#=GF ID   Apis_Csd
#=GF AC   PF11671.12
#=GF DE   Complementary sex determiner protein
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   Pfam-B_4678 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   28.40 25.20;
#=GF NC   24.50 22.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12941271
#=GF RT   The gene csd is the primary signal for sexual development in the
#=GF RT   honeybee and encodes an SR-type protein. 
#=GF RA   Beye M, Hasselmann M, Fondrk MK, Page RE, Omholt SW; 
#=GF RL   Cell. 2003;114:419-429.
#=GF RN   [2]
#=GF RM   15382141
#=GF RT   The dice of fate: the csd gene and how its allelic composition
#=GF RT   regulates sexual development in the honey bee, Apis mellifera. 
#=GF RA   Beye M; 
#=GF RL   Bioessays. 2004;26:1131-1139.
#=GF DR   INTERPRO; IPR021007;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins represents the complementary sex
#=GF CC   determiner in the honeybee. In the honeybee, the mechanism of
#=GF CC   sex determination depends on the csd gene which produces an
#=GF CC   SR-type protein. Males are homozygous while females are
#=GF CC   homozygous for the csd gene. Heterozygosity generates an active
#=GF CC   protein which initiates female development [2].
#=GF SQ   37
#=GS E2BCX3_HARSA/69-143        AC E2BCX3.1
#=GS A0A6I9W8E0_9HYME/290-452   AC A0A6I9W8E0.1
#=GS E1ZWU4_CAMFO/185-267       AC E1ZWU4.1
#=GS F4WWP5_ACREC/289-435       AC F4WWP5.1
#=GS E2C628_HARSA/61-139        AC E2C628.1
#=GS A0A834MZP9_VESPE/46-202    AC A0A834MZP9.1
#=GS A0A2A3E9M7_APICC/308-380   AC A0A2A3E9M7.1
#=GS A0A8N1S5C4_9HYME/286-448   AC A0A8N1S5C4.1
#=GS A0A834J004_VESVU/337-479   AC A0A834J004.1
#=GS A0A0N0U378_9HYME/358-430   AC A0A0N0U378.1
#=GS A0A7D0IUX4_9HYME/267-328   AC A0A7D0IUX4.1
#=GS A0A154P620_DUFNO/343-417   AC A0A154P620.1
#=GS A0A6J3KZ24_9HYME/283-357   AC A0A6J3KZ24.1
#=GS A0A4E0S3S9_9HYME/244-399   AC A0A4E0S3S9.1
#=GS Q6V5L4_APIME/283-334       AC Q6V5L4.1
#=GS A0A158NJA0_ATTCE/281-429   AC A0A158NJA0.1
#=GS A0A6J3KWG9_9HYME/343-417   AC A0A6J3KWG9.1
#=GS A0A7M7KZZ7_APIME/10-134    AC A0A7M7KZZ7.1
#=GS A0A836G194_9HYME/286-433   AC A0A836G194.1
#=GS A0A6P3Y0D7_DINQU/290-434   AC A0A6P3Y0D7.1
#=GS A0A4S2K9V8_9HYME/908-1052  AC A0A4S2K9V8.1
#=GS A0A232EG63_9HYME/321-399   AC A0A232EG63.1
#=GS E1ZWU2_CAMFO/349-500       AC E1ZWU2.1
#=GS A0A836FR47_9HYME/251-398   AC A0A836FR47.1
#=GS A0A836FR47_9HYME/745-863   AC A0A836FR47.1
#=GS Q6V5L4_APIME/332-401       AC Q6V5L4.1
#=GS A0A310SLF9_9HYME/345-418   AC A0A310SLF9.1
#=GS A0A7M7KZ32_APIME/266-412   AC A0A7M7KZ32.1
#=GS A0A158NJA2_ATTCE/288-435   AC A0A158NJA2.1
#=GS A0A6J3L7I2_9HYME/352-425   AC A0A6J3L7I2.1
#=GS A0A2A3E9M7_APICC/374-464   AC A0A2A3E9M7.1
#=GS A0A0J7K6K8_LASNI/79-226    AC A0A0J7K6K8.1
#=GS A0A2A3EB46_APICC/1-36      AC A0A2A3EB46.1
#=GS A0A7D0IUX4_9HYME/326-397   AC A0A7D0IUX4.1
#=GS A0A6P3YAY8_DINQU/283-427   AC A0A6P3YAY8.1
#=GS A0A026WXG5_OOCBI/291-427   AC A0A026WXG5.1
#=GS B3VN92_NASVI/326-405       AC B3VN92.1
E2BCX3_HARSA/69-143                   .................eiqchimlnmhq-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.---------..--..-....CLFIM.NLPPGPIMISPMVT.IpRRQVPplgRS......Q......HpplMG...LTR......PFPPRFIAP.DMYRI.R.S.P.A--------pnss.......
