#=GF ID Adeno_L433K_22K
#=GF AC PF11081.12
#=GF DE Adenovirus L4-33K/L4-22K
#=GF PI DUF2890;
#=GF AU Mistry J;0000-0003-2479-5322
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE Pfam-B_629 (release 23.0)
#=GF GA 19.20 19.20;
#=GF TC 19.20 19.20;
#=GF NC 19.10 18.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 19176628
#=GF RT Adenovirus serotype 5 L4-22K and L4-33K proteins have distinct
#=GF RT functions in regulating late gene expression.
#=GF RA Morris SJ, Leppard KN;
#=GF RL J Virol. 2009;83:3049-3058.
#=GF RN [2]
#=GF RM 17028184
#=GF RT L4-33K, an adenovirus-encoded alternative RNA splicing factor.
#=GF RA Tormanen H, Backstrom E, Carlsson A, Akusjarvi G;
#=GF RL J Biol Chem. 2006;281:36510-36517.
#=GF RN [3]
#=GF RM 16809303
#=GF RT The L4 22-kilodalton protein plays a role in packaging of the
#=GF RT adenovirus genome.
#=GF RA Ostapchuk P, Anderson ME, Chandrasekhar S, Hearing P;
#=GF RL J Virol. 2006;80:6973-6981.
#=GF RN [4]
#=GF RM 2363740
#=GF RT Decreased activity of Reiter's syndrome after urethrectomy.
#=GF RA Rubin RA, Goldfarb RA, Lidsky MD, Abrams J;
#=GF RL Arthritis Rheum. 1990;33:885-887.
#=GF RN [5]
#=GF RM 22811519
#=GF RT The adenovirus L4-22K protein is multifunctional and is an
#=GF RT integral component of crucial aspects of infection.
#=GF RA Wu K, Orozco D, Hearing P;
#=GF RL J Virol. 2012;86:10474-10483.
#=GF DR INTERPRO; IPR021304;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Adenoviruses express up to 20 distinct mRNAs from five major
#=GF CC late transcription unit (MLTU) regions, L1 to L5. The L4 region
#=GF CC expresses L4-33K and a related protein, L4-22K [1]. L4-22K and
#=GF CC L4-33K have complementary but not redundant functions that
#=GF CC provide the normal pattern of mRNA production during the late
#=GF CC phase of infection [1]. L4-33K is an alternative RNA splicing
#=GF CC factor that up-regulates several MLTU splice acceptor sites as
#=GF CC the late phase progresses [1,2]. L4-22K plays a role in genome
#=GF CC packaging via its binding, in association with IVa2, to the A2
#=GF CC sequence within the packaging signal [3]. Additionally, L4-22K
#=GF CC plays an important role in the temporal switch from the early to
#=GF CC late phase of infection by regulating both early and late gene
#=GF CC expression [4,5].
#=GF SQ 63
#=GS Q997H5_ADEB4/89-134 AC Q997H5.1
#=GS E7CH46_9ADEN/1-160 AC E7CH46.1
#=GS A0A0M4MEU4_9ADEN/14-213 AC A0A0M4MEU4.1
#=GS A4H3D8_LEIBR/558-685 AC A4H3D8.2
#=GS A0A6N3IR72_9ADEN/32-205 AC A0A6N3IR72.1
#=GS Q83891_ADEO7/87-133 AC Q83891.2
#=GS Q32UG9_9ADEN/138-223 AC Q32UG9.1
#=GS B6JGR9_AFIC5/99-245 AC B6JGR9.1
#=GS A0A516UYQ0_9ADEN/1-224 AC A0A516UYQ0.1
#=GS E7CH47_9ADEN/16-191 AC E7CH47.1
#=GS C3UZK9_9ADEN/5-169 AC C3UZK9.1
#=GS Q5GFA4_ADE04/4-210 AC Q5GFA4.1
#=GS A0A097IWD0_9ADEN/124-206 AC A0A097IWD0.1
#=GS A0A223PYS1_9ADEN/88-137 AC A0A223PYS1.1
#=GS SF33K_ADE40/14-208 AC P11805.2
#=GS A0A516UYS3_9ADEN/1-179 AC A0A516UYS3.1
#=GS A0A5J6SG94_ADE01/1-179 AC A0A5J6SG94.1
#=GS A0A1L5LC47_9ADEN/15-179 AC A0A1L5LC47.1
#=GS A0A0M4N3T3_9ADEN/14-187 AC A0A0M4N3T3.1
#=GS A0A5P9VI50_9ADEN/29-154 AC A0A5P9VI50.1
#=GS Q83891_ADEO7/48-95 AC Q83891.2
#=GS A0A3Q9HKN0_9ADEN/1-179 AC A0A3Q9HKN0.1
#=GS Q32UG9_9ADEN/5-148 AC Q32UG9.1
#=GS Q2KSA8_9ADEN/5-224 AC Q2KSA8.1
#=GS A0A225WIP1_9STRA/416-508 AC A0A225WIP1.1
#=GS A0A0M4MQH3_9ADEN/14-178 AC A0A0M4MQH3.1
#=GS A0A1J0FAQ9_9ADEN/2-160 AC A0A1J0FAQ9.1
#=GS B9A5Z0_9ADEN/2-137 AC B9A5Z0.1
#=GS A0A0M5L5L8_9ADEN/14-196 AC A0A0M5L5L8.1
#=GS A0A2Z4QJ49_9ADEN/19-107 AC A0A2Z4QJ49.1
#=GS H9AAW9_9ADEN/14-185 AC H9AAW9.1
