-225 ..................sveyallh---------TTKLLKEN.TQSNIVSNIF.D..TLTLPVICKSESNNIG....N-RIV.N..F.................SCLNSLFTYVNKS....R.D.GN...FK.---..............AITKM...AK..NdSIn..rmHYTCIDVFKK.....-G......SKIDLVVYESAc.............lqGI.AS.AGPDYGVKY.LrNVLKDQFT.....K.GKIkpE.....NIRV..GVIEI..GIQNSPSDCAIFSVSTAKNLY....KN.TET---------selmfskl................................................................
Y4LO_SINFN/42-211 ..........................SSLMEYGRQVARHLSAN.VQPDEKILSL.D..IRNLPLLAASYNRRYP....DLDLR.H..M.................DSPARFFDALNDR....S.S.DG...AW.--R..............AVVRL...AD..G.EQ.....HHVAADVRTR.....AG......AAPTIIVMEGA................--.--.-NFYTFVAS.Y.FKLRGDSF.....R.QLG..T.....QAKW..AFIEV..GAQKSAADCVMFGVQFALAAY....RE.LPTFDAWHDNL-h.......................................................................
A0A421DJQ9_9GAMM/1-168 ..........................--MSNYLEKLESNALGA.MQPNVRTEET.-..-RLQKYLIMAQNDKYHlqigLLNIS.A..T.................KGNELKNALLMMD....N.N.TK...W-.--R..............AVINI...ED..D.DEpnkspHSVAVEAEKK.....-N......DKISLVVVDAY................-I.SP.MTDS-----.-.-DIAKHIT.....S.Y--..D.....DAAL..TVLFT..AVQKTVSGCKIFSLHDVKAMV....SN.EEAINQFHQL--ny......................................................................
Q8P4H6_XANCP/1-140 ..........................-----------------.----------.-..------MVAAQNHIHP....NLDVK.V..F.................DASASEPHALRQA....I.V.NT...GR.GQRw............rAVVNV...ER.iH.GKga.psHGIAVDVSGG.....-R......GKVSVLAVDSV................--.WG.CADTLSV--.-.--MTAAL-.....-.KGV..K.....NATL..TILNT..GTQKDVINCKTFALANAKAMA....DN.DDLMVDLHKKN-f.......................................................................
Q8Y164_RALSO/86-256 .........................p-EFISYAETTLHNLASH.TQPSVMETNL.D..IRHLDTIVQSY--RYN....NLNLQ.A..F.................NSREAFVASLVEG....Q.G.SG...RA.ER-..............GVVR-...DY..P.NL.....HHFAADVRHH.....ED......GRTTVIILEPA................--.-S.AGNQENLPG.Y.TELASALR.....Y.NLG..S.....QCRM..VVIEA..EAQKSLSDCVAFALDFALAAY....QErRTTFDQWHENL-a.......................................................................
A0A1H2PNN8_9BURK/55-227 ........................ta--LDSQLERIERSLEDG.SWAERDFARL.D..RHWMPRLVERANQRKD....GLDLV.F..L.................QRPAEFTDELSRI....A.R.DE...IP.ASR..............YIVGL...GD..G.GM.....HFAVLDVRQS.....-E......RGISVLLFEPA................TL.DA.DAPGMLA--.-.FQTDLAIG.....A.SAV..P.....NVRC..CKLEL..DLQRSHSECGVFSLFLAKKVH....KA.SDEIEVLHRAN-l.......................................................................
A0A1S6XIC2_9HYPH/43-214 ....................sllevn------VTRLENDIIHG.SWFDMCYEEL.D..FEMMPTLIKRANEKYP....LMNLK.F..S.................ATPEDVPILIQNT....I.D.DN...IQ.SSR..............LIVNV...GN..D.RI.....HFSVIDHQTL.....-N......NKTSLILFEPV................SF.IH.MKPAILA--.-.MKVKIALE.....A.SRL..P.....-CHF..SIVEM..DIQRSYSECGIISLALAKKLY....NE.ADKLERLHRDNI........................................................................
