#=GF ID   Antimicrobial10
#=GF AC   PF08105.15
#=GF DE   Metchnikowin family
#=GF AU   Lee SC;0000-0002-0504-0859
#=GF SE   Short protein clustering
#=GF GA   25.00 25.00;
#=GF TC   32.20 55.30;
#=GF NC   22.00 18.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9600835
#=GF RT   Two distinct pathways can control expression of the gene
#=GF RT   encoding the Drosophila antimicrobial peptide metchnikowin. 
#=GF RA   Levashina EA, Ohresser S, Lemaitre B, Imler JL; 
#=GF RL   J Mol Biol 1998;278:515-527.
#=GF DR   INTERPRO; IPR012513;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of the metchnikowin family of antimicrobial
#=GF CC   peptides from Drosophila.                    metchnikowin is a
#=GF CC   proline-rich peptide whose expression is immune-inducible.
#=GF CC   Induction of the metchnikowin gene expression can be mediated
#=GF CC   either by the TOLL pathway or by the imd gene product. The
#=GF CC   metchnikowin peptide is unique among the Drosophila
#=GF CC   antimicrobial peptides in that it is active against both
#=GF CC   bacteria and fungi [1].
#=GF SQ   10
#=GS B4QGU4_DROSI/1-50        AC B4QGU4.1
#=GS B4H8D4_DROPE/1-50        AC B4H8D4.1
#=GS A0A6P4IXM8_DROKI/1-50    AC A0A6P4IXM8.1
#=GS A0A6I8VQ66_DROPS/1-50    AC A0A6I8VQ66.1
#=GS A0A6P8X8F6_DROAB/1-54    AC A0A6P8X8F6.1
#=GS A0A6P4E3C5_DRORH/1-50    AC A0A6P4E3C5.1
#=GS B4J5Q0_DROGR/1-50        AC B4J5Q0.1
#=GS B4HS37_DROSE/1-50        AC B4HS37.1
#=GS MTK_DROME/1-50           AC Q24395.1
#=GS A0A484BU82_DRONA/90-138  AC A0A484BU82.1
B4QGU4_DROSI/1-50                   MQLNLGAIF..LALLG..LMATATSVLAEP.HRHQGPIFDTRPSPFNPNQPRPGP..
B4H8D4_DROPE/1-50                   MHFNLGVVF..LAMLG..LLAAGPLAPTEA.RHRQGPIFDTRPSPFNPNPPRGGP..
A0A6P4IXM8_DROKI/1-50               MQLNLGAIF..LALLG..VLATAPFTIAEP.HRQQGPIFDTRPSPYNPNPPRGG-r.
A0A6I8VQ66_DROPS/1-50               MHFNLGAVF..LAMLG..LLAAGPLAPTEA.RHRQGPIFDTRPSPFNPNPPRGGP..
A0A6P8X8F6_DROAB/1-54               MQLNLGNICstPLLLVllLLASLGVALSEP.-RHRGPIFDTRPSPFNPQQPRPG-gp
A0A6P4E3C5_DRORH/1-50               MQLNLGALF..LALLG..VMAAAPTVLSEP.HRHQGPIFDTRPSPFNPNQPRPGP..
B4J5Q0_DROGR/1-50                   MQLNPSKLM..PLLLP..LLLLLGVAFSEA.SRRQGPIFDTRPSPFNPNPPRGGP..
B4HS37_DROSE/1-50                   MQLNLGAIF..LALLG..VMATATSVLAEP.HRHQGPIFDTRPSPFNPNQPRPGP..
MTK_DROME/1-50                      MQLNLGAIF..LALLG..VMATATSVLAEP.HRHQGPIFDTRPSPFNPNQPRPGP..
A0A484BU82_DRONA/90-138             MQLKLREL-..-LLLP..LLLLLGLGLSEArHRENRFPFDTRPSPFNPNPPRPGP..
#=GC seq_cons                       MQLNLGAlF..LALLG..LLAsusssLoEP.HR+QGPIFDTRPSPFNPN.PRPGP..
//