#=GS A0A3Q9HJU3_9ADEN/1-224 AC A0A3Q9HJU3.1
#=GS Q64859_ADE40/10-180 AC Q64859.1
#=GS E0YC72_9ADEN/30-195 AC E0YC72.1
#=GS 33K_ADES1/23-179 AC A9CB92.1
#=GS H9AAQ4_9ADEN/14-185 AC H9AAQ4.1
#=GS Q5GFA3_ADE04/4-170 AC Q5GFA3.1
#=GS A0A223PYS1_9ADEN/49-97 AC A0A223PYS1.1
#=GS A0A384ZUP6_9ADEN/2-171 AC A0A384ZUP6.1
#=GS A0A6M6AEB7_9ADEN/10-180 AC A0A6M6AEB7.1
#=GS PKG2_ADE02/1-178 AC P0DJX1.1
#=GS A0A163HIM3_9ADEN/30-206 AC A0A163HIM3.1
#=GS Q6QPD6_9ADEN/4-218 AC Q6QPD6.1
#=GS A0A7R7FSS2_ADEB7/93-135 AC A0A7R7FSS2.1
#=GS A0A7H0S547_9ADEN/29-119 AC A0A7H0S547.1
#=GS A0A076FYV9_9ADEN/19-177 AC A0A076FYV9.1
#=GS B2VQG0_9ADEN/2-137 AC B2VQG0.1
#=GS A0A161DY84_9ADEN/47-248 AC A0A161DY84.1
#=GS SF33K_ADE02/1-225 AC P24939.1
#=GS Q997H5_ADEB4/40-94 AC Q997H5.1
#=GS C9SVH0_VERA1/30-189 AC C9SVH0.1
#=GS A0A7R7FSS2_ADEB7/48-97 AC A0A7R7FSS2.1
#=GS Q6H1B9_9ADEN/4-170 AC Q6H1B9.1
#=GS A0A097DBP2_9ADEN/4-127 AC A0A097DBP2.1
#=GS A0A6M6AB38_9ADEN/14-208 AC A0A6M6AB38.1
#=GS A0A1P8SW71_9ADEN/10-110 AC A0A1P8SW71.1
#=GS A0A384ZUR3_9ADEN/2-137 AC A0A384ZUR3.1
#=GS A0A135UYP2_9PEZI/151-323 AC A0A135UYP2.1
#=GS A0A0A7JTJ4_9ADEN/96-143 AC A0A0A7JTJ4.1
#=GS Q2KSA7_9ADEN/5-179 AC Q2KSA7.1
#=GS A0A097IWC9_9ADEN/1-159 AC A0A097IWC9.1
#=GS A0A1X9RIX0_9ADEN/3-135 AC A0A1X9RIX0.1
#=GS A0A097IWD0_9ADEN/1-123 AC A0A097IWD0.1
Q997H5_ADEB4/89-134 ......................................................................krpe--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.-----.------.....-----.....-----.-.....----....................-----..............................................---....--.---..-----.-.....R.V.HQIRNRTPASIT..........KRYLYERDVKKLFQYLEDAKKLLAKY----qs.........................................................
E7CH46_9ADEN/1-160 mptkrpsgparrgghraavatysppeseaeevdpsdlssspsededdlegqtlsddsevseaswtdpeeeedqe--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.-----.------.....-----.....---TP.S.....ARAT....................SAAEPgqlse...................................lrehifPTI....YA.AFQ..QCRGG.HgglcsD.T.VKVRNRTLRSLT..........RSCLYHRKIEQLERTRKDAEELLQRLCA--rr.........................................................
A0A0M4MEU4_9ADEN/14-213 .......................................................................qra----KKQELLQQQV.....E......DEEE.LW.DSQAEEVSEGE.EE.-ME.....S.WD.S.......LD..E..EE......DelS..eEEATEEKP-....PAS...SAP.SLSRQ----..---.......-...-.PK.PRPPT.PPAGSL.....-KASR.....RWDAT.G.....SPAAaataaa.......ptkrsekK---Akassaarknsaaaaa................akdppateelrkrifPTL....YA.IFQ..QSRGQ.Hp...qR.E.LKIKNRSFRSLT..........RSCLYHKREDQLQRTLDDAEALFSKYCSA-s..........................................................
A4H3D8_LEIBR/558-685 ....................................................aqlhgchtastaaalgfstqtp--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---PLALVT..VPS.......A...A.TS.TAPLA.PPALPSw...kRGKLR.....RLAAP.S.....LGGAg.................lvGRKLP..............................................PTV....SA.AASiiQGRSP.R.....T.P.RSQREAHLMSLM..........RVALID--ARSVRSHLEELRALLPK-----hrsg.......................................................
A0A6N3IR72_9ADEN/32-205 .....................................................gnsgglplspipsvdgeslrs--------------.....-......----.--.-----------.--.--E.....E.ED.E.......EE..E..VE......E..E...EEEAEQTP-....PMA...TPP.ERSAE--ET..EGK.......V...N.TR.RSTAA.AANKAP.....RKANR.....AAAATkK.....TKTP....................QQHQQeqapkrsnfgvp.....................syqqhlaikheigEVL....EE.IRL..RSVSR.P.....DfV.PSIRNRTHPSIT..........KRYLYEKDLRKLQQFLDDSKKLLSKY----t..........................................................