Q8ZMI3_SALTY/40-212 ..........................EALTCIVERLESEIIDG.SWIHISYEET.D..LEMMPFLVAQANKKYP....ELNLK.F..V.................MSVHELVSSIKET....R.M.EG...VE.SAR..............FLVNM...GS..S.GI.....HISVVDFRVM.....-D......GKTSVILFEPA................AC.SA.FGPALLA--.-.LRTKAALE.....R.EQL..P.....DCYF..AMVEL..DIQRSSSECGIFSLALAKKLQ....LE.FMNLVKIHEDNI........................................................................
A0A068QW43_9GAMM/4-172 ......................nnll----EYRDEILRKKETH.KQF--DKFSL.D..QGNIRQIINVLNMKYV....NMNTE.L..L.................LSQL-LTPDILNN....L.P.PS...SH.KR-..............FILQT...NT..G.GTg...qHFTATNVFKD.....SE......GRISIIAIDSG................--.--.IGSNAFI--.H.FNIHRNFL.....N.SNP..E.....KLKK..LYIYS..QIQNSPADCLIFSVHFVKKMY....KH.QTHFVELHHK--lf......................................................................
A0A1S6XI99_9HYPH/102-274 .........................k-SLQGVIADLENDIKNN.KFTNVDYAHI.D..LTMMPRLVERENSQNP....GLNLQ.F..T.................MNPDSLIKSIHRT....V.N.NG...IT.SSR..............FLVGL...EG..E.EP.....HFAVIDHQTI.....-N......KKTSLILFDTT................RF.MN.MNAQILG--.-.LTMKSAIE.....D.SQL..P.....YCYF..SMAEI..NLQENSSESGILSLVLAKKLY....LE.ADKLKVMHQDNI........................................................................
A0A0M2KAV7_9GAMM/155-327 .........................g--LYEYAKMAIERVNEK.KGADKQLSEL.D..KKMLPLFAEAENARHP....DLNLH.V..F.................RGPEACYKAIKEQ....N.K.KA...WD.SRQpm..........nmRVVFS...PS..R.GIp...dHHVALDVQLR.....PG......HHPSVVCFESA................-L.WG.M--------.M.NEIRQDI-.....E.HGL..K.....ESKV..KLIGN..FVQASDWDCAMFALSNALKLY....KHhDEYTSRLHAG--ee......................................................................
F2JZ26_MARM1/145-319 ..........................SDLHDYAQHAISCIKTG.ESGGYEMNKF.D..KKLLPLIAEAENKRTL....GLNLH.V..F.................KSTQECTDALHQM....E.A.KT...NS.TRKpn..........hvRIVYP...PA..S.GVs..pnHHAALDVKFT.....PK......NPPSIVGFEPA................--.--.------TFE.N.SVMLEHSL.....R.YSM..P.....HAKL..NVVNP..DIQKSDWDCAMFSLNHALKAH....KHeDGYVEKLHQGE-k.......................................................................
A1TQP0_ACIAC/91-261 ..........................SSIVKYGERTLKMLAAN.KQPDEALLKL.D..IKNLPALASVYNRRYP....GLNIQ.H..F.................DSPIDFLQSLSEQ....T.T.SV...VS.QR-..............AVLRL...ER..D.GE.....HHVAADVRRR.....PN......GEASVIVLEPA................--.--.-RLLTFVTG.H.TQLRRQAL.....S.QLG..E.....NAKF..AFIQV..GAQKSAADCLMFDLHFALHAH....QH.SSLFDQWHDNM-v.......................................................................
A0A2S0PDD2_9NEIS/267-438 .......................drl---TSALRLAQRYVQCG.RQPDTAVTLS.D..MVSMREVARCENDRKT....GLNLS.L..A.................GSMDEVAALLAGK....A.P.PF...HL.--R..............LVFRE...PR..H.GY.....HHVFADIDAQ.....PG......QPLSAILIETA................AA.AS.AHPL--YQR.F.SQALGQFA.....D.RH-..D.....GMLL..AVIDS..HVQRSRGDCLIFCMSFALKSH....RH.ASSFTRLHHDH-r.......................................................................
