#=GF ID   Attachment_P66
#=GF AC   PF11263.12
#=GF DE   Borrelia burgdorferi attachment protein P66 
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_003349 (release 23.0)
#=GF GA   25.20 25.20;
#=GF TC   25.60 437.90;
#=GF NC   20.80 25.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12748384
#=GF RT   Targeted mutation of the outer membrane protein P66 disrupts
#=GF RT   attachment of the Lyme disease agent, Borrelia burgdorferi, to
#=GF RT   integrin alphavbeta3. 
#=GF RA   Coburn J, Cugini C; 
#=GF RL   Proc Natl Acad Sci U S A. 2003;100:7301-7306.
#=GF DR   INTERPRO; IPR020967;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   P66 is an outer membrane protein in Borrelia burgdorferi, the
#=GF CC   agent of Lyme disease. P66 has a role in the attachment of
#=GF CC   Borrelia burgdorferi to human cell-surface receptors [1].
#=GF SQ   2
#=GS W6TMW5_9SPIR/336-566  AC W6TMW5.1
#=GS H7C7N8_BORBU/328-580  AC H7C7N8.1
W6TMW5_9SPIR/336-566             SDFSILGHISRKAN------TDEKKQ---FDPVSNKLQFDTKRTPNFEFSVGTGIGLAWNTDEGEEESWEIKGSKSYNKRIFGAQDKKSGIGFGINYGKSLYRPTSSNTLIQNIAKKSFQTLNAELSTYEDNKKGIIPGLGWIASIGIYDLLRDKPKSD--DIIAALTPN-------T-TLTNKTNIEFASATQLGGALYLDYAIPLKSMSPNTYIIPYVGAHMLG---TLNFPKNTLYLKAGLELENLIKLT
H7C7N8_BORBU/328-580             SDFSIFGHISKAANFKKETPSDPNKKAEIFDPNGNALNFSKNTELGIAFSTGASIGFAWNKDTGEKESWAIKGSDSYSTRLFGEQDKKSGVALGISYGQNLYRSKDTEKRLKTISENAFQSLNVEISSYEDNKKGIINGLGWITSIGLYDILRQKSVENYPTTISSTTENNQTEQSSTSTKTTTPNLTFEDAMKLGLALYLDYAIPIASISTEAYVVPYIGAYILGPSNKLSSDATKIYLKTGLSLEKLIRFT
#=GC seq_cons                    SDFSIhGHIS+tAN......oD.pKp...FDPsuNtLpFspppp.shtFSsGsuIGhAWNpDpGEcESWtIKGScSYspRlFGtQDKKSGluhGIsYGpsLYRspsopphlpsIucpuFQoLNsElSoYEDNKKGIIsGLGWIsSIGlYDlLRpKshps..shIuuhT.N.......T.ThTspsNlpFtsAhpLGhALYLDYAIPltShSspsYllPYlGAahLG...pLs.stsplYLKsGLpLEpLI+hT
//