#=GF ID   Arena_ncap_C
#=GF AC   PF17290.6
#=GF DE   Arenavirus nucleocapsid C-terminal domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Bateman A
#=GF GA   27.00 27.00;
#=GF TC   34.10 32.80;
#=GF NC   21.90 21.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0219
#=GF RN   [1]
#=GF RM   21085117
#=GF RT   Cap binding and immune evasion revealed by Lassa nucleoprotein
#=GF RT   structure.
#=GF RA   Qi X, Lan S, Wang W, Schelde LM, Dong H, Wallat GD, Ly H, Liang
#=GF RA   Y, Dong C;
#=GF RL   Nature. 2010;468:779-783.
#=GF DR   INTERPRO; IPR035084;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain represents the the C-terminal domain that contains
#=GF CC   3'-5' exoribonuclease activity involved in suppressing
#=GF CC   interferon induction [1]. This domain has an RNaseH-like fold.
#=GF SQ   20
#=GS NCAP_LASSJ/363-543        AC P13699.1
#=GS J7HCF9_9VIRU/393-573      AC J7HCF9.1
#=GS NCAP_PIRVV/353-534        AC Q8BDE4.1
#=GS A0A2Z5DEG4_9VIRU/352-532  AC A0A2Z5DEG4.1
#=GS A0A1P8PFC6_9VIRU/398-513  AC A0A1P8PFC6.1
#=GS NCAP_PIARV/356-535        AC P03541.1
#=GS NCAP_LYCVA/356-532        AC P09992.1
#=GS A0A6C0PIK7_9VIRU/400-576  AC A0A6C0PIK7.1
#=GS NCAP_GTOVV/354-535        AC Q8AZ66.1
#=GS NCAP_GOGV/404-579         AC J7H5M4.1
#=GS A0A6C0PID8_9VIRU/407-577  AC A0A6C0PID8.1
#=GS A0A0H3YA18_9VIRU/399-579  AC A0A0H3YA18.1
#=GS Q8BD27_BCNVU/360-536      AC Q8BD27.1
#=GS NCAP_IPPYV/364-544        AC Q27YE3.1
#=GS C5ILC2_9VIRU/354-533      AC C5ILC2.1
#=GS NCAP_LATVB/353-532        AC Q8BDE6.1
#=GS A0A2U7PK98_9VIRU/355-537  AC A0A2U7PK98.1
#=GS NCAP_TACVF/360-545        AC P18140.1
#=GS Q8BDE3_TAMVU/358-539      AC Q8BDE3.1
#=GS A0A0F7LDH0_9VIRU/399-579  AC A0A0F7LDH0.1
NCAP_LASSJ/363-543                   .....................AGLTYSQLMTLKDAMLQLDPNA.KTWMDIEGRPEDPVE..IALYQP.S...SGCY.I...HFFREPTDLKQFKQDAKYSHGIDVTDLFAT...QP.GLT....SAVIDA....LPRNMVITCQGSDDIRKLLESQGRK.DIKLIDI.ALSKTDSR...KYENAVWDQYK.D.L.CHMHTGVVVEKK.KRGGK.EEIT.....PHCALMDCIMFDAAVSG........
J7HCF9_9VIRU/393-573                 ...............eiidpr-------SLVLSDMAQKLFKNNkEVFIDIEGSATDPVE..IALYGV.E...KNQY.I...HIFRLPKDSESFKKASRHSHGLIASDMADH...IN.LFIdkniKSMFSA....IPKDQIVHCQGS-DIKELLKFYGRS.DINVADS.KWKKKDYM...SYHEGILDIVS.DiL.PCKHSGTVKDKT.GA---.-LTS.....PHCALVDCMMFACAAKG........
NCAP_PIRVV/353-534                   ...................sq--LSHAKEEQILEGLKRLDSKA.TTWIDIEGTPNDPVE..LAIFQP.E...SGNY.I...HCYREPHDVKSFKDQSKYSHGMLLKDLTNT...QP.GLI....SFIIKN....LPAGIVLTAQGSDDIEKLLEMHARR.DISIIDV.RLTSEQAR...QFEDKVWDKFG.I.L.CNKHKGIVLARK.KKGSPpGSKN.....PHCALLDCIMFCSTI--gg......
A0A2Z5DEG4_9VIRU/352-532             ...................sp--ITSMQEAVIKEAIQKLDVGS.STWIDIEGAPTDPVE..LAIYQP.D...SGAY.I...HCFRKPHDEKGFKTGSKYSHGILLKDIEEA...QP.GLM....SKIITM....LPRNMVLTAQGTDDIKKFLELHGRR.DLILVDV.SMTSEQAR...HYEDRILDEYS.H.L.CTRHNGVVIVKK.KKNHG.HSGE.....PHCALMDCLMYQCS---ldg.....
