#=GF ID Adeno_E1B_19K
#=GF AC PF01691.20
#=GF DE Adenovirus E1B 19K protein / small t-antigen
#=GF AU Bashton M;0000-0002-6847-1525
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_1569 (release 4.1)
#=GF GA 25.00 25.00;
#=GF TC 71.90 71.60;
#=GF NC 23.70 23.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 8600029
#=GF RT The E1B 19K protein blocks apoptosis by interacting with and
#=GF RT inhibiting the p53-inducible and death-promoting Bax protein.
#=GF RA Han J, Sabbatini P, Perez D, Rao L, Modha D, White E;
#=GF RL Genes Dev 1996;10:461-477.
#=GF RN [2]
#=GF RM 8083992
#=GF RT Functional complementation of the adenovirus E1B 19-kilodalton
#=GF RT protein with Bcl-2 in the inhibition of apoptosis in infected
#=GF RT cells.
#=GF RA Chiou SK, Tseng CC, Rao L, White E;
#=GF RL J Virol 1994;68:6553-6566.
#=GF DR INTERPRO; IPR002924;
#=GF DR PROSITE; PDOC00829;
#=GF DC The Prosite family contains members not in the Pfam family.
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists of adenovirus E1B 19K protein or small
#=GF CC t-antigen. The E1B 19K protein inhibits E1A induced apoptosis
#=GF CC and hence prolongs the viability of the host cell [2]. It can
#=GF CC also inhibit apoptosis mediated by tumour necrosis factor alpha
#=GF CC and Fas antigen [2]. E1B 19K blocks apoptosis by interacting
#=GF CC with and inhibiting the p53-inducible and death- promoting Bax
#=GF CC protein [1]. The E1B region of adenovirus encodes two proteins
#=GF CC E1B 19K the small t-antigen as found in this family and E1B 55K
#=GF CC the large t-antigen which is not found in this family; both of
#=GF CC these proteins inhibit E1A induced apoptosis [2].
#=GF SQ 34
#=GS A0A384ZUM9_9ADEN/1-137 AC A0A384ZUM9.1
#=GS Q2KS85_9ADEN/1-137 AC Q2KS85.1
#=GS A0A516UYM9_9ADEN/1-135 AC A0A516UYM9.1
#=GS A0A163HHM5_9ADEN/1-134 AC A0A163HHM5.1
#=GS J7H4R9_9ADEN/1-137 AC J7H4R9.1
#=GS H9AAN8_9ADEN/31-164 AC H9AAN8.1
#=GS H9AAV3_9ADEN/31-164 AC H9AAV3.1
#=GS A0A097IW62_9ADEN/1-135 AC A0A097IW62.1
#=GS A0A1Y0B6F3_9ADEN/1-137 AC A0A1Y0B6F3.1
#=GS A0A1J0FAP3_9ADEN/1-135 AC A0A1J0FAP3.1
#=GS E1BS_ADE40/1-135 AC P10543.1
#=GS A0A2H5AI99_9ADEN/1-134 AC A0A2H5AI99.1
#=GS E1BS_ADE02/1-135 AC P03247.2
#=GS Q6QPF3_9ADEN/1-137 AC Q6QPF3.1
#=GS A0A7H0S529_9ADEN/1-133 AC A0A7H0S529.1
#=GS Q5GFC8_ADE04/1-137 AC Q5GFC8.1
#=GS A0A1X9RIT9_9ADEN/1-139 AC A0A1X9RIT9.1
#=GS A0A059XJ33_9ADEN/1-131 AC A0A059XJ33.1
#=GS A0A1J0MUK8_9ADEN/1-135 AC A0A1J0MUK8.1
#=GS A0A2Z4QJM3_9ADEN/1-136 AC A0A2Z4QJM3.1
#=GS A0A898KBR0_ADE41/1-135 AC A0A898KBR0.1
#=GS E7CH29_9ADEN/1-132 AC E7CH29.1
#=GS Q32UI6_9ADEN/1-137 AC Q32UI6.1
#=GS Q6H1D7_9ADEN/1-137 AC Q6H1D7.1
#=GS A0A0M5L3Y4_9ADEN/1-135 AC A0A0M5L3Y4.1
#=GS A0A6M4W5T4_9ADEN/1-135 AC A0A6M4W5T4.1
#=GS A0A2H5AI21_9ADEN/1-135 AC A0A2H5AI21.1
#=GS A0A0M4NHE0_9ADEN/36-169 AC A0A0M4NHE0.1
#=GS B2VQE3_9ADEN/1-137 AC B2VQE3.1
#=GS A0A0K1DBT8_ADEE2/1-131 AC A0A0K1DBT8.1
#=GS A0A6H1TFX1_9ADEN/1-137 AC A0A6H1TFX1.1
#=GS A0A6M6AEV2_9ADEN/1-135 AC A0A6M6AEV2.1
#=GS B9A5T7_9ADEN/1-137 AC B9A5T7.1
#=GS E1BS_ADE12/1-134 AC P04492.1
A0A384ZUM9_9ADEN/1-137 .........MDVW.TILADFSKTRRLVEDS..SDGCSGFWRHWFGTPLSRLVYTVKKDYKEEFENLFADCSGLLDSLNLGHQSLFQERVLHSLDFSSPGRTTAGVAFVVFLVDKWS.QDTQ...LSRGYILDFAAMHLWRAW..IRQR-----gqrilsy...
