#=GF ID   Alpha_Helical
#=GF AC   PF18489.5
#=GF DE   Alpha helical domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF04960
#=GF GA   32.40 32.40;
#=GF TC   33.50 37.30;
#=GF NC   27.40 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   18186487
#=GF RT   Structure of protein PH0536 from Pyrococcus horikoshii at 1.7 A
#=GF RT   resolution reveals a novel assembly of an
#=GF RT   oligonucleotide/oligosaccharide-binding fold and an
#=GF RT   alpha-helical bundle.
#=GF RA   Gao YG, Yao M, Tanaka I;
#=GF RL   Proteins. 2008;71:503-508.
#=GF DR   INTERPRO; IPR041169;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the N-terminal domain found in putative tRNA-binding
#=GF CC   proteins found in archaea. Structural analysis from Pyrococcus
#=GF CC   horikoshii indicate that it is a helical domain where many
#=GF CC   conserved residues are found in the first three helices and are
#=GF CC   mainly located on the inverse side of the putative tRNA-binding
#=GF CC   site. A structural homology search suggested that this fold
#=GF CC   prefers to bind proteins/peptides [1].
#=GF SQ   35
#=GS U6EEY0_9EURY/1-127      AC U6EEY0.1
#=GS A0A0V8RTX0_PYROC/1-121  AC A0A0V8RTX0.1
#=GS A0A315XM27_9EURY/1-127  AC A0A315XM27.1
#=GS A0A1D3L4H9_9EURY/1-127  AC A0A1D3L4H9.1
#=GS D3E1W3_METRM/1-127      AC D3E1W3.1
#=GS A0A2Z4LB78_9EURY/1-127  AC A0A2Z4LB78.1
#=GS O27056_METTH/7-133      AC O27056.1
#=GS F0T946_METLA/1-127      AC F0T946.1
#=GS A0A166E4L3_9EURY/1-127  AC A0A166E4L3.1
#=GS D2RH61_ARCPA/1-93       AC D2RH61.1
#=GS F2KPZ3_ARCVS/1-92       AC F2KPZ3.1
#=GS A0A0F7DCB3_9EURY/1-119  AC A0A0F7DCB3.1
#=GS A0A328RZG1_9EURY/1-127  AC A0A328RZG1.1
#=GS A0A328SAP4_9EURY/1-127  AC A0A328SAP4.1
#=GS F0LHR9_THEBM/1-127      AC F0LHR9.1
#=GS A0A1D2W923_9EURY/1-127  AC A0A1D2W923.1
#=GS A0A328SI31_9EURY/1-127  AC A0A328SI31.1
#=GS D3T9F7_ACIB4/1-114      AC D3T9F7.1
#=GS A0A2U1S8V4_9EURY/1-127  AC A0A2U1S8V4.1
#=GS Q8U3R9_PYRFU/1-127      AC Q8U3R9.1
#=GS Q5JF78_THEKO/1-127      AC Q5JF78.1
#=GS A2BJS3_HYPBU/1-121      AC A2BJS3.1
#=GS A0A166AV85_9EURY/1-127  AC A0A166AV85.1
#=GS A0A328PDF2_9EURY/1-125  AC A0A328PDF2.1
#=GS O29872_ARCFU/1-115      AC O29872.1
#=GS Q2NF72_METST/4-130      AC Q2NF72.1
#=GS R9SJH7_9EURY/1-127      AC R9SJH7.1
#=GS D3RY29_FERPA/1-100      AC D3RY29.1
#=GS C6A443_THESM/1-127      AC C6A443.1
#=GS A3DMX0_STAMF/1-118      AC A3DMX0.1
#=GS A0A166F489_9EURY/1-127  AC A0A166F489.1
#=GS G0EHC0_PYRF1/1-121      AC G0EHC0.1
#=GS N0BNH7_9EURY/3-94       AC N0BNH7.1
#=GS A0A366MFH3_9EURY/4-130  AC A0A366MFH3.1
#=GS A0A1V6N1Q5_METAZ/1-127  AC A0A1V6N1Q5.1
U6EEY0_9EURY/1-127                 .MWDTSNDYRLLVAEKSVELFLRTVEGANLKGKWNKKQALQSARKMTSEIQTLYYSYLEPSALVKTPQIDLLEEQARDIVEALG.G..DQWHRQFLELANREEKPKLEEALAKIKFFLNTIFGLKDRISLG.....................................
