#=GF ID Adhesin_P1_N
#=GF AC PF18652.5
#=GF DE Adhesin P1 N-terminal domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF08792
#=GF GA 27.10 27.10;
#=GF TC 27.10 27.30;
#=GF NC 27.00 27.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 25331888
#=GF RT An intramolecular lock facilitates folding and stabilizes the
#=GF RT tertiary structure of Streptococcus mutans adhesin P1.
#=GF RA Heim KP, Crowley PJ, Long JR, Kailasan S, McKenna R, Brady LJ;
#=GF RL Proc Natl Acad Sci U S A. 2014;111:15746-15751.
#=GF DR INTERPRO; IPR041324;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The cariogenic bacterium Streptococcus mutans uses adhesin P1 to
#=GF CC adhere to tooth surfaces, extracellular matrix components, and
#=GF CC other bacteria. The N terminus forms a stabilizing scaffold by
#=GF CC wrapping behind the base of P1's elongated stalk and physically
#=GF CC 'locking' it into place. It is suggested that the N-terminal
#=GF CC has such a pronounced impact on P1 immunogenicity, antigenicity,
#=GF CC folding, stability, and adherent function [1].
#=GF SQ 94
#=GS G5JTU0_STRCG/81-196 AC G5JTU0.1
#=GS A0A3L8GB29_STRIN/90-195 AC A0A3L8GB29.1
#=GS G5KG40_9STRE/91-196 AC G5KG40.1
#=GS A0A7G3MPF7_9CAUD/90-195 AC A0A7G3MPF7.1
#=GS A0A2L0D5N0_9STRE/55-153 AC A0A2L0D5N0.1
#=GS A0A139NGK2_9STRE/66-171 AC A0A139NGK2.1
#=GS A0A3M8H4Z6_9BACI/38-148 AC A0A3M8H4Z6.1
#=GS A0A0J1I7T9_NIACI/31-149 AC A0A0J1I7T9.1
#=GS A0A433H0W7_9MICC/55-163 AC A0A433H0W7.1
#=GS A0A2N5NB77_9BACL/58-164 AC A0A2N5NB77.1
#=GS A0A5R9F1W5_9BACI/47-166 AC A0A5R9F1W5.1
#=GS A0A1G6GJ03_9LACO/70-157 AC A0A1G6GJ03.1
#=GS A0A133YCN0_9FIRM/42-151 AC A0A133YCN0.1
#=GS A0A7X6S2D7_9STRE/91-196 AC A0A7X6S2D7.1
#=GS A0A069CVW9_WEIOS/54-153 AC A0A069CVW9.1
#=GS E6K201_PARDN/95-195 AC E6K201.1
#=GS C4GC60_9FIRM/33-144 AC C4GC60.1
#=GS A0A385NPP9_9BACI/46-154 AC A0A385NPP9.1
#=GS SSPB_STRGC/78-183 AC A8AUS1.1
#=GS W4RPK4_9BACI/50-159 AC W4RPK4.1
#=GS J6H9U3_9FIRM/8-119 AC J6H9U3.1
#=GS A0A2N0ZC60_9BACI/52-158 AC A0A2N0ZC60.1
#=GS A0A0C2V0W4_9BACL/37-155 AC A0A0C2V0W4.1
#=GS A0A069D133_WEIOS/54-153 AC A0A069D133.1
#=GS A0A0D1K432_9LACO/43-146 AC A0A0D1K432.1
#=GS H1PL80_9FIRM/33-144 AC H1PL80.1
#=GS G5K438_9STRE/15-104 AC G5K438.1
#=GS Q838H0_ENTFA/150-255 AC Q838H0.1
#=GS A0A1X9MI42_9BACI/42-160 AC A0A1X9MI42.1
#=GS A3CKQ5_STRSV/78-183 AC A3CKQ5.1
#=GS A0A7G3MHS5_9CAUD/90-195 AC A0A7G3MHS5.1
#=GS A0A0E4CT00_9STRE/86-188 AC A0A0E4CT00.1
#=GS A0A139NL68_9STRE/88-186 AC A0A139NL68.1
#=GS SPAP_STRMU/80-185 AC P23504.2
#=GS G5JRZ6_STRCG/83-188 AC G5JRZ6.1
#=GS C4GC63_9FIRM/33-144 AC C4GC63.1
#=GS A0A437K7S3_9BACI/43-151 AC A0A437K7S3.1
#=GS V1CAZ2_9FIRM/27-138 AC V1CAZ2.1
#=GS A0A3L8GVQ6_STRIN/67-165 AC A0A3L8GVQ6.1
#=GS A0A380KDM4_9STRE/80-178 AC A0A380KDM4.1
#=GS G5K328_9STRE/90-195 AC G5K328.1
#=GS T1ZHQ3_STRIT/79-184 AC T1ZHQ3.1
#=GS A0A069D1V5_WEIOS/54-154 AC A0A069D1V5.1
#=GS A3CMH1_STRSV/71-174 AC A3CMH1.1
#=GS G5K443_9STRE/67-165 AC G5K443.1