Q2KS85_9ADEN/1-137 .........MEVW.AILEDLRQTRLLLENA..SDGVSGFWRFWFGGDLARLVFRIKQDYREEFEKLLDDSPGLFEALNLGHQAHFKEKVLSVLDFSTPGRTAAAVAFLTFILDKWI.RQTH...FSKGYVLDFIAAALWRTWkaRRMR-----tildy.....
A0A516UYM9_9ADEN/1-135 .........MEAW.ECLEDFSAVRNLLEQS..SNSTSWFWRFLWGSSQAKLVCRIKEDYKWEFEELLKSCGELFDSLNLGHQALFQEKVIKTLDFSTPGRAAAAVAFLSFIKDKWS.EETH...LSGGYLLDFLAMHLWRAV..VRHKNRL--ll........
A0A163HHM5_9ADEN/1-134 .........MDYL.KFLTNYAVLKRIIRDS..SERTGPWRRYFFCGPLANFIHKIKEENKELFAQCLDSEGQFLELLRSGDLALYNTKVVPALQFENPGRVASSLAFVVWLLDQWD.LQNQ...FSPEFSLEALCIPVWKII..K--------qevaqre...
J7H4R9_9ADEN/1-137 .........MEVW.AILEDLRKTRQLLENA..SDGVSGFWRFWFASELARVVFRIKQDYKEEFEKLLVDCPGLFEALNLGHQVHFKEKVLSVLDFSTPGRTAAAVAFLTFILDKWI.PQTH...FSRGYVLDFVATALWRTW.kVRKMR----tilgy.....
H9AAN8_9ADEN/31-164 .........MDLR.VELQTFESTRCLLELC..SNRASWWKRLLFGTSLCRLVRQVKEEYQSEFEHILSTCQGLFESLELGHHTVFQEKIVKALDFSSPGRAVAAIAFAAFILDRWN.TQTQ...LSPGYTLDYISLQLWRFW..LRR-RVY--ny........
H9AAV3_9ADEN/31-164 .........MDLR.VELQTFESTRCLLELC..SNRASWWKRLLFGTSLCRLVRQVKEEYQSEFEHILSTCQGLFESLELGHHTVFQEKIVKALDFSSPGRAVAAIAFAAFILDRWN.TQTQ...LSPGYTLDYISLQLWRFW..LRR-RVY--ny........
A0A097IW62_9ADEN/1-135 .........MDLD.RVLENYNSLRKVVEEA..SEQTSGWWRKLFGCRLSCLVVQAKFEYREEFERLFAEVPGLLESLNFCHHAVFYEKIICSLDFCTPGRTIAALAFCTYILDRWN.KETH...LSAGYTLDYITLQLWKAY..MRKGK----iytf......
A0A1Y0B6F3_9ADEN/1-137 .........MDHL.DILIDLRLLRSVIAGA..SNRTGAWKRRLWLGRLTQLVHNICSENQESFLNSLPGNANFLRLLRTGYFEVYDVFVVPELHLDSPGRVVAALALLVFILNDLD.AHSAasgFDSGFLIDRLCVPLWLKA..---------raykitqs..
A0A1J0FAP3_9ADEN/1-135 .........MDLF.SMCADYSSFRYILRGS..LCGSSWVRKWCFPA-LADAITGIADDYEDGYWRAFPPDDINWNLLRRGYTFAAFTDLFSSVDLGNAGRFMSFLGFLNFILRNWP.SDSV...VLSADRLDLICVPAWTKI.mLWSQTMR--qm........
E1BS_ADE40/1-135 .........MELW.SELQSYQNLRRLLELA..SARTSSCWRILFGSTLTNVIYRAKEEYSSRFADLLSHNPGIFASLNLGHHSFFQEIVIRNLDFSSPGRTVSGLAFICFILDQWS.AQTH...LSQGYTLDYMAMALWRTL..LRRKRVL--gc........