A0A0G4JW18_9GAMM/87-255 .........................k-QLNNYLNKLESHASDS.IQPNVRTEES.-..-ALQKYLIMAQNDKHH....-LQIG.L..Ls..............isATNGDELKNALRM....M.D.NN...TK.W-R..............AVMNI...AD..D.DEpneppHSVAVEAEKK.....-N......NKISLVVVDAY................--.--.--ASAFT--.D.SDIAEHIT.....D.---..H.....DAAL..TVLFT..SVQKSPSGCKIFSLHDVKAMA....SR.EEVMNQFHQRN-y.......................................................................
Q8XXI2_RALSO/155-342 ........................pa--LPHYLERLEAAYGSD.TVL---HPIE.D..IDHMETIIKGLNLADP....MLNLH.L..Dkm............qadDSPEQIRESVLAK....TlE.AE...LRlEPRqras......ngwrEIIH-...--..D.TG.....HSIAMGVQCS.....RS.....sNDVSILVIDSG................SA.DR.EVTKKWRGV.V.QAIAPDIQ.....A.KLG..PsvspvRLRV..QFFAI..NTQRSQEGSGIFALSAAKKMA....SD.------------rairglqd................................................................
A0A859PN67_9ENTR/14-184 .........................s-KLKKAMEHYQTDIEAH.ISQGRQYANV.DfeAQLIKILIFSLNTNRP....GVNAE.Y..I.................EGFDRLFSKIEQA....-.G.PV...NQ.HRR..............IILK-...-G..Q.GL.....HFGAMNVFTD.....EN......NRKSVIYLDSV................GE.NS.GVAAMNM--.-.--FRIASR.....Y.RQD..D.....HIKV..MLVPM..GIQTSMEDCMIYSLHFVSRMF....KH.RDRFESLHAK--lf......................................................................
A0A1S6XG80_9HYPH/28-201 .........................t-SLENIITALEDDIESN.RFYNTEYARI.D..FKMMPALVKQANNKYP....EMNLT.L..I.................KEPIDFVSPFKKT....I.K.KG...IQ.SSR..............YMINV...GA..N.NQ....fHFGVVDHQTL.....-N......NKISLILFEPV................SF.NL.IKPALLG--.-.AKMQTIIE.....T.RLP..S.....SIYF..SMVEM..NIQRSMSECGIFSLSLAKKLY....LQ.SDKLKKLHIDNI........................................................................
A0A3S4G8F4_SALBN/25-197 ..........................ETLTCIIERLENDIIDG.SWMNASYEET.D..LRVMPLLVAQANKKYP....ALNLE.F..V.................MSTPELVSAIKEA....R.M.GG...SE.SAR..............FIVNL...GS..G.GI.....HFSVVDFRAV.....-A......GKTSVILFEPA................EC.DA.FGPALLA--.-.LSTKAAIE.....R.EQM..S.....DCYF..AMVEL..DIQRSASECGIFSLALAKKCY....LE.SANLARIHEDNI........................................................................
A0A0G3EL98_9BURK/1-39 .......................mvf-----------------.----------.-..----------------....-----.-..-.................-------------....-.-.--...--.---..............-----...--..-.--.....----------.....--......-----------................--.--.---------.-.--------.....-.---..-.....----..----S..AAQKSPFDCAIFSLSFALKMR....RA.EAFFDELHDSN-d.......................................................................
A0A2G8DX34_9GAMM/26-198 ..........................EEIKKIITQLETDLVNG.TWTHKDYGKN.D..MKIMPALITQANNKYP....EMNAH.Y..I.................LYPRDLSITIKRT....I.E.KR...IK.SAR..............FIISM...GS..D.GI.....HFAVIDYKHI.....-N......NNTSVILFEPA................KF.KG.SGASLLA--.-.LRARMSIQ.....R.NPL..P.....DCHF..SVVEM..DIQRSSSECGIFSLALAKKLY....LE.QDSLLKIHEDNI........................................................................
