#=GF ID Adeno_E1B_55K_N
#=GF AC PF04623.16
#=GF DE Adenovirus E1B protein N-terminus
#=GF AU Kerrison ND;0000-0002-1471-953X
#=GF AU Bashton M;0000-0002-6847-1525
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE DOMO:DM04583;
#=GF GA 25.00 25.00;
#=GF TC 29.90 31.90;
#=GF NC 23.10 21.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 10207064
#=GF RT Corepressor required for adenovirus E1B 55,000-molecular-weight
#=GF RT protein repression of basal transcription.
#=GF RA Martin ME, Berk AJ;
#=GF RL Mol Cell Biol 1999;19:3403-3414.
#=GF DR INTERPRO; IPR006717;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family constitutes the amino termini of E1B 55 kDa
#=GF CC (Pfam:PF01696). E1B 55K binds p53 the tumour suppressor protein
#=GF CC converting it from a transcriptional activator which responds to
#=GF CC damaged DNA in to an unregulated repressor of genes with a p53
#=GF CC binding site [1]. This protects the virus against p53 induced
#=GF CC host antiviral responses and prevents apoptosis as induced by
#=GF CC the by the adenovirus E1A protein [1]. The role of the N
#=GF CC terminus in the function of E1B is not known.
#=GF SQ 22
#=GS Q5GFC6_ADE04/1-71 AC Q5GFC6.1
#=GS A0A6M6ADD8_9ADEN/1-60 AC A0A6M6ADD8.1
#=GS A0A516UYP1_9ADEN/1-71 AC A0A516UYP1.1
#=GS A0A0M3TGZ6_9ADEN/1-73 AC A0A0M3TGZ6.1
#=GS Q6H1D6_9ADEN/1-71 AC Q6H1D6.1
#=GS A0A411LD92_ADE41/1-64 AC A0A411LD92.1
#=GS B9A5T8_9ADEN/1-70 AC B9A5T8.1
#=GS B2VQE4_9ADEN/1-70 AC B2VQE4.1
#=GS H9AAV4_9ADEN/1-70 AC H9AAV4.1
#=GS E1B55_ADE12/1-65 AC P04491.1
#=GS Q6QPF2_9ADEN/1-76 AC Q6QPF2.1
#=GS Q2KS84_9ADEN/1-68 AC Q2KS84.1
#=GS E1B55_ADE02/1-65 AC P03244.2
#=GS A0A2H5AI55_9ADEN/1-73 AC A0A2H5AI55.1
#=GS A0A0M3TH04_9ADEN/1-70 AC A0A0M3TH04.1
#=GS A0A384ZUP3_9ADEN/1-70 AC A0A384ZUP3.1
#=GS C3UZJ4_9ADEN/1-69 AC C3UZJ4.1
#=GS A0A5J6SF81_ADE01/1-71 AC A0A5J6SF81.1
#=GS A0A2H5AI97_9ADEN/1-66 AC A0A2H5AI97.1
#=GS H9AAN9_9ADEN/1-70 AC H9AAN9.1
#=GS A0A6M6AA48_9ADEN/1-69 AC A0A6M6AA48.1
#=GS E1B55_ADE40/1-60 AC P10545.1
Q5GFC6_ADE04/1-71 ...MESRNPFQQGLPAGFLSSSFVENMEVPAPECNLRLLAGTAARHSEDPESPAaGGSR....RE....SESRP..------.---gpsgggva..............
A0A6M6ADD8_9ADEN/1-60 ...MERPNSSVAGLYSGLHGNGSVENL--ATEEEGLRLLAGAASARFGSS----.--A-....GR....GGGGG..------.---epegrpg...............
A0A516UYP1_9ADEN/1-71 ...MERRNPSERGVPAGFSGHASVESGGETQE-------SPATVVFRPPGNNTD.GRAAaaaaAA....AGGSQaaAAAGAEpMEP......................
A0A0M3TGZ6_9ADEN/1-73 meq--QRQPPVVGVHAGLHGDGSVEGH--AAE-EGLHLLAGAASAAGPSG----.----....--....--GGE.rAGGDRE.S--esrpgpssgrlgaeddp.....
Q6H1D6_9ADEN/1-71 ...MESRNPFQQGLPAGFLSSSFVENMEVPAPECNLRLLAGTAARHSEDPESPAaGGSR....RE....SESRP..------.---gpsgggva..............