Q83891_ADEO7/87-133 ......................................................................kkyp--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.-----.------.....-----.....-----.-.....----....................-----..............................................---....--.---..-----.E.....K.V.YQIRNRTPASIT..........KRYLYERDLKKLFQYLEDAKKLYAKY----qs.........................................................
Q32UG9_9ADEN/138-223 ........................................................yttsaatgglkitanepa--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.-----.------.....-----.....-----.Q.....TREL....................RNRIF..............................................PTL....YA.IFQ..QSRGQ.E.....Q.E.LKIKNRSLRSLT..........RSCLYHKSEDQLQRTLEDAEALFNKYCALT...........................................................
B6JGR9_AFIC5/99-245 ...................................................................spsfept-----------ARR.....T......SEDH.VD.DHEDEEVLEAE.ED.EAE.....DsLD.E.......AD..E..ED......E..A...EDIEIETESpplgPSM...DFV.PSMSERIGP..LSP.......R...A.VR.PAPEI.PVATVT.....APAGM.....RASTH.H.....SNGA....................DAYAP..............................................PGV....RQ.ELR..RKS--.-.....-.-.------------..........------------------------------lhtddqaklrsvlddlvgaralldr..................................
A0A516UYQ0_9ADEN/1-224 ..........................................................................MAPKKKLQL-PPPP.....T......DEEE.YW.DSQAEEVLDEE.EEdMME.....D.WE.S.......LD.eE..AS......E..A...EEVSDETPS....PSV...AFP.SPAPQKSAT..GPS.......M...A.TT.SAPQA.PPALPV.....RRPNR.....RWDTT.G.....TRAAptapaaa.....aataaatqKQRRPdsktltkpkkstaaaaaggg......alrlapnepvstrelrnrifPTL....YA.IFQ..QSRGQ.E.....Q.E.LKIKNRSLRSLT..........RSCLYHKSEDQLRRTLEDAEALFSKYCALT...........................................................
E7CH47_9ADEN/16-191 ..................................................................raavatys-----------PPE.....S......EAEE.VD.PSDLSSSPSED.ED.DLEgqtlsD.DS.E.......VS..E..AS......W..TdpeEEEDQEVQA....P--...ATP.APPPP----..VPV.......A...A.VA.AAPAA.PAKPTA.....ALPVR.....RWDSA.R.....SPAHg.................eqSSRRR..............................................GNL....PS.-TE..PPAAK.R.....S.W.RRYRYQIVEALFtfngdraaakRYLLFNRGVLVPAAVLKYYYH---------rhyrkp.....................................................
C3UZK9_9ADEN/5-169 ........................................................................re---SKKLKVQPPPP.....E......DMEE.DW.DSQAEEAEEDS.LE.DSL.....E.ED.S.......LE.eE..NE......E..A...EEVEEVTAD....KQL...---.SPAAE----..TSN.......S...A.II.SA---.PSRGTR.....RRPSS.....RWDET.G.....RFP-....................---NP..............................................TTA....SKtGKK..DRQGY.K.....S.W.RGHKNAIISCLHecggnisftrRYLLFHHGVNFPRNVLHYYRHLHSPYYSQ-q..........................................................
Q5GFA4_ADE04/4-210 ........................................................................gs---SKKLKVELPPV.....E......DLEE.DWeSSQAEEEEMED.WD.STQ.....A.ED.S.......LQ..D..SL......E..D...EEEAEEVEE...vAAA...ARP.SSSAEK---..ASS.......T...D.TI.SAPGR.GPA---.....-RPHS.....RWDET.G.....RFPNpttqta.......pttskkrQ---Kktkpaarkstaaaaggl...........riaanepaqtrelrnrifPTL....YA.IFQ..QSRGQ.E.....Q.E.LKVKNRSLRSLT..........RSCLYHKSEDQLQRTLEDAEALFNKYCALT...........................................................
A0A097IWD0_9ADEN/124-206 ..................................................................gnislpqq--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.-----.------.....---AK.....KQDSP.S.....TKEL....................RNRIF..............................................PTL....YA.IFQ..QSRGQ.E.....P.E.LKIKNRSLRSLT..........RSCLYHKNEEQLQRTLDDAEALFNKYCAST...........................................................
A0A223PYS1_9ADEN/88-137 .......................................................................qes--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.-----.------.....-----.....-----.-.....----....................-----..............................................---....--.---..-KKHP.E.....K.V.HQIRNRTPASIT..........KRYLYERDIKKLFQYLEDAKRLLVKY----qs.........................................................
SF33K_ADE40/14-208 ................................................................qsqqklqkqw--------------.....-......DEEE.TWdDSQAEEVSDEEaEE.QME.....S.WD.S.......LD..E..ED......L..-...EDVEEETIA....SDK...A--.---PSFKKP..VRS.......Q...P.PK.TIPPL.PPQPCS.....LKASR.....RWDTV.S.....IAGSptapaa.......ptkrlekT---Prvrktssaiatrq....................dspatqelrkrifPTL....YA.IFQ..QSRGQ.Q.....L.E.LKVKNRSLRSLT..........RSCLYHRSEDQLQRTLEDAEALFNKYCSV-s..........................................................
