GenomeNet

Database: Pfam
Entry: Adeno_E1B_55K_N
LinkDB: Adeno_E1B_55K_N
Original site: Adeno_E1B_55K_N 
#=GF ID   Adeno_E1B_55K_N
#=GF AC   PF04623.16
#=GF DE   Adenovirus E1B protein N-terminus
#=GF AU   Kerrison ND;0000-0002-1471-953X
#=GF AU   Bashton M;0000-0002-6847-1525
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   DOMO:DM04583;
#=GF GA   25.00 25.00;
#=GF TC   29.90 31.90;
#=GF NC   23.10 21.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10207064
#=GF RT   Corepressor required for adenovirus E1B 55,000-molecular-weight
#=GF RT   protein repression of basal transcription. 
#=GF RA   Martin ME, Berk AJ; 
#=GF RL   Mol Cell Biol 1999;19:3403-3414.
#=GF DR   INTERPRO; IPR006717;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family constitutes the amino termini of E1B 55 kDa
#=GF CC   (Pfam:PF01696). E1B 55K binds p53 the tumour suppressor protein
#=GF CC   converting it from a transcriptional activator which responds to
#=GF CC   damaged DNA in to an unregulated repressor of genes with a p53
#=GF CC   binding site [1]. This protects the virus against p53 induced
#=GF CC   host antiviral responses and prevents apoptosis as induced by
#=GF CC   the by the adenovirus E1A protein [1]. The role of the N
#=GF CC   terminus in the function of E1B is not known.
#=GF SQ   22
#=GS Q5GFC6_ADE04/1-71      AC Q5GFC6.1
#=GS A0A6M6ADD8_9ADEN/1-60  AC A0A6M6ADD8.1
#=GS A0A516UYP1_9ADEN/1-71  AC A0A516UYP1.1
#=GS A0A0M3TGZ6_9ADEN/1-73  AC A0A0M3TGZ6.1
#=GS Q6H1D6_9ADEN/1-71      AC Q6H1D6.1
#=GS A0A411LD92_ADE41/1-64  AC A0A411LD92.1
#=GS B9A5T8_9ADEN/1-70      AC B9A5T8.1
#=GS B2VQE4_9ADEN/1-70      AC B2VQE4.1
#=GS H9AAV4_9ADEN/1-70      AC H9AAV4.1
#=GS E1B55_ADE12/1-65       AC P04491.1
#=GS Q6QPF2_9ADEN/1-76      AC Q6QPF2.1
#=GS Q2KS84_9ADEN/1-68      AC Q2KS84.1
#=GS E1B55_ADE02/1-65       AC P03244.2
#=GS A0A2H5AI55_9ADEN/1-73  AC A0A2H5AI55.1
#=GS A0A0M3TH04_9ADEN/1-70  AC A0A0M3TH04.1
#=GS A0A384ZUP3_9ADEN/1-70  AC A0A384ZUP3.1
#=GS C3UZJ4_9ADEN/1-69      AC C3UZJ4.1
#=GS A0A5J6SF81_ADE01/1-71  AC A0A5J6SF81.1
#=GS A0A2H5AI97_9ADEN/1-66  AC A0A2H5AI97.1
#=GS H9AAN9_9ADEN/1-70      AC H9AAN9.1
#=GS A0A6M6AA48_9ADEN/1-69  AC A0A6M6AA48.1
#=GS E1B55_ADE40/1-60       AC P10545.1
Q5GFC6_ADE04/1-71                 ...MESRNPFQQGLPAGFLSSSFVENMEVPAPECNLRLLAGTAARHSEDPESPAaGGSR....RE....SESRP..------.---gpsgggva..............
A0A6M6ADD8_9ADEN/1-60             ...MERPNSSVAGLYSGLHGNGSVENL--ATEEEGLRLLAGAASARFGSS----.--A-....GR....GGGGG..------.---epegrpg...............
A0A516UYP1_9ADEN/1-71             ...MERRNPSERGVPAGFSGHASVESGGETQE-------SPATVVFRPPGNNTD.GRAAaaaaAA....AGGSQaaAAAGAEpMEP......................
A0A0M3TGZ6_9ADEN/1-73             meq--QRQPPVVGVHAGLHGDGSVEGH--AAE-EGLHLLAGAASAAGPSG----.----....--....--GGE.rAGGDRE.S--esrpgpssgrlgaeddp.....