A0A6I9W8E0_9HYME/290-452              ......................vskhitn-----RSRSRE.RNP........HSrpFL....EERSYR.ErYR.ERSKERS.LER.R.TRERDRNRDRDRDKDGDRDrardrERD.....RDRSRNKDR..SREQR.NVTPHYIES.pIP..V....PIYYG.SFPPRPIVVSPMVP.L.RGQIPpigRG......R......HpalMA...PVR......PFPPRFVPP.DMYRLgH.P.P.PNPRYGP--f..........
E1ZWU4_CAMFO/185-267                  .....................srerrdva-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.---SHYIEP.pIH..V....PIYY-.NLPPRPIVVSPMVP.F.RGQVPpmaRG......R......HsalMA...PVR......PFPPRFIPP.DMYRL.G.PpP.PNPRYGP--f..........
F4WWP5_ACREC/289-435                  ......................nkhdnnr----SHSRERN.SHS........RP..FI....EERSYR.DrYR.ERSNERS.YER.R.DRDRERNRER---------.....DRN.....RERTKTRDR..SRERR.DITPRYIES.pIP..V....PIYYG.SFPPRPIVVGPMVP.L.RGQIPpmgRG......R......HptlMA...QVR......PFPPRF-PP.DIYRLgH.P.P.PNPRYGP--f..........
E2C628_HARSA/61-139                   .................iqhhimlntyqc-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.---------..--..-....-LFIM.NFPPRPYMVSPMVT.IpRGQVPplgRG......R......HpplMG...PVR......PFPPRFVPP.DIYRM.G.P.PaPNPRYGPMF...........
A0A834MZP9_VESPE/46-202               psnryrssrnrespsqeyrehrrdfysgq-----------.---........-D..FR....HKNESR.K.EEgSSSSSKP.RNR.S.TGNRERERRSRSR--SRSH.....SRS.....RDNRYGERQ..-----.MMPSHCIDQ..VP..Y....PVYYG.---PRPMMVGPMMP.L.RGQIP...IA......RgrippsV...MG...PIR......PFPPRFVPP.NVYRL.G.P.P.PNYRFGPMF...........
A0A2A3E9M7_APICC/308-380              .............................TSRKRYSRSRE.REQ........KS..YK....NENSYR.E.YR.ETSRERS.RDR.R.EREKSREHKITSSLSNNYN.....YNN.....YNNNYNNNN..-YNN-.---------..--..-....-----.--------------.-.-----...--......-......-...--...---......---------.-----.-.-.-.---------y..........
A0A8N1S5C4_9HYME/286-448              .......................vskhia------NRSRS.RDR........NS..YSrpflEERSYC.ErYR.ERSKERS.LER.R.TRERDRNRDRDRDKDGDRD.....RAKdrerdRDRSRNKDR..FREQR.NVTPHYIES.pIP..V....PIYYG.SFPPRPIVVSPMVP.L.RRQIPpmgRG......R......HpalMA...PVR......PFLPRFVPP.DMYRLgH.P.P.PKPRYGP--f..........