A0A516UYS3_9ADEN/1-179 ..........................................................................MAPKKKLQL-PPPP.....T......DEEE.YW.DSQAEEVLDEE.EEdMME.....D.WE.S.......LD.eE..AS......E..A...EEVSDETPS....PSV...AFP.SPAPQKSAT..GPS.......M...A.TT.SAPQA.PPALPV.....RRPNR.....RWDTT.G.....TRAG....................KSKQP..............................................PPL....AQ.EQQ..QRQGY.R.....S.W.RGHKNAIVACLQdcggnisfarRFLLYHHGVAFPRNILHYYRHLYSPYCTG-g..........................................................
A0A5J6SG94_ADE01/1-179 ..........................................................................MAPKKKLQL-PPPP.....T......DEEE.YW.DSQAEEVLDEE.EEdMME.....D.WE.S.......LD.eE..AS......E..A...EEVSDETPS....PSV...AFP.SPAPQKSAT..GPS.......M...A.TT.SAPQA.PPALPV.....RRPNR.....RWDTT.G.....TRAG....................KSKQP..............................................PPL....AQ.EQQ..QRQGY.R.....S.W.RGHKNAIVACLQdcggnisfarRFLLYHHGVAFPRNILHYYRHLYSPYCTG-g..........................................................
A0A1L5LC47_9ADEN/15-179 .............................................kgdahrtmeeeeedidgeslgsqdsvleg--------------.....-......----.--.-----------.--.---.....-.-E.T.......ED..E..ME......K..A...ELVEKETNI....QSKkksNHP.MSQKRKSKT.eVKN.......RarpA.ST.RSSSR.KSAIKK.....VREIA.....SAETD.E.....TLAI....................RSDIL..............................................HTL....VA.IDQ..YAREH.P....gR.K.IAIRNRTRESIT..........RQLHYEKNEDRLTRLQQDAHKLL-------dlwssa.....................................................
A0A0M4N3T3_9ADEN/14-187 .......................................................................rsk---KQERRLPQEPQ.....T......WDEE.SQ.DSWESQAATTE.EE.--E.....D.WEeS.......LG..E..TE......E..E...AEGTDEEPA....EEE...T-P.NAAAP-LRS..GAG.......S...K.TP.RTPPA.PPKLPP.....KKASR.....RWDAK.P.....SAPA....................AS-VG..............................................KMM....AG.QRR..QRGAY.C.....S.W.RAYKSDILACLLhcggnvsftrRYLLFHHGVAVPRNVLHYYRHLYSPFH---qqq........................................................
A0A5P9VI50_9ADEN/29-154 .....................................................................elrtp--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.--EQT.PKAKPV.....KK--R.....RWDLM.P.....EDAAaikdsfl......epagkrkAHRQPrprspsprpd.........................paikalqnqifPTL....YT.VFQ..QIQAQ.G....gK.Q.YTVRNRTFRSLV..........KSCLYHQSETQLRRTLEDADKLFQKYCG--aa.........................................................
Q83891_ADEO7/48-95 ..........................................................................TTIPKKMKF-----.....T......KNSS.VQ.SYQVHLPLKHE.--.IAE.....I.LE.K.......IR.lE..SK......K..Y...---------....---...---.---------..---.......-...-.--.-----.------.....-----.....-----.-.....----....................-----..............................................---....--.---..-----.-.....-.-.------------..........------------------------------pekvyq.....................................................
A0A3Q9HKN0_9ADEN/1-179 ..........................................................................MAPKKKLQLPPPPP.....T......DEEE.YW.DSQAEEVLDEE.EEdMME.....D.WE.S.......LD..E..AS......E..A...EEVSDETPS....PSV...AFP.SPAPQKLAT..VPS.......I...A.TT.SAPQA.PPALPV.....RRPNR.....RWDTT.G.....TRAG....................KSKQP..............................................PPL....AQ.EQQ..QRQGY.R.....S.W.RGHKNAIVACLQdcggnisfarRFLLYHHGVAFPRNILHYYRHLYSPYCTG-g..........................................................
Q32UG9_9ADEN/5-148 ........................................................................re---SKKLKVQPPPP.....E......DMEE.DW.DSQAEEAEEDS.LE.DSL.....E.ED.S.......LE.eE..NE......E..A...EEVEEVTAD....KQL...---.SPAAE----..TSN.......S...A.II.SA---.PSRGTR.....RRPSS.....RWDET.G.....RFPNp.................ttASKTA..............................................PTI....AS.KSR..QSRQK.K.....T.A.AATSNRKPAAAV..........KKY---------------------------ttsaatgglk.................................................
Q2KSA8_9ADEN/5-224 .......................................................................rgs----KKLKVQLSPP.....E......DMEE.DW.DSQAEEEMEDW.DS.QAE.....E.VD.S.......LE..E..DSleeedeE..A...EEVEEATAA....KQL...SS-.-AAETSKSP..DSS.......T...A.TI.SAPGR.---GAQ.....RRPNS.....RWDET.GrfpnpTTAS...................kTARQPrqkktaattvtrkpavrksttsaaggglritanepaqtrelrnrifPTL....YA.IFQ..QSRGQ.E.....Q.E.LKVKNRSLRSLT..........RSCLYHKSEDQLQRTLEDAEALFNKYCALT...........................................................
A0A225WIP1_9STRA/416-508 ..........................................................arkkeeddassdssdd--------------.....-......----.--.--------DFS.EE.LFE.....V.ES.R.......IT..E..LR......I..A...HEEAHKTVA....PPV...ATP.VKRERKFSTasVSS.......I...G.TA.SVTST.PTASPV.....RTFRR.....-----.-.....----....................-----..............................................---....--.---..-----.-.....-.-.------------..........------------------------------sgpwshdee..................................................