A0A1H2PNL8_9BURK/49-221 .......................sfl---AAKIEEIERSLNDG.SWTEMDFAEV.D..EALMPGLVAMANDKKT....GLDLC.Y..L.................PAPKDLCDSLDAF....W.R.DG...LE.SKR..............YVVNS...GN..S.AT.....HFVALDVAVV.....-D......GKVSVALFEPT................TF.DH.TTPCLLA--.-.ALIKVAVK.....R.TAL..P.....HAKV..VSVAL..DIQRSNAECGMFSLALAKKLL....KE.RDQILALHKAN-l.......................................................................
D2U4P0_9GAMM/27-200 ........................tl--LCKYISDIEQSLKDG.TWATKNFSII.D..KELLPPMVKLANEKKE....GLNLK.Y..L.................TSPDKLYDEIFKI....K.N.ND...IK.SSR..............YIINV...GE..K.DT.....HFGVIDTRLI.....-E......GKISILLFEPA................SLtNS.MSSSILA--.-.FRTKLAIE.....K.CGL..K.....NIIF..SIIEM..DIQRSKYECAIFSLSLGKKLA....KE.SDSINIIHKLN-i.......................................................................
Q87GH0_VIBPA/21-193 ..........................EQLSSYIDLMDDAIRQG.KQLPKDTAAAnD..IALMDDFIAIANQKKE....GLNAH.F..F.................RSPLDMVNYVKSL....I.P.SE...DT.TAR..............FVVNM...GS..G.GI.....HCIAVDCAIK.....-N......GKCSLIGIDPV................TM.NS.LGASMLA--.-.-IRLQSVC.....K.REL..P.....ETSL..VIMET..DMQRSQGECLMFSLFLVKKMH....KE.CDEFQSLHDKNI........................................................................
A0A078L0R4_9GAMM/3-160 ............ddgkikdakfpfne-----------------.----------.-..VEIKELIAKQS-FKPH....LMIVK.A..N.................AQPTAFVDYLMNL....S.Q.SN...KS.FRE.............qCIVL-...Y-..-.NE.....HWFGLDLERK.....KR.....tGKISIVILDAA...............aPF.TK.VAAFMFLMK.Q.ISQNGSIA.....F.DTL..L.....IGS-..-NSDK..NLQRNNRDCSTYAWELLKWAK....E-.------------spnlhdklfkl.............................................................
A0A0F5JSW9_9BURK/60-236 .........................p--LRKYAKAAVERVRHR.MADAPSFANV.D..AAHLDALVATEKQRNP....GLNLE.H..F.................SHQDDFVEAIRRG....T.R.QS...FQ.---..............AIFPY...PD..P.AThqsesHHVMADVRHH.....AD......GTTTVVVVESA................-E.IF.AGRGTRLGK.H.NQIVLALN.....E.VGV..D.....SNNI..AVIET..QAQKSTDDCVMYSLNYALKAH....KN.QRVFDKFHAR--lq......................................................................
A0A0G3ER55_9BURK/111-216 ....................mvcnnp-----------------.------MTLR.D..RQVLPDLVAAE-RRRT....GQDLR.F..Y.................NTLGEFAQALHAQ....T.I.DA...GA.MRY.............qAVVAMtdrPD..G.GA.....HFAAFDMRRRa..lsDE......SPLSMVYVEPS................--.--.---------.-.--------.....-.---..-.....----..-----..---------------------....--.------------flvegqvaega.............................................................
B2VJH3_ERWT9/142-315 .........................n-NLHEYGKMATELAKEG.SGSSSALTRM.D..KKVLPLLADAENARHP....GLNLH.V..Y.................KKGEECYQAIKDQ....H.K.SV...QQ.SGQpk..........tmRALYP...PF..K.GMp...dHHIALDIQLR.....PG......HRPSIVGFESA................--.--.------LGH.M.VEHLKQGI.....A.EGV..R.....GAKV..HMVGN..TIQNSQWDCTMYSLSNALKSF....KHhDEYTARLHKGE-k.......................................................................