A0A1P8PFC6_9VIRU/398-513             vevsdprilymsqmsdelfkg--------------------GE.TVFMDIEGTAQDPVE..IVLLNG.E...TSKF.V...HIFRMPKDKDNFKRSSKHAHGLLLDDISDH...PN.LCT....EKSIEVffsrIPQSAKIFSQGSD------------.-------.--------...-----------.-.-.------------.-----.----.....-----------------ieeclkff
NCAP_PIARV/356-535                   ..............ipkeked---------TVVSSIQMLDPRA.TTWIDIEGTPNDPVE..MAIYQP.D...TGNY.I...HCYRFPHDEKSFKEQSKYSHGLLLKDLADA...QP.GLI....SSIIRH....LPQNMVFTAQGSDDIIRLFEMHGRR.DLKVLDV.KLSAEQAR...TFEDEIWERYN.Q.L.CTKHKGLVIKKK.KKGAV.QTTA....nPHCALLDTIMFDATVTG........
NCAP_LYCVA/356-532                   .....................VGLSYSQTMLLKDLMGGIDPNA.PTWIDIEGRFNDPVE..IAIFQP.Q...NGQF.I...HFYREPVDQKQFKQDSKYSHGMDLADLFNA...QP.GLT....SSVIGA....LPQGMVLSCQGSDDIRKLLDSQNRK.DIKLIDV.EMTREASR...EYEDKVWDKYG.W.L.CKMHTGIVRDKK.KK---.-EIT.....PHCALMDCIIFESASKA........
A0A6C0PIK7_9VIRU/400-576             .........ieksnfnadlic----------------------.-SYLDIEGSPEKPVE..VGIVVFtKsgnKSQFyE...NVIYSDKPSDTYISEKSYCHGIDLTIINNSpkcSD.TIH....SDAKKL....LSKIEKVHCFGDDVIK-FLKLCDFKgKIWPIELpKWSDRLQR...GYGTKLQSKCC.N.K.EEIHSSKLKAKD.-KDIK.EKLL.....PHCAVTDCFMMHN----yly.....
NCAP_GTOVV/354-535                   ....................s-NLSEMQEAIVKEAMRKLDSSD.TIWMDIEGPPTDPVE..LAVFQP.S...SGNY.V...HCFRKPHDEKGFKNGSRHSHGILLKDLEDA...QP.GLL....SYVIGL....LPQGSVITVQGADDIKKLFDIHGRK.DLKLVDV.RLTGEQSR...IFEQEVWEKFG.H.L.CRAHNGVIVPKKkNKEAN.STKE.....PHCALLDCIMFQSVL--dg......
NCAP_GOGV/404-579                    .....rvlymanacedlfkgg---------------------D.SVFMDIEGTAQDPVE..IALFNP.D...TGKF.V...HIFRMPKDKDGFKKASKHAHGLLLDDISDH...PD.LQT....DKNIEAffskVPLSARIFCQGS-DIEECLKFFGRK.DLKPTDC.KWKREEFM...KYHENILDELS.E.VfPCKHSGTVKDKK.GA---.-LTA.....PHCALLDCLMFSRTAS-g.......
A0A6C0PID8_9VIRU/407-577             ...............hadlic----------------------.-SYIDIEGSPERPVEvgLAIFVK.S...NGKS.VlyeNVIYSDKPSDAYISEKTYCHGIDLTIISSSpkcSD.NIH....SDTRKL....LDKIEKVYCFG-DDVIKFLKLCGFK.G-KIWPI.ELPKWADRikkGYETKLLSGCC.N.K.EDIHSSKLKAKD.-KDIK.EKLL.....PHCAVVDCFMMHN----yly.....
A0A0H3YA18_9VIRU/399-579             ..evsdprvlymsnackelfk-------------------GGD.TVFMDIEGTAQDPVE..IALLNP.D...TGKF.I...HIFRMPKDKDDFKKASKHAHGLLLDDISNH...PD.LQT....EKSIEAffsdIPPSAKIFCQGS-DIEECLKFFGRK.DLKTTDC.KWKREEYM...KYHESILDELSeK.L.PCKHSGTVKDKK.GA---.-LAA.....PHCALIDCLMFSKTAS-g.......
