#=GF ID Alpha_E2_glycop
#=GF AC PF00943.23
#=GF DE Alphavirus E2 glycoprotein
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_308 (release 3.0)
#=GF GA 27.00 27.00;
#=GF TC 737.90 737.90;
#=GF NC 22.60 18.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Family
#=GF WK Alphavirus
#=GF CL CL0159
#=GF RN [1]
#=GF RM 7867069
#=GF RT Nucleocapsid and glycoprotein organization in an enveloped
#=GF RT virus.
#=GF RA Cheng RH, Kuhn RJ, Olson NH, Rossmann MG, Choi HK, Smith TJ,
#=GF RA Baker TS;
#=GF RL Cell 1995;80:621-630.
#=GF RN [2]
#=GF RM 9557679
#=GF RT The transmembrane domains of Sindbis virus envelope
#=GF RT glycoproteins induce cell death.
#=GF RA Joe AK, Foo HH, Kleeman L, Levine B;
#=GF RL J Virol 1998;72:3935-3943.
#=GF RN [3]
#=GF RM 8995682
#=GF RT Role of glycoprotein PE2 in formation and maturation of the
#=GF RT Sindbis virus spike.
#=GF RA Carleton M, Lee H, Mulvey M, Brown DT;
#=GF RL J Virol 1997;71:1558-1566.
#=GF RN [4]
#=GF RM 9311874
#=GF RT The nucleocapsid-binding spike subunit E2 of Semliki Forest
#=GF RT virus requires complex formation with the E1 subunit for
#=GF RT activity.
#=GF RA Barth BU, Garoff H;
#=GF RL J Virol 1997;71:7857-7865.
#=GF DR INTERPRO; IPR000936;
#=GF DR TC; 1.A.34;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC E2 forms a heterodimer with E1. The virus spikes are made up of
#=GF CC 80 trimers of these heterodimers (sindbis virus) [3].
#=GF SQ 5
#=GS POLS_CHIKS/339-742 AC Q8JUX5.3
#=GS POLSF_SINDV/339-745 AC P0DOK0.1
#=GS POLS_SINDV/339-745 AC P03316.1
#=GS POLS_SFV/347-749 AC P03315.1
#=GS POLSF_CHIKS/339-742 AC P0DOK1.1
POLS_CHIKS/339-742 PYLAHCPDCGEGHSCHSPVALERIRNEATDGTLKIQVSLQIGIGTDDSHDWTKLRYM...DNHIPADAGRAGLFVRTSAPCTITGTMGHFILARCPKGETLTVGFTDSRKISHSCTHPFHHDPPVIGREKFHSRPQHGKELPCSTYVQSNAATAEEIEVHMPPDTPDRTLLSQQSGNVKIT.VNGRTVRYKCNCGGSNEGLITTDKVINNC.KVDQCHAAVTNHKKWQYNSPLVPRNAELGdRKGKIHIPFPLANVTCMVPKARNPTVTYGKNQVIMLLYPDHPTLLSYRSMGEEPNYQEEWVTHKKEVVLTVPTEGLEVTWGNNEPYKYWPQLSANGTAHGHPHEIILYYYELYPTMTVVVVSVASFILLSMVGMAVGMCMCARRRCITPYELTPGATVPFLLSLICC