A0A0M4MQH3_9ADEN/14-178 .......................................................................qra----KKQELLQQQV.....E......DEEE.LW.DSQAEEVSEGE.EE.-ME.....S.WD.S.......LD..E..EE......DelS..eEEATEEKP-....PAS...SAP.SLSRQ----..---.......-...-.PK.PRPPT.PPAGSL.....-KASR.....RWDAT.G.....SPAA....................AATA-..............................................--A....GK.AKR..ERRGY.C.....S.W.RAHKSSIVNCLQhcggnisfarRYLLFHHGVAFPRNVLYYYRHLYSPYET--lg.........................................................
A0A1J0FAQ9_9ADEN/2-160 ....................................................................eethsl--------------.....-......----.--.--------SVE.EI.SEE.....D.LE.S.......LP..EltVP......E..S...EEALPEQRA....PRW...DQK.TKTPGRGST..FPTtsfititL...A.TT.AKKHR.RPATPP.....KRNRVaslttSEDTQ.Q.....TRQL....................RNRIF..............................................PTL....YA.IFQ..QSRGS.P.....T.A.FKIKNRSLRSLL..........KSCLYHKSEAQLLRTEDDAEALLNKYCQ--ae.........................................................
B9A5Z0_9ADEN/2-137 .....................................................................prkkq--------------.....-......----.--.-----EPLVEE.--.MEE.....E.WD.S.......QA..E..ED......E..W...EEETEEEDL....EEV...---.---EEEQAT..EQP.......V...A.AP.SAPAA.PPVTDTtsaapAKPPR.....RWDRV.K.....G---....................-----..............................................---....-D.GKH..ERQGY.R.....S.W.RAHKAAIIACLQdcggniafarRYLLFHRGVNIPRNVLHYYRHLHS------...........................................................
A0A0M5L5L8_9ADEN/14-196 .......................................................................rsk---KQERRLPQEPQ.....T......WDEE.SQ.DSWESQAATTE.EE.--E.....D.WEeS.......LG..E..TE......E..E...AEGTDEEPA....EEE...T-P.NAAAP-LRS..GAG.......S...K.TP.RTPPA.PPKLPP.....KKASR.....RWDAK.P.....SAPAasvgk.........mmagqrR---Qrgayc....................................strifPTL....YA.IFQ..QSRGQ.R.....H.E.LKIKNRTLRSLT..........RSCLYHRREDQLQRTLEDAEALFNKYCSA-t..........................................................
A0A2Z4QJ49_9ADEN/19-107 ..................................................................rdspvmes--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.-----.------.....-----.....RIQST.A.....QRPA....................RSKAQ..............................................TVHrrwdQK.EKQ..RGKSY.H.....S.W.RKHKSAILLCLTesngdisfarRYMLFKKGVLLPRNIIHYYN----------shrs.......................................................
H9AAW9_9ADEN/14-185 .......................................................................rsk---KQEQRLPPTPE.....T......WDEE.SQ.DSWESQAATTE.EE.DWE.....E.TS.S.......LG..E..AE......E..Q..pDEEQAEEET....PSA...AAP.SRSVA----..GP-.......-...K.TP.RPPAP.TPPLPP.....KKANR.....RWDAK.-.....TPAP....................AAPVG..............................................KML....VG.QRR..QRGAY.C.....S.W.RAYKSDILACLLhcggnvsftrRYLLFHRGVAVPRNVLHYYRHLYSPFH---qqq........................................................
A0A3Q9HJU3_9ADEN/1-224 ..........................................................................MAPKKKLQLPPPPP.....T......DEEE.YW.DSQAEEVLDEE.EEdMME.....D.WE.S.......LD..E..AS......E..A...EEVSDETPS....PSV...AFP.SPAPQKLAT..VPS.......I...A.TT.SAPQA.PPALPV.....RRPNR.....RWDTT.G.....TRAAptapaaa.....aatsaatqKQRRPdsktltkpkkstaaaaaggg......alrlapnepvstrelrnrifPTL....YA.IFQ..QSRGQ.E.....Q.E.LKIKNRSLRSLT..........RSCLYHKSEDQLRRTLEDAEALFSKYCALT...........................................................
Q64859_ADE40/10-180 .............................................................iaqrqsqqklqkq--------------.....W......DEEE.TWdDSQAEEVSDEEaEE.QME.....S.WD.S.......LD..E..ED......L..-...EDVEEETIA....SDK...A--.---PSFKKP..VRS.......Q...P.PK.TIPPL.PPQPCS.....LKASR.....RWDTV.S.....I--A....................GSPTA..............................................PAG....KQ.PKR..ARRGY.C.....S.W.RAHKSNIVACLQhcrgnisfarRYLLFHDGVAVPRNVLYYYRHLYSPYET--fg.........................................................
E0YC72_9ADEN/30-195 .................................................................alaapadpl------------AP.....T......DDVSdGE.TLGSQDTYSQE.ED.SEE.....D.YT.E.......EE.eE..ED......E..Q...EQGGEEEPT...dPLL...QHR.HPSQSPLAR..PPI.......K...RrEP.PAPRR.PPSSPA.....EPPRE.....R--AT.K.....KRRG....................NYRSW..............................................ARH....RI.EAV..ARHHP.E.....S.S.FAIRNRTRQSIT..........RQVHYVNDERRLTKMKEDAGKLLSL-----wlnl.......................................................