A0A411LD92_ADE41/1-64 ...MERPNPSVGGVYSGLHDNGPVENP--AAEEEGLRLLAGAASARSGSS----.--AG....GG....GGGGE..------.---pegrsgssng............
B9A5T8_9ADEN/1-70 ...MEPEHPTEQGLHSGLRSHAPVEGMGEAAGTENLELLAYTAS---SSGSSSS.TQTN....IH....VGGRN.eAGHGREpEE-r.....................
B2VQE4_9ADEN/1-70 ...MEPEHPTEQGLHSGLRSHAPVEGMGEAAGTENLELLAYTAS---SSGSSSS.TQTN....IH....VGGRN.eAGHGREpEE-r.....................
H9AAV4_9ADEN/1-70 ...MEHPDPAVPGVHPGLHQPAAVEVL--AAP-AGLQLLAGAASARAGIV-AGG.AVAG....GE....AGGGG..AGGGA-.---gagasaa...............
E1B55_ADE12/1-65 ...MEREIPPELGLHAGLHVNAAVEGM---AEEEGLHLLAGAA----FDHAAAA.DVAR....GE....GGGAE..PCGGGE.VNMe.....................
Q6QPF2_9ADEN/1-76 ...MESRNPFQQGLPSGLLSSSFVENMEVPAPECNLRLLASTAGRHAEDPESPV.TPG-....--....-----..------.---tptppaaaagaaarggprrepe
Q2KS84_9ADEN/1-68 ...MDPPNPLQQGIRFGFHSSSFVENMEGSQDEDNLRLLASAASGSSRDTETPT.GHA-....--....SGSGG..GAAGGQ.SES......................
E1B55_ADE02/1-65 ...MERRNPSERGVPAGFSGHASVESGGETQE-------SPATVVFRPPGNNTD.GGA-....TA....GGSQA.aAAAGAEpMEP......................
A0A2H5AI55_9ADEN/1-73 meq--QRQPPVVGVHAGLHGDGSVEGH--AAE-EGLHLLAGAASAAGPSG----.----....--....--GGE.rAGGDRE.S--esrpgpssgrlgaeddp.....
A0A0M3TH04_9ADEN/1-70 ...MERPDPAVPGVHPGLHQLAAVEVL--AAP-AGLQLLAGAASARAGVGGGGA.FGG-....IQ....AGGEP.gGAGGGE.---ggsaa.................
A0A384ZUP3_9ADEN/1-70 ...MEPGHPTEQGLHPGLRSHAPVEGLDQAAGTENLELLASTAS---SSGSSSS.TQTN....IH....VGGRN.eAGHGREpEE-r.....................
C3UZJ4_9ADEN/1-69 ...MDPADSFQQGIRFGFRSHSIVENMEGSQDEDNLRLLASAAFGCSGNPEAST.GHA-....--....SGSGG..GTARG-.---qpesr.................
A0A5J6SF81_ADE01/1-71 ...MERRNPSERGVPAGFSGHASVESGGETQE-------SPATVVFRPPGNNTD.GGAA....AAaaggAGGSQaaAAAGAEpMEP......................
A0A2H5AI97_9ADEN/1-66 ...MEQRQPPVMELHAGLPVDGGVEGH---AEEEGLHILAGAASAVGSSGGG--.GR--....--....-----..AGG---.---nrqsesrpgpssgrl.......
H9AAN9_9ADEN/1-70 ...MEHPDPAVPGVHPGLHQPAAVEVL--AAP-AGLQLLAGAASARAGIV-AGG.AVAG....GE....AGGGG..AGGGA-.---gagasaa...............
A0A6M6AA48_9ADEN/1-69 ...MERRNPSERGVPAGFSGHASVESGGETQE-------SPATVVFRPPGNNTD.GGAAa..aAA....AGGNQaaAAAGAEpMEP......................
E1B55_ADE40/1-60 ...MERPNSSVAGLYSGLHGNGSVENL--ATEEEGLRLLAGAASARFGSS----.--A-....GR....GGGGG..------.---epegrpg...............
#=GC seq_cons ...MEptsPs.tGlhuGL+upusVEsh..sAt.psLcLLAuAAushtssutsss.s.u.....ht....uGGtt..uutst.....t.....................
//
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