#=GF ID Anthrax-tox_M
#=GF AC PF09156.14
#=GF DE Anthrax toxin lethal factor, middle domain
#=GF AU Sammut SJ;0000-0003-4472-904X
#=GF SE pdb_1j7n
#=GF GA 25.00 25.00;
#=GF TC 27.20 26.00;
#=GF NC 21.70 20.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF WK Anthrax_toxin
#=GF CL CL0084
#=GF RN [1]
#=GF RM 11700563
#=GF RT Crystal structure of the anthrax lethal factor.
#=GF RA Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C,
#=GF RA Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P,
#=GF RA Liddington RC;
#=GF RL Nature. 2001;414:229-233.
#=GF DR INTERPRO; IPR015239;
#=GF DR SCOP; 1j7n; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Members of this family, which are predominantly found in anthrax
#=GF CC toxin lethal factor, adopt a structure consisting of a core of
#=GF CC antiparallel beta sheets and alpha helices. They form a long
#=GF CC deep groove within the protein that anchors the 16-residue
#=GF CC N-terminal tail of MAPKK-2 before cleavage. It has been noted
#=GF CC that this domain resembles the ADP-ribosylating toxin from
#=GF CC Bacillus cereus, but the active site has been modified to
#=GF CC augment substrate recognition [1].
#=GF SQ 1
#=GS LEF_BACAN/297-583 AC P15917.2
LEF_BACAN/297-583 ................................................................................MLARYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTK.INRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVV
#=GC seq_cons ................................................................................MLARYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTK.INRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVV
//