A0A834J004_VESVU/337-479              ..............sqeyrehrrdsysgq-----------.---........-D..FR....HKNESR.K.EEgSSSSSKP.RNR.S.TGNRERERRSRSR--SRSH.....SRS.....RDNRYGERQ..-----.MMPSHCIDQ..VP..Y....PVYYG.---PRPMMVGPMMP.L.RGQIP...IA......RgrippsV...MG...PIR......PFPPRFIPP.NVYRL.G.P.P.PNYRFGPMF...........
A0A0N0U378_9HYME/358-430              ..........................tss-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.----HYIEQ..IT..V....PFYYG.DFPARPIMVGPLVP.I.RGQVP..lGP......R......H..mMG...PLR......PFPPRFIPP.DMYRL.R.P.P.LNPRFGPMY...........
A0A7D0IUX4_9HYME/267-328              .........................erkg--HRDHSRSRE.REQrtwsreshKS..FK....DERSHR.E.YR.ERSRERS.RER.S.ERDRSREHRVPSS------.....---.....---------..-----.---------..--..-....-----.--------------.-.-----...--......-......-...--...---......---------.-----.-.-.-.---------h..........
A0A154P620_DUFNO/343-417              ...........................pp-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.----HYIEQ..IP..V....PIYYG.NFPPRPILMGPLIP.I.RGQMPl.rGG......R......HpsmMA...PIR......PFPPRFISS.DVYRL.R.P.P.SNPRFGPMF...........
A0A6J3KZ24_9HYME/283-357              ..........................pps-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.----HYIEQ..IP..V....PVYYG.DFPPRPIMVGPLVP.I.RGQVPplgGT......R......H..mIG...PLR......PFPPRFIPP.DMYRL.R.P.P.LNPRFRPMY...........
A0A4E0S3S9_9HYME/244-399              ..............terhdrghsydrgst-----------.--T........ND..RY....HERKYP.S.SR.KSSPERV.RDS.RsRRSQDRNARAGSHRDSTCR.....EYQ.....DYDSYSHPRrhEVDRR.PAALSYAEP..IT..F....PMYYD.NL-VRPMMMDPMMM.M.RTPMP...MM......R......G...RV...PAMiptfrpPFRPRFMPS.EMFRL.N.G.P.PTQRYGRMF...........
Q6V5L4_APIME/283-334                  .............................TSRRRYSRSRE.REQ........KS..YK....NEREYR.E.YR.ETSRERS.RDR.R.ERGRSREHRIIPS------.....---.....---------..-----.---------..--..-....-----.--------------.-.-----...--......-......-...--...---......---------.-----.-.-.-.---------h..........
A0A158NJA0_ATTCE/281-429              ......................ankhdnn-----RSRSRE.RNS........HSrpFI....EERSYR.DrYR.EKSNECS.YER.R.DRERERNRERGRN----RD.....RTK.....-----TRDR..SRERR.NIASRYIES.pIS..V....PICYG.SFPPRPIVVNPMVP.L.RGQIS...SMg...rgR......HptlMV...PVR......PFPPRF-PP.NMYSLgH.S.S.PNP------ivslif.....
A0A6J3KWG9_9HYME/343-417              ..........................pps-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.----HYIEQ..IP..V....PVYYG.DFPPRPIMVGPLVP.I.RGQVPplgGT......R......H..mIG...PLR......PFPPRFIPP.DMYRL.R.P.P.LNPRFRPMY...........
A0A7M7KZZ7_APIME/10-134               ......................gersqdk------ERSPD.KER........CQ..DK....ERSEDR.E.KS.EDKRRSGdIERsA.DRERSREQGVILSLSN---.....---.....---SYRSL-..----Q.YYNINYSEQiyIPvsV....PVYYG.NVPPNPKIIGLRIQ.-.--YIP...RS......R......F...NT...LIF......PV-RRSIPP.TIYRF.R.-.-.---------h..........
A0A836G194_9HYME/286-433              .....................ankhdnnr----SHSRERN.SHS........RP..FI....EERSYR.DrYR.ERSNERS.YER.R.DRDRERNRE----RDRNRD.....---.....--RTKTRDR..SRERR.DIAPHYIES.pIP..V....PIYYG.SFPPRPIVVGPMVP.L.RGQIPpmgRG......R......HptlMA...QVR......PFPPRF-PP.DMYRLgH.P.P.PNPKH----eil........