Q8BD27_BCNVU/360-536                 ................eledq----------VRKGVEGLSPNL.TTWIDIEGPPNEPVE..LAIYQP.E...TQKY.L...HCYRRPNDIKSFKDQSKYCHGILLKDVENA...RP.GLI....STIIRH....LPKSMAFTAQGEDDIKRLFDMHGRQ.DLKIVDV.KLSAEQSR...VFEELVWKKFE.H.L.CDRHKGIVIKSK.KKGSK.PAST....nAHCALMDCIMFNAV---lvg.....
NCAP_IPPYV/364-544                   ....................s-GLTMSQILALKDLMAAVDPNA.KTWIDIEGRAEDPVE..IAFYQP.Q...TGAY.I...HFYREPTDAKQFKQDSKYSHGIDIGDLFNV...QP.GLT....SAVLEL....LPPNMVLTCQGSEDIRRLLDSQGRK.DIKLIDV.LMSKSEAR...KFEDEVWDKFG.F.L.CKIHTGHVVEKK.KRGNK.EEIT.....PHCALLDCLMYEAASTG........
C5ILC2_9VIRU/354-533                 .....................VGVSFSQSQLLDDIMKNLNPKG.RTWMDIEGRPDDPVE..IAIFQP.E...ERLC.L...HFYREPTDQKQFKNDSKYCHGMDFTQLCST...QP.GLT....TAVLER....LPLGMVITCQGKDDIEKLLHSQGRR.DVKFIDI.QMSKEASR...KFEDQVWDSYK.T.F.CNQHTGIVVTKS.KK-GK.KEIT.....PHCALMDCIMYESAVNG........
NCAP_LATVB/353-532                   ...................sp--LSDTQEAVIKEAIGKLDMDE.TIWIDIEGPPNDPVE..LAIYQP.S...TGNY.I...HCFRVPHDEKGFKNGSKYSHGILLRDIENA...RS.GLL....SRILMR....LPQKVVFTCQGSDDIQKLLQMNGRP.DIATIDM.SFSSEQAR...FFEGVVWEKFG.H.L.CTRHNGVVLSRK.KKGGN.S-GE.....PHCALLDCIIFQAAFE-g.......
A0A2U7PK98_9VIRU/355-537             ...................sh--LTELQESVIREAMGKINPAQ.TTWIDIEGPSNDPVE..LALYQP.D...SGHY.I...LCYRKPHDEKGFKNGSRHSHGMLLKDLESA...QP.GLL....SYVIGL....LPQDMVLTTQGSDDIKRLLETHGRK.DLKLVDI.KLSSDQAR...SFEEIIWSDYG.H.L.CKKHNGVVVPKK.KKDKE.SPQSs...ePHCALLDCLMFQSALD-g.......
NCAP_TACVF/360-545                   .....................ASLTEGQELIVRAAISELDPSN.TIWLDIEDLQLDPVE..LALYQP.A...KKQY.I...HCFRKPHDEKGFKNGSRHSHGILMKDIEDA...VP.GVL....SYVIGL....LPPNMVITTQGSDDIRKLLDIHGRK.DLKLIDV.KFTSDQAR...LFEHQVWDKFG.H.L.CKQHNGVIISKK.NKSKD.SPPSpspdePHCALLDCIMFHSAVSG........
Q8BDE3_TAMVU/358-539                 ............tlkpeveeq----------IKRSIESLSVHD.TTWIDIEGPPFDPVE..MAIYQP.D...SLKY.I...HCYRKPNDVKSFKDQSKYCHGILLKDIEYC...SSlALY....QPSLRH....LPKSMVFTAQGSEDIRRLFDMHGRQ.DLKIVDV.KFTAEQSR...VFEELTWKRFE.H.L.CDKHKGIVIKSK.KKGTT.PAST....nAHCALMDCIMFSG----vllg....
A0A0F7LDH0_9VIRU/399-579             ..evsdprvlymsnackelfk-------------------GGD.TVFMDIEGTAQDPVE..IALLNP.D...TGKF.I...HIFRMPKDKDDFKKASKHAHGLLLDDISNH...PD.LQT....EKNIEAffsdIPPSAKIFCQGS-DIEECLKFFGRK.DLKTTDC.KWKREEYM...KYHESILDELS.EiL.PCKHSGTVKDKK.GA---.-LAA.....PHCALIDCLMFSKTAS-g.......
#=GC seq_cons                        ....................p..........lpchhttlssss.ooWlDIEGsspDPVE..lAlaQP.-...oGpY.I...HhaRpP+DpKuFKpsSKYuHGlLLcDlpss...ps.GLh....SplIct....LPpshVlTsQGSDDIc+LLchaGR+.DlKllDl.+hopEpuR...paE-plW-cau.c.L.CspHsGlVlsKK.pKstt.ttts.....PHCALlDClMFpushp.h.......
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