#=GF ID   Astro_VPg
#=GF AC   PF19416.3
#=GF DE   Astrovirus VPg protein
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   P0C6K4
#=GF GA   25.00 25.00;
#=GF TC   27.60 144.30;
#=GF NC   24.00 21.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22787221
#=GF RT   Identification of human astrovirus genome-linked protein (VPg)
#=GF RT   essential for virus infectivity.
#=GF RA   Fuentes C, Bosch A, Pinto RM, Guix S;
#=GF RL   J Virol. 2012;86:10070-10078.
#=GF DR   INTERPRO; IPR045836;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents the presumed VPg protein from human
#=GF CC   astrovirus. Viral genome-linked proteins (VPgs) are
#=GF CC   virus-encoded small proteins that are covalently linked to the
#=GF CC   5' terminus of many RNA viral genomes through a phosphodiester
#=GF CC   bond.  Viral genome-linked proteins (VPgs) have been identified
#=GF CC   in several single-stranded positive-sense RNA virus families.
#=GF CC   The protein resulting from this putative VPg coding region is a
#=GF CC   highly disordered protein [1]. A common feature of VPgs is that
#=GF CC   they are rich in basic amino acids [mostly Lys (K), Gly (G), Thr
#=GF CC   (T), and Arg (R)], which favors the interaction with the
#=GF CC   negatively charged RNA. Tyr-693 at the conserved TEEEY-like
#=GF CC   motif has been postulated to be the residue responsible for the
#=GF CC   covalent linkage to viral RNA. Mutagenesis of Tyr-693 in the VPg
#=GF CC   protein is lethal for HAstV replication [1].
#=GF SQ   4
#=GS NS1AB_HASV1/664-755  AC Q67726.1
#=GS NS1A_TASV1/795-889   AC Q9JH70.1
#=GS NS1A_HASV1/664-755   AC P0C6K4.1
#=GS NS1AB_TASV1/795-889  AC Q9JH69.3
NS1AB_HASV1/664-755             QKKKGKT-------KHGRGRVRRNLRKG----VKLLTEEEYRELLEKGLDRETFLDLIDRIIGERSGYPDY-DDEDYYDEDDDGWGMVGDDVEFDYTEVINFDQ
NS1A_TASV1/795-889              QKKKGKTKRTARGGKHALG--KKYLSKAHFSRMRMLTEEEYNKMVEDGFSPDEIKEVVDQL--REQAWQNYLIDNDIGEDDDLDW---YDDMLED--ERLNEEI
NS1A_HASV1/664-755              QKKKGKT-------KHGRGRVRRNLRKG----VKLLTEEEYRELLEKGLDRETFLDLIDRIIGERSGYPDY-DDEDYYDEDDDGWGMVGDDVEFDYTEVINFDQ
NS1AB_TASV1/795-889             QKKKGKTKRTARGGKHALG--KKYLSKAHFSRMRMLTEEEYNKMVEDGFSPDEIKEVVDQL--REQAWQNYLIDNDIGEDDDLDW---YDDMLED--ERLNEEI
#=GC seq_cons                   QKKKGKT.......KHuhG..++.LpKu....h+hLTEEEYpchlEcGhs.-phh-llDpl..ccpua.sY..DpDhh--DD.sW...hDDh..D..EhlN.-.
//