#=GS A0A2N5MGL1_9BACI/47-156 AC A0A2N5MGL1.1
#=GS Q8DZ37_STRA5/90-195 AC Q8DZ37.1
#=GS A0A2X4R2S7_9BACL/72-177 AC A0A2X4R2S7.1
#=GS A0A4P6UTC8_9BACL/43-149 AC A0A4P6UTC8.1
#=GS F9PYK1_9STRE/57-163 AC F9PYK1.1
#=GS A0A5C8NRT7_9BACI/56-155 AC A0A5C8NRT7.1
#=GS A0A437SSN9_9LACO/164-271 AC A0A437SSN9.1
#=GS A0A0Q3VH62_9BACI/49-157 AC A0A0Q3VH62.1
#=GS A0A0J5PDU4_9LACO/67-147 AC A0A0J5PDU4.1
#=GS A0A317L1B1_9BACI/53-158 AC A0A317L1B1.1
#=GS A0A0W7YC94_9BACI/29-150 AC A0A0W7YC94.1
#=GS ASA1_ENTFA/150-255 AC P17953.1
#=GS W4QDL7_9BACI/19-125 AC W4QDL7.1
#=GS A0A2X3VPW7_9STRE/80-185 AC A0A2X3VPW7.1
#=GS A0A3E2JWI0_9BACI/29-149 AC A0A3E2JWI0.1
#=GS A0A380KAR1_9STRE/81-186 AC A0A380KAR1.1
#=GS C7MLU5_CRYCD/31-146 AC C7MLU5.1
#=GS A0A1G6AD98_9STRE/91-196 AC A0A1G6AD98.1
#=GS A0A3A1R3H7_9BACI/35-144 AC A0A3A1R3H7.1
#=GS A4VUZ2_STRSY/109-214 AC A4VUZ2.1
#=GS A0A0R1HPN7_9LACO/85-177 AC A0A0R1HPN7.1
#=GS C8W9Q6_LANP1/34-156 AC C8W9Q6.1
#=GS G5KEX2_9STRE/53-151 AC G5KEX2.1
#=GS E1MAV5_9STRE/50-136 AC E1MAV5.1
#=GS A0A3L8GED4_STRIN/54-152 AC A0A3L8GED4.1
#=GS G5K076_9STRE/67-155 AC G5K076.1
#=GS A0A3L8GMM8_STRIN/54-163 AC A0A3L8GMM8.1
#=GS Q82YN1_ENTFA/150-255 AC Q82YN1.1
#=GS F9PX77_9STRE/1-66 AC F9PX77.1
#=GS A0A347WMN8_9LACT/90-195 AC A0A347WMN8.1
#=GS A0A0B4RZB2_9FIRM/28-139 AC A0A0B4RZB2.1
#=GS A0A3D8YYE3_9BACL/38-145 AC A0A3D8YYE3.1
#=GS A0A542AKK8_9CLOT/46-165 AC A0A542AKK8.1
#=GS M2NE41_9FIRM/31-142 AC M2NE41.1
#=GS A0A0M0GDX4_SPOGL/50-159 AC A0A0M0GDX4.1
#=GS A0A1J7JPP4_9PEZI/264-324 AC A0A1J7JPP4.1
#=GS A0A7X9QUX5_9BACI/43-150 AC A0A7X9QUX5.1
#=GS A0A0R2FKS8_9LACO/93-192 AC A0A0R2FKS8.1
#=GS SSPA_STRGC/79-184 AC A8AUS0.1
#=GS A0A347WKC7_9LACT/74-181 AC A0A347WKC7.1
#=GS C0W2X4_9ACTO/53-146 AC C0W2X4.1
#=GS C7MNZ6_CRYCD/31-146 AC C7MNZ6.1
#=GS G5JRZ4_STRCG/83-189 AC G5JRZ4.1
#=GS C8NFE4_9LACT/77-182 AC C8NFE4.1
#=GS A0A3L8GPT8_STRIN/44-144 AC A0A3L8GPT8.1
#=GS A0A1G6BP68_9STRE/83-176 AC A0A1G6BP68.1
#=GS V1D4P3_9FIRM/28-139 AC V1D4P3.1
#=GS Q839L6_ENTFA/150-255 AC Q839L6.1
#=GS F5X6Z9_STRPX/90-195 AC F5X6Z9.1
G5JTU0_STRCG/81-196 ...................................QAGQSEGE.LIVDVPSP......ELEQT.....IKDA.YQAGV.K.V..QRDDVVDQGAAQTP.DEAAAKQADIEADYAQQVKQSKEI.....IANYSSSKAIYDAkkevydnakfQYDQDKA...AYDIAKSQYDQDKAAY.............................
A0A3L8GB29_STRIN/90-195 ..................................l-TGQSNGA.IAVTVPHD......TVTQV.....VEVA.KAEGV.S.T..VEDSPMDLGNTTSV.AETNQQISKAEADAQKQVEAINEV.....TETYKADKVAYED..........EKLRIEQ...ENRELIQAYEGANQT-g............................
G5KG40_9STRE/91-196 ..................................s-TGQSDGA.ITVTVPHD......VVTQA.....VNQA.TAEGV.T.T..VQDQPMDLGNTTSA.SETSKQLDKAEADAARQAEAITQL.....TNTYKADKATYEQ..........DKTRVEQ...GNAALAASHKDATQA-g............................
A0A7G3MPF7_9CAUD/90-195 ..................................l-TGQSNGA.IAVTVPHD......TVTQA.....VEEA.KAEGV.S.T..VEDSQMDLGNTTSA.AETNQQISKAEADAQNQVEAINEV.....TETYKADKAAYVD..........EKARIEQ...ENKELSQAYEGANQT-g............................