Q6H1D6_9ADEN/1-71                 ...MESRNPFQQGLPAGFLSSSFVENMEVPAPECNLRLLAGTAARHSEDPESPAaGGSR....RE....SESRP..------.---gpsgggva..............
A0A411LD92_ADE41/1-64             ...MERPNPSVGGVYSGLHDNGPVENP--AAEEEGLRLLAGAASARSGSS----.--AG....GG....GGGGE..------.---pegrsgssng............
B9A5T8_9ADEN/1-70                 ...MEPEHPTEQGLHSGLRSHAPVEGMGEAAGTENLELLAYTAS---SSGSSSS.TQTN....IH....VGGRN.eAGHGREpEE-r.....................
B2VQE4_9ADEN/1-70                 ...MEPEHPTEQGLHSGLRSHAPVEGMGEAAGTENLELLAYTAS---SSGSSSS.TQTN....IH....VGGRN.eAGHGREpEE-r.....................
H9AAV4_9ADEN/1-70                 ...MEHPDPAVPGVHPGLHQPAAVEVL--AAP-AGLQLLAGAASARAGIV-AGG.AVAG....GE....AGGGG..AGGGA-.---gagasaa...............
E1B55_ADE12/1-65                  ...MEREIPPELGLHAGLHVNAAVEGM---AEEEGLHLLAGAA----FDHAAAA.DVAR....GE....GGGAE..PCGGGE.VNMe.....................
Q6QPF2_9ADEN/1-76                 ...MESRNPFQQGLPSGLLSSSFVENMEVPAPECNLRLLASTAGRHAEDPESPV.TPG-....--....-----..------.---tptppaaaagaaarggprrepe
Q2KS84_9ADEN/1-68                 ...MDPPNPLQQGIRFGFHSSSFVENMEGSQDEDNLRLLASAASGSSRDTETPT.GHA-....--....SGSGG..GAAGGQ.SES......................
E1B55_ADE02/1-65                  ...MERRNPSERGVPAGFSGHASVESGGETQE-------SPATVVFRPPGNNTD.GGA-....TA....GGSQA.aAAAGAEpMEP......................
A0A2H5AI55_9ADEN/1-73             meq--QRQPPVVGVHAGLHGDGSVEGH--AAE-EGLHLLAGAASAAGPSG----.----....--....--GGE.rAGGDRE.S--esrpgpssgrlgaeddp.....
A0A0M3TH04_9ADEN/1-70             ...MERPDPAVPGVHPGLHQLAAVEVL--AAP-AGLQLLAGAASARAGVGGGGA.FGG-....IQ....AGGEP.gGAGGGE.---ggsaa.................
A0A384ZUP3_9ADEN/1-70             ...MEPGHPTEQGLHPGLRSHAPVEGLDQAAGTENLELLASTAS---SSGSSSS.TQTN....IH....VGGRN.eAGHGREpEE-r.....................
C3UZJ4_9ADEN/1-69                 ...MDPADSFQQGIRFGFRSHSIVENMEGSQDEDNLRLLASAAFGCSGNPEAST.GHA-....--....SGSGG..GTARG-.---qpesr.................
A0A5J6SF81_ADE01/1-71             ...MERRNPSERGVPAGFSGHASVESGGETQE-------SPATVVFRPPGNNTD.GGAA....AAaaggAGGSQaaAAAGAEpMEP......................
A0A2H5AI97_9ADEN/1-66             ...MEQRQPPVMELHAGLPVDGGVEGH---AEEEGLHILAGAASAVGSSGGG--.GR--....--....-----..AGG---.---nrqsesrpgpssgrl.......
H9AAN9_9ADEN/1-70                 ...MEHPDPAVPGVHPGLHQPAAVEVL--AAP-AGLQLLAGAASARAGIV-AGG.AVAG....GE....AGGGG..AGGGA-.---gagasaa...............
A0A6M6AA48_9ADEN/1-69             ...MERRNPSERGVPAGFSGHASVESGGETQE-------SPATVVFRPPGNNTD.GGAAa..aAA....AGGNQaaAAAGAEpMEP......................
E1B55_ADE40/1-60                  ...MERPNSSVAGLYSGLHGNGSVENL--ATEEEGLRLLAGAASARFGSS----.--A-....GR....GGGGG..------.---epegrpg...............
#=GC seq_cons                     ...MEptsPs.tGlhuGL+upusVEsh..sAt.psLcLLAuAAushtssutsss.s.u.....ht....uGGtt..uutst.....t.....................
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