33K_ADES1/23-179 ...................hmgnktqsleeaykqlekelgetqapppspqssldgeplsegeleeiseeeeeeg--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.---EA.PPPIPA.....KKRQR.....KNPSK.A.....-PAA....................KAPRNygtpsyml.............................hvdlkhdiaGVL....EE.IRR..ASLKKpA.....H.T.PSIRNRTYPSIT..........KRYLYERDSKKLQQYLDDSKKLLAKYS---eg.........................................................
H9AAQ4_9ADEN/14-185 .......................................................................rsk---KQEQRLPPTPE.....T......WDEE.SQ.DSWESQAATTE.EE.DWE.....E.TS.S.......LG..E..AE......E..Q..pDEEQAEEET....PSA...AAP.L------RS..VAG.......P...K.TP.RPPAP.TPPLPP.....KKANR.....RWDAK.-.....TPAP....................AAPVG..............................................KML....AG.QRR..QRGAY.C.....S.W.RAYKSDILACLLhcggnvsftrRYLLFHRGVAVPRNVLHYYRHLYSPFH---qqq........................................................
Q5GFA3_ADE04/4-170 ........................................................................gs---SKKLKVELPPV.....E......DLEE.DWeSSQAEEEEMED.WD.STQ.....A.ED.S.......LQ..D..SL......E..D...EEEAEEVEE...vAAA...ARP.SSSAEK---..ASS.......T...D.TI.SAPGR.GPA---.....-RPHS.....RWDET.G.....RFP-....................----N..............................................PTT....QT.GKK..ERQGY.K.....S.W.RGHKNAIVSCLQacggnisftrRYLLFHRGVNFPRNILHYYRHLHSPYY---fqe........................................................
A0A223PYS1_9ADEN/49-97 .....................................................................ateel-----KLKL--EKQ.....S......KSRS.VQ.SYQTHLPLKHE.--.IAE.....I.LE.K.......IR.qE..SK......K..H...---------....---...---.---------..---.......-...-.--.-----.------.....-----.....-----.-.....----....................-----..............................................---....--.---..-----.-.....-.-.------------..........------------------------------pekv.......................................................
A0A384ZUP6_9ADEN/2-171 .....................................................................prkkq--------------.....-......----.--.-----EPLVEE.--.MEE.....E.WD.S.......QA..E..ED......E..W...EEETEEEEL....---...---.EEVEEERAT..EQP.......V...A.AP.SAPAA.PPVTDTtsaapAKPPR.....RWDRV.K.....GDAK....................KKSEVrgvaggglriaan....................eplttrelrnrifPTL....YA.IFQ..QSRGQ.Q.....Q.E.LKVKNRSLRSLT..........RSCLYHKNEDQLQRTLEDAEALFHKYCALT...........................................................
A0A6M6AEB7_9ADEN/10-180 .............................................................iaqrqsqqklqkq--------------.....W......DEEE.TWdDSQAEEVSDEEaEE.QME.....S.WD.S.......LD..E..ED......L..-...EDVEEETIA....SDK...A--.---PSFKKP..VRS.......Q...P.PK.TIPPL.PPQPCS.....LKASR.....RWDTV.S.....I--A....................GSPTA..............................................PAG....KQ.PKR..ARRGY.C.....S.W.RAHKSNIVACLQhcrgnisfarRYLLFHDGVAVPRNVLYYYRHLYSPYET--fg.........................................................
PKG2_ADE02/1-178 ..........................................................................MAPKKKLQLPPPPP.....T......DEEE.YW.DSQAEEVLDEE.EE.MME.....D.WD.S.......LD..E..AS......E..A...EEVSDETPS....PSV...AFP.SPAPQKLAT..VPS.......I...A.TT.SAPQA.PPALPV.....RRPNR.....RWDTT.G.....TRAG....................KSKQP..............................................PPL....AQ.EQQ..QRQGY.R.....S.W.RGHKNAIVACLQdcggnisfarRFLLYHHGVAFPRNILHYYRHLYSPYCTG-g..........................................................
A0A163HIM3_9ADEN/30-206 ....................................................vdmqtepisseeeeyseeegsy--------------.....T......DEED.YS.SS--EELVDLE.DL.PEE.....V.LA.R.......LP.pE..AL......E..A..lKSVRQTSEA....PKA...ASP.PAAAP--SE..PPA.......A...A.AA.EAPLAsSPAPPA....pKKAKR.....RWDQV.Q.....K---....................DGKTT..............................................PDH....HD.HPS..GRRAY.R.....S.W.RQHKNAILGCLLesggnvafsrRYMLFHEGVLLPKNVIRYYNSYY-------r..........................................................
Q6QPD6_9ADEN/4-218 ........................................................................gs---SKKLKVELPPP.....E......DLEE.DWeSSQAEEE----.--.EME.....D.WD.StqaeedsLQ..D..SL......E..E..eDEVEEAEEE....AAA...ARP.SSSAEKA--..-SS.......T...D.TI.SAPG-.--RGRG.....GRAHS.....RWDET.G.....RFPNpttqta........pttvskKRQKPsssrkpaaaaarkstaaag.......glriaanepaqtrelrnrifPTL....YA.IFQ..QSRGQ.E.....Q.E.LKVKNRSLRSLT..........RSCLYHKSEDQLQRTLEDAEALFNKYCALT...........................................................