A0A2L0D5N0_9STRE/55-153 .................................tl--TEPTTN.QPQAVTSP......ELNKA.....VTEA.EAAGV.T.V..TTEPTVSHTN----.------EASAQADLDQQTQAVKEA.....TEQVNANTQAIKEa.......taQNAQIDA...QNQAEKERVEAENKA-g............................
A0A139NGK2_9STRE/66-171 ...................................QADTSTGT.VAVASDSA......GLDQA.....ITNA.EKAGV.S.V..EQTQTIDHGTVSTA.EDVAQKQAEIKTDYDKQASQITET.....TKQYQEDVANHKE..........QVQKITA...ENAQTEAQYQADVAKH.............................
A0A3M8H4Z6_9BACI/38-148 ...........................nvdkglln--------.VEVTLPASmfegeeDIDTV.....IADA.EADGIdK.V..TKNDDGSVTLKMSK.SKHKELMNEIETSIKESIEEMKTS.....GDYASIKDIAHND..........--KFTDF...TVVVDKAAYENSMD--gf...........................
A0A0J1I7T9_NIACI/31-149 .................nnkqadeqkvnvdkglln--------.VEITLPASlf.egeDIDSV.....IADV.EKEGI.K.V..TKNEDGSLTYKMSK.AKHKEMMKEMETSLEESIKEIKES.....DDYVSIKDITHNK..........--AFSEF...TLVVDKKKYEDSMD--sf...........................
A0A433H0W7_9MICC/55-163 ..................................a-QELASTS.EEVPLDHS......ALDRA.....VQRA.KKAGV.P.VnlVQEATESVGR----.DAVGAARERLAASIARQATDIDGA.....TDRWVSQLSQWES..........-------...LKRAAQEEYDSAMQTYrrdhetfqqqmg.................
A0A2N5NB77_9BACL/58-164 .................dkgllnheitlpasffeg--------.-------Q......ELDAA.....IEAA.KKNGV.TdV..KRNEDGSVTYKMPR.SVHGKMMDEMKASLLTSIDELKAG.....ETFQSVKDIEYSK..........D------...----------------fseftlivdqakfegsfda..........
A0A5R9F1W5_9BACI/47-166 peesndegesvevdknllsvevklpasmfegespe--------.--------......---DI.....IAGA.KEEGV.K.V..TQNDDGSYTYKMSK.SKHKEMMKELSTNIDQTVDEMKTS.....DDYASIKDITHND..........--DYSEF...TMVVEKETYKNSMD--gf...........................
A0A1G6GJ03_9LACO/70-157 ..............................snqtv-----QKD.EKSKVPSP......SLDQA.....VKNA.QDAGL.K.T..QEVPGKNFPGRI--.DDYSNLVKQADADYQQQVDTINQQ.....VSQKQQNTADQKA..........-TQE---...----------------snat.........................
A0A133YCN0_9FIRM/42-151 ...............................akll----DDKG.QLVISNQA......KLMEK.....IAEA.KDIGV.K.V..TEQDQTNKNLYDTEtEKLKEAKKKIEESYTTSINNLDNA.....INEQKKNNAAYYE..........KLKASFApflKDGWDFEKFKNFL---ltp..........................
A0A7X6S2D7_9STRE/91-196 ..................................s-TGQSHGA.ITVTVPHD......VVTQA.....VNQA.TAEGV.T.T..VQDQPMDLGNTTSA.SETSKQLDKAEADAAKQAEAITQV.....TNTYKADKATYEQ..........DKTRVEQ...GNAALAASHKDATQA-g............................
A0A069CVW9_WEIOS/54-153 ..................................t-AKKGDNG.ISINVGND......DLKAA.....AKEA.QDAGL.K.V..TEKATKYQTVTE--.KDADETQKKVAADNAAQAKSIREK.....VAKYKADKAQYDK..........-------...----DKAAYDKGN---saipnqdnan...................
E6K201_PARDN/95-195 ....................aqasqsaqpsqqaag--------.--NQTTED......QLLQA.....VARA.KKAGV.T.V..TEDPQQQK------.----QSQAEVSDDYAQQIKQLNDV.....TAKQEANMKAYND.........sKSSRQAQ...IDQIKKSAMA------sddan........................
C4GC60_9FIRM/33-144 ..................................s-AADSVKG.LETNVDRT......ALDKA.....VADA.RNAGV.P.V..TKGQDQDMGVAHSK.SEVDAKIAEIKADYQQQIQKLEEAk..kaIAKCDEEQKAYDAa.......kkKYDEELA...KYNIAKQKYDEDMVI-y............................
A0A385NPP9_9BACI/46-154 ............................evdkgll-------N.VEVTLPASmf.egeDVDAT.....IAEV.EKEGV.E.A..TKNEDGSVTYKMSK.SKHKEMLKELETGIIESIEDMKNN.....EDFVSIQEITYNK..........--SFSEF...TMVVDKTIYENSMD--sf...........................
SSPB_STRGC/78-183 ...................................QAGSKDGA.LPVEVSAD......DLNKA.....VTDA.KAAGV.N.V..VQDQTSDKGTATTA.AENAQKQAEIKSDYAKQAEEIKKT.....TEAYKKEVEAHQA..........ETDKINA...ENKAAEDKYQEDLKAH.............................