A0A0V8RTX0_PYROC/1-121             .MSDTRSDYRILMAEHALGMLESIIKSKKLPLPVNWKKAQELHAQARSILMQMKYSFMPPTMLARSEEARKLQEISRQLASILL.P..REWLERA------QLDQRARRVMADVKYAIRMLYGLPARLSLG.....................................
A0A315XM27_9EURY/1-127             .MWDTTKDYRILVASKARENYLNLIPTASFRGSWNKKQAVDMGKQMNSDFQSLTYSYLEGDELVNSPDVAALKEKALKIIEYLG.G..DDWNKKFLSNAPKEDRQKTQENIAKVRFFLDTIIGLKDRLALG.....................................
A0A1D3L4H9_9EURY/1-127             .MWDTSKDYRLRVAEKSVELFIRTAEGANLKGIWNKRKSLNSARDMVPEIQTLYYSYLEPDELAKSPQIKDMKAKVADIVDALG.G..EGWQNEFFKLVNKDEKEKLEESIAKMKFALNTINDIDKRLLLG.....................................
D3E1W3_METRM/1-127                 .MWDTAKDYRILVAMHARELFLRTVQTGSFRGNWNKKATIEETKKMEADLKSLLYCYLEGDALANCEDVQKLEDKAGRIIEFLG.G..EDWNHKFMQGAPKDEREKTEENIAKVRFFLDTILGLRNRFKFG.....................................
A0A2Z4LB78_9EURY/1-127             .MWDTSKDYRLKVAEKAVEDFIRVVEGSNLRGSWNKKQVRLIAKNMNPDIQTLYYSYVSPQELAKTPQMENLLKSMDEIIENLG.G..EDYAKKFQSELNRQEREKLDLPLSKMKFFFNTIRGLPDRLMLG.....................................
O27056_METTH/7-133                 .MWDTSKDYRLMVAVKAVDLFRRTLESGGFRGQWKKKPALQAAGEIERILQGLTYCYMEPEDLASSPEVMEIKGKVEEIVEALG.G..EDWSRRFLEEAPREEREKVEENIARVRFFLNTLGNLDRRLMLG.....................................
F0T946_METLA/1-127                 .MWDSSKDYRLRVLEKSVELFIKTAEGANLKGIWNKKKCLTSARSMLPEIQIMYFSYMEPAALAESPQVEDMKLKVKDIIDALG.G..DQWHVQFLNLVNKDEKEKLVESIAKMKFALNTISTVDERLKLG.....................................
A0A166E4L3_9EURY/1-127             .MWDTTKDYRLVLGQKTIDLFIRTVRGGSFRGRWNKKMALESATDMESDFQSLLYSYLDPQDLAETQEIVNLEEKANLVIRYLG.G..DDWAHLFLEQTPKNDKEKSEEAIAKARFFLDTVLGLKKRILFG.....................................
D2RH61_ARCPA/1-93                  m--DTSRDFRLILAEKGIKELERVINAVKVQR---RKEILKKVREMENDIQVVKWSYLDIDELLNFENFVKLVETAKELREALK.Q..AE-----------------------------------------kdfnwkladyw..........................
F2KPZ3_ARCVS/1-92                  m--DTSQDFRIRMAEKAIAELEKLMQNVKVQR---RKEFLKELKTMQSYVQVVKYSYMPPEQLAQLSEFSNLVKKAWEIRNAIK.N..AE-----------------------------------------kdfnyvqany...........................
A0A0F7DCB3_9EURY/1-119             m--DTASDFRIRLAEKGVEELEKSLNNVKVQR---RKELIRAISGLKSEVQIVKYSYMPFEELAELESVVKISETAKSVLEVVL.K..AE-----------------------------------------rdfhqlnskywleylahlpellkrgeiekayeairyf
A0A328RZG1_9EURY/1-127             .MWDTSKDYRLRVAEKAIEQFIRVVEGSNLRGSWNKKQVRLIAKNMNPDIQTMYYSYVSPQELAQTPQMENLLKGVDEIIDNLG.G..EDYSKKFLSELNREEREKLELPLSKMKFFFNTIRGLPDRLKLG.....................................