A0A6P3Y0D7_DINQU/290-434              ......................ernasss-------HSRSiIEN........RS..YC....NR--YRdR.YR.NRSNERS.QEK.G.DRDKDRDRNRCTERDRNRN.....RDS.....FRNRKDTA-..-----.---PHCVKP..VP..M....DIYYG.TLPPRPLLMSPMVP.IpRGQFP...LL......Rg...rrHpslMA...PVR......SFPPQFIPP.DVYRM.ElP.V.PNIKYKPMF...........
A0A4S2K9V8_9HYME/908-1052             ...........................ds------SRDRD.RDR........DR..DR....DRERER.ErKK.ERDRDRD.RDR.-.ERQRKREKEKDRDRDRDRN.....KDR.....--DRSREGK..DI---.--APHYIKS.pIP..VikipPIYYG.SFPPRPIVASPMVP.L.RGQIS...PMgigrlpA......L...MA...PVR......PFPPRF-PP.DMYRLgH.P.P.PNPRFGP--f..........
A0A232EG63_9HYME/321-399              .........................rlpp-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.---VQYVEQ..VP..Y....PVYYSaGFAPRPMLVGPAIPpL.RGPLA...GR.....gR.....pL...MA...PIR.....pPFPPRFIGPqDMFRA.V.L.P.SDPRFGRMF...........
E1ZWU2_CAMFO/349-500                  .............................-SRKRKDRNRD.SD-........RS..RK....RRRDKD.R.DR.DKSRERR.RDRdR.DRDRSRERKDVAPHYVEPP.....IHV.....PDRDRDRDK..SKERK.DVAPHYVES.pIH..V....PIYY-.NLPPSPIVVSPMVP.F.RGQVPpmaRG......R......HsalMA...PVR......PFPPWFIPP.DMYRL.R.P.PpPNP------skyryy.....
A0A836FR47_9HYME/251-398              .....................ankhdnnr----SHSRERN.SHS........RP..FI....EERSYR.DrYR.ERSNERS.YER.R.DRDRERNRE----RDRNRD.....---.....--RTKTRDR..SRERR.DIAPHYIES.pIP..V....PIYYG.SFPPRPIVVGPMVP.L.RGQIPpmgRG......R......HptlMA...QVR......PFPPRF-PP.DMYRLgH.P.P.PNPKH----eis........
A0A836FR47_9HYME/745-863              ......................ankhdnn---RSHSRERN.SHS........RP..FI....EERSYR.DrYR.ERSNERS.YER.R.DRDRERNRE----RDRNRD.....---.....--RTKTRDR..SRERR.DIAPHYIES.pIP..V....PIYYG.SFPPSPIVVGPMVP.L.RGQIS...--......-......-...--...---......---------.-----.-.-.-.---------pmekgrhptlm
Q6V5L4_APIME/332-401                  ...........................ps-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.----HYIEQ..IP..V....PVYYG.NFPPRPIMVRPWVP.M.RGQVP...GS......R......H...IG...PLT......PFPPRFIPP.DMYRL.R.P.P.PNPRFGPMY...........
A0A310SLF9_9HYME/345-418              ..........................pts-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.----HYFEQ..IH..V....PLYYS.NFSPRPIMVGPLVP.M.RGQVP..lSS......R......H...MMspfPLR......PFPPRFIPP.DMYRL.R.P.P.PNPSGDP--r..........
A0A7M7KZ32_APIME/266-412              .............................TSRNRYSRSRE.REQ........NS..YK....NEREYQ.K.YR.ETSKERS.RDR.T.ERERCKEPKIISSLSNNYK.....YSN.....YNNYNNNYN.tNYKKLqYYNIINIEQipVP..V....PIYCG.NFPPRPM--GPWIS.I.QEQVP...RF......R......Y...IG...PPT......PF-PRFIPP.NAYRF.R.P.P.LNPRFGPTH...........