A0A7R7FSS2_ADEB7/93-135 ......................................................................dvvf--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.-----.------.....-----.....-----.-.....----....................-----..............................................---....--.---..-----.-.....-.-.-QIRNRTPASIT..........KRYLYERDLKKLFQYLEDAKKLQAKY----qs.........................................................
A0A7H0S547_9ADEN/29-119 .....................................................................elrtp--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.--EQT.PKAKPV.....KK--R.....RWDLM.P.....EDAA....................AIKE-..............................................---....--.KF-..-DSRY.H.....S.W.RRHKQSIIDCLHasdgdvgfvrRYMLYHHGVSLPRNIIYYYNSHY-------rlvsga.....................................................
A0A076FYV9_9ADEN/19-177 ..............................................................iyhqlgksqsle--------------.....-......----.--.-----------.--.--E.....A.YK.E.......LE.kE..IS......S..M...EQAPAPPPS....PSS...SLDgEPLSE--GE..LED.......I...S.EEeEEVET.PPPLPP.....KQKGK.....KKKEA.-.....AKAPrnfgvps......yllhlnqKQEIA..............................................AVL....EE.IRR..ASQRN.P.....S.FtPSIRNRTYPSIT..........KRYLYERDSRKLQQYLEDSKKLLLKY----qega.......................................................
B2VQG0_9ADEN/2-137 .....................................................................prkkq--------------.....-......----.--.-----EPLVEE.--.MEE.....E.WD.S.......QA..E..ED......E..W...EEETEEEDL....EEV...---.---EEEQAT..EQP.......V...A.AP.SAPAA.PPVTDTtsaapAKPPR.....RWDRV.K.....G---....................-----..............................................---....-D.GKH..ERQGY.R.....S.W.RAHKAAIIACLQdcggniafarRYLLFHRGVNIPRNVLHYYRHLHS------...........................................................
A0A161DY84_9ADEN/47-248 .....................................................................eegsy--------------.....T......DEED.YS.SS--EELVDLE.DL.PEE.....V.LA.R.......LP.pE..AL......E..A..lKSVRQTSEA....PKA...ASP.PAAAP--SE..PPA.......A...A.AA.EAPLAsSPAPPA....pKKAKR.....RWDQV.Q.....KDDNpgsp...........vlkkpQ---Traatrrankqaapaaasl.........fvagprepattkalrekifPTL....YA.VFQ..QSRGQ.E.....R.D.LKVKNRSLRSLT..........RSCLYHKSEAQLQRTLEDSEALFSKYCSL-a..........................................................
SF33K_ADE02/1-225 ..........................................................................MAPKKKLQLPPPPP.....T......DEEE.YW.DSQAEEVLDEE.EE.MME.....D.WD.S.......LD..E..AS......E..A...EEVSDETPS....PSV...AFP.SPAPQKLAT..VPS.......I...A.TT.SAPQA.PPALPV.....RRPNR.....RWDTT.G.....TRAAptapaaaa...aaataavtqKQRRPdsktltkpkkstaaaaaggg......alrlapnepvstrelrnrifPTL....YA.IFQ..QSRGQ.E.....Q.E.LKIKNRSLRSLT..........RSCLYHKSEDQLRRTLEDAEALFSKYCALT...........................................................
Q997H5_ADEB4/40-94 ...................................................................seeettd--------LPHPPPlpdkiT......KSYS.VH.SYQTHLPLKHE.--.IAE.....V.LE.K.......IR.hE..SK......K..R...---------....---...---.---------..---.......-...-.--.-----.------.....-----.....-----.-.....----....................-----..............................................---....--.---..-----.-.....-.-.------------..........------------------------------perv.......................................................
C9SVH0_VERA1/30-189 ......................................................................hfea-------QFAPLPE.....T......KKPK.VA.EPEAEEILEDD.AE.VDS.....E.WD.G.......VSedE..AE......K..A...IEVVDHTDS...kPHD...PTA.GMTKRQLKA..FMA.......V...L.TT.AYADG.QAAAAA.....RQAVR.....RARTT.S.....RRSApghcaaapplrippprlpepRRRRP..............................................PAA....AA.K--..-----.-.....-.-.------------..........------------------------------pfaagklrqrttdlriqslaaaga...................................
A0A7R7FSS2_ADEB7/48-97 ..................................................................sippaakk-----------PKL.....T......KNHS.VH.SYQTHLPLKHE.--.IAE.....V.LE.K.......IR.qE..SK......K..R...PD-------....---...---.---------..---.......-...-.--.-----.------.....-----.....-----.-.....----....................-----..............................................---....--.---..-----.-.....-.-.------------..........------------------------------vvfq.......................................................
Q6H1B9_9ADEN/4-170 ........................................................................gs---SKKLKVELPPV.....E......DLEE.DWeSSQAEEEEMED.WD.STQ.....A.ED.S.......LQ..D..SL......E..D...EEEAEEVEE...vAAA...ARP.SSSAEK---..ASS.......T...D.TI.SAPGR.GPA---.....-RPHS.....RWDET.G.....RFP-....................----N..............................................PTT....QT.GKK..ERQGY.K.....S.W.RGHKNAIVSCLQacggnisftrRYLLFHRGVNFPRNILHYYRHLHSPYY---fqe........................................................
A0A097DBP2_9ADEN/4-127 ....................................................ittvtstaptiasksrqsqqkk--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.----T.AAATSN.....RKPAA.....AVKKY.T.....TSAAtgglkita...nepaqtrelRNRIF..............................................PTL....YA.IFQ..QSRGQ.E.....Q.E.LKIKNRSLRSLT..........RSCLYHKSEDQLQRTLEDAEALFNKYCALT...........................................................