POLSF_SINDV/339-745 PYLGTCSYCHHTVPCFSPVKIEQVWDEADDNTIRIQTSAQFGYDQSGAASANKYRYMslkQDHTVKEGTMDDIKISTSGPCRRLSYKGYFLLAKCPPGDSVTVSIVSSNSAT-SCTLARKIKPKFVGREKYDLPPVHGKKIPCTVYDRLKETTAGYITMHRPRPHAYTSYLEESSGKVYAKpPSGKNITYECKCGDYKTGTVSTRTEITGCtAIKQCVAYKSDQTKWVFNSPDLIRHDDHT.AQGKLHLPFKLIPSTCMVPVAHAPNVIHGFKHISLQLDTDHLTLLTTRRLGANPEPTTEWIVGKTVRNFTVDRDGLEYIWGNHEPVRVYAQESAPGDPHGWPHEIVQHYYHRHPVYTILAVASATVAMMIGVTVAVLCACKARRECLTPYALAPNAVIPTSLALLCC
POLS_SINDV/339-745 PYLGTCSYCHHTVPCFSPVKIEQVWDEADDNTIRIQTSAQFGYDQSGAASANKYRYMslkQDHTVKEGTMDDIKISTSGPCRRLSYKGYFLLAKCPPGDSVTVSIVSSNSAT-SCTLARKIKPKFVGREKYDLPPVHGKKIPCTVYDRLKETTAGYITMHRPRPHAYTSYLEESSGKVYAKpPSGKNITYECKCGDYKTGTVSTRTEITGCtAIKQCVAYKSDQTKWVFNSPDLIRHDDHT.AQGKLHLPFKLIPSTCMVPVAHAPNVIHGFKHISLQLDTDHLTLLTTRRLGANPEPTTEWIVGKTVRNFTVDRDGLEYIWGNHEPVRVYAQESAPGDPHGWPHEIVQHYYHRHPVYTILAVASATVAMMIGVTVAVLCACKARRECLTPYALAPNAVIPTSLALLCC
POLS_SFV/347-749 PYIAYCADCGAGHSCHSPVAIEAVRSEATDGMLKIQFSAQIGIDKSDNHDYTKIRYA...DGHAIENAVRSSLKVATSGDCFVHGTMGHFILAKCPPGEFLQVSIQDTRNAVRACRIQYHHDPQPVGREKFTIRPHYGKEIPCTTYQQTTAETVEEIDMHMPPDTPDRTLLSQQSGNVKIT.VGGKKVKYNCTCGTGNVGTTNSDMTINTC.LIEQCHVSVTDHKKWQFNSPFVPRADEPA.RKGKVHIPFPLDNITCRVPMAREPTVIHGKREVTLHLHPDHPTLFSYRTLGEDPQYHEEWVTAAVERTIPVPVDGMEYHWGNNDPVRLWSQLTTEGKPHGWPHQIVQYYYGLYPAATVSAVVGMSLLALISIFASCYMLVAARSKCLTPYALTPGAAVPWTLGILCC
POLSF_CHIKS/339-742 PYLAHCPDCGEGHSCHSPVALERIRNEATDGTLKIQVSLQIGIGTDDSHDWTKLRYM...DNHIPADAGRAGLFVRTSAPCTITGTMGHFILARCPKGETLTVGFTDSRKISHSCTHPFHHDPPVIGREKFHSRPQHGKELPCSTYVQSNAATAEEIEVHMPPDTPDRTLLSQQSGNVKIT.VNSQTVRYKCNCGGSNEGLITTDKVINNC.KVDQCHAAVTNHKKWQYNSPLVPRNAELGdRKGKIHIPFPLANVTCMVPKARNPTVTYGKNQVIMLLYPDHPTLLSYRSMGEEPNYQEEWVTHKKEVVLTVPTEGLEVTWGNNEPYKYWPQLSANGTAHGHPHEIILYYYELYPTMTVVVVSVASFILLSMVGMAVGMCMCARRRCITPYELTPGATVPFLLSLICC
#=GC seq_cons PYLAaCuDCGcGHSCHSPVAIEpVRsEATDGTLKIQsSAQIGIDpSDuHDaTKlRYM...DsHslc-AsRuuLKVuTSGPCplpGTMGHFILAKCPPGEoLTVSIsDSRsAo+SCTlsaHHDPpsVGREKFclRPpHGKEIPCTTYsQosAsTAEEI-MHMPPDTPDRTLLSQQSGNVKIT.VuGKsV+YcCsCGsuNsGTloTDpsINsC.tI-QCHAuVTDHKKWQFNSPhVPRsDEhu.RKGKlHIPFPLsNlTCMVPhARsPTVIHGK+cVoLpLaPDHPTLLSYRoLGE-PpYpEEWVTuKsERslTVPsDGLEYpWGNNEPVRlWuQLSAsGcPHGWPHEIVQYYYcLYPshTVlAVuuASllhLIuVssAVhMsssARR+CLTPYALTPGAsVPaoLuLLCC
//