A0A158NJA2_ATTCE/288-435              .......................ankhdn------NRSRS.RER........NS..YSrpfiEERSYR.DrYR.ERSNERS.YER.R.DRDRERNRE----RDRNRD.....---.....--RTKTRDR..SRERR.DIAPHYIES.pIP..V....PIYYG.SFPPRPIVVSPMVP.L.RGQIPpmgRG......R......HptlMA...QVR......PFPPRF-PP.DMYRLgH.P.P.PNPRYGP--f..........
A0A6J3L7I2_9HYME/352-425              ..........................pps-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.----HYIEP..IP..V....PVYYG.GFPPRPIMVGPLVP.I.PRQVPl.kGS......R......H..mMS...PLR......PYPPRFIQP.DIYRF.C.P.F.PNPRFRPMY...........
A0A2A3E9M7_APICC/374-464              ............................n-----------.---........--..--....------.-.--.-------.---.-.-----------------NN.....YNN.....YNNNYNNYN..NKKLY.YCNINYIEQ..IP..V....PVYYG.NFPPNPIMVRPWVP.M.QEQIP...RF......R......Y...IG...PLT......SFPPRFIPP.NMYR-.R.P.P.LNPRFRPMY...........
A0A0J7K6K8_LASNI/79-226               ..........shqsryrtdskrqdnrtef-------RDHH.KNN........GS..IM....EERSYR.DrYR.DRSNEHS.RER.R.DRDRDKDR-----------.....---.....-----DRDR..SRERR.DVAPHYIEP.pIH..V....PFYAY.NLPPRPIVVSPMVP.FpRGQVPpmgRG......R......H...SGlmaPVR......PFPPRFIPP.DMYRL.G.PpP.PNPRYGP--f..........
A0A2A3EB46_APICC/1-36                 .............................-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.---------..--..-....-----.--------------.M.RGQVP...GY......R......H...IG...P--......SFPPQFITR.NR---.N.P.P.PNPRFRPIF...........
A0A7D0IUX4_9HYME/326-397              ...........................ss-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.----HYIEQ..IP..V....PFYYG.DFPARPIMVGPLVP.I.RGQVP..lGT......R......H..mMG...PLR......PFPPRFIPP.DMYRL.R.P.P.PNPSM----htcr.......
A0A6P3YAY8_DINQU/283-427              ................nrsysgergtgsf-----------.-HS........KS..IV....ENKSYRsR.YR.DRSSERS.RER.R.DRDRDRDRD---RDRDRDR.....NRN.....RDRSKD---..----R.KDTPHYVEH..VP..L....RIYYD.TFPPRPFVVSPMVI.P.RGQVPplgRG......R......HpplMA...PVR......PFPPRFVPP.DMYRM.G.P.PaPNPRYGPIF...........
A0A026WXG5_OOCBI/291-427              ............................a-SKRNINRSRS.RER........DS..HSrqcmEEKPYR.DrYY.DRSSERS.HER.R.ERERDRNRN----------.....KRE.....---SRS---..-RERR.DLTPHYIEP..VH..V....PIYYS.NFP-RPIVVSPMVP.V.RGQIPpmgRG......R......H..lMA...PVR......PFSPRFVPP.DMYRF.G.P.P.PNPRYGPMF...........
B3VN92_NASVI/326-405                  ........................rrlpp-----------.---........--..--....------.-.--.-------.---.-.-------------------.....---.....---------..-----.---VQYIEQ..VP..F....PIYYSaGFAPRPMLVGPAIPpI.RGPLA...GR.....gR.....pL...MA...PIR.....pPFPPRFIGPqDMYRA.G.L.P.SDPRFGQMY...........
#=GC seq_cons                         ...........................ss................................................................................................................HYIEp..IP..V....PlYYu.sFPPRPIhVuPhVP.l.RGQlP...ts......R......H...Mu...PlR......PFPPRFlPP.DMYRh.p.P.P.PNPRatP.............
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