A0A328SAP4_9EURY/1-127             .MWDTSKDYRLKVAQKSVEEFIKVVEGSNLRGSWNKKQVRLLAKNMIPEIQTMYYSYLSPQELAKTEYVDNLLNSADEIIENLG.G..EDYASKFQSELNRQEREKLDLPISKMKFFFSTIRGLPDRLMLG.....................................
F0LHR9_THEBM/1-127                 .MWDTSKDYRLLTAEKAVELFLKTIEHAKFKGRWDKKKAIKLAKEMIPELQAMRYSYLDPKELIDTPQMEALKEKAQGIIEALG.G..EEWHHKFLSLADKSEKEKVEEAVAKVRFFLNTILNLDKRLALG.....................................
A0A1D2W923_9EURY/1-127             .MWDTSNDYRLLICEKSVDLFLRTIEGANLRGRWNKRDVRQIARDMIPEIQSMYYSYVEPADLAKMPQIESLKEKAGKIIENFG.G..EKWYSHFLDMVNKEEKIKLEEAIAKIRFFLDTVLNLDKRLALG.....................................
A0A328SI31_9EURY/1-127             .MWDTSKDYRLKVAEKAVEQFIRVVEGSNLRGSWNKKQVRLIAKNMNPDIQTMYYSYVSPQELAKTPQMDNLLKSVDDIIENLG.G..EDYSKKFLGELNREEREKLDLPLSRMKFFFNTIRGLPDRLMLG.....................................
D3T9F7_ACIB4/1-114                 m--DTANDPRILMAEKCTKDMKNLFN--NMRGV--GKEASKIMNDIERKILEIKYSYAELDALQS--LLKEIESKILELYELLG.G..KEWVNRL-KRVNID-----DGRIAKVKFCMNILYNLSSRLKL-p....................................
A0A2U1S8V4_9EURY/1-127             .MWDTSKDYRILVANEAREVYLNLIPTASFRGNWNKKMAIEMGKTMNSDFQSLLYSYLEGNDLPNSPDVAALTEKAEKIIEYLG.G..PDWNKTFLNGAPKEDRDKTIENIAKVRFFIDSILGLKDRLALG.....................................
Q8U3R9_PYRFU/1-127                 .MWDTSKDYRLLVAEKAVELFLRTIEGAKFRGQWDKKKAVQLAKEMIPDIQALRYSYIDPEELVDTPQIKSLKEKAQGIIEALG.G..EDWHHKFLSQATKEEREKVEEQVAKIKFFLNTILRLDKRLKLG.....................................
Q5JF78_THEKO/1-127                 .MWDTSKDYRLLVAEKSVELFLKTIEGAKFKGKWDKKRTIQLAKEMIPEIQAMRYSYIDPKELVDTPQMKALKEKALGIIEALG.G..EDWHHKFLSLADKSEREKVEEAVAKVRFFLNTILGLDRRLALG.....................................
A2BJS3_HYPBU/1-121                 .MSDTRNDYRILVAEHAVSLLENIVRARRIPIPVNWHEVEALVSELRSLIVRIKYSFIPPTMLAGSEEVERVREYAGKLAKTLL.S..KE------RLAGAKLDSKTRMAIAEARYALRTLYGLGYRLSLG.....................................
A0A166AV85_9EURY/1-127             .MWDSNKDYRLLIAQKSKDLFERTIESGSFRGRWNKKMAREIARNLNTDFQTLLYSYMEPKDMANSKDVEEIISKAHELIRYLG.G..EDWYHIFLREAKKEDKEKTEESVAKVKFFLRTLLGLKDRLAHG.....................................
A0A328PDF2_9EURY/1-125             .MWDTSRDYRFKVADKSISLFLKAVESGSLRGQWNKKLAVQMADEIKKVLQSLIYSYLEPKELTSAPEMRLIKEKGENIIEALG.G..EGWAELFLKEA--EDKEKTEENIARIKFFLNTILKLKERIMLG.....................................