A0A6M6AB38_9ADEN/14-208 ................................................................qsqqklqkqw--------------.....-......DEEE.TWdDSQAEEVSDEEaEE.QME.....S.WD.S.......LD..E..ED......L..-...EDVEEETIA....SDK...A--.---PSFKKP..VRS.......Q...P.PK.TIPPL.PPQPCS.....LKASR.....RWDTV.S.....IAGSptapaa.......ptkrlekT---Prvrktssaiatrq....................dspatqelrkrifPTL....YA.IFQ..QSRGQ.Q.....L.E.LKVKNRSLRSLT..........RSCLYHRSEDQLQRTLEDAEALFNKYCSV-s..........................................................
A0A1P8SW71_9ADEN/10-110 ................kqiesdrsrspaslrrppikttakqirdrepeteevldirsqilrilleidslarlsp--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.-----.------.....-----.....-----.-.....----....................-----..............................................---....--.---..-----.N.....R.R.VAIRNRTRESIT..........RQLHYEKDLTKLTRLRTDANKLLSL-----wqs........................................................
A0A384ZUR3_9ADEN/2-137 .....................................................................prkkq--------------.....-......----.--.-----EPLVEE.--.MEE.....E.WD.S.......QA..E..ED......E..W...EEETEEEEL....---...---.EEVEEERAT..EQP.......V...A.AP.SAPAA.PPVTDTtsaapAKPPR.....RWDRV.K.....G---....................-----..............................................---....-D.GKH..ERQGY.R.....S.W.RAHKAAIIACLQdcggniafarRYLLFHRGVNIPRNVLHYYRHLHS------...........................................................
A0A135UYP2_9PEZI/151-323 .......................................................................kqk---EKKEDLPPPPP.....H......GDKT.PW.EVF-RETLTTE.FG.KSK.....E.WN.E.......ST..K..AL......S..-...GEIQDFTES....ERV...RKA.REAYEKSSG..AIS.......S...A.AT.SAVKT.TAGAIG.....KGAAW.....TWDTT.A.....MKGV....................RKVAN..............................................VTG....DA.L--..-----.-.....-.-.------------..........------------------------------dkatkpireteayknvkdviddgsssryggwvekeerrkkreaeaakngtpeimeedpn
A0A0A7JTJ4_9ADEN/96-143 .....................................................................knpha--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.-----.------.....-----.....-----.-.....----....................-----..............................................---....--.---..-----.-.....-.H.VQVRNRTLASIT..........KRYLYEREYEKASKCLEDAKKLLQKYR---srq........................................................
Q2KSA7_9ADEN/5-179 .......................................................................rgs----KKLKVQLSPP.....E......DMEE.DW.DSQAEEEMEDW.DS.QAE.....E.VD.S.......LE..E..DSleeedeE..A...EEVEEATAA....KQL...SS-.-AAETSKSP..DSS.......T...A.TI.SAPGR.---GAQ.....RRPNS.....RWDET.G.....RFP-....................---NP..............................................TTA....SKtGKK..ERQGY.K.....S.W.RGHKNAIISCLHecggnisftrRYLLFHHGVNFPRNILHYYRHLHSPYCSQ-q..........................................................
A0A097IWC9_9ADEN/1-159 ........................................................................mp--AKKRTALPPT-S.....TqrlkqrKQEK.HW.SAE-ESDWESQ.GD.MEE.....E.WD.S.......LA.sD..EG......E..A...E---AETE-....DTV...AKP.SQK------..RPS.......N...A.TT.SSDQP.------.....-TINR.....RWDNT.A.....AAAM....................GK---..............................................---....TT.LKK..SRQGY.R.....S.W.RKHKNAIITCLEncggnisftrRFMLFRNGIAIPRNVLHYYRHFYSPQ----kti........................................................
A0A1X9RIX0_9ADEN/3-135 .....................................aqdkapkaqesmevetissadensqsseasldanysh--------------.....-......----.--.-----------.--.---.....-.--.-.......--..-..--......-..-...---------....---...---.---------..---.......-...-.--.-----.-KEEPQ.....TKPN-.....RWDLA.P.....GEKF....................KKHQNeesmitq................................qlresifPTL....YA.IFQ..QSRGK.T.....T.C.IKVKNRSLRSLT..........RSCLYHKKEQQLRRTQQDAELLLQKCCART...........................................................
A0A097IWD0_9ADEN/1-123 ........................................................................mp--AKKRTALPPT-S.....TqrlkqrKQEK.HW.SAE-ESDWESQ.GD.MEE.....E.WD.S.......LA.sD..EG......E..A...E---AETE-....DTV...AKP.SQK------..RPS.......N...A.TT.SSDQP.------.....-TINR.....RWDNT.A.....AAAM....................GK---..............................................---....TT.LKK..SRQGY.R.....S.W.RKHKNAIITCLE..........------------------------------ncg........................................................
#=GC seq_cons .......................................................................tpt.............................p........pp...tp......E.....t.h-.p.......lt..E..tt......c......cp.tttp.............................s.............s..t.s.h.ss..s......h+stp.....RWDps.t.....t.s.....................t..................................................ssh.....t.hhp..pppu..p.....p...hthKNphltsLp..........R.hLaH+s.t..pphLc.hctLhs.a...............................................................
//