W4RPK4_9BACI/50-159 ...........................evdkglfn--------.VEVTLPASmf.egeDIDSA.....IEEA.KAEGV.KeV..IKNDDGSITYKMSK.SEHKKMMKELETGIQESLEEMKTS.....GDFASIKDVTHNK..........NYSEF--...TLEVDKATYENSMD--gf...........................
J6H9U3_9FIRM/8-119 .................................fg--ADATKG.IETKVDRT......ELDKS.....VQSA.KDAGV.P.V..NKTQDIDKGIAKSK.AEVDAKISEIKTDYQQQIKELEEAk..kaIAKCKEEKKAYEIa.......kkKYDEELA...KYNIAKKKYDEEMVKY.............................
A0A2N0ZC60_9BACI/52-158 ................kgllnvqitipasfmegen--------.--------......-TDTA.....IEEA.KANGI.KeV..TKNEDGSITYKMSK.SEHKKMLKELQTTMTESMDEIKND.....KEIASIKDITHNK..........--DFSEF...TLVVDQEAYENS----fdsi.........................
A0A0C2V0W4_9BACL/37-155 ...........qqtteekslevdkgllnvevtlpv--------.-------Smf.egeDIDQV.....IADA.KADGV.EeV..TKNEDGSLTYRMSK.SKHKEMMQEIEKSIKESLEDMKTS.....GDFASIKDITHND..........--SFSEF...TLTVDKAEYENSMDA-f............................
A0A069D133_WEIOS/54-153 ..................................t-AKKGDNG.ISINVGND......DLKAA.....AKEA.QDAGL.K.V..TEKATKYQTVTE--.KDADETQKKVAADNAAQAKSIREK.....VAKYKADKAQYDK..........-------...----DKAAYDKGN---saipnqdnan...................
A0A0D1K432_9LACO/43-146 ...................................TAGDKSQG.LAVTPDAT......KLNAA.....VKNA.EEAGV.K.V..TQGKTKTTTV--SA.KVAAENKSRIDGTYADKVKELTDL.....ATKQKAADTQYAK..........----DEK...AYKAALEEYNAAV---kgqtdda......................
H1PL80_9FIRM/33-144 ..................................f-AADSTKG.IETKVDRT......ELDNV.....VQSA.KDVGV.P.I..QKDSDLDMGVATTK.SEVDAKVAEIKQDYENQIKAIKAEi..ekKKECDKKQKEYEEk.......laKYNQELE...KYNKDMEKYKKEVLAY.............................
G5K438_9STRE/15-104 ...................................QAGHQSGE.LVSEVSNT......EWDNA.....VTTA.QEAGV.T.V..KQSEKVTH------.----DSLSSAQADLEKQTQAVTEA.....TTKQEANKAAFNQ..........AMAE---...----------------nklllkpivmkkk................
Q838H0_ENTFA/150-255 .................................ne--VNKSTS.IPKEFETP......DVDKA.....VDEVkKDPNI.T.V..VEKPAEDLGNVSS-.KDLAAKEKEVDQLQKEQAKKIAQQ.....AAELKAKNEKIAK..........ENAEIAA...KNKAEKERYEKEVAEY.............................
A0A1X9MI42_9BACI/42-160 ......eeateedeqsvevdrgllnveitippmml--------.-----EDQ......DIDQV.....IADA.KEAGV.KeV..TENEDGSLTYKMSR.STHNEMMSEMREGIEANIEEIKQSddypsI------------..........-------...----------------advrsnqsyseftlvvdqeafensfd...
A3CKQ5_STRSV/78-183 ...................................QAGQADGG.VTVTVPTA......GLDES.....AKKA.QEAGL.T.V..VKDPAVDKGVAQTD.QDTADKKAEIAADYQAQVTEIDAK.....VKEYKEKVSAYEA..........EVVRITA...ENKATAEQYAKDLVAH.............................
A0A7G3MHS5_9CAUD/90-195 ..................................s-TGQSNGA.IAVTVPHD......TVTQA.....VEEA.KAEGV.S.T..VEDSPMDLGNTTSA.TETKQQISKAEADAQNQIEAINEV.....TETYKADKAAYED..........EKVRIEQ...ENKVLSQAYEEANQT-g............................
A0A0E4CT00_9STRE/86-188 .............................svtqdq------AV.TAVEDAQD......TLKGN.....VDTA.KNTGV.V.V..TEGEPQEVVIDD--.ANAAEKTSEVLTDLNKQDQAVKQA.....TAKQADNQKAYEE..........TSAEHEA...VTKEGQEALDKSTA--e............................
A0A139NL68_9STRE/88-186 ...............................tsen----GVTQ.TTQTVQTP......DLTAA.....VEEA.KATGL.T.V..NQDAAQVK------.----DTLDQAVADNAQQAKDIAAK.....TAQYKEDKDGYDQd.......vaWYNEEKA...KSDARTAAYNQRVA--dl...........................
SPAP_STRMU/80-185 ...................................QAGETNGS.IPVEVPKT......DLDQA.....AKDA.KSAGV.N.V..VQDADVNKGTVKTA.EEAVQKETEIKEDYTKQAEDIKKT.....TDQYKSDVAAHEA..........EVAKIKA...KNQATKEQYEKDMAAH.............................