A0A2H5AI99_9ADEN/1-134 .........MDLL.KELRDFDVVRQLLESA..SDKTSKFWRFCFGSTLSNVVYRVKKEQAEQFSRLLAEIPGVFVALDLGHHALFQEKVIKSLTFSSPGRVVTSLAFICHLLDKWS.SDSH...LSWNYMLDYLSMAVWRAM..LRK-RVCI-y.........
E1BS_ADE02/1-135 .........MEAW.ECLEDFSAVRNLLEQS..SNSTSWFWRFLWGSSQAKLVCRIKEDYKWEFEELLKSCGELFDSLNLGHQALFQEKVIKTLDFSTPGRAAAAVAFLSFIKDKWS.EETH...LSGGYLLDFLAMHLWRAV..VRHKNRL--ll........
Q6QPF3_9ADEN/1-137 .........MEIW.TVLEDFHQTRQLLENS..SEGVSYLWRFCFGGPLAKLVYRAKQDYKEQFEDILRECPGIFDSLNLGHQSHFNQSILRALDFSTPGRTTAAVAFFAFILDKWS.QETH...FSRDYRLDCLAVALWRTWrcQRL------naisgy....
A0A7H0S529_9ADEN/1-133 .........MDLLdHILADYSYLRHLVQQT..AKGLSWWQRYLWGSALLVTVEDILQKHESSFG-AFDHVQQACDDLRSGDPTAVLEQILPVVPLHTPGHVLTGIAFCAYLVRRCS.IGTP...LTPGFILDTICLHLWLML..-RRDA----frr.......
Q5GFC8_ADE04/1-137 .........MEIW.TVLEDFHKTRQLLENA..SNGVSYLWRFCFGGDLAKLVYRAKQDYREQFEDILRECPGLFDALNLGHQSHFNQRISRALDFTTPGRTTAAVAFFAFIFDKWS.QETH...FSRDYQLDFLAVALWRTWkcQRLN-----aisgy.....
A0A1X9RIT9_9ADEN/1-139 meraidipf----.----SFQGLRHILTLSykASKSSWFWRKFCTPSLILAIVDAKESYAEDFNSFLTTDFCLQSFLDTLDWPSLEKSLIPNLDFSSPGRAIASLAFLSSIIDRLE.FATV...FTPSYLIENFSFAVWRWA..---------itltkesrts
A0A059XJ33_9ADEN/1-131 ........m----.EQLKDYSFFKEVVEHA..SLRTGNLYRFFFSSSLAKVVFQVYLEKVGEFDR-LDSTASALLALSQGNNFLFEKLIIPELPFYSFGHILASLAFCSFCVNKAD.ISAT...VSSGFILDAVCRPAWQKF..MMSHNM---men.......
A0A1J0MUK8_9ADEN/1-135 .........MDPL.KICENYLTFRSIIKGS..TFSPGVFRRWRFHA-LADVVGNIVEREEGRFWEIVPETHTLWALFRGGFTVAPFTEILTSLQLENRGRQLAFLAFLSFLLRNWP.SDSV...VSEDARLDLVCAPAWSRI.qIWSQAARL-i.........
A0A2Z4QJM3_9ADEN/1-136 .........MDFL.RVFLQYSRVRELVRGV..SARTGVWWRRIFYSRLINFIHQVKVDYWQEFARLAPEDAPFMRGLKEGNVFLLKGFISGHLSFENPGRFVVAVAFLGYVFDQWDrSNTV...FSADFLLEFVSVELWLAV..RRY------ytqmmd....
A0A898KBR0_ADE41/1-135 .........MEFW.SELQSYQSLRRLLELA..SARTSSCWRFIFGSTLTNVIYRAKEDYSSRFAELLSFNPGIFASLNLGHHSFFQEIVIKNLDFSSPGRTVSGLAFICFILDQWS.AQTH...LSEGYTLDYMTMALWRTL..LRRKRVL--gc........
E7CH29_9ADEN/1-132 .........MDLL.KHLSEYKVLRDLVLES..SSFKPWWWRR---RGLSNLVRETIEKFRTEYEEVLGQ--VFFTRLNHQDFFLYHYVIREELDLSTPGHQISGISFVVYVLERWAlLEQR...FGRDYLVDSLVFPLYQRV..-RS------elrwqsrq..
Q32UI6_9ADEN/1-137 .........MEVW.AILEDLRKTRQLLENA..SDGVSGFWRFWFASELARVVFRIKQDYKEEFEKLLVDCPGLFEALNLGHQVHFKEKVLSVLDFSTPGRTAAAVAFLTFILDKWI.PQTH...FSRGYVLDFVATALWRTW.kVRKMR----tilgy.....