O29872_ARCFU/1-115                 m--DTANDFRILLAEKGVEELIRVSQSLQVQGR---KKFVEALKSISSELQNVKYCYLSVDELLEFESFLKVVDTASSLRKMLPdS..KDY----------------------------------------staiadywleylahlpelmkrgeierigeai......
Q2NF72_METST/4-130                 .IWDTSNDYRLKVAEKAIEDFIRVVEGSNLRGSWNKKKVRLIAKDMNPDIQTLYYSYISPDQLAKTPQVNNLLKSVDEIIENLG.G..ENYSKKFLSELNREEREKLELPLSKMKFFFNTIRGLPARLMLG.....................................
R9SJH7_9EURY/1-127                 .MWDTSKDYRILIAIKSQELYLNTVQTGSFRGNWNKKAAIDEAKNMTSTFQSLKYSYLEGDNLTNTEDVSKLEENAERIIEFLG.G..PEWNHKFMNAAPKDDKSKTEENIAKVKFFLDTILGLRNRLAYG.....................................
D3RY29_FERPA/1-100                 m--DTANDFRILIAERGALELEKALQNVKVQ---KRKELAGLAGKIKNELQVLKYSYMPPDELAKASE--SIVRTSEEILNALQ.KaeEDFNRK-------------------------------------iaeywlnylislpd.......................
C6A443_THESM/1-127                 .MWDTSNDYRLLVAEKAIELFLKTIEGAKFKGKWDKKRAVQLAKRMIPELQALRYSYLEPSELIETPQMKDLKEKVEGIIEALG.G..EEWYVRFLELADRHEREKLEESIAKVRFFLNTIMNLDKRLALG.....................................
A3DMX0_STAMF/1-118                 m--DTANDYRFIIAEDAINRLRKIITSGQLPHHINKNRALSIIDEIKSRIMRLKYSFLPVTLLLRMRELDEIINYSMELSKMLL.P..KKHI--------GSKKSKLQLLISEIRYSLWILMGLKHRLRFG.....................................
A0A166F489_9EURY/1-127             .MWDTDKDYRILIAQKALDLYNRTVNSGTLRGRWNKRMAIDTANSMSSDFQSLTYSYLDPADLAKSPEVKSLEDKYQLVIRYLG.G..DDWNHEFLRQTPKNEKHKAEESIAKIRFFLRTISGLKDRLNFG.....................................
G0EHC0_PYRF1/1-121                 .MSDTRSDYRLLVAEHAVSLLEGIVRGRRIPAPIDWEEAARLLREARGIVKRMRFSFMPATMLARSPDAKSLQEIAKRLVDVVL.P..REWVERL------RGDQRARMPIAEARYAIRTLYTLPARLALG.....................................
N0BNH7_9EURY/3-94                  y-FDTSKDFRILMAEKAIVELEKLFNVLKLQ---KRKEYVRKMKDLYSKVQNLKYSYVAPDGIKALDDFKEIVTSTKKF-----.-..-------------------------------------------kedvrkldrdaqvikal....................
A0A366MFH3_9EURY/4-130             .MWDTTKDYRLLLGQKTIGMFVGTVRSGSFRGRWNKKMAIESAENMESDFQTLNYSYLDPEDLANTFEISTLEEKADLVVKYLG.G..EDWAHQFMSQTPKEDKEKVEEAIAKTRFFIDTISGIKNRILFG.....................................
A0A1V6N1Q5_METAZ/1-127             .MWDTTKDYRLLLGQKTINMFVGTARSGSFRGRWNKKMAIESAESMESDFQVLNYSYLDPEDLANTPEIANLEEKANLVLRYLG.G..EDWAHQFMAQTPKEEKEKAEEAIAKARFFIDTILGLKNRILFG.....................................
#=GC seq_cons                      .MWDTo+DYRlLlAEKul-hal+slcuusl+GpWNKKpslphA+pMps-lQslpYSYl-Pp-LAposplcsLp-pupcIl-sLG.G..--WtcpFhp.ss+c-+pKh-tslAKh+FFlsTlhsLppRLhLG.....................................
//