G5JRZ6_STRCG/83-188 ...................................QAEQKTGS.MPVDVATT......ELDEA.....VKSA.AEAGV.T.V..SQDETVDKGTVGTS.QEADEKSGEIKADYSKQAETIKIT.....TETYKADVAANQS..........ETNRINQ...ENAAKKAQYEQDLAA-n............................
C4GC63_9FIRM/33-144 ..................................y-AADPVKG.IEIKADRT......ELDQS.....VSDA.KNAGA.E.I..VQDADVDKGVVKSE.AEADSKRSEIEADYKQQVQQLKDAk..kaAQKYSQDKKKYDEa.......kkKYDAELA...KYNIAKKKYDDELTAY.............................
A0A437K7S3_9BACI/43-151 ............................avdkgll-------S.VEITMPAAfv.egqDMEST.....IKEA.EAEGI.E.V..TKNEDGSLTYKMSK.SEHKQMMKDLKKNAEESLEEIKTV.....GTFPSVKNIDYNK..........--SFSKF...TMTVDKAAYENSMDAW.............................
V1CAZ2_9FIRM/27-138 ..................................y-AADPVRG.VQTNVDSS......GLDKA.....VEDA.KNAGV.Q.V..TQGNTEDKGTVDSK.AAADAKRAEITADYERQIRELNEAr..akLDDYNVKKAEYDKk.......kkQYDKDLA...QYEIDKKKYEKALEE-l............................
A0A3L8GVQ6_STRIN/67-165 ...................................QAGHQSGE.LVSDVTSA......ELEQA.....VTAA.QEAGV.D.V..KQSDKVTH------.----DSLSAAQTDLEKQTETVREA.....TAKQETNTTAINQa.......laENKAIDQ...ANRDEKARVDAINA--kg...........................
A0A380KDM4_9STRE/80-178 ...................................QANTQTGT.LTSPVTSQ......ELDNA.....VNAA.TAAGV.T.V..TEEKTVSH------.----DSLEKAQDDLSQQTAEVKAA.....TENQEANTTAIKEa.......teENARIDA...ENKAEAERVEAINKA-g............................
G5K328_9STRE/90-195 ..................................a-TGQSEGA.LSVTVPHD......TVTNA.....VEAA.QVEGV.T.T..VQDSPMDLGNTTSA.SETTTQLDKAEADAAKQVQAITSV.....TESYKTEKATYEA..........EKNRVET...HNSELTSAYDKATQA-g............................
T1ZHQ3_STRIT/79-184 ...................................QAGETNGS.IPVEVPKT......DLDQA.....AKEA.KSAGV.N.V..VQDADVNKGTVKTA.GEAAQKETEIKEDYTKQAEDIKKT.....TDQYKSDVAAHEA..........EVAKIKA...KNQATKEQYEKDMAAH.............................
A0A069D1V5_WEIOS/54-154 ..................................t-AKKGDNG.ISINVGND......DLKAA.....AKEA.QDAGL.K.V..TEKATKYQTVTE--.KDADETEKKVAADNAAQAKSIREK.....VAKYKADKAQYDK..........-------...----DKAAYDKGN---saipsqdnand..................
A3CMH1_STRSV/71-174 ................................pvs-----QDK.LPLEVSHA......DLDQA.....VAEA.EKAGV.Q.L..KQEPPVDLGTARNP.EEAASKRETALADYATQVKEIRET.....TAAYQEQLKTYEK..........ELSQKES...ANQALKDQYDKALASY.............................
G5K443_9STRE/67-165 ...................................QAGHQSGE.LVSEVSNT......EWDNA.....VTTA.QEAGV.T.V..KQSEKVTH------.----DSLSSAQADLEKQTQAVTEA.....TTKQEANKAAINQa.......maENKAIAQ...ANRDEKERVDALNA--kg...........................
A0A2N5MGL1_9BACI/47-156 ..........................svdkgllnv--------.-EITLPASmf.egeDIDTV.....IADA.KKDGV.KeV..TKNEDGSLTYKMSK.SKHKEMMQELETGIKDSIKEAKTS.....GDFVSVKDITHND..........--SFSEF...TLTVDKAAYENSMD--gf...........................
Q8DZ37_STRA5/90-195 ..................................s-TGQSNGA.IAVTVPHD......TVTQA.....VEEA.KAEGV.S.T..VEDSPMDLGNTRSA.VETNQQISKADADTQKQVETINEV.....TKTYKADKATYES..........NKARIEQ...ENKELSQAYEGANQT-g............................
A0A2X4R2S7_9BACL/72-177 .................................kv--NQSQGS.VEVNLKSP......ELEKA.....VEKA.VNGGV.K.V..EKSEIVDKGTVKST.EELSKVTKEVQEEYKKKAEEISNK.....TETYLKDKQKNQE..........EISKVTK...ENEDKKIAYEKALSEY.............................
A0A4P6UTC8_9BACL/43-149 ...........................nvdkglfn--------.VEVTLPASff.eggDIDQS.....IAEA.EKEGI.E.V..TKNEDGSLTYKMSK.TKHKEMMSEMKTSLLETIEDLKNG.....EDFASIKDVEYNK..........-------...----------------dfseftlwvdrndyensfd..........