Q9RI13_YERPE/26-198 ..........................EELKNIITQLETDISDG.SWFHKNYSRM.D..VEVMPALVIQANNKYP....EMNLN.L..V.................TSPLDLSIEIKNV....I.E.NG...VR.SSR..............FIINM...GE..G.GI.....HFSVIDYKHI.....-N......GKTSLILFEPA................NF.NS.MGPAMLA--.-.IRTKTAIE.....R.YQL..P.....DCHF..SMVEM..DIQRSSSECGIFSFALAKKLY....IE.RDSLLKIHEDNI........................................................................
A1TP56_ACIAC/85-258 ..........................SDLRAYAEAALTAAKIG.S--TSDMTDL.D..VQNKQYLADAYNTRFP....DLKLI.C..H.................DSAQAFFSDFMTS....E.K.PV...WR.---..............SLVQL...SP..H.SL.....HHVAIDVRLQ.....-D......GKRTAVVLEPAi.............gyGM.RS.DGKITMLAG.Y.EPLGRNIQ.....K.YLG..E.....NGDM..AVVQL..GAQKSHYDCIIFSLNLALCAY....QR.DDVIDGLHERL-r.......................................................................
A0A1S6XI49_9HYPH/25-198 ........................ev--LEGVITRLENDITDG.SWIRKDYVSI.D..FKMMPALIKQANSKYP....AMNLK.L..A.................MTSEDLCLSIKTT....I.N.DG...VQ.SSR..............FITDV...LN..G.SI....pHFVVIDHKTI.....-D......RKTSLILFEAT................KL.DH.EVSNILI--.-.SRMKRVIE.....A.SQL..P.....DCYY..SIVEM..DIQRSFSECAIFSLALAKKLY....RE.TDKLERIHKDNI........................................................................
W1IPC6_9GAMM/5-173 ........................ds--LNRYIAKIQSNKQNN.I--QFSDMRM.D..MLNCKIILKNLNAKYS....DMNAH.P..T................iITAREFANSINEL....N.NlKS...NE.HKR..............FVINS...DN..G.GV.....HFAAANVFKD.....MN......DNISIIFVDSS................--.--.RGKNQFI--.-.-FFILNFR.....L.KDV..S.....NIKT..LYIYN..QIQNSDADCLLFSLHFLKKMH....KY.SDHFVKLHQD--if......................................................................
A0A0G4JVB0_9GAMM/75-250 .........................p-ELAHYARKTLEQASSG.Q-TTVEITNL.D..IGNIRTLVNTYNDRFS....SLNLK.Y..F.................SSQEDFLDELRDT....D.T.SA...WR.---..............AILKA...AP..N.SR.....HHFAIDIRTH.....DD......GQKTLIALEPSva............frPI.-D.DERFHSMPG.Y.YSLHRGIQ.....R.QSD..D.....DVKF..AVIQT..EAQKSTQDCVIFSLNFALNAY....QK.DSFFDDLHDNL-k.......................................................................
A0A1Y6ITH2_9VIBR/146-320 .........................p-DLHQYAQQTISRIQKG.REPNSAITTL.D..AKLLPLLAEAENHRHP....GLNLH.T..F.................TDQNSCYEAIKAQ....Q.K.TV...QE.TKQpq..........qmRVVYP...PL..P.GMa...qHHIALDIRFK.....PG......HQPSILGFESA................--.--.--LSTLA--.-.TEPIKNVL.....S.QAF..P.....KAKI..QIVDH..SIQNSSWDCVMFSLNNALKAY....KShEEYTDKIHNQ--aq......................................................................
Q8Y125_RALSO/174-347 ...........qalsaqnmdpelaqf-----------------.-----RVLDV.D..RAIMPLLIVAENARNP....GLNLV.P..Lhmdmae.....deevrtQPPMAGSRHIAEF....V.A.SA...RP.GRY.............rAVID-...--..D.GS.....HTRAADIRKD.....-A......SGTSVIVVDPL................--.-R.KEKDESA--.Y.VDYADNVN.....M.EFG..E.....HAKC..AFIPV..DIQKSFFDCRILSLSLALKMH....DK.DDAFAAFHET--lr......................................................................