Q6H1D7_9ADEN/1-137 .........MEIW.TVLEDFHKTRQLLENA..SNGVSYLWRFCFGGDLAKLVYRAKQDYREQFEDILRECPGLFDALNLGHQSHFNQRISRALDFTTPGRTTAAVAFFAFIFDKWS.QETH...FSRDYQLDFLAVALWRTWkcQRLN-----aisgy.....
A0A0M5L3Y4_9ADEN/1-135 .........MDLL.GDLREFGVVRRLLELA..SDRTSKFWRFCFGSTLSNVLYRVKKEQETQFARLLADTPGVFVALDLGHHSLFQEKIIKNLTFTSPGRTVASAAFITYILDQWSnSDSH...LSWEYMLDYMAMALWRAM..LRR-RVCI-y.........
A0A6M4W5T4_9ADEN/1-135 .........MEAW.ECLEDFSAVRNLLEQS..SNSTSWFWRFLWGSSQAKLVCRIKEDYKWEFEELLKSCGELFDSLNLGHQALFQEKVIKTLDFSTPGRAAAAVAFLSFIKDKWS.EETH...LSGGYLLDFLAMHLWRAV..VRHKNRL--ll........
A0A2H5AI21_9ADEN/1-135 .........MDLL.GDLREFGVVRRLLELA..SDRTSKFWRFCFGSTLSNVLYRVKKEQETQFARLLADTPGVFVALDLGHHSLFQEKIIKNLTFTSPGRTVASAAFITYILDQWSnSDSH...LSWEYMLDYMAMALWRAM..LRR-RVCI-y.........
A0A0M4NHE0_9ADEN/36-169 .........MDLR.AELQTFESTRRLVELC..SNRSSWFGRFLFGSTLCRVVRQVKEEYQSEFEHILSNCPGLFVSLDLGHHTVFQEKIVKALDFSSPGRAVAAIAFAAFLLDRWN.AQTQ...LSPGYTLDYISLQLWRFW..LRR-RVY--ny........
B2VQE3_9ADEN/1-137 .........MDVW.TILADFSKTRRLVEDS..SDGCSGFWRHWFGTPLSRLVYTVKKDYNEEFENLFADCSGLLDSLNLGHQSLFQERVLHSLDFSSPGRTTAGVAFVVFLVDKWS.QNTQ...LSRGYILDFAAMHLWRAWvrQRGQRI---lny.......
A0A0K1DBT8_ADEE2/1-131 .........MDLM.-KLLDFKEFKRCVYLA..SNRCRWWEKI-FCTRFIKFVRQIKKENFLEFAELILCNTAFSSCLKSGQVSLFHNTVLCELDFSNPGRVVTNLAFLSYLIDMWD.QVDV...FSHEFILESVCFPAWQRF..N--------qtqpkg....
A0A6H1TFX1_9ADEN/1-137 .........MELA.EYLENFAVLRRVLYQS..SDRYGDWWRWLTGYKLARLVHEVRAEHRYSFEALCGD--EVLQRLLRDQGRRLEPFFHSVLDFSTAGRSVTSLAFAVHVLGALT.RDGRgqpLSDDFWLDTVCVAVHRAI..---------cltlqchrrr
A0A6M6AEV2_9ADEN/1-135 .........MELW.SELQSYQNLRRLLELA..SARTSSCWRILFGSTLTNVIYRAKEEYSSRFADLLSHNPGIFASLNLGHHSFFQEIVIRNLDFSSPGRTVSGLAFICFILDQWS.AQTH...LSQGYTLDYMAMALWRTL..LRRKRVL--gc........
B9A5T7_9ADEN/1-137 .........MDVW.TILADFSKTRRLVEDS..SDGCSGFWRHWFGTPLSRLVYTVKKDYNEEFENLFADCSGLLDSLNLGHQSLFQERVLHSLDFSSPGRTTAGVAFVVFLVDKWS.QNTQ...LSRGYILDFAAMHLWRAWvrQRGQRI---lny.......
E1BS_ADE12/1-134 .........MELE.TVLQSFQSVRQLLQYT..SKNTSGFWRYLFGSTLSKVVNRVKEDYREEFENILADCPGLLASLDLCYHLVFQEKVVRSLDFSSVGRTVASIAFLATILDKWS.EKSH...LSWDYMLDYMSMQLWRAW..LKR-RVCI-y.........
#=GC seq_cons .........M-lh.phLp-apphRpLLEtu..SspsShaWRahFGosLuclVhclKc-YppcFpclLssssulasuLsLGHpshFpEcllpsLDFSoPGRssAulAFlsFILD+Ws.ppTp...lStuYhLDaluhsLWRsh..hRp.t....hh........
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