F9PYK1_9STRE/57-163 ...................................QAGKATGS.QSVAIDNG......AVTKA.....AEKA.KEAGV.N.V..SETQIVDKGTDTTA.PKLEQSKSEIKQDQDKQVKELEEA.....TTKQVENNTAFKE..........AQKAIQA...NNQFVADEKAKHE---gett.........................
A0A5C8NRT7_9BACI/56-155 ...........................eitlpeml--------.----FEED......NMDDV.....VERA.KEDGA.KeV..KKNDDGSVTFKMSK.KDHKKMMEEMKEDVAESLDEIKKD.....DAFTSIKDITYNK..........--DFSDI...TLVVDKEAYENS----fdg..........................
A0A437SSN9_9LACO/164-271 .....................yqesldkveeinkd--------.-----NND......KLQDA.....IDKA.EQEGI.I.I..DTKDPIKIPTTT--.GGIDINKDKLEQLTQAEIDKINAA.....ISEYQAAKDKYEKe.......lsQYKDDLE...KYNIALAEYNKARDEY.............................
A0A0Q3VH62_9BACI/49-157 ....................evdkgllnveitlpa--------.-------Slf.edqDINAV.....IAEA.KNEGI.EdV..KQNADGSLTYKMSK.SKHKEMMKELEEGLMESIEDAKNN.....EDYVSIKDVTHNKt.......fsE------...----------------ftlivdqdkfensfdg.............
A0A0J5PDU4_9LACO/67-147 ......................hqgemnqvnglkd--------.-----THN......ALNQA.....VTTA.QAAGV.T.V..TDQGTTTKTVTQ--.DQVSNERQAVKNDETAQTAQVNQA.....TANINSLKDSN--..........-------...----------------kk...........................
A0A317L1B1_9BACI/53-158 ...............................evdk----NLLS.VEVTIPSSm...ieSTDES.....IAKA.EEEGL.K.V..TENEDGSLTYKMSK.SKHKEMMNEIKKQLDQSMEEIKTS.....GDFPSIQDITSNE..........--DFSEF...HLSVDREGYE------nsmdg........................
A0A0W7YC94_9BACI/29-150 ...............kkegaekaseetlkvdkgll-------N.VEVTIPATly.kgqDIDSI.....ISEA.KNSGI.KeV..IKNDDGSLTYKMSK.SEHKKMMKELKERIVKSVEELKTS.....EDFASINDVAYNK..........SFSE---...----------------ftltvnkekfegsfda.............
ASA1_ENTFA/150-255 .................................ne--ANKSTS.IPKEFETP......DVDKA.....VDEAkKDPNI.T.V..VEKPAEDLGNVSS-.KDLAAKEKEVDQLQKEQAKKIAQQ.....AAELKAKNEKIAK..........ENAEIAA...KNKAEKERYEKEVAEY.............................
W4QDL7_9BACI/19-125 .............................acsqga------SN.VEITIPASfl.egeDVESA.....IEEA.KAEGI.EeV..EENEDGSLTYIMSK.STHDELMEEIEASLQESIEEMKTS.....ED-----------..........-------...----------------fvsisdvsansafseftvvvdqemyensf
A0A2X3VPW7_9STRE/80-185 ...................................QAGQAQGS.MPIDVSTS......ELDQA.....VEEA.KAAGI.T.V..VEDETVDKGTVTTA.EEAAQKEAEIKDDYASQAEAIKET.....TDQYKADVAANQA..........ETDRITA...ENAAKKAQYEQDRKAY.............................
A0A3E2JWI0_9BACI/29-149 .................etkdekkneevsvdkgll-------N.VEVTLPASmf.egeDIDSV.....IAEA.KKDGV.KeV..TKNEDGSLTYKMSK.SKHKEMMKELETNVKDTIEETKTS.....GDFASIKDITHND..........--SFSEF...TLLVDKSAYENSMD--gf...........................
A0A380KAR1_9STRE/81-186 ...................................QANTSTGT.ETVAVDNS......VVESA.....VKEA.QDTGV.A.V..SQNATQDQGTPTTS.AELDTAKETIKADQDKQVEAIKAT.....TAQQAQNNTAYEA..........AQSAITA...NNDYVADAQKTYE---agt..........................
C7MLU5_CRYCD/31-146 ..................................a-AVDPEKG.IEVAVDSS......SLDAA.....VTAA.KADGV.T.V..TQDADVDKGSATSQ.AELDAKKAEITEDYNSQIEALKAA.....AQEARQKLAEYATk.......kaAYDTALA...QYNTDKAQYDSDLAQYntdlaay......................
A0A1G6AD98_9STRE/91-196 ..................................s-TGQSHGA.ITVTVPHD......VVTQA.....VNQA.TAEGV.T.T..VQDQPMDLGNTTSA.SETSKQLDKAEADAARQAEDITQV.....TNTYKADKAVYEQ..........DKTRVEQ...GNAALAASHKDATQA-g............................
A0A3A1R3H7_9BACI/35-144 ..................................d-AENSSGT.VEITLPAStf.egsDVEQV.....IADA.KAEGV.KeV..IKNEDDSLTYKMSE.SVHSKIMKRFEENIMESIEGMKEN.....GNYPFVHDISYDE..........S--FSRF...TIVVDKAAYENSV---sks..........................
