#=GF ID   Atg11_middle
#=GF AC   PF19697.3
#=GF DE   Atg11 middle domain
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF AU   Wood V;0000-0001-6330-7526
#=GF SE   UniProt accession O14261
#=GF GA   26.00 26.00;
#=GF TC   26.40 26.40;
#=GF NC   25.50 22.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   32909946
#=GF RT   Atg1 kinase in fission yeast is activated by Atg11-mediated
#=GF RT   dimerization and cis-autophosphorylation.
#=GF RA   Pan ZQ, Shao GC, Liu XM, Chen Q, Dong MQ, Du LL;
#=GF RL   Elife. 2020; [Epub ahead of print]
#=GF DR   INTERPRO; IPR045593;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain represents the region comprised between residues 522
#=GF CC   and 583 from fission yeast protein Atg11, which is necessary and
#=GF CC   sufficient for Atg11 autophagy function and for supporting Atg1
#=GF CC   kinase activity as it harbours an Atg1-binding domain at the
#=GF CC   N-terminal and a homodimerisation domain at the C-terminal. The
#=GF CC   N-terminal part contains the conserved aromatic residues Phe and
#=GF CC   Tyr necessary for the direct and specific interaction with the
#=GF CC   tMIT domain of Atg1. This interaction is required for the
#=GF CC   autophagy function of Atg11. The C-terminal part of this domain,
#=GF CC   residues 546-583, is predicted to adopt a coiled-coil
#=GF CC   conformation which mediates Atg11 homodimerisation [1]. It seems
#=GF CC   to be conserved among Schizosaccharomyces.
#=GF SQ   3
#=GS ATG11_SCHPO/511-589   AC O14261.2
#=GS S9VXW3_SCHCR/519-597  AC S9VXW3.1
#=GS B6K701_SCHJY/519-594  AC B6K701.1
ATG11_SCHPO/511-589              ....APHPPINEQSNSSQPFYRVSPSIVPLNVIRKLTNRKTSFTDS.HILRLQDEVNQLRNELDLVNKRNEDLLIELQGKEEKI...
S9VXW3_SCHCR/519-597             ....PNTPRADVMDDGSQPFYRTSPSIVPLNIIRKFSQRKTSFSEG.LASKYQVEVEQLRHELGEVVKRNSNLSIELNSKKERV...
B6K701_SCHJY/519-594             leks--------KSQGTAPFFEESPSLIPISVIQQLSRGGSNPQESaQIQQLKSEISNLQTQLAQANLRIEEQNGELKSKN---ili
#=GC seq_cons                    ....sspP.hs.pSsGSQPFYRsSPSIVPLNVIRKLSpRKTSFoES.pIp+LQsEVsQLRsELupVNKRNE-LsIELpSKcE+l...
//