A0A2U8I5I1_9GAMM/435-609 .........................d-KLVNYFLKIKKSIDNH.IQMGASDSLTwD..KKFLAPIVALANEKKP....GLDLF.L..C.................DNPDDFVKKIKTLvgsdH.Q.NQ...VK.TAR..............FIVP-...SC..D.GG.....HFAAFDCRVT.....TE......NKISIIGVDSS................--.SK.MGAGILT--.-.-MQLLKIL.....S.TKL..P.....NASF..KMMLT..FLQSSHGECAIFSLALAKKMF....EE.QTIFQELHEKN-l.......................................................................
A0A370MZA9_9BURK/201-374 .....ldqvkahfqalllgnwspgpt-----------------.------DDKY.D..AAILPAIVAAENDRSP....ALNLT.L..L.................SPKEDFASWLKAT....R.P.AR...AR.---..............VMFPM...PG..N.DA.....HYVTADIRRI.....-G......GKTSVIVIEPLs..............lKD.NAdLKDSTRDKY.E.KRTLPLLK.....K.ALK..S.....DVTL..SVLTV..DTQKSTNDCRVFALSAAAKLA....DN.AFLIDSLHQQN-l.......................................................................
A1TST1_ACIAC/148-332 .............elralaaevhaeg--------------ASP.DDEPAAFRKL.D..KLAMPAIVSALNAEDP....RLRLVyA..H.................ASVPDDRGVVPDH....R.G.FG...SV.EWRsflad...aapgrwRIVL-...-D..N.AA.....HNLALDLHVEglpgePG......RRGSVVHMNSS................VA.EG.AEPIITA--.-.AEMAAHLR.....L.PEG..-.....-WPL..LLLDV..PAQKSLRSCRIFALSMALKCA....-A.DASLEELHAR--ql......................................................................
A0A418X4N1_9BURK/113-286 .........................n-EIGAYITYSVRKLRDN.FQPATFSTHK.D..IAAMSAIILALNAKHP....GLNLV.R..A.................NSPRELVQHLQLK....K.A.-V...LE.FADcdflf....pfderAIVRM...GT..-.-L.....HHAIADVRFE.....RD......GSVNLTFVDAG................HA.RY.DGVKDGL--.-.KALNEQLE.....-.-AI..P.....DARC..TYITS..GAQDSIADCVIFSLCQAIDMH....RN.D-----------fanrir..................................................................
G6YIH2_9HYPH/1-161 ......................mary-------------LSAN.LQPDEELLSL.D..VDNIDCLADNYNRRYP....DLNLR.Y..M.................GSPAEFLGALADR....S.S.DG...AW.--R..............AVVRL...AD..G.EM.....HHFAADVRTR.....AA......AGPTVIVMEPA................--.--.-DLYTFVTP.Y.SRLRRETL.....Q.QLG..T.....EQKW..AFIGV..GAQKSSSDCLMFGMQFALASY....QK.SSTFDNWHENL-h.......................................................................
A0A4Z0KVH8_SALET/40-212 ..........................EALTCIVERLESEIIDG.SWIHISYEET.D..LEMMPFLVAQANKKYP....ELNLK.F..V.................MSVHELVSSIKET....R.M.EG...VE.SAR..............FLVNM...GS..S.GI.....HISVVDFRVM.....-D......GKTSVILFEPA................AC.SA.FGPALLA--.-.LRTKAALE.....R.EQL..P.....DCYF..AMVEL..DIQRSSSECCIFSLALAKKLQ....LE.FMNLVKIHEDNI........................................................................
#=GC seq_cons ..............................thhpth.pthtts.t..t.phtph.D..hphhshlltstNp+pP....sLsLp.h..h.................ssspshhptltpt....h.t.ss...hp.ttp..............hllph...ss..s.uh.....HasuhDlcpp......s......spsSlllh-su....................t.hs.thhh......phttslt.....p.tth..s.....psph..shlph..shQ+Sst-CtIFuLshAhKhh....pc.pphhpplHpp..h.......................................................................
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