A4VUZ2_STRSY/109-214 ..................................l-TGQSNGA.IAVTVPHD......TVTQA.....VEEA.KAEGV.S.T..DEDSPMDLGNTTSA.TETSQQISKAEVDAQNQVEAINEV.....TETYKADKATYES..........NKARIEQ...ENKELSQAYEGVNQT-g............................
A0A0R1HPN7_9LACO/85-177 .................................ps--VDNTNT.QKLATSAS......DLQSA.....VDTA.KSTGV.A.V..TQNPSKTITTT--P.DKLATTADQVKADYESQTQALNQA.....TDKQKANNSTYAS..........-------...----DKEKYDKNEV--ti...........................
C8W9Q6_LANP1/34-156 ..................................y-ATDPAKG.IEVREDAS......KLEAS.....VAAA.KAAGV.D.V..QKDDDVDKGSVESS.SDIDAKKSEIQDDYNKQSQDLDAI.....TEEAKQKLADYATkkaaydtakaKYDADKA...QYDADKAQYDADMIAYnkamael......................
G5KEX2_9STRE/53-151 .................................tl--TEPTNN.QSQPVTSP......SLDKA.....VDTA.KEAGV.T.V..NTTSTVSHTDVP--.--------SAQADLDKQTQAVKDA.....TAKAQANTQAIKDa.......taKNAQIDA...QNKAEAERVAQENKA-g............................
E1MAV5_9STRE/50-136 .................................va--VEKKAE.FEVAISHE......SLDKA.....MTEA.KEAGV.N.V..EIDDVQDEGVATS-.ETVVSKQKEIEAEYAKHESEVKQK.....TDEYKKAKTNNEA..........E------...----------------rrav.........................
A0A3L8GED4_STRIN/54-152 .................................tl--TEPTTN.QAQPVTSS......ELDKS.....VDTA.KKAGV.T.V..NTTGAVSHTDVP--.--------SAQADLASQTQTVKDA.....TAKAEANTQAIKDa.......taKNAQIDA...ENQAEATRVEEANKA-g............................
G5K076_9STRE/67-155 ...................................QAGHQSGE.LVSEVSNT......EWDNA.....VTTA.QEAGV.T.V..KQSEKVTH------.----DSLSSAQADLEKQTQAVTEA.....TTKQEANKAAINQ..........AMAE---...----------------tklllkpivmkk.................
A0A3L8GMM8_STRIN/54-163 .................................tl--TEPTNN.QAQPVTSP......ALDTA.....VDSA.KDAGV.V.V..NTTQPVSHTDVPS-.---------AQADLANQTQAVKDA.....TAKAEANTQAIKDa.......taQNAQIDA...QNQAEATRVAEANKA-gqlavdqknaqg.................
Q82YN1_ENTFA/150-255 .................................ne--ANKSTS.ILKEFETP......DVDKA.....VDEAkKDPNI.T.V..VEKPAEDLGNVSS-.KDLAAKEKEVDQLQKEQAKKIAQQ.....AAELKAKNEKIAK..........ENAEIAA...KNKAEKERYEKEVAEY.............................
F9PX77_9STRE/1-66 ...................................--------.--------......-----.....----.-----.-.-..---------TDTTA.PKLEQSKSEIKQDQDKQVKELEEA.....TTKQVENNTAFKE..........AQKAIQA...NNQFVADEKAKHE---gett.........................
A0A347WMN8_9LACT/90-195 ..................................s-TGQSNGA.IAVTVPHD......TVTQA.....VEQA.KAEGV.S.T..VEDSPMDLGNTTSA.SETSQQISKAEADAQNQVVAINEV.....TESYKADKATYES..........NKARIEQ...ENKELSQAYEGANQT-g............................
A0A0B4RZB2_9FIRM/28-139 ...................................YAADPTRG.VEVNADHS......KLDQA.....VQEA.KDSGV.D.V..SKETTQDKGTASSN.SEADAKLAAVKADYENQIQKIKAAk..ldMDNYNAKKKEYDKl.......kkKYDEDLA...KYKIAKKKYEEELKAY.............................
A0A3D8YYE3_9BACL/38-145 .............................avekgl------LS.VEVTIPQS......FLDEEnpddiIASA.KEEGI.E.V..KKNEDGSLTYHMTK.AQHKKMLKDMKEGITKSVAEFEEN.....EDMPSVKKIDHNG..........--NFSKF...TVTVDREAYENS----fdg..........................
A0A542AKK8_9CLOT/46-165 ....aseptssaqklevdknlldvtitfpasmfeg--------.-------T......DTSQA.....IENA.EAEGV.Q.V..TKNSDGSLTYKMSK.ATHKKLMDGMKKSTSDSLSQLKTS.....GDYESITDVKYND..........DFSQIS-...-IVVNKAKYES-----sldsf........................
M2NE41_9FIRM/31-142 ..................................f-AIDSNKG.IEMSVDRT......KLDKS.....VADA.KSSGV.K.V..TKGADIDKGTAKTK.AELNAKKAEIIADYNQQIQELNNAk..laMDKYNEDKKAYDEa.......kkKYDEALA...KYTIAKKKYDDAMIEY.............................
A0A0M0GDX4_SPOGL/50-159 ..........................svkvdkgll-------N.VEVTLPASml.egeDMDSS.....IADA.EKEGI.K.V..TKNNDGSVTYKMYK.SKHKEMIKEIETELQKTIADTKNG.....EDYPSVEEVTHNK..........--DFSEF...TLEVEREAYEN-----sfdg.........................
A0A1J7JPP4_9PEZI/264-324 ..................lrveinkrgmredgglg--------.--------......-----.....----.-----.-.-..--------------.EEVEAKAKKILEDYEKQIQHLKKE.....VEQIKQDFEDYEK..........EHN----...----------------ptpa.........................
A0A7X9QUX5_9BACI/43-150 ..........................ievdkglln--------.VEVTLPASmf.edeDVDSA.....IAKA.EANGI.K.V..TKYNDGSVTYKMSK.SRHKEMIKDLEKELIKSIDEMKND.....AELASIQDITHNQ..........-------...----------------sfseltlivdkvayensfd..........
A0A0R2FKS8_9LACO/93-192 ...................................TAESTTNT.DQLKTTSA......DLQSA.....VDTA.KTTGV.V.V..TQNPTKTVTTTP--.DKLADTVSSVKADNDAQAQALADA.....TATQVVNQKTYDD..........AKQAVQA...----------------gtltitsgnqtk.................
SSPA_STRGC/79-184 ...................................QAGSKEGA.LPVEVSAD......DLNQA.....VTDA.KAAGV.N.V..VQDQTSDKGTATTA.AENAQKQAEIKSDYAKQAEEIKKT.....TEAYKKEVEAHQA..........ETDKINA...ENKAAEDKYQEDLKAH.............................
A0A347WKC7_9LACT/74-181 .................................aa-TEGTQGA.TEIAVDNT......PVEAA.....VETQ.KDNLV.-.-..VTEETKDLGIAQSE.EELSNKMSEIKKDQEKQVAEISNK.....GNQYQAEKTQHDKe.......leKYNKEKA...QYDQEKSKYDKDKQQY.............................
C0W2X4_9ACTO/53-146 .................................wd-----ENG.YIVASNQA......ELNNA.....IAKA.REAGV.T.V..TTSEQKLDAVAS--.NDAEQAKTRIERSNAEAIKALNTA.....VTKQQEYNLAFET..........KLKEELK...K---------------vlevesnk.....................
C7MNZ6_CRYCD/31-146 ..................................a-AVDPEKG.IEVAVDSS......SLDAA.....VTAA.KADGV.T.V..TQDADVDKGSATSQ.AELDAKKAEITEDYNSQIEALKAA.....AQEARQKLAEYATk.......kaAYDTALA...QYNTDKAQYDSDLAQYntdlaay......................
G5JRZ4_STRCG/83-189 ..................................q-AGQNNGEkLVVEAPSP......ELEQA.....VKEA.YQAGV.T.V..QEEADVDAGTVQTS.DQAAAKQAEIDADYAQQVEQIKTT.....VNSYKEEVAKHKA..........EVEQIDA...ENKAAAEQYDKDLAAH.............................
C8NFE4_9LACT/77-182 ...................................QAGQTTGS.IPVEVPTT......DVDQA.....VENA.KNAGV.K.V..EKDETVDKGTVKTA.EEADQKETEIKDDYAKQTEEIKKV.....TEQYKADVASNQK..........ETDRINA...ENKAIKDQYEKDMAAH.............................
A0A3L8GPT8_STRIN/44-144 ..............................qattq---TVTQN.QAETVTST......QLDKA.....VDTA.KTAGV.A.V..TTTAAVNHATTT--.--------DAQADLANQTQAVKDV.....TAKAQANTQAIKDa.......taENAKIDA...ENKAEAERVAKANKA-g............................
A0A1G6BP68_9STRE/83-176 .............................anvtqe-----QAV.EAVDQAQD......TLKEN.....VATA.QEAGV.V.V..KEEGTQEVVITD--.STAAEKTSEVLTDLNKQDQAVKEA.....TAKHLDNLKAYEE..........SQAAY--...----------------eetieag......................
V1D4P3_9FIRM/28-139 ..................................y-AADPING.VKVNADNS......KLDRA.....AKNA.RDSGA.E.V..TQGDTENKGTVDSK.EAADAKRAEIAADYEKQIKKLNEAk..vkMDEYNAKKAEYDKk.......keKYDKDLA...QYHKDYDKYKKDYE--sf...........................
Q839L6_ENTFA/150-255 .................................nd--ANKSTS.IPKEFETP......DVDKA.....VDEAkKDPNI.T.V..VEKPTEDLGNVSS-.KDLAAKEKEVDQLQKEQAQKIAQQ.....AAELKAKNEKIAK..........ENAEIAA...KNKAEKERYEKEVAEY.............................
F5X6Z9_STRPX/90-195 ..................................s-TGQSNGA.IAVTVPHD......TVTQA.....VEQA.NAEGV.S.T..VEDSPMDLGNTTSA.TETNQQISKAEADAQKQVEVIDEV.....TEIYKADKATYES..........NKARIEQ...ENKELSQAYEGANQT-g............................
#=GC seq_cons ......................................p.pts.ltlslsps......cl-pA.....lppA.cssGV.p.V..spspshshssshot.schspphpclcsDhpcQscplcps.....ssphptcptsapp..........p.st.tt...p.phtpttY-pt....t............................
//
